Hoon Ryu, PhD

Adjunct Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.

Research Interests:

Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.

Publications

  • Published 4/24/2026

    Verkhratsky A, Lee CJ, Chun H, Göritz C, Harkany T, Lee JH, Lee S, Lindskog M, Koh W, Mulder J, Nam MH, Ottersen OP, Pekna M, Pekny M, Pekowska A, Ryu H, Sohn CH, Tretiakov EO, Untiet V, Viney TJ, Youn W, Yi C, Zorec R, Yun M, Cheong E, Nordberg A. Curing the brain: in search for new astrocyte-specific therapies. Exp Mol Med. 2026 Apr; 58(4):1086-1127. PMID: 42032208.

    Read at: PubMed

  • Published 4/9/2026

    Darsono WHW, Hwang Y, Valencia E, Gunawan LT, Hyeon SJ, Ryu H, Stein TD, Chang MY, Wulansari N, Lee SH. Dysregulation of astrocytic DNAJC6 contributes to sporadic Parkinson's disease pathogenesis. J Clin Invest. 2026 Jun 01; 136(11). PMID: 41955024.

    Read at: PubMed

  • Published 2/5/2026

    Kim HY, Kim S, Akaydin AN, Kim S, Hyeon SJ, Lee J, Ryu H. The rise of astrocytes: are they guardians or troublemakers of the brain disorder? Exp Mol Med. 2026 Mar; 58(2):301-318. PMID: 41639424.

    Read at: PubMed

  • Published 1/21/2026

    Lee E, Park MY, Park M, Kim NY, Wei S, Hwang N, Ryu D, Ryu H, Park D, Lee G, Oh CM. Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology in a Parkinson's disease mouse model. NPJ Parkinsons Dis. 2026 Jan 21; 12(1):49. PMID: 41559062.

    Read at: PubMed

  • Published 1/19/2026

    Nguyen PTT, Yousefian-Jazi A, Hyeon SJ, Lee S, Kim SC, Park U, Jeong Y, Kim S, Kim S, Kim Y, Ryu HL, Lee KE, Stein TD, Myers RH, Hwang EM, Lee J, Ryu H. Astrocytic noncanonical WNT5B signaling modulates extracellular matrix remodeling and neuropathology in Huntington's disease. Signal Transduct Target Ther. 2026 Jan 19; 11(1):23. PMID: 41549079.

    Read at: PubMed

View All 191 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • Chonbuk National University, PhD
  • Chonbuk National University, MS
  • Chonbuk National University, BS

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