Barbara A. Corkey, PhD

Professor, Medicine

Barbara Corkey
617.638.7091
650 Albany St Evans Biomed Research Ctr

Biography

Expertise includes: Metabolic regulation; pancreatic ß-cell metabolism and signal transduction; adipocyte metabolism and metabolic signal transduction; mitochondrial metabolism; cellular imaging of cations; reactive oxygen species; membrane potential and lipids; branched chain amino acid metabolism; inborn errors of mitochondrial metabolism; and acyl CoA regulation.

Other Positions

  • Zoltan Kohn Professor, Medicine, Boston University School of Medicine
  • Section Chief, Research Implementation, Medicine, Boston University School of Medicine
  • Professor, Biochemistry, Boston University School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Boston Medical Center

Education

  • University of Pennsylvania School of Medicine, PhD

Publications

  • Published on 4/3/2018

    Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 Apr 03; 27(4):869-885.e6. PMID: 29617645.

    Read at: PubMed
  • Published on 5/24/2017

    Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138. PMID: 28539390.

    Read at: PubMed
  • Published on 1/1/2017

    Mugabo Y, Zhao S, Lamontagne J, Al-Mass A, Peyot ML, Corkey BE, Joly E, Murthy Madiraju SR, Prentki M. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic ß-cells. Journal of Biological Chemistry. 2017; 292(18).

    Read at: Custom
  • Published on 1/1/2017

    Schwartz S, Epstein S, Corkey BE, Grant SFA, Gavin JR, Aguilar RB, Herman ME. A Unified Pathophysiological Construct of Diabetes and its Complications. Trends in Endocrinology and Metabolism. 2017; 28(9).

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  • Published on 1/1/2017

    Jones AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS ONE. 2017; 12(12).

    Read at: Custom
  • Published on 1/1/2017

    Erion K, Corkey BE. Hyperinsulinemia: a Cause of Obesity?. 2017.

    Read at: Custom
  • Published on 1/1/2017

    Lamontagne J, Al-Mass A, Nolan C, Corkey BE, Madiraju SRM, Joly E, Prentki M. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) ß-cells using metformin-induced metabolic deceleration as a model. Journal of Biological Chemistry. 2017; 292(47).

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  • Published on 1/1/2016

    Berdan CA, Erion K, Burritt NE, Corkey BE, Deeney JT. Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets. PLoS ONE. 2016; 11(2).

    Read at: Custom
  • Published on 1/1/2016

    Deeney JT, Belkina AC, Shirhai OS, Corkey BE, Denis GV. BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic ß-Cell. PLoS ONE. 2016; 11(3).

    Read at: Custom
  • Published on 1/1/2016

    Pizarro-Delgado J, Deeney JT, Corkey BE, Tamarit-Rodriguez J. Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS ONE. 2016; 11(11).

    Read at: Custom

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