Irving J. Bigio, PhD

Professor, Boston University College of Engineering

Biography

Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Publications

  • Published 10/28/2025

    Gray AJ, Robinson RE, Berghol SA, Rosene DL, Moore TL, Bigio IJ. Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury. Neurophotonics. 2025 Oct; 12(4):045006. PMID: 41181030.

    Read at: PubMed

  • Published 9/3/2025

    Halvorsen SC, Gkousioudi A, Nicks R, Alvarez VE, Bigio IJ, Zaia J, Stein TD, Zhang Y. Cerebrovascular remodeling in aging and neurodegenerative disease progression. Front Bioeng Biotechnol. 2025; 13:1597917. PMID: 40969224.

    Read at: PubMed

  • Published 8/13/2025

    Abdelhakeem AA, Chang S, Novoseltseva A, Hyman M, Mckee AC, Bigio IJ, Boas DA, Huber BR, Wang H. Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy. Neurophotonics. 2025 Jul; 12(3):035007. PMID: 40809089.

    Read at: PubMed

  • Published 8/1/2025

    Novoseltseva A, Kureli G, Chang S, Yang J, Antinew PD, Chandra A, Berghol S, Spurlock E, McKee AC, Huber B, Wang H, Boas DA, Bigio IJ. Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy. Alzheimers Dement. 2025 Aug; 21(8):e70582. PMID: 40843933.

    Read at: PubMed

  • Published 7/14/2025

    Aslan M, Gray AJ, Packard L, Giorgetta C, Bigio IJ, Ünlü MS. Impact of uniform illumination in widefield microscopy and mesoscopy. Sci Rep. 2025 Jul 14; 15(1):25400. PMID: 40659689.

    Read at: PubMed

View All 102 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS

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