Brian W. Jack, MD
Professor, Family Medicine

Biography
Brian Jack, MD, is Professor and former Chair of the Department of Family Medicine at Chobanian and Avedisian School of Medicine. He is Director of the Boston University Center for Health System Design & Implementation, a center within the Institute for Health System Innovation & Policy.
Dr. Jack graduated from the University of Massachusetts Medical School and completed his residency at Brown University. He completed a fellowship at the University of Washington. He came to BU in 1997 as the founding Vice Chair of the Department of Family Medicine. He authored over 190 peer-reviewed articles or book chapters, reviewed papers for major medical journals, and served on NICHHD, HRSA and AHRQ grant review panels. He was PI on grants from NHLBI, NIMHD, Fogarty Center, AHRQ, PCORI, HRSA, European Union, Global Fund, and the Izumi, Dreyfus, Kellogg, Kirby and Blue Cross Blue Shield Foundations.
His research team has developed the “ReEngineered Discharge” (Project RED), adapted by the National Quality Forum as a national safe practice. RED is used in many hospitals throughout the US and internationally. He completed projects with AHRQ funding to conduct an in-depth analysis of the hospital discharge process. The article describing the RCT testing RED is listed in the book “50 Studies Every Physician Should Know.” He explored implementation of RED in a project in 10 hospitals across the US (AHRQ). He developed a conversational agent system to deliver RED at the bedside called “Louise” (NHLBI) that was highlighted on the front page of the Wall Street Journal. Dr. Jack then completed AHRQ funded projects to adapt Louise for use by patients being discharged from the hospital and to design a tool kit describing the RED processes https://www.ahrq.gov/patient-safety/settings/hospital/red/toolkit/index.html. Two PCORI funded projects explored causes of readmission from the patient perspective, and explored the optimal transitional care components (Project ACHIEVE). His team then RCT of a mental health intervention to reduce rehospitalizations for those with depressive symptoms (AHRQ R01, Blue Cross/Blue Shield Foundation).
In 1990, Dr. Jack published a paper in JAMA that was the first describing the new concept of preconception care. He received the 2008 CDC “Partner in Public Health Improvement” award for his work with the CDC’s Select Panel on the Content of Preconception Care that helped define the content of preconception care. He designed a preconception care health IT system (Gabby) to assist in the delivery of preconception care (AHRQ, Kellogg) and conducted an RCT of its impact (HRSA MCHB, NIMHD R01) published in The Lancet Digital Health in 2020. He is now studying the implementation of Gabby into Healthy Start sites and community health centers (AHRQ), culturally adapting the system to the southern African country of Lesotho (Fogarty Center) and adapting the system to men (Kellogg). He is now working with a team in Ethiopia to expand this work.
Dr. Jack received the Peter F. Drucker Award for Non-Profit Innovation in 2013. He received the AHRQ “Patient Safety Investigator” award and was named one of AHRQ grantees “whose work has led to significant changes in health care policy and notably influenced research and practice.” He received the “Patient Care Award for Excellence in Patent Education Innovation”, the “Best Research Paper of the Year” award, and the Gabriel Smilkstein Award for career work in global health from the Society of Teachers of Family Medicine. HealthLeaders magazines selected him to its annual “People Who Make Healthcare Better” list, and his 2016 article in the Journal for Healthcare Quality was the Impact Article of the Year. He was one of Boston’s “Best Doctors” in each of 2010-2015. He was elected to the National Academy of Medicine in 2013.
Dr. Jack is active in the worldwide development of family medicine. He is Director of the Lesotho Boston Health Alliance (LeBoHA) that aims to increase human resources in the health sector in Lesotho. Over 20 years LeBoHA initiated the first physician-training program in the country. He is a founding member of the AAFP’s Center for International Initiatives and received the Gabriel Smilkstein Award for global family medicine education. He spent a sabbatical year in Budapest, Hungary in 1995 where he received a special citation from the mayor of Budapest. He taught in Jordan and Pakistan and worked to help develop family medicine in Albania, Jordan, Romania, and Vietnam.
