Barbara E. Corkey, PhD

Professor Emeritus, Medicine

Barbara Corkey
617.638.7091
650 Albany St Evans Biomed Research Ctr

Biography

Dr. Barbara Corkey is Emeritus Professor of Medicine and Biochemistry. Dr. Corkey’s work focuses on the metabolic regulation of signal transduction and energy metabolism in fat cells, β-cells, and human fibroblasts. She and her colleagues have been studying fuel-stimulated insulin secretion by the pancreatic β-cell; fuel partitioning in rat adipocytes; cytokine signaling; and Ca2+ transients in human fibroblasts from patients with inborn errors of fatty acid oxidation and Type 1 diabetes.

Other Positions

  • Zoltan Kohn Professor, Medicine, Boston University School of Medicine
  • Professor Emeritus, Biochemistry, Boston University School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Full Member, Boston Nutrition Obesity Research Center, Boston University Medical Center
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Boston Medical Center

Education

  • University of Pennsylvania School of Medicine, PhD

Publications

  • Published on 10/1/2021

    Corkey BE, Deeney JT, Merrins MJ. What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia? Diabetes. 2021 Oct; 70(10):2174-2182. PMID: 34593535.

    Read at: PubMed
  • Published on 9/27/2021

    Istfan N, Hasson B, Apovian C, Meshulam T, Yu L, Anderson W, Corkey BE. Acute Carbohydrate Overfeeding: A Redox Model of Insulin Action and Its Impact on Metabolic Dysfunction in Humans. Am J Physiol Endocrinol Metab. 2021 Sep 27. PMID: 34569273.

    Read at: PubMed
  • Published on 4/6/2021

    Roth J, Ashcroft FM, Wollheim CB, Kieffer TJ, Cherrington AD, Bergman RN, Taylor R, Najjar SM, Pedersen O, Ellingsgaard H, Holst JJ, Nauck MA, Kadowaki T, Czech MP, Corvera S, Saltiel AR, Corkey BE, Atkinson MA. Voices: Insulin and beyond. Cell Metab. 2021 04 06; 33(4):692-699. PMID: 33826910.

    Read at: PubMed
  • Published on 12/3/2020

    Veliova M, Ferreira CM, Benador IY, Jones AE, Mahdaviani K, Brownstein AJ, Desousa BR, Acín-Pérez R, Petcherski A, Assali EA, Stiles L, Divakaruni AS, Prentki M, Corkey BE, Liesa M, Oliveira MF, Shirihai OS. Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling. EMBO Rep. 2020 12 03; 21(12):e49634. PMID: 33275313.

    Read at: PubMed
  • Published on 11/3/2020

    Corkey BE. Targeting Pyruvate Kinase PEPs Up Insulin Secretion and Improves Glucose Homeostasis. Cell Metab. 2020 11 03; 32(5):693-694. PMID: 33147479.

    Read at: PubMed
  • Published on 10/15/2020

    Corkey BE, Deeney JT. The Redox Communication Network as a Regulator of Metabolism. Front Physiol. 2020; 11:567796. PMID: 33178037.

    Read at: PubMed
  • Published on 1/22/2020

    Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE. Exposure of Pancreatic ß-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. 2020 Feb 21; 23(2):100858. PMID: 32058969.

    Read at: PubMed
  • Published on 12/23/2019

    Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200. PMID: 31869355.

    Read at: PubMed
  • Published on 8/19/2019

    Prentki M, Corkey BE, Madiraju SRM. Lipid-associated metabolic signalling networks in pancreatic beta cell function. Diabetologia. 2020 01; 63(1):10-20. PMID: 31423551.

    Read at: PubMed
  • Published on 8/1/2019

    Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Fatty Acid Metabolites Combine with Reduced ß Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Cell Metab. 2019 09 03; 30(3):447-461.e5. PMID: 31378464.

    Read at: PubMed

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