Hoon Ryu, PhD

Adjunct Associate Professor, Neurology

Hoon Ryu
150 S Huntington Avenue


Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Boston University School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • VA Boston Healthcare System



  • Chonbuk National University, PhD
  • Chonbuk National University, MS
  • Chonbuk National University, BS


  • Published on 4/7/2022

    Yoon Y, Kim S, Seol Y, Im H, Park U, Han HB, Choi JH, Ryu H. Increases of Phosphorylated Tau (Ser202/Thr205) in the Olfactory Regions Are Associated with Impaired EEG and Olfactory Behavior in Traumatic Brain Injury Mice. Biomedicines. 2022 Apr 07; 10(4). PMID: 35453615.

    Read at: PubMed
  • Published on 2/24/2022

    Woo HY, Oh SY, Lim L, Im H, Lee H, Ryu HG. Efficacy of nutritional support protocol for patients with pressure ulcer: comparison of before and after the protocol. Nutrition. 2022 Feb 24; 99-100:111638. PMID: 35576874.

    Read at: PubMed
  • Published on 2/23/2022

    Kim JH, Kwon O, Bhusal A, Lee J, Hwang EM, Ryu H, Park JY, Suk K. Neuroinflammation Induced by Transgenic Expression of Lipocalin-2 in Astrocytes. Front Cell Neurosci. 2022; 16:839118. PMID: 35281301.

    Read at: PubMed
  • Published on 1/10/2022

    Gyawali A, Latif S, Choi SH, Hyeon SJ, Ryu H, Kang YS. Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis. J Biomed Sci. 2022 Jan 10; 29(1):2. PMID: 35012534.

    Read at: PubMed
  • Published on 1/1/2022

    Lee S, Kim TK, Choi JE, Choi Y, You M, Ryu J, Chun YL, Ham S, Hyeon SJ, Ryu H, Kim HS, Im HI. Dysfunction of striatal MeCP2 is associated with cognitive decline in a mouse model of Alzheimer's disease. Theranostics. 2022; 12(3):1404-1418. PMID: 35154497.

    Read at: PubMed
  • Published on 12/1/2021

    Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim J, Londhe AM, Gotina L, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo H, Ryu H, Min SJ. Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model. J Enzyme Inhib Med Chem. 2021 Dec; 36(1):856-868. PMID: 33771089.

    Read at: PubMed
  • Published on 11/19/2021

    Kim C, Yousefian-Jazi A, Choi SH, Chang I, Lee J, Ryu H. Non-Cell Autonomous and Epigenetic Mechanisms of Huntington's Disease. Int J Mol Sci. 2021 Nov 19; 22(22). PMID: 34830381.

    Read at: PubMed
  • Published on 10/20/2021

    Koh W, Park M, Chun YE, Lee J, Shim HS, Park MG, Kim S, Sa M, Joo J, Kang H, Oh SJ, Woo J, Chun H, Lee SE, Hong J, Feng J, Li Y, Ryu H, Cho J, Lee CJ. Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biol Psychiatry. 2022 04 15; 91(8):740-752. PMID: 34952697.

    Read at: PubMed
  • Published on 10/8/2021

    Prasad R, Jung H, Tan A, Song Y, Moon S, Shaker MR, Sun W, Lee J, Ryu H, Lim HK, Jho EH. Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Sci Rep. 2021 10 08; 11(1):20075. PMID: 34625606.

    Read at: PubMed
  • Published on 7/7/2021

    Subramanian M, Hyeon SJ, Das T, Suh YS, Kim YK, Lee JS, Song EJ, Ryu H, Yu K. Publisher Correction: UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation. Nat Commun. 2021 Jul 07; 12(1):4257. PMID: 34234153.

    Read at: PubMed

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