Category: Uncategorized

Department of Pathology & Laboratory Medicine: New News SUMMER 2021

August 6th, 2021 in Uncategorized

Department of Pathology & Laboratory Medicine: New News SUMMER 2021

Announcements

  • Tiffany Mellott, PhD has been appointed as the Nancy L.R. Bucher, MD Assistant Professor in the Department of Pathology & Laboratory Medicine at BUSM. 
    • Dr Mellott served as a Research Assistant Professor in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) since 2010 and was recently promoted to Assistant Professor.  Dr Mellott completed her PhD at BUSM in Dr Krzysztof Blusztajn’s laboratory in 2005 and has maintained her research program and active scholarly collaborations with our neuroscience group since then
    • Dr Mellott is an active research scientist with expertise in neuroscience and the mechanisms and role of dietary choline in cognitive enhancement and disease prevention. Dr Mellott has also contributed significantly to the department and BUSM, with a strong record of research, scholarship, “good citizenship”, mentorship and as an educational leader. We are fortunate to have Dr Mellott in the department and I anticipate that she will continue to advance her academic career at BUSM
    • The professorship is named for Dr. Nancy Bucher, a long time faculty member in our department, who made significant scientific contributions to the understanding of liver regeneration and the cholesterol synthesis pathway.  Dr Bucher was a ground-breaking, female, physician-scientist. Dr Bucher was a fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences and has received the Distinguished Scientific Achievement Award from the American Liver Foundation. She was named as a significant contributor to her field in two Nobel Prize awardee speeches
  • Yachana Kataria, PhD, DABCC gave the Annual Stanley L. Robbins Lecture to the New England Society of Pathologists on January 26, 2021. Her talk was “Seroprevalence of SARS-CoV-2 IgG Antibodies and Risk Factors in Health Care Workers at Boston Medical Center”
  • Daniel Remick, M.D., has been appointed as the Editor-in-Chief for the scientific journal Shock®Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches. Dr. Remick is a Professor of Pathology & Laboratory Medicine at Boston University School of Medicine and former Department Chair. SHOCK® publishes papers detailing novel therapeutic approaches including immunomodulation, gene therapy, nutrition, and others. The journal’s mission fosters and promotes multidisciplinary studies that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiology. The journal excels as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related states. Papers in Shock® emphasize biologic mechanisms that determine the response to injury since this information ultimately facilitates improved care of the traumatized or septic individual
    • Shock® is The Official Journal of the Shock Society, the European Shock Society, the Indonesian Shock Society, the International Federation of Shock Societies, and the Official and International Journal of the Japan Shock Society.
  • CONGRATULATIONS!! We want to celebrate the recognition of our very own Microbiology Labas the Recipient of a BMC 2021 Be Exceptional Award! There was a virtual celebration on Wednesday, June 23 from 12-1 hosted by BMC President Kate Walsh and SVP Lisa Kelly-Croswell. Many went on and supported their fellow laboratorians who could not have done it without the support from the entire Clinical Lab and AP team.  I am so very proud of everyone!  We made it through COVID-19 (so far!). Congratulations, Bev Orr
    • From BMC Communications: This past year was a truly exceptional year, as our personal and professional lives were upended by the pandemic. While the year brought out the best in everyone at BMC, on June 23 we will be celebrating a special group of 31 colleagues who were chosen as truly exceptional by their peers
    • The winners were nominated by employees and providers, who were invited to submit nominations for individuals and teams who demonstrate exceptional performance in the areas of core valuesand priority goals. This year, a record-breaking 248 individual and team nominations were submitted – a testament to what an exceptional year it was and to the incredible admiration and respect BMC colleagues have for each other. A hospital-wide selection committee then chose the final 2021 Be Exceptional Award recipients based on their extraordinary performance, initiative, and teamwork.
    • Congratulations to all our 2021 Be Exceptional Award winners!
  • Nick Crossland was the recipient of a CTSI pilot award for the proposal entitled “Multimodal Microscopic Characterization of Novel Humanized Mouse Models of COVID-19″. In collaboration with fellow BUSM faculty members including Drs. Douam, Emili, and Connor and external collaborator Dr. Ploss (Princeton), this project will provide unprecedented insights into the cellular and molecular mechanisms that define SARS-CoV-2 immunopathogenesis and severe COVID-19 disease. Importantly, findings will be integrated with transcriptomics and proteomics datasets to elucidate specific biological pathways driving morphomolecular outcomes of disease and aims to identify novel therapeutic pathways to prevent or ameliorate outcomes of severe COVID-19
