David J. Waxman, PhD

Professor, Boston University

Biography

David J. Waxman, PhD is a Biologist with extensive experience in the fields of biochemistry, molecular biology, and enzymology. Over the past 35 years, his lab has made seminal contributions to the research of cancer pharmacology and therapeutics, and steroid-metabolizing enzymes. His current interests include genomic and epigenetic mechanisms controlling liver gene expression, molecular endocrinology and cell signaling through transcriptional networks, role of angiogenesis and innate immune system in cancer therapy and pharmacology, and nuclear receptors and responses to environmental chemicals.

Dr. Waxman has spoken at over 130 conferences and has held appointments at a variety of universities including Harvard Medical School, MIT, and the Weizmann Institute.

Publications

  • Published 5/28/2026

    Tay JK, Sia KC, Mohd Rodhi SH, Gan SU, Fu ZY, Pyatkov M, Kopchick JJ, Waters MJ, Waxman DJ, Lee KO. GH-resistant (Laron) mice: gene therapy with a liver-specific GH receptor causes unbalanced upregulation of female-biased and growth-related genes. Front Endocrinol (Lausanne). 2026; 17:1808977. PMID: 42290866.

    Read at: PubMed

  • Published 5/6/2026

    Lee HK, Pyatkov M, Gavrilova O, Liu N, Demby T, Ye B, Furth PA, Hennighausen L, Waxman DJ. Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism. Endocrinology. 2026 May 06; 167(6). PMID: 42084328.

    Read at: PubMed

  • Published 4/7/2026

    Chang TY, Waxman DJ. HDI-STARR-seq identifies functional GH-regulated sex-biased hepatocyte enhancers linked to liver metabolism and disease. Endocrinology. 2026 Apr 07; 167(5). PMID: 41866306.

    Read at: PubMed

  • Published 1/11/2026

    Chang TY, Waxman DJ. HDI-STARR-seq Identifies Functional GH-regulated Sex-Biased Hepatocyte Enhancers Linked to Liver Metabolism and Disease. bioRxiv. 2026 Jan 11. PMID: 41279641.

    Read at: PubMed

  • Published 12/1/2025

    Lee HK, Pyatkov M, Gavrilova O, Liu N, Demby T, Ye B, Furth PA, Hennighausen L, Waxman DJ. Disease-associated mutations in the STAT5B SH2 domain reprogram hepatic cholesterol and lipid metabolism. bioRxiv. 2025 Dec 01. PMID: 41383779.

    Read at: PubMed

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Other Positions

  • Member, Genome Science Institute
    Boston University
  • Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • Harvard University, PhD
  • Harvard University, PhD
  • Harvard University, AM
  • Queens College, City University of New York, BA

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