Barbara E. Corkey, PhD

Barbara Corkey
617.638.7091
650 Albany St Evans Biomed Research Ctr

Biography

Dr. Barbara Corkey is Emeritus Professor of Medicine and Biochemistry. Dr. Corkey’s work focuses on the metabolic regulation of signal transduction and energy metabolism in fat cells, β-cells, and human fibroblasts. She and her colleagues have been studying fuel-stimulated insulin secretion by the pancreatic β-cell; fuel partitioning in rat adipocytes; cytokine signaling; and Ca2+ transients in human fibroblasts from patients with inborn errors of fatty acid oxidation and Type 1 diabetes.

Other Positions

  • Zoltan Kohn Professor, Medicine, Boston University School of Medicine
  • Professor Emeritus, Biochemistry, Boston University School of Medicine
  • Professor Emeritus, Research Implementation, Medicine, Boston University School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Full Member, Boston Nutrition Obesity Research Center, Boston University Medical Center
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of Pennsylvania School of Medicine, PhD

Publications

  • Published on 1/22/2020

    Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE. Exposure of Pancreatic ß-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. 2020 Feb 21; 23(2):100858. PMID: 32058969.

    Read at: PubMed
  • Published on 12/23/2019

    Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM. Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study. PLoS One. 2019; 14(12):e0226200. PMID: 31869355.

    Read at: PubMed
  • Published on 8/19/2019

    Prentki M, Corkey BE, Madiraju SRM. Lipid-associated metabolic signalling networks in pancreatic beta cell function. Diabetologia. 2020 01; 63(1):10-20. PMID: 31423551.

    Read at: PubMed
  • Published on 8/1/2019

    Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Fatty Acid Metabolites Combine with Reduced ß Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Cell Metab. 2019 09 03; 30(3):447-461.e5. PMID: 31378464.

    Read at: PubMed
  • Published on 7/24/2019

    Thomas DD, Corkey BE, Istfan NW, Apovian CM. Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction. J Endocr Soc. 2019 Sep 01; 3(9):1727-1747. PMID: 31528832.

    Read at: PubMed
  • Published on 9/13/2018

    Erion K, Corkey BE. ß-Cell Failure or ß-Cell Abuse? Front Endocrinol (Lausanne). 2018; 9:532. PMID: 30271382.

    Read at: PubMed
  • Published on 5/5/2018

    Pino EC, Zuo Y, Maciel De Olivera C, Mahalingaiah S, Keiser O, Moore LL, Li F, Vasan RS, Corkey BE, Kalesan B. Cohort profile: The MULTI sTUdy Diabetes rEsearch (MULTITUDE) consortium. BMJ Open. 2018 05 05; 8(5):e020640. PMID: 29730626.

    Read at: PubMed
  • Published on 4/3/2018

    Benador IY, Veliova M, Mahdaviani K, Petcherski A, Wikstrom JD, Assali EA, Acín-Pérez R, Shum M, Oliveira MF, Cinti S, Sztalryd C, Barshop WD, Wohlschlegel JA, Corkey BE, Liesa M, Shirihai OS. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion. Cell Metab. 2018 04 03; 27(4):869-885.e6. PMID: 29617645.

    Read at: PubMed
  • Published on 12/4/2017

    Jones Iv AR, Coleman EL, Husni NR, Deeney JT, Raval F, Steenkamp D, Dooms H, Nikolajczyk BS, Corkey BE. Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells. PLoS One. 2017; 12(12):e0188474. PMID: 29206239.

    Read at: PubMed
  • Published on 10/2/2017

    Lamontagne J, Al-Mass A, Nolan CJ, Corkey BE, Madiraju SRM, Joly E, Prentki M. Identification of the signals for glucose-induced insulin secretion in INS1 (832/13) ß-cells using metformin-induced metabolic deceleration as a model. J Biol Chem. 2017 11 24; 292(47):19458-19468. PMID: 28972173.

    Read at: PubMed

View 239 more publications: View full profile at BUMC

View all profiles