Deborah J. Stearns-Kurosawa, PhD
Emeritus Associate Professor, Pathology & Laboratory Medicine
Biography
Graduate Education and Administration
My position as Associate Provost and Associate Dean ad interim has oversight of the PhD and Master’s programs within the Graduate Medical Sciences of BU’s School of Medicine. Our group takes care of the graduate students from matriculation to graduation and alumni development. My responsibilities are to ensure we provide the highest quality graduate education in the basic and biomedical sciences. Providing resources, budgets, high caliber faculty, thought leaders and career opportunities are our priorities. Our diverse students not only learn the latest in their field of interest, but contribute to paradigm shifts and moving their field forward.
Research Interests (joint appointment in Department of Pathology)
Why is it that some people get a bacterial infection, feel lousy for a few days, take antibiotics and then forget about it when they go back to class or work, but other people get the same infection and die in two weeks in the intensive care unit? It’s all about what pathogen is invading and how our bodies respond to the infection. It’s a highly orchestrated response that requires input from our immune, coagulation, neurologic, and inflammatory pathways. Research interests include:
• Study of enterohemorrhagic Shiga toxin-producing E.coli infection and the toxins from these bacteria. The E.coli O157:H7 serotype is the most common clinical problem.
• Development of models and cell systems to study thrombotic microangiopathies such as HUS, aHUS,TTP and the related DIC
Other Positions
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Genome Science Institute, Boston University
Education
- Cleveland State University, PhD
- Pennsylvania State University, BS
Publications
- Published on 1/1/2021
Hall G, Kurosawa S, Stearns-Kurosawa DJ. Infection of Immunocompetent Conventional Mice with Shiga Toxin-Producing E. coli: The DSS + STEC Model. Methods Mol Biol. 2021; 2291:353-364. PMID: 33704763.
Read at: PubMed - Published on 4/17/2019
Feng F, Thompson MP, Thomas BE, Duffy ER, Kim J, Kurosawa S, Tashjian JY, Wei Y, Andry C, Stearns-Kurosawa DJ. A computational solution to improve biomarker reproducibility during long-term projects. PLoS One. 2019; 14(4):e0209060. PMID: 30995241.
Read at: PubMed - Published on 10/25/2018
Hall G, Kurosawa S, Stearns-Kurosawa DJ. Dextran Sulfate Sodium Colitis Facilitates Colonization with Shiga Toxin-Producing Escherichia coli: a Novel Murine Model for the Study of Shiga Toxicosis. Infect Immun. 2018 11; 86(11). PMID: 30150257.
Read at: PubMed - Published on 2/27/2018
Kara V, Duan C, Gupta K, Kurosawa S, Stearns-Kurosawa DJ, Ekinci KL. Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing. Lab Chip. 2018 02 27; 18(5):743-753. PMID: 29387860.
Read at: PubMed - Published on 9/19/2017
Hall G, Kurosawa S, Stearns-Kurosawa DJ. Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel). 2017 Sep 19; 9(9). PMID: 28925976.
Read at: PubMed - Published on 4/7/2015
Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155. PMID: 25904918.
Read at: PubMed - Published on 1/20/2015
Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86. PMID: 25609181.
Read at: PubMed - Published on 12/31/2014
Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65. PMID: 25705421.
Read at: PubMed - Published on 7/1/2013
Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88. PMID: 23899564.
Read at: PubMed - Published on 6/3/2013
Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6. PMID: 23733336.
Read at: PubMed
View 31 more publications: View full profile at BUMC