Jacqueline Sharon, PhD is a current Professor of Pathology and Laboratory Medicine at the Boston University School of Medicine. After earning her PhD at Columbia University, she completed a Postdoc at Harvard University. She currently receives funding from the National Institutes of Health for her research on B Cell Epitope Discovery and Mechanisms of Antibody Protection. Dr. Sharon’s laboratory is interested in the development of vaccines and immunotherapeutics against bacterial pathogens. Current research focuses on the discovery and validation of antigens and epitopes that induce protective antibodies to Francisella tularensis, a Gram negative facultative intracellular bacterium that causes tularemia.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Research Associate Professor, Biochemistry, Boston University School of Medicine
- Columbia University, PhD
- Columbia University, MPhil
- Queens College, City University of New York, MA
- Queens College, City University of New York, BA
- Published on 8/1/2014
Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45. PMID: 25171003.
- Published on 6/26/2014
Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847. PMID: 24968190.
- Published on 5/1/2014
Sharon J, Rynkiewicz MJ, Lu Z, Yang CY. Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. Immunology. 2014 May; 142(1):1-23. PMID: 24219801.
- Published on 12/18/2013
Lu Z, Perkins HM, Sharon J. Antibodies to both terminal and internal B-cell epitopes of Francisella tularensis O-polysaccharide produced by patients with tularemia. Clin Vaccine Immunol. 2014 Feb; 21(2):227-33. PMID: 24351753.
- Published on 11/1/2013
Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89. PMID: 23844703.
- Published on 7/2/2012
Rynkiewicz MJ, Lu Z, Hui JH, Sharon J, Seaton BA. Structural analysis of a protective epitope of the Francisella tularensis O-polysaccharide. Biochemistry. 2012 Jul 17; 51(28):5684-94. PMID: 22747335.
- Published on 7/1/2012
Lu Z, Madico G, Roche MI, Wang Q, Hui JH, Perkins HM, Zaia J, Costello CE, Sharon J. Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia. Immunology. 2012 Jul; 136(3):352-60. PMID: 22486311.
- Published on 11/28/2011
Wang Q, Shi X, Leymarie N, Madico G, Sharon J, Costello CE, Zaia J. A typical preparation of Francisella tularensis O-antigen yields a mixture of three types of saccharides. Biochemistry. 2011 Dec 20; 50(50):10941-50. PMID: 22091710.
- Published on 2/1/2011
Roche MI, Lu Z, Hui JH, Sharon J. Characterization of monoclonal antibodies to terminal and internal O-antigen epitopes of Francisella tularensis lipopolysaccharide. Hybridoma (Larchmt). 2011 Feb; 30(1):19-28. PMID: 21466282.
- Published on 9/17/2007
Liebman MA, Roche MI, Williams BR, Kim J, Pageau SC, Sharon J. Antibody treatment of human tumor xenografts elicits active anti-tumor immunity in nude mice. Immunol Lett. 2007 Nov 30; 114(1):16-22. PMID: 17920694.
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