Christopher V. Gabel, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.

Publications

  • Published 10/11/2025

    Dowrey TW, Cranston SF, Skvir NJ, Lok Y, Bock P, Kharitonova EK, MacDonald E, Zeldich E, Gabel CV, Tyshkovskiy A, Monti S, Gladyshev VN, Sebastiani P, Perls TT, Andersen S, Murphy GJ. IPSC-based modeling of resiliency in centenarians reveals longevity-specific signatures. bioRxiv. 2025 Oct 11. PMID: 41279005.

    Read at: PubMed

  • Published 8/2/2025

    Karakullukcu B, White H, Connor C, Gabel C. Global excitatory synchrony: Ketamine induces global common-mode excitatory network oscillation by decoupling key interneurons. bioRxiv. 2025 Aug 02. PMID: 40766714.

    Read at: PubMed

  • Published 8/1/2025

    Carbonero D, Noueihed J, Gabel CV, Kramer MA, White JA. CaNetiCs - An Open-Source Toolbox for Standardized Dimensionality Reduction of Neuronal Calcium Activity. bioRxiv. 2025 Aug 01. PMID: 40766727.

    Read at: PubMed

  • Published 5/30/2025

    Chang AS, Mazuera L, Gabel CV, Connor CW. Anesthesia isn't sleep: The neuronal dynamics of immobility in isoflurane-anesthetized C. elegans differ from the activity patterns of previously established sleep-like quiescent states. PLoS One. 2025; 20(5):e0324323. PMID: 40446059.

    Read at: PubMed

  • Published 6/26/2024

    Guo R, Yang Q, Chang AS, Hu G, Greene J, Gabel CV, You S, Tian L. EventLFM: event camera integrated Fourier light field microscopy for ultrafast 3D imaging. Light Sci Appl. 2024 Jun 26; 13(1):144. PMID: 38918363.

    Read at: PubMed

View All 49 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Pharmacology, Physiology & Biophysics
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Harvard University, PhD
  • Princeton University, BA

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