Christopher Heaphy, PhD

Assistant Professor, Medicine

Christopher Heaphy


Dr. Christopher Heaphy is a cancer biologist that has been conducting basic and translational studies focused on elucidating the role of telomere alterations across a range of cancer types (e.g. prostate, breast, brain, pancreatic, ovarian). Overall, his research program uses a combination of tissue-based, cell-based, and molecular approaches to study normal and abnormal telomere biology as it relates to cancer initiation and progression, with a particular interest in the Alternative Lengthening of Telomeres (ALT) phenotype – a telomerase-independent telomere maintenance mechanism. In addition, his laboratory focuses on how these findings may be readily translated into accurately predicting cancer risk, early detection, prognosis, and potential response to targeted therapies. Dr. Heaphy received his Ph.D. from the University of New Mexico School of Medicine and did his postdoctoral training at the Johns Hopkins University School of Medicine. He is currently affiliated with Boston Medical Center and is a member of the Boston University-Boston Medical Center (BU-BMC) Cancer Center.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences


  • University of New Mexico School of Medicine, PhD
  • University of New Mexico, BS


  • Published on 12/1/2022

    Jafari N, Chen A, Kolla M, Pompa IR, Qiu Y, Yu R, Llevenes P, Ennis CS, Mori J, Mahdaviani K, Halpin M, Gignac GA, Heaphy CM, Monti S, Denis GV. Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease. Advances in Cancer Biology – Metastasis. 2022; 6:100073.

  • Published on 10/26/2022

    Low JY, Ko M, Hanratty B, Patel RA, Bhamidipati A, Heaphy CM, Sayar E, Lee JK, Li S, De Marzo AM, Nelson WG, Gupta A, Yegnasubramanian S, Ha G, Epstein JI, Haffner MC. Genomic Characterization of Prostatic Basal Cell Carcinoma. Am J Pathol. 2023 Jan; 193(1):4-10. PMID: 36309102.

    Read at: PubMed
  • Published on 8/2/2022

    Hackeng WM, Assi HA, Westerbeke FHM, Brosens LAA, Heaphy CM. Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors. Surg Pathol Clin. 2022 Sep; 15(3):541-554. PMID: 36049835.

    Read at: PubMed
  • Published on 7/21/2022

    Heaphy CM, Singhi AD. The diagnostic and prognostic utility of incorporating DAXX, ATRX, and alternative lengthening of telomeres to the evaluation of pancreatic neuroendocrine tumors. Hum Pathol. 2022 Nov; 129:11-20. PMID: 35872157.

    Read at: PubMed
  • Published on 7/14/2022

    Heaphy CM, Joshu CE, Barber JR, Davis C, Lu J, Zarinshenas R, Giovannucci E, Mucci LA, Stampfer MJ, Han M, De Marzo AM, Lotan TL, Platz EA, Meeker AK. The prostate tissue-based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy. J Pathol Clin Res. 2022 Sep; 8(5):481-491. PMID: 35836303.

    Read at: PubMed
  • Published on 6/19/2022

    Yuan M, Eberhart CG, Pratilas CA, Blakeley JO, Davis C, Stojanova M, Reilly K, Meeker AK, Heaphy CM, Rodriguez FJ. Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors. Cancers (Basel). 2022 Jun 19; 14(12). PMID: 35740680.

    Read at: PubMed
  • Published on 4/14/2022

    Holdhoff M, Guner G, Rodriguez FJ, Hicks JL, Zheng Q, Forman MS, Ye X, Grossman SA, Meeker AK, Heaphy CM, Eberhart CG, De Marzo AM, Arav-Boger R. Correction: Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization. Clin Cancer Res. 2022 Apr 14; 28(8):1737. PMID: 35419593.

    Read at: PubMed
  • Published on 4/11/2022

    Mori JO, Shafran JS, Stojanova M, Katz MH, Gignac GA, Wisco JJ, Heaphy CM, Denis GV. Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins. Prostate. 2022 Jun; 82(10):1005-1015. PMID: 35403746.

    Read at: PubMed
  • Published on 1/24/2022

    Lally SE, Milman T, Orloff M, Dalvin LA, Eberhart CG, Heaphy CM, Rodriguez FJ, Lin CC, Dockery PW, Shields JA, Shields CL. Mutational Landscape and Outcomes of Conjunctival Melanoma in 101 Patients. Ophthalmology. 2022 Jun; 129(6):679-693. PMID: 35085662.

    Read at: PubMed
  • Published on 12/18/2021

    Dreijerink KM, Hackeng WM, Singhi AD, Heaphy CM, Brosens LA. Clinical implications of cell-of-origin epigenetic characteristics in non-functional pancreatic neuroendocrine tumors. J Pathol. 2022 02; 256(2):143-148. PMID: 34750813.

    Read at: PubMed

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