David C. Henderson, MD

Professor, Psychiatry

David Henderson
720 Harrison Ave


Dr. David Henderson is a leader in the fields of schizophrenia, medical co-morbidity, and global psychiatry. He directs the Chester Pierce Division of Global Psychiatry and the MGH Schizophrenia Clinical and Research Program (SCRP) and is principal investigator and director of the MGH Global Mental Health Clinical Research Fellowship.

His research interests include treatment-resistant schizophrenia, the use of psychopharmacological and antipsychotic agents in the treatment of schizophrenia, and the impact of antipsychotic agents on weight, cardiovascular disease, and lipid and glucose metabolism. Dr. Henderson noticed a high rate of diabetes mellitus (DM) in his clozapine-treated patients. As a result, he developed procedures for screening and early detection of diabetes in this population. Dr. Henderson focused on metabolic effects of atypical antipsychotic agents, the role of serotonin receptors, and augmentation strategies to reduce or reverse metabolic disturbances.

As Director of the SCRP, Dr. Henderson directs a leading center for the study and treatment of schizophrenia worldwide. SCRP combines clinical care, training, and clinical and neuroimaging research, with programs designed to improve long-term health and quality of life of seriously mentally ill patients though a multidisciplinary, collaborative approach with community agencies. ]SCRP has more than 20 studies and clinical trials and has trained numerous clinical researchers, fellows and residents who have pursued successful careers in academic medicine. SCRP consults in diabetes and weight management (Dr. Henderson’s current research area), psychosocial therapy, first-episode psychosis, smoking cessation and other psychosis-related issues.

Other Positions

  • Chair, Psychiatry, Boston University School of Medicine
  • Assistant Dean, Diversity & Multicultural Affairs, Boston University School of Medicine


  • University of Massachusetts Medical School, MD
  • Tufts University, BS


  • Published on 3/9/2018

    Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM, Öngür D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol Psychiatry. 2018 Mar 09. PMID: 29523870.

    Read at: PubMed
  • Published on 3/1/2018

    Petruzzi LJ, Pullen SJ, Lange BCL, Parnarouskis L, Dominguez S, Harris B, Quiterio N, Lekpeh G, Manobah B, Henderson DC, Borba CPC. Contributing Risk Factors for Substance Use Among Youth in Postconflict Liberia. Qual Health Res. 2018 Mar 01; 1049732318761863. PMID: 29542398.

    Read at: PubMed
  • Published on 11/23/2017

    Jackson JW, Fulchino L, Rogers J, Mogun H, Polinski J, Henderson DC, Schneeweiss S, Fischer MA. "Impact of drug-reimbursement policies on prescribing: A case-study of a newly marketed long-acting injectable antipsychotic among relapsed schizophrenia patients". Pharmacoepidemiol Drug Saf. 2018 Jan; 27(1):95-104. PMID: 29168261.

    Read at: PubMed
  • Published on 11/22/2017

    Nemani KL, Greene MC, Ulloa M, Vincenzi B, Copeland PM, Al-Khadari S, Henderson DC. Clozapine, Diabetes Mellitus, Cardiovascular Risk and Mortality: Results of a 21-year Naturalistic Study in Patients with Schizophrenia and Schizoaffective Disorder. Clin Schizophr Relat Psychoses. 2017 Nov 22. PMID: 29164928.

    Read at: PubMed
  • Published on 11/21/2017

    Halim N, Beard J, Mesic A, Patel A, Henderson D, Hibberd P. Intimate partner violence during pregnancy and perinatal mental disorders in low and lower middle income countries: A systematic review of literature, 1990-2017. Clin Psychol Rev. 2017 Nov 21. PMID: 29198412.

    Read at: PubMed
  • Published on 11/2/2017

    Denckla CA, Consedine NS, Spies G, Cherner M, Henderson DC, Koenen KC, Seedat S. Associations between neurocognitive functioning and social and occupational resilience among South African women exposed to childhood trauma. Eur J Psychotraumatol. 2017; 8(1):1394146. PMID: 29163865.

    Read at: PubMed
  • Published on 10/6/2017

    Mehralizade A, Schor S, Coleman CM, Oppenheim CE, Denckla CA, Borba CP, Henderson DC, Wolff J, Crane S, Nettles-Gomez P, Pal A, Milanovic S. Mobile Health Apps in OB-GYN-Embedded Psychiatric Care: Commentary. JMIR Mhealth Uhealth. 2017 Oct 06; 5(10):e152. PMID: 28986335.

    Read at: PubMed
  • Published on 9/13/2017

    Levey EJ, Gelaye B, Koenen K, Zhong QY, Basu A, Rondon MB, Sanchez S, Henderson DC, Williams MA. Trauma exposure and post-traumatic stress disorder in a cohort of pregnant Peruvian women. Arch Womens Ment Health. 2018 Apr; 21(2):193-202. PMID: 28905129.

    Read at: PubMed
  • Published on 9/11/2017

    Denckla CA, Mancini AD, Consedine NS, Milanovic SM, Basu A, Seedat S, Spies G, Henderson DC, Bonanno GA, Koenen KC. Distinguishing postpartum and antepartum depressive trajectories in a large population-based cohort: the impact of exposure to adversity and offspring gender. Psychol Med. 2017 Sep 11; 1-11. PMID: 28889814.

    Read at: PubMed
  • Published on 9/8/2017

    Pino EC, Damus K, Jack B, Henderson D, Milanovic S, Kalesan B. Adolescent socioeconomic status and depressive symptoms in later life: Evidence from structural equation models. J Affect Disord. 2018 Jan 01; 225:702-708. PMID: 28917197.

    Read at: PubMed

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