  • Several Resident Awards were given at the Residency Program Graduation on June 11th:
    •  Ilyas Yambayev, MD won this year 2021 Robert Foley MBA Award, The Academic Excellence Award at graduation ceremony on Friday, June 11, 2021.
      • Yambayev also received the Early Career Award for his abstract submission for the IASLC 2021
    •  Michael Kritselis, DO won the 2021 Vernon S. Truell Autopsy Award
    •  Lubna Suaiti M.B. B.Ch. – 2021 Leo Goodman Photomicrography Award
    •  Lina Ma, M.D. – 2021 Leo Goodman Gross Photography Award
  • Lina Ma will have a poster presentation at ASC’s 69th Annual Scientific Meeting being held in Las Vegas, November 11-14, 2021.  Lina Ma, MD, and Sandra Cerda, MDEvaluation of Malignant Cytologic Parameters to Distinguish Hürthle Cell Carcinoma (HCC) from Hürthle Cell Adenoma (HCA) in Thyroid Fine Needle Aspirate (FNA) with Hürthle Cell Lesion (HCL)
  • BUSM Faculty Promotions to Associate Professor
    •  Thor Stein, Pathology & Laboratory Medicine, is a neuropathologist who focuses on understanding the role of age, trauma and genetics on the development of multiple types of neurodegenerative disease. He is associate director of the Neuropathology Core for BU Alzheimer’s Disease & CTE Center and a site PI and neuropathologist for a number of brain biorepositories.
  • Ilyas Yambayev’s was accepted at IASLC 2021 WCLC and he received an Early Career Award for his work: Novel Low Malignant Potential/Vascular Invasive (LMPVI) Grade is Superior to WHO 2015 and IASLC 2020 Adenocarcinoma Grade; Ilyas Yambayev1, M.D., Travis B. Sullivan2, M.S., Kei Suzuki3, M.D., Virginia R. Litle3, M.D. Elliot L. Servais4, M.D., Cameron T. Stock4, M.D., Syed M. Quadri4, M.D., Kimberly M. Rieger-Christ2, Ph.D., Eric J. Burks1, M.D.
  • Eric Burks is on another abstract which was accepted for an oral presentation at the New England Section American Urological Association 90th Annual Meeting, Burlington, VT on Oct. 14, 2021: Urine miRNA Biomarkers that are Differentially Expressed in Lichen Sclerosus Induced and Non-Lichen Sclerosus Induced Urethral Stricture Disease
    • Additional presentations by Eric Burks:
    • 26, 2021 Fatal Consequences of COVID-19: Case studies from the Boston Medical Center autopsy experience
    • * SARS-CoV-2 Associated Hemophagocytic Lymphohistiocytosis: Charitha Vadlamudi, MD & Eric J. Burks, MD
    • * SARS-CoV-2 Associated Coagulopahty: Sanket Choksi, MD & Eric J. Burks, MD
    • * SARS-CoV-2 Post-Viral Pulmonary Inflammatory Reactions: Eric J. Burks, MD
      New England Society of Pathologists, Case Presentations, Boston, MA
    • 22, 2021 Pleomorphic Mantle Cell Lymphoma; New England Lymphoma Rounds, Boston, MA
    • 23, 2021 Immunopathology of SARS-CoV-2 Associated Diffuse Alveolar Damage: A case-control autopsy study using multiplex immunohistochemistry; Inaugural Mallory Alumni Rounds, Boston, USA & Dublin, Ireland
    • 13, 2021 Pulmonary Adenocarcinoma of Low Malignant Potential: An indolent lesion of epithelial origin? Early Detection Research Network Lung Collaborative Group, National Cancer Institute/National Institutes of Health
  • Burks also is a co-investigator on a BU CTSI grant that was funded:
    Highly Multiplexed Immunophenotyping of Aggressive Histologic Patterns of Early-Stage Lung Adenocarcinomas https://www.bumc.bu.edu/compbiomed/2021/06/15/cbm-faculty-members-awarded-ctsi-2021-integrated-pilot-grants/
  • Dennis Jones is lead and co-corresponding author on a study published in Nature Biomedical Engineering; https://www.nature.com/articles/s41551-021-00766-1
    • Zixiong (Mervin) Wang, an incoming Master’s student in the department, is 2ndauthor; https://www.nature.com/articles/s41551-021-00766-1
  • Jones was selected for the NIH Early Career Reviewer Program and will participate in the Tumor Progression and Metastasis study section in October
  • Nick Crossland gave a talk on Thursday, July 22nd at the ASV Conference Viral Pathogenesis Segment entitled “Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially independent on hACE2 expression”
  • Pathology PhD Candidate, Razie Amraei, successfully completed her Qualifying Exams! Razie is completing her thesis work in Dr.Richard Wainford’s Lab
  • Welcome New Residents!!
    •  Dr. Isa Jacoba
    •  Soo Hyun Lee
    •  Ramya Narasimhan
    •  Adeyemi Sofoluwe
  • Welcome Incoming PhD/Masters Graduate Students:
    •  Samantha Calderazzo – MD/PhD
    •  Samantha Boyd – Masters Candidate
    •  Frankie Cervone-Maffa – Masters Candidate
      •  Farimah Ghorbani – Masters Candidate
      •  Tyler Lebner – Masters Candidate
      •  Yunqi Lu – Masters Candidate
      •  Kavya Menon – Masters Candidate
      •  Thea Nalan – Masters Candidate
      •  Melissa Pesta – Masters Candidate
      •  Egbe Tambe-Sangaya – Masters Candidate
      •  Wongel Zerihan – Masters Candidate
      •  Zixiong “Mervin” Wang – Masters Candidate

 

 

 

 

 

 

Publications Accepted:

