George J. Murphy, PhD

Associate Professor, Medicine

George Murphy
617.358.0846
670 Albany St., Suite 208

Biography

I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Developmental hematopoiesis
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Pluripotent stem cell-based modeling of hematopoiesis: a Platform for Production of Transfusable Human Blood Cells
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’: Sickle Cell Anemia; Amyloidosis
5.) Understanding the molecular and functional basis of exceptional longevity: Dissecting resistance to aging-related disease

Other Positions

  • Member, Pulmonary Center, Boston University
  • Co-Director, Center for Regenerative Medicine, Boston University
  • Member, Center of Excellence in Sickle Cell Disease, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Boston Medical Center
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute, Boston University

Education

  • University of Oxford, PhD
  • Trinity College, BS

Publications

  • Published on 11/28/2023

    Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912. PMID: 37729429.

    Read at: PubMed
  • Published on 9/27/2023

    Hoffman SE, Dowrey TW, Villacorta Martin C, Bi K, Titchen B, Johri S, DelloStritto L, Patel M, Mackichan C, Inga S, Chen J, Grimaldi G, Napolitano S, Wakiro I, Wu J, Yeung J, Rotem A, Sicinska E, Shannon E, Clancy T, Wang J, Denning S, Brais L, Besson NR, Pfaff KL, Huang Y, Kao KZ, Rodig S, Hornick JL, Vigneau S, Park J, Kulke MH, Chan J, Van Allen EM, Murphy GJ. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. Sci Adv. 2023 Sep 29; 9(39):eadd9668. PMID: 37756410.

    Read at: PubMed
  • Published on 7/19/2023

    Kretov DA, Folkes L, Mora-Martin A, Syedah N, Walawalkar IA, Vanyustel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. bioRxiv. 2023 Jul 19. PMID: 37503141.

    Read at: PubMed
  • Published on 7/13/2023

    Ghosh S, Villacorta-Martin C, Lindstrom-Vautrin J, Kenney D, Golden CS, Edwards CV, Sanchorawala V, Connors LH, Giadone RM, Murphy GJ. Mapping cellular response to destabilized transthyretin reveals cell- and amyloidogenic protein-specific signatures. Amyloid. 2023 Dec; 30(4):379-393. PMID: 37439769.

    Read at: PubMed
  • Published on 3/31/2023

    Karagiannis TT, Dowrey TW, Villacorta-Martin C, Montano M, Reed E, Belkina AC, Andersen SL, Perls TT, Monti S, Murphy GJ, Sebastiani P. Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity. EBioMedicine. 2023 Apr; 90:104514. PMID: 37005201.

    Read at: PubMed
  • Published on 11/3/2022

    Heinze D, Park S, McCracken A, Haratianfar M, Lindstrom J, Villacorta-Martin C, Mithal A, Wang F, Yang MW, Murphy G, Mostoslavsky G. Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs. Stem Cell Reports. 2022 Dec 13; 17(12):2610-2628. PMID: 36332629.

    Read at: PubMed
  • Published on 7/19/2022

    Sae-Lee W, McCafferty CL, Verbeke EJ, Havugimana PC, Papoulas O, McWhite CD, Houser JR, Vanuytsel K, Murphy GJ, Drew K, Emili A, Taylor DW, Marcotte EM. The protein organization of a red blood cell. Cell Rep. 2022 Jul 19; 40(3):111103. PMID: 35858567.

    Read at: PubMed
  • Published on 4/11/2022

    Teo WW, Cao X, Wu CS, Tan HK, Zhou Q, Gao C, Vanuytsel K, Kumar SS, Murphy GJ, Yang H, Chai L, Tenen DG. Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation. Commun Biol. 2022 Apr 11; 5(1):343. PMID: 35411071.

    Read at: PubMed
  • Published on 3/7/2022

    Vanuytsel K, Yeung AK, Dowrey TW, Murphy GJ, Belkina AC. CPHEN-013: Comprehensive phenotyping of hematopoietic stem and progenitor cells in the human fetal liver. Cytometry A. 2022 Nov; 101(11):903-908. PMID: 35253987.

    Read at: PubMed
  • Published on 3/1/2022

    Vanuytsel K, Villacorta-Martin C, Lindstrom-Vautrin J, Wang Z, Garcia-Beltran WF, Vrbanac V, Parsons D, Lam EC, Matte TM, Dowrey TW, Kumar SS, Li M, Wang F, Yeung AK, Mostoslavsky G, Dries R, Campbell JD, Belkina AC, Balazs AB, Murphy GJ. Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment. Nat Commun. 2022 03 01; 13(1):1103. PMID: 35232959.

    Read at: PubMed

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