Avrum E. Spira, MD

Alexander Graham Bell Professor in Health Care Entrepreneurship, Medicine

Avrum Spira
617.414.6980
75 E. Newton St Evans Building

Biography

Dr. Spira is a Professor of Medicine, Pathology and Bioinformatics, and the Alexander Graham Bell Professor in Health Care Entrepreneurship at Boston University. He is founding Chief of the Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center. He is also an attending physician in the Medical Intensive Care Unit at Boston Medical Center.

Dr. Spira obtained his MD from McGill University in Montreal, and completed his Internal medicine residency at the University of Toronto and his fellowship in Pulmonary and Critical Care Medicine at BMC. During his fellowship, Dr. Spira obtained a master’s degree in Bioinformatics from Boston University.

Since his 2003 appointment to the BU faculty, Dr. Spira has built a translational research program that focuses on genomic alterations associated with smoking-related lung disease, leading to a molecular test for the early detection of lung cancer that has successfully translated into the clinic (PerceptaTM) as well as a novel therapeutic for COPD that is in preclinical development. His research program is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He has co-founded both a molecular diagnostics company and a pharmaceutical company in order to translate these tools from “bench to bedside”.

He serves as Principal Investigator on grants from the National Cancer Institute (NCI); National Heart, Lung, Blood Institute (NHLBI), National Institute of Environmental Health Sciences (NIEHS) and the Department of Defense (DoD), and has authored more than 100 peer-reviewed publications. Dr. Spira was a permanent member of the NIH’s Cancer Biomarker Study Section (CBSS) and currently serves as Senior Editor at Cancer Prevention Research as well as Associate Editor at the American Journal of Respiratory and Critical Care Medicine. He was elected a member of the American Society for Clinical Investigation (ASCI) in 2010 and a member of the Association of American Physicians (AAP) in 2017.

Other Positions

  • Professor, Computational Biomedicine, Medicine, Boston University School of Medicine
  • Section Chief of Medicine in Computational Biomedicine, Computational Biomedicine, Medicine, Boston University School of Medicine
  • Director, Cancer Research Center, Boston University School of Medicine
  • Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
  • Mentor for Graduate Medical Students, Boston University School of Medicine, Graduate Medical Sciences
  • Active Staff Privileges, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston Medical Center
  • Member, Bioinformatics Graduate Program, Boston University

Education

  • McGill University, MD
  • Boston University, MSc
  • Vanier College, DEC

Publications

  • Published on 9/15/2019

    Kadara H, Sivakumar S, Jakubek Y, San Lucas FA, Lang W, McDowell T, Weber Z, Behrens C, Davies GE, Kalhor N, Moran C, El-Zein R, Mehran R, Swisher SG, Wang J, Zhang J, Fujimoto J, Fowler J, Heymach JV, Dubinett S, Spira AE, Ehli EA, Wistuba II, Scheet P. Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer. Am J Respir Crit Care Med. 2019 Sep 15; 200(6):742-750. PMID: 30896962.

    Read at: PubMed
  • Published on 8/26/2019

    Garland L, Guillen-Rodriguez J, Hsu CH, Yozwiak M, Zhang HH, Alberts DS, Davis LE, Szabo E, Merenstein C, Lel J, Zhang X, Liu H, Liu G, Spira AE, Beane J, Wojtowicz M, Chow HS. Effect of intermittent versus continuous low dose aspirin on nasal epithelium gene expression in current smokers: A randomized, double-blinded trial. Cancer Prev Res (Phila). 2019 Aug 26. PMID: 31451521.

    Read at: PubMed
  • Published on 6/26/2019

    Mascaux C, Angelova M, Vasaturo A, Beane J, Hijazi K, Anthoine G, Buttard B, Rothe F, Willard-Gallo K, Haller A, Ninane V, Burny A, Sculier JP, Spira A, Galon J. Immune evasion before tumour invasion in early lung squamous carcinogenesis. Nature. 2019 Jul; 571(7766):570-575. PMID: 31243362.

    Read at: PubMed
  • Published on 6/22/2019

    Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME. Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. Chest. 2019 Jun 22. PMID: 31233743.

    Read at: PubMed
  • Published on 5/29/2019

    Krysan K, Tran LM, Grimes BS, Fishbein GA, Seki A, Gardner BK, Walser TC, Salehi-Rad R, Yanagawa J, Lee JM, Sharma S, Aberle DR, Spira AE, Elashoff DA, Wallace WD, Fishbein MC, Dubinett SM. The Immune Contexture Associates with the Genomic Landscape in Lung Adenomatous Premalignancy. Cancer Res. 2019 May 29. PMID: 31142513.

    Read at: PubMed
  • Published on 5/6/2019

    Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 May 06; 9(1):6978. PMID: 31061400.

    Read at: PubMed
  • Published on 4/25/2019

    Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019 Apr; 53(4). PMID: 30846474.

    Read at: PubMed
  • Published on 4/23/2019

    Beane JE, Mazzilli SA, Campbell JD, Duclos G, Krysan K, Moy C, Perdomo C, Schaffer M, Liu G, Zhang S, Liu H, Vick J, Dhillon SS, Platero SJ, Dubinett SM, Stevenson C, Reid ME, Lenburg ME, Spira AE. Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions. Nat Commun. 2019 04 23; 10(1):1856. PMID: 31015447.

    Read at: PubMed
  • Published on 3/7/2019

    Billatos E, Duan F, Moses E, Marques H, Mahon I, Dymond L, Apgar C, Aberle D, Washko G, Spira A. Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols. BMC Pulm Med. 2019 Mar 07; 19(1):59. PMID: 30845938.

    Read at: PubMed
  • Published on 1/31/2019

    Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F. Electronic cigarettes: a task force report from the European Respiratory Society. Eur Respir J. 2019 Feb; 53(2). PMID: 30464018.

    Read at: PubMed

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