Dr. Landesman’s research has focused on studying the role of protein kinase CK2, a highly conserved and constitutively expressed serine-threonine kinase. In vitro and transgenic mouse models were used to study the role of CK2 in breast tumorigenesis and the synergism of CK2 with the absence of p53 in lymphoma development. Genetic disruption of the catalytic subunits of CK2: CK2a and CK2a’ have uncovered the impact of CK2 in mouse embryonic development. Current research attempts to characterize the consequences of compounded reduction of CK2 catalytic subunits in mice. Dr. Landesman-Bollag obtained her PhD and did her postdoctoral training at Boston University School of Medicine in the laboratory of the late Dr. David Seldin. She is Instructor of Hematology & Medical Oncology at Boston University School of Medicine.
- Boston University, PhD
- The Hebrew University of Jerusalem, MS
- The Hebrew University of Jerusalem, BS
- Published on 5/1/2021
Zhou Y, Lian H, Shen N, Korm S, Kwok Ping Lam A, Layton O, Huiting LN, Li D, Miao K, Zeng A, Landesman-Bollag E, Seldin DC, Fu H, Hong L, Feng H. The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 2021 05 01; 106(5):1461-1465. PMID: 32817283.
- Published on 10/6/2016
Lian H, Li D, Zhou Y, Landesman-Bollag E, Zhang G, Anderson NM, Tang KC, Roderick JE, Kelliher MA, Seldin DC, Fu H, Feng H. CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica. 2017 01; 102(1):e17-e21. PMID: 27758824.
- Published on 8/29/2016
Novikov O, Wang Z, Stanford EA, Parks AJ, Ramirez-Cardenas A, Landesman E, Laklouk I, Sarita-Reyes C, Gusenleitner D, Li A, Monti S, Manteiga S, Lee K, Sherr DH. An Aryl Hydrocarbon Receptor-Mediated Amplification Loop That Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells. Mol Pharmacol. 2016 Nov; 90(5):674-688. PMID: 27573671.
- Published on 3/16/2016
Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol. 2016 Mar 16; 14:20. PMID: 26984638.
- Published on 10/10/2012
Romagnoli M, Belguise K, Yu Z, Wang X, Landesman-Bollag E, Seldin DC, Chalbos D, Barillé-Nion S, Jézéquel P, Seldin ML, Sonenshein GE. Epithelial-to-mesenchymal transition induced by TGF-ß1 is mediated by Blimp-1-dependent repression of BMP-5. Cancer Res. 2012 Dec 1; 72(23):6268-78. PMID: 23054396.
- Published on 7/19/2011
Landesman-Bollag E, Belkina A, Hovey B, Connors E, Cox C, Seldin DC. Developmental and growth defects in mice with combined deficiency of CK2 catalytic genes. Mol Cell Biochem. 2011 Oct; 356(1-2):227-31. PMID: 21769451.
- Published on 7/2/2008
Seldin DC, Lou DY, Toselli P, Landesman-Bollag E, Dominguez I. Gene targeting of CK2 catalytic subunits. Mol Cell Biochem. 2008 Sep; 316(1-2):141-7. PMID: 18594950.
- Published on 10/22/2007
Lou DY, Dominguez I, Toselli P, Landesman-Bollag E, O'Brien C, Seldin DC. The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol. 2008 Jan; 28(1):131-9. PMID: 17954558.
- Published on 12/15/2005
Eddy SF, Guo S, Demicco EG, Romieu-Mourez R, Landesman-Bollag E, Seldin DC, Sonenshein GE. Inducible IkappaB kinase/IkappaB kinase epsilon expression is induced by CK2 and promotes aberrant nuclear factor-kappaB activation in breast cancer cells. Cancer Res. 2005 Dec 15; 65(24):11375-83. PMID: 16357145.
- Published on 11/1/2005
Demicco EG, Kavanagh KT, Romieu-Mourez R, Wang X, Shin SR, Landesman-Bollag E, Seldin DC, Sonenshein GE. RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland. Mol Cell Biol. 2005 Nov; 25(22):10136-47. PMID: 16260626.
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