Publications Published:

  • Brosnan-Cashman JA, Davis CM, Diplas BH, Meeker AK, Rodriguez FJ, Heaphy CM.; SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma. Modern Pathology. 2021 Jun 8. doi: 10.1038/s41379-021-00841-7.
  • Kang HJ, Oh JH, Kim YW, Kim W, An J, Sung CO, Kim J, Shim JH, Hwang S, Yu E, Heaphy CM*, Hong SM*. *Co-senior authors; Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma. Liver International. 2021 May 25. doi: 10.1111/liv.14975
  • Barker KA, Etesami NS, Shenoy AT, Arafa EI, Lyon de Ana C, Smith NM, Martin IM, Goltry WN, Barron AM, Browning JL, Kathuria H, Belkina AC, Guillon A, Zhong X, Crossland NA, Jones MR, Quinton LJ, Mizgerd JPLung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021 Jun 1;131(11). doi: 10.1172/JCI141810. PubMed PMID: 34060477; PubMed Central PMCID: PMC8159694
  • Kritselis M, Yambayev I, Prilutskiy A, Shevtsov A, Vadlamudi C, Zheng H, Elsadwai M, Ma L, Aniskovich E, Kataria Y, Higgins S, Sarita-Reyes C, Zuo T, Zhao Q, Quillen KBurks EJ.; Distinctive Pseudopalisaded Histiocytic Hyperplasia Characterizes the Transition of Exudative to Proliferative Phase of Diffuse Alveolar Damage in Patients Dying of COVID-19. Hum Pathol 2021 Jul 14;S0046-8177(21)00122-2. doi:10.1016/j.humpath.2021.06.008
  • Dennis JonesZixiong WangIvy X. ChenSue ZhangRohin BanerjiPin-Ji LeiHengbo ZhouVictoria XiaoCecilia KwongJan Willem M. van WijnbergenEthel R. PereiraBenjamin J. VakocPeigen HuangHadi T. NiaTimothy P. Padera: Solid stress impairs lymphocyte infiltration into lymph-node metastases: Nature Biomedical Engineering (2021)
  • Nick Crossland, et al; SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. J Virol. PMID: 34260266
  • Sham Nambulli, Yufei Xiang, Natasha L Tilston-Lunel, Linda J Rennick, Zhe Sang, William B Klimstra, Douglas S Reed, Nicholas A Crossland, Yi Shi, W Paul Duprex. Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. Sci Adv. 2021. PMID: 34039613
  • Kimberly A Barker, Neelou S Etesami, Anukul T Shenoy, Emad I Arafa, Carolina Lydon de Ana, Nichole Ms Smith, Ian Mc Martin, Wesley N Goltry, Alexander Ms Barron, Jeffrey L Browning, Hasmeena Kathuria, Anna C Belkina, Antoine Guillon, Xuemei Zhong, Nicholas A Crossland, Matthew R Jones, Lee J Quinton, Joseph P Mizgerd. Lung-resident memory B cells protect against bacterial pneumonia. J Clin Invest. 2021. PMID: 34060477
  • Zaroug Jaleel, Elizabeth Blasberg, Chelsea Troiano, Paige Montanaro, Sarah Mazzilli, Hans P Gertje, Nicholas A Crossland, Michael Platt, Jeffrey Spiegel. Association of Vaping with Decreased Vascular Endothelial Growth Factor Expression and Decreased Microvessel Density in Cutaneous Wound Healing Tissue in Rats. Wound Repair and Regen. PMID: 34129265
  • Da-Yuan Chen, Nazimuddin Khan, Brianna J Close, Raghuveera K Goel, Benjamin Blum, Alexander H Tavares, Devin Kenney, Hasahn L Conway, Jourdan K Ewoldt, Vipul C Chitalia,Nicholas A Crossland, Christopher S Chen, Darrell N Kotton, Susan C Baker, Serge Y Fuchs, John H Connor, Florian Douam, Andrew Emili, Mohsan Saeed SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway. J Vir.  2021. PMID: 34260266
  • Yuen RR, Steiner D, Pihl RMF, Chavez E, Olson A, Smith EL, Baird LA, Korkmaz F, Urick P, Sagar M, Berrigan JL, Gummuluru S, Corley RB, Quillen KBelkina AC, Mostoslavsky G, Rifkin IR, Kataria Y, Cappione AJ 3rd, Gao W, Lin NH, Bhadelia N, Snyder-Cappione JE. Novel ELISA Protocol Links Pre-Existing SARS-CoV-2 Reactive Antibodies With Endemic Coronavirus Immunity and Age and Reveals Improved Serologic Identification of Acute COVID-19 viaMulti-Parameter Detection. Front Immunol. 2021;12:614676. doi: 10.3389/fimmu.2021.614676. eCollection 2021. PubMed PMID: 33897682; PubMed Central PMCID: PMC8062931

 

 

Department of Pathology & Laboratory Medicine: New News Spring 2021

June 8th, 2021 in Uncategorized

Announcements

Bravo Manisha Cole, rising MS Graduate:A Token of Gratitude: Student Employees of the Year Celebrated for Their Work” from BU Today

