Christopher V. Gabel, PhD

Associate Professor, Physiology & Biophysics

Christopher Gabel
617.638.4390
72 E. Concord St Instructional (L)

Biography

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Other Positions

  • Associate Professor, Pharmacology & Experimental Therapeutics, Boston University School of Medicine
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Websites

Education

  • Harvard University, PhD
  • Princeton University, BA

Classes Taught

  • GMSBN777
  • GMSBN778
  • GMSBN779
  • GMSFC764
  • GMSMS703
  • GMSOH730

Publications

  • Published on 3/1/2021

    Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997. PMID: 33654671.

    Read at: PubMed
  • Published on 9/1/2020

    Wirak GS, Gabel CV, Connor CW. Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics. Anesthesiology. 2020 09; 133(3):569-582. PMID: 32452864.

    Read at: PubMed
  • Published on 7/1/2020

    Awal MR, Wirak GS, Gabel CV, Connor CW. Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia. Anesthesiology. 2020 07; 133(1):133-144. PMID: 32282426.

    Read at: PubMed
  • Published on 4/1/2020

    Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650. PMID: 32235964.

    Read at: PubMed
  • Published on 3/11/2020

    Harreguy MB, Marfil V, Grooms NWF, Gabel CV, Chung SH, Haspel G. Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons. Sci Rep. 2020 03 11; 10(1):4545. PMID: 32161333.

    Read at: PubMed
  • Published on 11/28/2019

    Cai H, Wang YL, Wainner RT, Iftimia NV, Gabel CV, Chung SH. Wedge prism approach for simultaneous multichannel microscopy. Sci Rep. 2019 11 28; 9(1):17795. PMID: 31780755.

    Read at: PubMed
  • Published on 9/16/2019

    Wang G, Sun L, Reina CP, Song I, Gabel CV, Driscoll M. CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis. Sci Rep. 2019 09 16; 9(1):13315. PMID: 31527664.

    Read at: PubMed
  • Published on 4/24/2019

    Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422. PMID: 31017899.

    Read at: PubMed
  • Published on 10/1/2018

    Awal MR, Austin D, Florman J, Alkema M, Gabel CV, Connor CW. Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans. Anesthesiology. 2018 10; 129(4):733-743. PMID: 30004907.

    Read at: PubMed
  • Published on 8/21/2018

    Taub DG, Awal MR, Gabel CV. O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans. Cell Rep. 2018 08 21; 24(8):1931-1938.e3. PMID: 30134155.

    Read at: PubMed

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