Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.
- Associate Professor, Pharmacology & Experimental Therapeutics, Boston University Chobanian & Avedisian School of Medicine
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Harvard University, PhD
- Princeton University, BA
- Published on 6/15/2022
Wirak GS, Florman J, Alkema MJ, Connor CW, Gabel CV. Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans. Elife. 2022 Jun 15; 11. PMID: 35703498.
- Published on 3/1/2021
Shao W, Kilic K, Yin W, Wirak G, Qin X, Feng H, Boas D, Gabel CV, Yi J. Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quant Imaging Med Surg. 2021 Mar; 11(3):983-997. PMID: 33654671.
- Published on 9/1/2020
Wirak GS, Gabel CV, Connor CW. Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics. Anesthesiology. 2020 09; 133(3):569-582. PMID: 32452864.
- Published on 7/1/2020
Awal MR, Wirak GS, Gabel CV, Connor CW. Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia. Anesthesiology. 2020 07; 133(1):133-144. PMID: 32282426.
- Published on 4/1/2020
Song W, Matlock A, Fu S, Qin X, Feng H, Gabel CV, Tian L, Yi J. LED array reflectance microscopy for scattering-based multi-contrast imaging. Opt Lett. 2020 Apr 01; 45(7):1647-1650. PMID: 32235964.
- Published on 3/11/2020
Harreguy MB, Marfil V, Grooms NWF, Gabel CV, Chung SH, Haspel G. Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons. Sci Rep. 2020 03 11; 10(1):4545. PMID: 32161333.
- Published on 11/28/2019
Cai H, Wang YL, Wainner RT, Iftimia NV, Gabel CV, Chung SH. Wedge prism approach for simultaneous multichannel microscopy. Sci Rep. 2019 11 28; 9(1):17795. PMID: 31780755.
- Published on 9/16/2019
Wang G, Sun L, Reina CP, Song I, Gabel CV, Driscoll M. CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis. Sci Rep. 2019 09 16; 9(1):13315. PMID: 31527664.
- Published on 4/24/2019
Lee Y, Kim MT, Rhodes G, Sack K, Son SJ, Rich CB, Kolachalama VB, Gabel CV, Trinkaus-Randall V. Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing. PLoS One. 2019; 14(4):e0213422. PMID: 31017899.
- Published on 3/21/2019
Badon A, Bensussen S, Gritton HJ, Awal MR, Gabel CV, Han X, Mertz J. Video-rate large-scale imaging with Multi-Z confocal microscopy. Optica. 2019 Apr 20; 6(4):389-395. PMID: 34504902.
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