David Hing-Kwei Chui, MD

Professor, Medicine

David Chui
75 E. Newton St Evans Building


Dr. Chui is a physician-scientist with a long standing clinical and research interest in hemoglobin disorders. He has contributed to the field ranging from population genetics, genotype-phenotype correlation, genetic modifiers, and regulation of HbF expression. He received MD,CM degree from McGill University, Montreal, Canada in 1963. In 1970, he joined the Faculty at the McMaster University, Hamilton, Ontario, Canada, and rose to become a full Professor in 1982. He has always enjoyed teaching and mentoring students, residents and fellows. He served on the Editorial Board of BLOOD (1980-84), American Society of Hematology (ASH) Committee on Educational Affairs and Training (1984-87), NIH Hematology Study Section (1987-91), ASH Scientific Affairs Subcommittee on Hemoglobin/Red Cell (1989-1991), and Chair of Medical Advisory Board, the Thalassemia Foundation of Canada (2000-2002). He was elected to two honorific societies, the American Society for Clinical Investigation (1980) and the Association of American Physicians (1991). In 2003, Dr. Chui joined Boston University School of Medicine, and was appointed a full Professor of Medicine, Pathology and Laboratory Medicine.

Expertise includes: Globin gene mutations; Hemoglobin diseases; Thalassmeias; and Regulation of fetal hemoglobin expression.

Other Positions

  • Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
  • Member, Center for Regenerative Medicine, Boston University
  • Member, Center of Excellence in Sickle Cell Disease, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • McGill University, MD
  • University of Maryland, BSc


  • Published on 5/11/2018

    Singh SA, Sarangi S, Appiah-Kubi A, Hsu P, Smith WB, Gallagher PG, Glader B, Chui DHK. Hb Adana (HBA2 or HBA1: c.179G > A) and alpha thalassemia: Genotype-phenotype correlation. Pediatr Blood Cancer. 2018 09; 65(9):e27220. PMID: 29749692.

    Read at: PubMed
  • Published on 4/1/2018

    Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ. Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells. Stem Cells. 2018 07; 36(7):1004-1019. PMID: 29569827.

    Read at: PubMed
  • Published on 4/1/2018

    Akinbami AO, Sobota AE, Luo HY, Chui DHK, Steinberg MH. A Mild Phenotype of Severe ß+ Thalassemia in a 16-Month-Old Boy. J Pediatr Hematol Oncol. 2018 04; 40(3):e145-e147. PMID: 29309373.

    Read at: PubMed
  • Published on 11/29/2017

    Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells Mol Dis. 2018 03; 69:1-9. PMID: 29227829.

    Read at: PubMed
  • Published on 8/11/2017

    Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH. A phased SNP-based classification of sickle cell anemia HBB haplotypes. BMC Genomics. 2017 Aug 11; 18(1):608. PMID: 28800727.

    Read at: PubMed
  • Published on 4/28/2017

    Cancio MI, Aygun B, Chui DHK, Rothman JA, Scott JP, Estepp JH, Hankins JS. The clinical severity of hemoglobin S/Black (A ?dß)0 -thalassemia. Pediatr Blood Cancer. 2017 Nov; 64(11). PMID: 28453928.

    Read at: PubMed
  • Published on 4/11/2017

    Pernudy-Ubau A, Salinas-Molina J, Requenez Y, Ortiz-Lopez M, Puller AC, García-Rosales K, Rodríguez-Estrada A, Rodríguez-Romero W, Mejía-Baltodano G, Luo HY, Chui DHK. Hb Presbyterian (HBB: c.327C>G) in a Nicaraguan Family. Hemoglobin. 2017 Jan; 41(1):50-52. PMID: 28395541.

    Read at: PubMed
  • Published on 2/27/2017

    Jiang Z, Luo HY, Farrell JJ, Zhang Z, Schulz VP, Albarawi D, Steinberg MH, Al-Allawi NAS, Gallagher PG, Forget BG, Chui DHK. A variant Sp1 (R218Q) transcription factor might enhance HbF expression in ß0 -thalassaemia homozygotes. Br J Haematol. 2018 03; 180(5):755-757. PMID: 28240767.

    Read at: PubMed
  • Published on 1/19/2017

    Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ. A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Apr 11; 8(4):1076-1085. PMID: 28111279.

    Read at: PubMed
  • Published on 8/22/2016

    Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016 Nov; 91(11):1118-1122. PMID: 27501013.

    Read at: PubMed

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