Jeffrey L. Browning, PhD

Research Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies.

Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is clear that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. Using this foundation, we have been studying the stromal underpinnings of the perivascular adventitial compartment. this compartment is considered crucial to harbor stem cells, tissue resident leucocytes and sense and initiate repair/remodelling efforts after injury. Human skin has provided an excellent tool to observe these stromal perivascular networks.

Publications

  • Published 8/7/2024

    Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M. ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. Arthritis Rheumatol. 2024 Nov; 76(11):1645-1657. PMID: 38965683.

    Read at: PubMed

  • Published 4/23/2024

    Etesami NS, Barker KA, Shenoy AT, De Ana CL, Arafa EI, Grifno GN, Matschulat AM, Vannini ME, Pihl RMF, Breen MP, Soucy AM, Goltry WN, Ha CT, Betsuyaku H, Browning JL, Varelas X, Traber KE, Jones MR, Quinton LJ, Maglione PJ, Nia HT, Belkina AC, Mizgerd JP. B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Front Immunol. 2024; 15:1382638. PMID: 38715601.

    Read at: PubMed

  • Published 1/19/2023

    Browning JL, Bhawan J, Tseng A, Crossland N, Bujor AM, Akassoglou K, Assassi S, Skaug B, Ho J. Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis. bioRxiv. 2023 Jan 19. PMID: 36711912.

    Read at: PubMed

  • Published 5/4/2022

    Nayar S, Pontarini E, Campos J, Berardicurti O, Smith CG, Asam S, Gardner DH, Colafrancesco S, Lucchesi D, Coleby R, Chung MM, Iannizzotto V, Hunter K, Bowman SJ, Carlesso G, Herbst R, McGettrick HM, Browning J, Buckley CD, Fisher BA, Bombardieri M, Barone F. Immunofibroblasts regulate LTa3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction. Commun Biol. 2022 May 04; 5(1):413. PMID: 35508704.

    Read at: PubMed

  • Published 8/1/2021

    Gommerman JL, Browning JL. Queen's Gambit: B Cell to Follicle. J Immunol. 2021 08 01; 207(3):753-754. PMID: 34321285.

    Read at: PubMed

View All 128 Publications:   View Full Profile in BUMC

Other Positions

  • Research Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Arthritis & Autoimmune Diseases Research Center
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Wisconsin Madison, PhD
  • Michigan State University, BS

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