Jacqueline Sharon, PhD

Professor, Pathology & Laboratory Medicine

Jacqueline Sharon
617.638.4652
670 Albany St Biosquare III

Biography

Jacqueline Sharon, PhD is a current Professor of Pathology and Laboratory Medicine at the Boston University School of Medicine. After earning her PhD at Columbia University, she completed a Postdoc at Harvard University. She currently receives funding from the National Institutes of Health for her research on B Cell Epitope Discovery and Mechanisms of Antibody Protection. Dr. Sharon’s laboratory is interested in the development of vaccines and immunotherapeutics against bacterial pathogens. Current research focuses on the discovery and validation of antigens and epitopes that induce protective antibodies to Francisella tularensis, a Gram negative facultative intracellular bacterium that causes tularemia.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Research Associate Professor, Biochemistry, Boston University School of Medicine

Education

  • Columbia University, PhD
  • Columbia University, MPhil
  • Queens College, City University of New York, MA
  • Queens College, City University of New York, BA

Publications

  • Published on 8/1/2014

    Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45. PMID: 25171003.

    Read at: PubMed
  • Published on 6/26/2014

    Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847. PMID: 24968190.

    Read at: PubMed
  • Published on 5/1/2014

    Sharon J, Rynkiewicz MJ, Lu Z, Yang CY. Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. Immunology. 2014 May; 142(1):1-23. PMID: 24219801.

    Read at: PubMed
  • Published on 12/18/2013

    Lu Z, Perkins HM, Sharon J. Antibodies to both terminal and internal B-cell epitopes of Francisella tularensis O-polysaccharide produced by patients with tularemia. Clin Vaccine Immunol. 2014 Feb; 21(2):227-33. PMID: 24351753.

    Read at: PubMed
  • Published on 11/1/2013

    Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89. PMID: 23844703.

    Read at: PubMed
  • Published on 7/2/2012

    Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94. PMID: 22747335.

    Read at: PubMed
  • Published on 7/1/2012

    Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60. PMID: 22486311.

    Read at: PubMed
  • Published on 11/28/2011

    Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50. PMID: 22091710.

    Read at: PubMed
  • Published on 2/1/2011

    Roche MI, Lu Z, Hui JH, Sharon J. Characterization of monoclonal antibodies to terminal and internal O-antigen epitopes of Francisella tularensis lipopolysaccharide. Hybridoma (Larchmt). 2011 Feb; 30(1):19-28. PMID: 21466282.

    Read at: PubMed
  • Published on 9/17/2007

    Liebman MA, Roche MI, Williams BR, Kim J, Pageau SC, Sharon J. Antibody treatment of human tumor xenografts elicits active anti-tumor immunity in nude mice. Immunol Lett. 2007 Nov 30; 114(1):16-22. PMID: 17920694.

    Read at: PubMed

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