Dr. Klings is an Associate Professor in the Department of Medicine. She attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center. Additionally, she has a clinic in the Pulmonary Hypertension Center at Boston Medical Center where she is involved in the diagnosis, evaluation and treatment of patients with pulmonary hypertension. She has special interest in the management of patients with chronic dyspnea and is the Medical Director of the Pulmonary Rehabilitation Program.
Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with the Boston Comprehensive Sickle Cell Center,Sickle Cell Genetics Research group and the Cardiovascular Proteomics Center at Boston University. She has phenotypically screened close to 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and has begun to study the role that genetic polymorphisms play in the pathogenesis of this disease process. Along with her collaborators at Boston University, she was instrumental in formation of the multi-center SickleGen consortium which has brought together the largest cohort of prospectively collected SCD patients with well-established cardiopulmonary phenotypes for genetic studies. Known nationally as a leader in the care and treatment of patients with sickle cell disease and pulmonary hypertension, she headed a committee of 25 hematologists, pulmonologists and cardiologists to develop clinical guidelines for the care and treatment of these patients, which is currently under review by the American Thoracic Society.
- Active Staff Privileges, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston Medical Center
- New York University School of Medicine, MD
- New York University, BA
- Published on 6/1/2018
Kim D, Lee KM, Freiman MR, Powell WR, Klings ES, Rinne ST, Miller DR, Rose AJ, Wiener RS. Phosphodiesterase-5 Inhibitor Therapy for Pulmonary Hypertension in the United States. Actual versus Recommended Use. Ann Am Thorac Soc. 2018 Jun; 15(6):693-701. PMID: 29485908.
- Published on 4/18/2018
Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm. 2018 May 07; 15(5):1954-1963. PMID: 29634905.
- Published on 1/20/2018
Cohen RT, Klings ES. Commentary: Heterogeneity of respiratory disease in children and young adults with sickle cell disease. Thorax. 2018 Jun; 73(6):503. PMID: 29353255.
- Published on 12/15/2017
Eckman JR, Hassell KL, Huggins W, Werner EM, Klings ES, Adams RJ, Panepinto JA, Hamilton CM. Standard measures for sickle cell disease research: the PhenX Toolkit sickle cell disease collections. Blood Adv. 2017 Dec 26; 1(27):2703-2711. PMID: 29296922.
- Published on 10/27/2017
Worsham CM, Martin ST, Nouraie SM, Cohen RT, Klings ES. Clinical and laboratory findings associated with sleep disordered breathing in sickle cell disease. Am J Hematol. 2017 12; 92(12):E649-E651. PMID: 28833466.
- Published on 1/25/2017
Weir NA, Saiyed R, Alam S, Conrey A, Desai HD, George MP, Keeley JH, Klings ES, Mehari A, Taylor JG, Minniti CP, Kato GJ. Prostacyclin-analog therapy in sickle cell pulmonary hypertension. Haematologica. 2017 05; 102(5):e163-e165. PMID: 28126964.
- Published on 6/23/2016
Whitesell PL, Owoyemi O, Oneal P, Nouraie M, Klings ES, Rock A, Mellman TA, Berihun T, Lavella J, Taylor RE, Perrine SP. Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease. Sleep Med. 2016 Jun; 22:47-49. PMID: 27544835.
- Published on 1/13/2016
Mehari A, Klings ES. Chronic Pulmonary Complications of Sickle Cell Disease. Chest. 2016 May; 149(5):1313-24. PMID: 26836905.
- Published on 12/8/2015
Cohen RT, Klings ES, Strunk RC. Sickle cell disease: wheeze or asthma? Asthma Res Pract. 2015; 1:14. PMID: 27965767.
- Published on 9/8/2015
Moy ML, Wayne PM, Litrownik D, Beach D, Klings ES, Davis RB, Yeh GY. Long-term Exercise After Pulmonary Rehabilitation (LEAP): Design and rationale of a randomized controlled trial of Tai Chi. Contemp Clin Trials. 2015 Nov; 45(Pt B):458-67. PMID: 26362690.
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