Beth C. Bragdon, PhD

Postdoctoral Fellow, Orthopaedic Surgery

Beth Bragdon
617.358.3655
72 E. Concord St Evans Building

Biography

I am interested in the effects of trauma and repair as it pertains to the musculoskeletal system with an emphasis on stem/progenitor cell recruitment, differentiation, and formation of bone tissue and the signaling pathways involved with these processes. Currently, the stem cell population(s) that drives heterotopic ossification (HO) due to trauma or even fracture repair is unknown. My work focuses on 1) the identification and isolation of the stem/progenitor cell populations that contribute to post-natal bone formation (HO and fracture) and 2) compare the transcriptome of these different populations for similarities and identify key signaling pathways that could be used as targets for future therapy.

Publications

  • Published on 8/1/2018

    Bragdon BC, Bahney CS. Origin of Reparative Stem Cells in Fracture Healing. Curr Osteoporos Rep. 2018 08; 16(4):490-503. PMID: 29959723.

    Read at: PubMed
  • Published on 4/12/2017

    Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61. PMID: 28412469.

    Read at: PubMed
  • Published on 11/7/2016

    Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214. PMID: 27324177.

    Read at: PubMed
  • Published on 3/2/2015

    Bragdon B, Lybrand K, Gerstenfeld L. Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming. Curr Protoc Mouse Biol. 2015; 5(1):21-34. PMID: 25727198.

    Read at: PubMed
  • Published on 3/2/2015

    Lybrand K, Bragdon B, Gerstenfeld L. Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis. Curr Protoc Mouse Biol. 2015; 5(1):35-49. PMID: 25727199.

    Read at: PubMed
  • Published on 2/1/2015

    Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells. J Cell Physiol. 2015 Feb; 230(2):296-307. PMID: 24962433.

    Read at: PubMed
  • Published on 10/20/2014

    Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic injection of CK2.3, a novel peptide acting downstream of bone morphogenetic protein receptor BMPRIa, leads to increased trabecular bone mass. J Orthop Res. 2015 Feb; 33(2):208-15. PMID: 25331517.

    Read at: PubMed
  • Published on 5/1/2013

    Moseychuk O, Akkiraju H, Dutta J, D'Angelo A, Bragdon B, Duncan RL, Nohe A. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes. J Cell Commun Signal. 2013 Dec; 7(4):265-78. PMID: 23637019.

    Read at: PubMed
  • Published on 5/1/2013

    Saldanha S, Bragdon B, Moseychuk O, Bonor J, Dhurjati P, Nohe A. Caveolae regulate Smad signaling as verified by novel imaging and system biology approaches. J Cell Physiol. 2013 May; 228(5):1060-9. PMID: 23041979.

    Read at: PubMed
  • Published on 7/1/2012

    Bonor J, Adams EL, Bragdon B, Moseychuk O, Czymmek KJ, Nohe A. Initiation of BMP2 signaling in domains on the plasma membrane. J Cell Physiol. 2012 Jul; 227(7):2880-8. PMID: 21938723.

    Read at: PubMed

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