Flora Sam, MD

Professor, Medicine

Flora Sam
88 E. Newton St Newton Pavilion


Dr. Sam is the present Director, ad interim, of the Whitaker Cardiovascular Institute. She is an advanced heart failure clinical cardiologist and a physician-scientist. She is a translational researcher and the PI of her NIH funded lab. She is an expert in cardiac myocyte biology and in mechanisms of myocardial remodeling in cardiomyopathy, both in humans and animal models. She is a recognized expert in “heart failure with preserved ejection fraction” (HFpEF) /diastolic heart failure and “heart failure with reduced ejection fraction” (HFrEF)/systolic heart failure and cardiomyopathies.

The Sam lab is focused on three major areas of investigation:
1) Pro-inflammatory and pro-fibrotic mechanisms that mediate cardiac remodeling in heart failure, cardiac hypertrophy and hypertension.
2) Investigating the relationship between matrix markers and heart failure in humans with cardiac amyloid and scleroderma.
3) Investigating cross talk between adipocyte-derived factors, myokines and cardiokines in heart failure.

Other Positions

  • Member, Whitaker Cardiovascular Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences


  • University of the Witwatersrand, MD


  • Published on 3/1/2021

    Saw EL, Ramachandran S, Valero-Muñoz M, Sam F. Skeletal muscle (dys)function in heart failure with preserved ejection fraction. Curr Opin Cardiol. 2021 Mar 01; 36(2):219-226. PMID: 33394707.

    Read at: PubMed
  • Published on 1/28/2021

    Valero-Muñoz M, Sam F. Reply to letter by Ye et al., blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy. Int J Cardiol. 2021 Jan 28. PMID: 33515616.

    Read at: PubMed
  • Published on 1/27/2021

    Valero-Muñoz M, Sam F. Reply to letter by Hou et al., Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes. Int J Cardiol. 2021 Jan 27. PMID: 33515614.

    Read at: PubMed
  • Published on 7/16/2020

    Valero-Muñoz M, Wilson RM, Bretón-Romero R, Croteau D, Seldin DC, Sam F. Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes. Int J Cardiol. 2020 Dec 15; 321:133-136. PMID: 32682005.

    Read at: PubMed
  • Published on 3/23/2020

    Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, Wang TJ, Desvigne-Nickens P, Adhikari BB. Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Circulation. 2020 03 24; 141(12):1001-1026. PMID: 32202936.

    Read at: PubMed
  • Published on 8/24/2019

    Butt SA, Jeppesen JL, Torp-Pedersen C, Sam F, Gislason GH, Jacobsen S, Andersson C. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study. J Am Heart Assoc. 2019 09 03; 8(17):e013405. PMID: 31446827.

    Read at: PubMed
  • Published on 8/2/2019

    Oh A, Okazaki R, Sam F, Valero-Muñoz M. Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales. Front Cardiovasc Med. 2019; 6:110. PMID: 31428620.

    Read at: PubMed
  • Published on 6/12/2019

    Tahir UA, Doros G, Kim JS, Connors LH, Seldin DC, Sam F. Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure. Sci Rep. 2019 06 12; 9(1):8552. PMID: 31189919.

    Read at: PubMed
  • Published on 4/9/2019

    Yunis A, Doros G, Luptak I, Connors LH, Sam F. Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis. Am J Cardiol. 2019 07 01; 124(1):122-130. PMID: 31053293.

    Read at: PubMed
  • Published on 3/1/2018

    Valero-Muñoz M, Sam F. Reply: Diet-Induced Obesity HFpEF Murine Models. JACC Basic Transl Sci. 2018 Feb; 3(1):158-159. PMID: 30062201.

    Read at: PubMed

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