Assen G. Marintchev, PhD
Associate Professor, Pharmacology, Physiology & Biophysics
Biography
Assen Marintchev, PhD, Physiology & Biophysics, is a scientist whose long-standing objective has been to provide a detailed structural and dynamic picture of the protein translation initiation in human cells, and its regulation. These interactions and the mechanisms they entail underlie pathological processes disrupting the integrated stress response, which, in turn, leads to a wide range of diseases, and neurodegenerative disorders in particular. His current research builds on his prior training to study the structure and dynamics of translation initiation complexes and involves his extensive training in NMR methodology and state-of-the-art understanding of biophysical chemistry.
Other Positions
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Connecticut, PhD
- Sofia University, MS
- Sofia University, BS
Publications
- Published on 4/25/2024
Wagner PA, Song M, Ficner R, Kuhle B, Marintchev A. Molecular basis for the interactions of eIF2ß with eIF5, eIF2B, and 5MP1 and their regulation by CK2. bioRxiv. 2024 Apr 25. PMID: 38712236.
Read at: PubMed - Published on 9/13/2022
Gamble N, Paul EE, Anand B, Marintchev A. Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase. Curr Res Struct Biol. 2022; 4:308-319. PMID: 36164648.
Read at: PubMed - Published on 9/12/2022
Paul EE, Marintchev A. The PCI domains are "winged" HEAT domains. PLoS One. 2022; 17(9):e0268664. PMID: 36094910.
Read at: PubMed - Published on 6/10/2022
Friedrich D, Marintchev A, Arthanari H. The metaphorical swiss army knife: The multitude and diverse roles of HEAT domains in eukaryotic translation initiation. Nucleic Acids Res. 2022 Jun 10; 50(10):5424-5442. PMID: 35552740.
Read at: PubMed - Published on 12/10/2021
Paul EE, Lin KY, Gamble N, Tsai AW, Swan SHK, Yang Y, Doran M, Marintchev A. Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5. Biophys Chem. 2022 02; 281:106740. PMID: 34923394.
Read at: PubMed - Published on 3/26/2020
Marintchev A, Ito T. eIF2B and the Integrated Stress Response: A Structural and Mechanistic View. Biochemistry. 2020 04 07; 59(13):1299-1308. PMID: 32200625.
Read at: PubMed - Published on 9/26/2018
Lin KY, Nag N, Pestova TV, Marintchev A. Human eIF5 and eIF1A Compete for Binding to eIF5B. Biochemistry. 2018 10 09; 57(40):5910-5920. PMID: 30211544.
Read at: PubMed - Published on 9/4/2018
Yu J, Marintchev A. Comparative sequence and structure analysis of eIF1A and eIF1AD. BMC Struct Biol. 2018 09 04; 18(1):11. PMID: 30180896.
Read at: PubMed - Published on 2/20/2018
Bogorad AM, Lin KY, Marintchev A. eIF2B Mechanisms of Action and Regulation: A Thermodynamic View. Biochemistry. 2018 03 06; 57(9):1426-1435. PMID: 29425030.
Read at: PubMed - Published on 11/16/2017
Bogorad AM, Lin KY, Marintchev A. Novel mechanisms of eIF2B action and regulation by eIF2a phosphorylation. Nucleic Acids Res. 2017 Nov 16; 45(20):11962-11979. PMID: 29036434.
Read at: PubMed
View 32 more publications: View full profile at BUMC