  • Cole, who works as a research assistant in the School of Medicine pathology and laboratory medicine department, has juggled several different roles in relation to COVID research, says Christopher Andry(GRS’87,’89, MED’94), department chair. In addition to her campus award, Cole’s work creating the COVID-19 biorepository has earned her the distinction of being chosen the Northeast Association of Student Employment Administrators regional winner.
  • “This amount of work, while continuing her studies, is truly remarkable and speaks to her commitment to her studies and humanitarian willingness to step up and help in a time of crisis,” Andry says.
  • In thanking her coworkers and supervisors, Cole says the work her team does “every day directly contributes to furthering advancements in overarching knowledge of SARS-CoV-2 as we are providing resources to researchers.”   http://www.bu.edu/articles/2021/student-employees-of-the-year-celebrated-for-their-work/?utm_campaign=bu_today&utm_source=email_20210412_faculty_staff_others&utm_medium=2_must_read_1&utm_content=student
  • Celebrating Laboratory Professionals Week April 18-24, 2021
    • “We Believe in Heroes: Avengers of the Laboratory”
    • Celebratory activities included:
      • BMC Spotlight & Social Media
      • Daily Raffles
      • Lab Coat Decorating Contest and much more!!

 

 

  •                           CRA Lab Coat                HEME Lab Coat            MICRO Lab Coat        Phebotomy Lab Coat
      • And… The Winner of the Lab Coat Decorating Contest was…Phlebotomy! Great Job by everyone!
    • Charitha Vadlamudi, Chief Resident of Anatomic Pathology, has been selected to serve as one of 15 Diversity and Inclusion Fellows for the BMC GME Diversity and Inclusion Council. The D&I Council and Fellowsare committed to creating and sustaining an inclusive workplace where everyone is valued and engaged, not in spite of, but because of, our differences – seen or unseen.  Fellows play a key role in the process of raising and addressing areas of concern related to diversity and inclusion.  More information can be found here:

https://hub.bmc.org/departments/graduate-medical-education/gme-di-council

  • In collaboration with Drs. Josh Campbell and Rachel Flynn, Christopher Heaphy recently received a $50K award from the BU CTSI Pilot Grant Program for "Identifying genomic alterations in prostate cancers from African American men"
  • Heaphy was also the co-senior author on a paper recently published that was an international collaboration with colleagues from the US, The Netherlands, Italy, and Republic of Korea to evaluate biomarkers in non-functional pancreatic neuroendocrine tumors. Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size. Hackeng WM, Brosens LAA, Kim JY, O'Sullivan R, Sung YN, Liu TC, Cao D, Heayn M, Brosnan-Cashman J, An S, Morsink FHM, Heidsma CM, Valk GD, Vriens MR, Nieveen van Dijkum E, Offerhaus GJA, Dreijerink KMA, Zeh H, Zureikat AH, Hogg M, Lee K, Geller D, Marsh JW, Paniccia A, Ongchin M, Pingpank JF, Bahary N, Aijazi M, Brand R, Chennat J, Das R, Fasanella KE, Khalid A, McGrath K, Sarkaria S, Singh H, Slivka A, Nalesnik M, Han X, Nikiforova MN, Lawlor RT, Mafficini A, Rusev B, Corbo V, Luchini C, Bersani S, Pea A, Cingarlini S, Landoni L, Salvia R, Milione M, Milella M, Scarpa A, Hong SM, Heaphy CM, Singhi AD.Gut. 2021 Apr 13:gutjnl-2020-322595

