Dr. Belkina received her M.D. from Russian State Medical University and her Ph.D. in Molecular Medicine from BU School of Medicine investigating the epigenetic regulation of inflammatory responses driven by bromodomain proteins. Her breadth of knowledge of flow cytometric applications includes the development of intra- and extra-cellular staining protocols and panels for use in a wide variety of applications, including immunophenotyping of mouse and human cells, apoptosis assays, cell cycle profiling and stem cell isolation. At the FCCF, Dr. Belkina assists our users with experimental design, panel development, data analysis and many other facets of flow cytometry, and is a fully proficient BD FACSARIA operator. She also trains new users and is responsible for instrument maintenance.
Anna’s research is focused on the intersection of immunology and computational biology, for her current research efforts include investigating the immune landscape of chronic inflammatory diseases and developing computational techniques to assess high-parameter single cell cytometry data. Anna is an active member of ISAC (International Society for the Advancement of Cytometry) and has been named 2015-2019 ISAC SRL Emerging Leader.
- Member, BU-BMC Cancer Center, Boston University
- Russian State Medical University, MD
- Boston University School of Medicine, PhD
- Rockefeller University, MS
- Published on 5/12/2020
Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 Jul 07; 32(1):44-55.e6. PMID: 32402267.
- Published on 3/18/2020
Belkina AC, Azer M, Lee JJ, Elgaali HH, Pihl R, Cleveland M, Carr J, Kim S, Habib C, Hasturk H, Snyder-Cappione JE, Nikolajczyk BS. Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes. J Dent Res. 2020 Jul; 99(7):855-862. PMID: 32186942.
- Published on 2/27/2020
Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP. Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 Feb 27; 5(4). PMID: 31990682.
- Published on 11/28/2019
Belkina AC, Ciccolella CO, Anno R, Halpert R, Spidlen J, Snyder-Cappione JE. Automated optimized parameters for T-distributed stochastic neighbor embedding improve visualization and analysis of large datasets. Nat Commun. 2019 11 28; 10(1):5415. PMID: 31780669.
- Published on 8/29/2019
Andrieu GP, Shafran JS, Smith CL, Belkina AC, Casey AN, Jafari N, Denis GV. BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Cancer Lett. 2019 11 28; 465:45-58. PMID: 31473251.
- Published on 8/1/2019
Nicholas DA, Proctor EA, Agrawal M, Belkina AC, Van Nostrand SC, Panneerseelan-Bharath L, Jones AR, Raval F, Ip BC, Zhu M, Cacicedo JM, Habib C, Sainz-Rueda N, Persky L, Sullivan PG, Corkey BE, Apovian CM, Kern PA, Lauffenburger DA, Nikolajczyk BS. Fatty Acid Metabolites Combine with Reduced ß Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Cell Metab. 2019 09 03; 30(3):447-461.e5. PMID: 31378464.
- Published on 12/5/2018
Belkina AC, Starchenko A, Drake KA, Proctor EA, Pihl RMF, Olson A, Lauffenburger DA, Lin N, Snyder-Cappione JE. Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging. Front Immunol. 2018; 9:2783. PMID: 30568654.
- Published on 8/27/2018
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction. Nat Commun. 2018 08 27; 9(1):3450. PMID: 30150664.
- Published on 7/20/2018
Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA. Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer. Genome Med. 2018 07 20; 10(1):54. PMID: 30029671.
- Published on 3/7/2018
Fleury M, Belkina AC, Proctor EA, Zammitti C, Simms RW, Lauffenburger DA, Snyder-Cappione JE, Lafyatis R, Dooms H. Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis. Arthritis Rheumatol. 2018 04; 70(4):566-577. PMID: 29245183.
View 19 more publications: View full profile at BUMC