Education
- University of Massachusetts Medical School, MD
- Brown University, MA
- Clark University, BA
Publications
- Published on 2/21/2025
Austad K, Lee JH, Lanney H, Rapoport VO, Wornhoff R, McDaniel K, Li-Garrison L, Jack BW. Evaluating the quality and equity of patient hospital discharge instructions. BMC Health Serv Res. 2025 Feb 21; 25(1):291. PMID: 39980004.
Read at: PubMed - Published on 1/17/2025
Akolbire D, Sabin LL, Lethunya PP, Sharma A, Cabral HJ, Jack BW, Scott NA. Implementation effectiveness of 'Problem solving for better health' training in Lesotho using mixed methods and the reach, effectiveness, adoption, implementation and maintenance (RE-AIM) framework. BMC Med Educ. 2025 Jan 17; 25(1):86. PMID: 39825403.
Read at: PubMed - Published on 12/21/2024
Austad K, Thai C, Zavatti A, Nguyen N, Bautista-Hurtado D, Kenney P, Lugo N, Lee JH, Lanney H, Xuan Z, Cordova-Ramos EG, Drainoni ML, Jack B. Tools to improve discharge equity: Protocol for the pilot TIDE trial. Contemp Clin Trials Commun. 2025 Feb; 43:101419. PMID: 39810841.
Read at: PubMed - Published on 11/22/2024
Mitchell SE, Kallen MA, Troost JP, De La Cruz BA, Bragg A, Martin-Howard J, Moldovan I, Miner JA, Jack BW, Carlozzi NE. Four New Patient-Reported Outcome Measures Examining Health-Seeking Behavior in Persons With Type 2 Diabetes Mellitus (REDD-CAT): Instrument Development Study. JMIR Diabetes. 2024 Nov 22; 9:e63434. PMID: 39576685.
Read at: PubMed - Published on 9/5/2024
Nkabane-Nkholongo E, Mpata Mokgatle M, Bickmore T, Julce C, Thompson D, Jack BW. Change in sexual and reproductive health knowledge among young women using the conversational agent "Nthabi" in Lesotho: a clinical trial. BMC Glob Public Health. 2024 Sep 05; 2(1):60. PMID: 39681895.
Read at: PubMed - Published on 3/12/2024
Nkabane-Nkholongo E, Mpata-Mokgatle M, Jack BW, Julce C, Bickmore T. Usability and Acceptability of a Conversational Agent Health Education App (Nthabi) for Young Women in Lesotho: Quantitative Study. JMIR Hum Factors. 2024 Mar 12; 11:e52048. PMID: 38470460.
Read at: PubMed - Published on 3/7/2024
McGuire CM, Kaiser JL, Vian T, Nkabane-Nkholongo E, Nash T, Jack BW, Scott NA. Learning from the End of the Public-Private Partnership for Lesotho's National Referral Hospital Network. Ann Glob Health. 2024; 90(1):19. PMID: 38463454.
Read at: PubMed - Published on 2/29/2024
Kambulandu M, Ogundipe RM, Bryden M, Sao L, Thompson DM, McGuire CM, Jack BW. Psychological distress and PTSD among clinicians in Roma, Lesotho during the COVID-19 pandemic. S Afr Fam Pract (2004). 2024 Feb 29; 66(1):e1-e7. PMID: 38572883.
Read at: PubMed - Published on 12/28/2023
Nkabane-Nkholongo E, Mokgatle M, Bickmore T, Julce C, Thompson D, JAck B. Change in Sexual and Reproductive Health Knowledge among Young Women Using the Conversational Agent "Nthabi" in Lesotho: A Clinical Trial. Res Sq. 2023 Dec 28. PMID: 38234736.
Read at: PubMed - Published on 10/4/2023
Nkabane-Nkholongo E, Mokgatle M, Bickmore T, Julce C, Jack BW. Adaptation of the Gabby conversational agent system to improve the sexual and reproductive health of young women in Lesotho. Front Digit Health. 2023; 5:1224429. PMID: 37860039.
Read at: PubMed
View 179 more publications: View full profile at BUMC