https://gut.bmj.com/content/early/2021/04/12/gutjnl-2020-322595

  • Eric Burks has two recent presentations:
    • 23, 2021 Immunopathology of SARS-CoV-2 Associated Diffuse Alveolar Damage: A case-control autopsy study using multiplex immunohistochemistry. Inaugural Mallory Alumni Rounds, Boston, USA & Dublin, Ireland
    • 13, 2021 Pulmonary Adenocarcinoma of Low Malignant Potential: An indolent lesion of epithelial origin? Early Detection Research Network Lung Collaborative Group, National Cancer Institute/National Institutes of Health
  • Dr Reggie Thomasson, Assistant Professor of Pathology & Laboratory Medicine, and Medical Director for Blood Bank and Transfusion Medicine has been selected as an Association of Pathology Chairs, Pathology Leadership  Fellow.  This was a competitive selection process at APC – congratulationsto Dr Thomasson
  • Graduates, Congratulations!!
    • Residents
    • :
      •  Michael Kritselis will be heading to Rhode Island Hospital for a Neuropathology Fellowship
      •  
      • Artem Shevtsov will stay in Boston at Beth Israel Deaconess Hospital in a Breast Pathology Fellowship
      •  
      • Ilyas Yambayev has accepted Rochester Medical Center with a Hematopathology Fellowship
      • Hanqiao Zheng will also be local at Beth Israel Deaconess Hospital in a General Surgical Pathology Fellowship
      • Celebration photos to follow in the next New News Edition!
    • Masters Graduate Students:
      •  Manisha Cole’s graduating thesis from her work in Dr. Yachana Kataria’s Lab was titled The Role of SARS-CoV-2 Testing in COVID-19.” Manisha has accepted a position at BU as a Senior Research Specialist. She'll be working with the COVID-19 biorepository, as well as BARC
      • Richard Darko’s graduating thesis will be (he technically graduates in September), “Evaluation of Podocyte Foot Process Effacement, SLIT2/ROBO2, and Nephrin in Podocytopathies.” Richard, who completed his research with Dr. Joel Henderson, has also accepted a position working with Dr. Henderson in the BMC Kidney Pathology Lab as a research assistant
      • Victoria Gibson’s did her research in Dr. Lawreen Connor’s Lab, her graduating thesis is entitled The Biophysical Characterization of Novel Amyloidogenic Beta2-microglobulin Variant P32L: Victoria will be getting her PhD at UVM in the Fall
      • Nola Tochukwu Ihejirika worked with Dr. Joel Henderson and her graduating thesis is Characterization and Differentiation of Protein Reabsorption Granules and Punctate IgG in Primary Podocytopathies. Nola is now working for BMC in the Covid Biorepository
      • Jessenia Laguna-Torres’s graduating thesis from Dr. Tiffany Mellot’s Lab was “The Effects of Perinatal Choline Supplementation on the Cognitive Function of the APPNL-G-F Mouse Model of Alzheimer's Disease.” Jessenia has been working at Voyager Therapeutics in Cambridge, MA as a Research Associate II in the Neuroscience Histology Team since March 2021
      • Paige Montanaro worked in Dr. Nick Crossland’s Lab and graduating thesis was Microscopic Morphomolecular Characterization of Humanized Mouse Models of SARS-CoV-2 Implanted with Human Fetal Lung Xenografts". Currently Paige is seeking a position in industry

 

 

 

 

 

 

 

 

 

 

 

 

The following colleagues joined our faculty and were appointed as Clinical Instructors in our department, Welcome Aboard:

    • Charitha Vadlamudi, MD
    • Katie Doonan, MD
    • Hanqiao (Ciao) Zheng, MD
    • Ilyas Yambayev, MD
  • Allan Stolarski, MS, MD (Surgical Resident doing research in Dr. Daniel Remick’s Lab) made several presentations at The 30th Grasberger Research Symposium Lecture and Visiting Professorship on May 21st
    • “Early Metabolic Support for Critically Ill Trauma Patients: A Prospective Randomized Controlled Trial”
    • “Defining Sepsis Phenotypes: Two Murine Models of Sepsis and Machine Learning
    • “Cytokine Drizzle: The Rationale for Abandoning “Cytokine Storm”
    • “Defining the Immunobiology of Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) in a Murine Pneumonia Model of Sepsis”

Publications. Published:

 

Department of Pathology & Laboratory Medicine: New News Winter 2020-21

March 24th, 2021 in Uncategorized

Department of Pathology & Laboratory Medicine:

