Assen G. Marintchev, PhD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Assen Marintchev, PhD, Physiology & Biophysics, is a scientist whose long-standing objective has been to provide a detailed structural and dynamic picture of the protein translation initiation in human cells, and its regulation. These interactions and the mechanisms they entail underlie pathological processes disrupting the integrated stress response, which, in turn, leads to a wide range of diseases, and neurodegenerative disorders in particular. His current research builds on his prior training to study the structure and dynamics of translation initiation complexes and involves his extensive training in NMR methodology and state-of-the-art understanding of biophysical chemistry.

Publications

  • Published 4/25/2024

    Wagner PA, Song M, Ficner R, Kuhle B, Marintchev A. Molecular basis for the interactions of eIF2ß with eIF5, eIF2B, and 5MP1 and their regulation by CK2. bioRxiv. 2024 Apr 25. PMID: 38712236.

    Read at: PubMed

  • Published 9/13/2022

    Gamble N, Paul EE, Anand B, Marintchev A. Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase. Curr Res Struct Biol. 2022; 4:308-319. PMID: 36164648.

    Read at: PubMed

  • Published 9/12/2022

    Paul EE, Marintchev A. The PCI domains are "winged" HEAT domains. PLoS One. 2022; 17(9):e0268664. PMID: 36094910.

    Read at: PubMed

  • Published 6/10/2022

    Friedrich D, Marintchev A, Arthanari H. The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Res. 2022 Jun 10; 50(10):5424-5442. PMID: 35552740.

    Read at: PubMed

  • Published 12/10/2021

    Paul EE, Lin KY, Gamble N, Tsai AW, Swan SHK, Yang Y, Doran M, Marintchev A. Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. Biophys Chem. 2022 02; 281:106740. PMID: 34923394.

    Read at: PubMed

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • University of Connecticut, PhD
  • Sofia University, MS
  • Sofia University, BS