Gwynneth D. Offner, PhD

Associate Professor, Medicine

Gwynneth Offner
(617) 638-8221
72 E. Concord St Instructional (L)

Biography

Gwynneth D. Offner, Ph.D. is the Director of the M.A. in Medical Sciences Program and an Associate Professor in the Department of Medicine. While her primary focus is teaching, advising and mentoring students, Dr. Offner has also directed an NIH-funded research program for nearly 25 years. Dr. Offner grew up in the Washington, D.C. area and came to Boston to attend Wellesley College where she majored in Chemistry. She subsequently received a Ph.D. in Biochemistry from BU School of Medicine and has been on the faculty here since 1986. She teaches in the Biochemistry courses for both medical and graduate students and is Director of the Biochemistry course for M.A. in Medical Sciences students. Her research focuses on the structure and biological functions of a group of glycoproteins called mucins. These proteins serve as part of the non-immune host defense system and have been linked to many diseases including cancer, cystic fibrosis and inflammatory bowel disease.

Other Positions

  • Assistant Dean, Admissions, Boston University School of Medicine
  • Research Assistant Professor, Biochemistry, Boston University School of Medicine
  • Mentor for Graduate Medical Students, Boston University School of Medicine, Division of Graduate Medical Sciences
  • Boston Medical Center

Education

  • Boston University, PhD
  • Wellesley College, BA

Publications

  • Published on 4/28/2016

    Gallan AJ, Offner GD, Symes K. Vertical integration of biochemistry and clinical medicine using a near-peer learning model. Biochem Mol Biol Educ. 2016 Nov 12; 44(6):507-516. PMID: 27123831.

    Read at: PubMed
  • Published on 12/12/2012

    Oppenheim FG, Helmerhorst EJ, Lendenmann U, Offner GD. Anti-candidal activity of genetically engineered histatin variants with multiple functional domains. PLoS One. 2012; 7(12):e51479. PMID: 23251551.

    Read at: PubMed
  • Published on 5/3/2011

    Soares RV, Offner GD, Assis MA, Silva KC, Zenóbio EG. An unusual glycoform of human salivary mucin MG2. Clin Oral Investig. 2012 Jun; 16(3):761-6. PMID: 21538073.

    Read at: PubMed
  • Published on 12/6/2010

    Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55. PMID: 21080726.

    Read at: PubMed
  • Published on 2/23/2010

    Nunes D, Fleming C, Offner G, Craven D, Fix O, Heeren T, Koziel MJ, Graham C, Tumilty S, Skolnik P, Stuver S, Horsburgh CR, Cotton D. Noninvasive markers of liver fibrosis are highly predictive of liver-related death in a cohort of HCV-infected individuals with and without HIV infection. Am J Gastroenterol. 2010 Jun; 105(6):1346-53. PMID: 20179698.

    Read at: PubMed
  • Published on 12/15/2005

    Nunes D, Fleming C, Offner G, O'Brien M, Tumilty S, Fix O, Heeren T, Koziel M, Graham C, Craven DE, Stuver S, Horsburgh CR. HIV infection does not affect the performance of noninvasive markers of fibrosis for the diagnosis of hepatitis C virus-related liver disease. J Acquir Immune Defic Syndr. 2005 Dec 15; 40(5):538-44. PMID: 16284529.

    Read at: PubMed
  • Published on 11/15/2005

    Chen ZY, Wang X, Zhou Y, Offner G, Tseng CC. Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway. Cancer Res. 2005 Nov 15; 65(22):10394-400. PMID: 16288030.

    Read at: PubMed
  • Published on 9/16/2005

    Bruno LS, Li X, Wang L, Soares RV, Siqueira CC, Oppenheim FG, Troxler RF, Offner GD. Two-hybrid analysis of human salivary mucin MUC7 interactions. Biochim Biophys Acta. 2005 Oct 30; 1746(1):65-72. PMID: 16203048.

    Read at: PubMed
  • Published on 9/13/2005

    Li X, Wang L, Nunes DP, Troxler RF, Offner GD. Suppression of MUC1 synthesis downregulates expression of the epidermal growth factor receptor. Cancer Biol Ther. 2005 Sep; 4(9):968-73. PMID: 16082192.

    Read at: PubMed
  • Published on 5/1/2004

    Soares RV, Lin T, Siqueira CC, Bruno LS, Li X, Oppenheim FG, Offner G, Troxler RF. Salivary micelles: identification of complexes containing MG2, sIgA, lactoferrin, amylase, glycosylated proline-rich protein and lysozyme. Arch Oral Biol. 2004 May; 49(5):337-43. PMID: 15041480.

    Read at: PubMed

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