New News Winter 2020-21

Announcements

  • Dennis Jones, PhD, Assistant Professor of Pathology & Laboratory Medicine, has been named the 2021 Dahod Assistant Professor; he will collaborate with Dr. Andrew Emili to identify immunosuppressive molecules contained in cancer cell derived-exosomes and investigate their impact on T cells, a type of immune cell that can recognize and kill breast cancer cells. Blocking such immunosuppressive mechanisms may promote the anti-tumor activity of T cells, thus enhancing their ability to eliminate breast cancers
  • Dr. Jones also received a Metavivior Early Career Investigator Award to study “Targeting breast cancer plasticity and immunosuppression in metastatic lymph nodes”
    • Metavivor Research and Support Inc., is a non-profit organization dedicated to funding research for stage IV metastatic breast cancer (MBC) that announced 23 new grant awards totaling $3,650,000.  These research grants will enhance the understanding of metastatic breast cancer, help improve current treatments and develop greatly needed therapeutic options to combat this complicated disease. Since its founding in 2009, METAvivor has put 100% of donations into its peer-reviewed research grant program. https://www.metavivor.org/blog/metavivor-announces-grant-awards-for-metastatic-breast-cancer-research/
  • Daniel Remick, M.D. has been recruited to serve on an NIH study section to review applications for the NCI’s Loan Repayment Program. This program encourages health professionals to participate in research by paying a portion of their student loans
  • USCAP Virtual Annual Meeting: March 13-18, 2021
    • Nola Tochukwu Ihejirika, Masters student in Dr. Joel Henderson’s Lab has a poster presentation at the 2021 USCAP Annual Meeting! The title of her presentation is "Definitive Characterization of Protein Reabsorption Granules vs. Punctate IgG Immunoreactivity in Primary Podocytopathies" Authors: Junbo Chen, MA, Hui Chen, Morgan Thompson, MA and Dr. Joel Henderson
    • Junbo Chen, MA will present: “Punctate Visceral Epithelial IgG Immunoreactivity Associated with Podocytopathies Exhibits Heterogeneous Oligoclonality and Absence of Complement” Authors: Junbo Chen, Gabriel Lerner, Hui A Chen, Astrid Weins, Joel M. Henderson
    • Charitha Vadlamudi, MD, Pathology Resident, will present “Amyloid Typing of Formalin Fixed Paraffin Embedded Tissue by Immunohistochemistry” Authors: Charitha Vadlamudi1, Emily Aniskovich1, Hui Chen1, Haili Cui2, Lawreen H Connors2, Vaishali Sanchorawala2, Eric J Burks
    • Manisha Cole, Masters student in Dr. Yachana Kataria’s Lab will present, “Seroprevalence of SARS-CoV-2 IgG Antibodies in Health Care Workers at an Academic Medical Center in Boston, Massachusetts” Authors: Manisha Cole1,2, Yachana Kataria1,2, Elizabeth Duffy2, Kyle de la Cena1,2, Elissa Perkins, Tara Bouton, Martha Werler, Cassandra Pierre, Karen Jacobson, Elizabeth Ragan, Chris Andry1,2
  • Also USCAP Related:
    • The Association of Indian Pathologists in North America (AIPNA) has awarded Best Abstract Competition USCAP-Second Prize to:
      • Charitha Vadlamudi, Emily Aniskovich, Hui Chen, Haili Cui, Lawreen H Connors, Vaishali Sanchorawala, Eric J Burks.  Amyloid Typing of Formalin Fixed Paraffin Embedded Tissue by Immunohistochemistry. USCAP 2021 Annual Meeting, Poster
    • Martin Steinbuck, Pathology BU PhD Graduate recent publication: https://advances.sciencemag.org/content/7/6/eabe5819/tab-article-info
    • Rachel Flynn is a recipient of a 2021 Shipley Pilot Grant
  • Welcome to:
    • Brian Moore, MD, MEd, new Faculty Member
    • Introducing our new incoming Residents for the 2021-22 academic year:
    • Isa M. Jacoba, MD
    • Boston, MA
    • University of the East/Ramon Magsasay Memorial Medical Center, Quezon City, Philippines
    • Soo Hyun Lee MD, PhD, MS
    • Houston, TX
    • Ewha Womans University School of Medicine, Seoul, South Korea
    • Ramya Narasimhan, MBBS
    • Rochester, MN
    • Kasturba Medical College, Manipal, India
    • Adeyemi Sofoluwe, MD, MBA
    • Boston, MA
    • University of Health Sciences Antigua School of Medicine, Piccadilly, Antigua & Barbuda
  • Thor D. Stein, MD, PhD has been awarded the Spivack Pilot Fund Award

 

 

 

Publications. Published:

  • Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A.; “Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2” Mol Cell. 2020 Dec 17;80(6):1104-1122.e9. doi: 10.1016/j.molcel.2020.11.028
  • Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A.; “Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2” Mol Cell. 2021 Jan 7;81(1):212. doi: 10.1016/j.molcel.2020.12.028
  • Kalantzakos TJ, Sullivan TB, Sebel LE, Canes D, Burks EJ, Moinzadeh A, Rieger-Christ KM; “MicroRNAs MiR-15a and MiR-26a cooperatively regulate O-GlcNAc-transferase to control proliferation in clear cell renal cell carcinoma” Cancer Biomark. 2020 Dec 3. doi: 10.3233/CBM-200553

       Publications. Accepted:

  • JeffersonChena, Pedro ViniciusStaziakia, HanqiaoZhengb, Eric J.Burks, SaraMeibomc, Virginia R.Litled, Hristina N.Natchevaa; “68Ga-DOTATATE-avid pulmonary sclerosing pneumocytoma in a man of North African descent: Case report, imaging findings and pathology” Clinical Imaging

 

 

Department of Pathology & Laboratory Medicine: New News Fall 2020

January 8th, 2021 in Uncategorized

Department of Pathology & Laboratory Medicine:

New News Fall 2020

Announcements

  • Anna Belkina has been elected as the 2020-2024 Councilor for the International Society for Advancement of Cytometry (ISAC)
  • Successful CAP Inspection:
    • Dr Beckwith and his inspection team were most complimentary about the work of the department. They recognized the important roles that faculty, support staff and residents play to ensure high quality care for our patients and community.
  • Carmen Sarita-Reyes presented a case of Placenta with Listeria monocytogenes in the Perinatal Conference for the Society for Pediatric Pathology on October 25th, 2020
  • Dennis Jones and his Lab published a review on COVID-19 and hyperinflammation in the American Journal of Pathology https://www.sciencedirect.com/science/article/pii/S0002944020304090
·       Shipley Prostate Cancer Pilot Grant Awardees Announced
  • Christopher Heaphy, PhD, Assistant Professor of Medicine/Hematology & Medical Oncology:

Current prognostic factors may not accurately predict outcomes for some men surgically treated for prostate cancer. Additional tissue-based biomarkers may improve personalized treatment strategies. Dr. Heaphy will investigate two promising biomarkers: telomere length alterations and nuclear lamin dysfunction. In preliminary studies, both biomarker levels show promise in predicting which patients will ultimately develop metastatic disease, thereby helping to oncologists to optimize the treatment plan. In collaboration with Pathology & Laboratory Medicine, these biomarkers will now be evaluated in BMC’s diverse patient population

  • Anna Belkina has been officially appointed as the Director of the Flow Cytometry Core Facility effective October 1, 2020
  • Jessica Kenison-White, PhD (Dave Sheer Lab) successfully defended her PhD Thesis, The Role for the Aryl Hydrocarbon Receptor in Autoimmunity and Tumor Immunityon Wednesday, November 18th. Bravo Dr. Kenison-White!

 

  • Nader Rahimi and his Team: "Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells" recently accepted for publication in the American Journal of Pathology and is now in press. In this study,  we demonstrate that TMIGD1 is progressively downregulated in sporadic human colon cancer and its downregulation correlates with poor overall survival. We have developed TMIGD1 knockout mice and demonstrated that the loss of TMIGD1 in mice results in the development of adenomas in small intestine and colon. Our findings identify TMIGD1 as a novel tumor suppressor gene, provide new insights into the pathogenesis of colorectal cancer and a novel potential therapeutic target. https://ajp.amjpathol.org/article/S0002-9440(20)30485-5/fulltext
  • Michael Kritselis, MD, PGY 2 has passed his COMLEX- USA Level 3 ex

 

Publications. Published:

  • Huang J., Hume A.J., Abo K.M., Werder R.B., Villacorta-Martin C., Alysandratos K.D., Beermann M.L., Simone-Roach C., Olejnik J., Suder E.L., Bullitt E., Hinds A., Sharma A., Bosmann M., Wang R., Hawkins F., Burks E.J., Saeed M., Wilson A.A., Mühlberger E., Kotton D.N. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. bioRxiv [Preprint]. 2020 Jun 30:2020.06.30.175695. doi: 10.1101/2020.06.30.175695. PMID: 32637964; PMCID: PMC7337394 23
  • Prilutskiy A., Kritselis M., Shevtsov A., Yambayev I., Vadlamudi C., Zhao Q., Kataria Y., Sarosiek S.R., Lerner A., Sloan J.M., Quillen K., Burks E.J. SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis: An autopsy series with clinical and laboratory correlation. Am J Clin Pathol. 2020;154:466-474. PMID: 32681166
  • Rainjade Chung, Haixia Guan, Cecilia Ponchiardi, Sandra R Cerda, Nitin Marwaha, Osman H Yilmaz, Emma Pinjic, David McAneny, Stephanie L Lee, Frederick Thurston Drake. Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Epidemiology and Long-Term Outcomes in a Strictly Defined Cohort" Thyroid Jun 2020
  • Guan H, Toraldo G, Cerda SR, Godley FA, Rao SR, McAneny D, Doherty GM, Braverman LE, Lee SL. Utilities of RAS mutations in preoperative fine needle biopsies for decision-making for thyroid nodule management: results from a single-center prospective cohort. 2020 Jan 29. PMID: 31996097
  • Shoreh R Fazeli , Bradley Zehr , Razie Amraei , Gianluca Toraldo , Haixia Guan , David Kindelberger , Stephanie Lee , Sandra Cerda. ThyroSeq v2 Testing: Impact on Cytologic Diagnosis, Management, and Cost of Care in Patients with Thyroid Nodule. 2020 Jun 19. PMID: 32349630
  • Rabhi N, Belkina AC, Desevin K, Cortez BN, Farmer; Shifts of Immune Cell Populations Differ in Response to Different Effectors of Beige Remodeling of Adipose Tissue.; iScience. 2020 Nov 4;23(12):101765. doi: 10.1016/j.isci.2020.101765. eCollection 2020 Dec 18.PMID:33294778 

 

       Publications. Accepted:

  • Haixia Guan, Gianluca Toraldo, Frederick A. Godley, Sowmya R Rao, Sandra Cerda, David McAneny, Gerard Doherty, Stephanie L. Lee; “The Real-world Performance of ThyroSeqV.2 to Diagnose Thyroid “Neoplasm Requiring Surgery” American Journal of Cancer Research

 

 

 

Department of Pathology & Laboratory Medicine: New News Summer 2020

September 2nd, 2020 in Uncategorized

Department of Pathology & Laboratory Medicine:

New News Summer 2020

Announcements

During the 2020 SARS CoV-2 pandemic Pathology Laboratory Sciences graduate students past and present stepped up to support the department in a major way. Manisha Cole (GMS 2021) and recent graduates Kyle de la Cena (GMS 2020) and Morgan Thompson (2017) have been instrumental in setting up and supporting the BMC-BU Covid 19 biobank initiative, led by faculty member Assistant Professor Elizabeth R Duffy (GMS 2009).  This team has processed thousands of discarded human biospecimens to ensure that sufficient Cov-2 related material is available to research scientists.  Some of this material was also used by the BU SARS CoV-2  testing laboratory during set up and validation of their test.  In addition, this team is supporting a longitudinal study of patients with Covid infection funded by the Mass Consortium on Pathogen Readiness (PI Nahid Bhadelia, MD).

Additionally on a project led by Assistant Professor in Pathology & Laboratory Medicine and student mentor Yachana Kataria, PhD, Liz Duffy, Manisha Cole and Kyle de la Cena prepared, initiated and led two hospital wide SARS Cov-2 seroprevalance studies called SIG-COV (PI Yachana Kataria) and STOP (PI Karen Jacobson). Over 1,700 employees registered to have their blood drawn and antibodies tested. Along with members of the BMC and BU pathology department students Richard Darko (GMS 2021), Victoria Gibson (GMS 2021) and  Tochukwu “Nola” Ihejirika (GMS 2021) supported the initiative during an intense two week period of recruiting and collecting from volunteer subjects.

Cheryl Spencer (GMS 2007) received special recognition at the 2020 graduation awards ceremony for her outstanding work supporting the autopsy service during the surge. Morgan Thompson (2017) also supported the SARS Cov-2 pcr testing during the pandemic surge.

Chris Andry, MPhil, PhD

Professor and Chair

Department of Pathology & Laboratory Medicine

Boston University School of Medicine

 

  • Boston University Clinical and Translational Science Institute (BU CTSI) has been selected to receive funding.
Proposal Title:   3D Printed COVID-19 Nasopharyngeal Swabs
Principal Investigator:   Alice White, PhD

Project has been led by a graduate student, Jessie Soong in the School of Bioengineering at BU CRC. Pathology & Lab Medicine participants include Drs Henderson, Miller, Fazeli, Andry and Beverley Orr and the Microbiology team.

Dear Dr. White:

Congratulations, we are pleased to inform you that your COVID-19 Related Research application to the Boston University Clinical and Translational Science Institute (BU CTSI) has been selected to receive funding. Based on available funding and the submitted budget for your project, you will receive total of $24,999.00 in direct costs. The project period for this award is June 1, 2020-March 31, 2021.

The BU CTSI is funded by a Clinical and Translational Science Award from the National Center for Advancing Translational Sciences, National Institutes of Health, and grant UL1TR001430. For more details regarding CTSI supported resources and services, please navigate to the BU CTSI Website at http://www.bu.edu/ctsi/. 

 
Anna Belkina, MD, PhD has been awarded CTSI Funds for a Mini Sabbatical Dr. Belkina will use the mini-sabbatical funds to support her advanced training in high-parameter imaging data analysis at the Flow Cytometry and Cellular Imaging Facility (FCCIF) at the University of Texas MD Anderson Cancer Center.

 Welcomes:

 Dear Colleagues,

  • On behalf of Dr Dennis Jones and the department I am really pleased to welcome Dr Samir Jana.  Dr Jana is from Kolkata, India. He obtained a Masters degree in Molecular Biology and Biotechnology from the University of Kalyani, India. He earned a PhD from the University of Calcutta and worked on the thesis topic “Regulation of miRNA in Breast Cancer Growth and Metastasis. Dr Jana continued his training as a postdoctoral researcher at City of Hope, California and worked on ER stress/autophagy pathway and chemosensitization of breast cancer.  In the Jones lab, he intends to study cancer stem cell maintenance and immune evasion during breast cancer progression. Dr Jana enjoys travelling, photography, cooking and playing cricket.

 

Please join me in welcoming him.

 

 

 

Christopher Heaphy, PhD, Assistant Professor of Medicine (Hematology & Oncology Section)  appointment asAssistant Professor of Pathology & Laboratory Medicine

  • Dr. Heaphy is a cancer biologist that has been conducting basic and translational studies focused on elucidating the role of telomere alterations in the initiation of human diseases, particularly cancer. Overall, his research program focuses on cancer biomarker discovery and validation with the ultimate aim to utilize novel tissue-based biomarkers to improve individualized prevention, detection, and treatment strategies. Dr. Heaphy received a Ph.D. from the University of New Mexico and completed his post-doctoral training in the Department of Pathology at Johns Hopkins School of Medicine. He is a recognized expert on telomere biology and its associations with cancer outcomes. He has authored over 70 papers, including a transformative study published in Science that uncovered the association between inactivating mutations in ATRX and DAXX and activation of a unique telomerase independent telomere maintenance mechanism. Subsequently, he has further expanded his work to include a wide range of malignancies (e.g. prostate cancer, breast cancer, gliomas, and neuroendocrine tumors).

 

Please join me in welcoming Dr Heaphy to the department. ~ Chris

 

 

 

  • Also Welcome New Incoming Masters Students:
    • Sarah Faress Barakat
    • James Ford
    • Jamail Ghafwari
    • Jordyn Osterland
    • Kevin Rop
    • Lila Sultan
    • Anna Tseng
    • Meng Wei "Winnie" Zhang
    • Qiuyang Zhang
    • Also, Razi Amraei is joining the department as a PhD Candidate

Welcome to Allan Stolarski is a new Surgery resident working in the Remick Lab starting from the 1stday of July

Faculty Promotions to Associate Professor: Joel Henderson

The Hematology Lab and DG-LIS (Angel) – The SYSMEX is live!!!!!  Wooo hoooo

 

 

 

Our Residents took theses pictures Friday, July 24th during the BMC Thank You Week

 

 

Daniel Remick, M.D., has been selected to serve as a Reviewing Editor for the journal Science Translational Medicine.  This is a prestigious journal with a very high impact factor (17.2). He will be responsible for reviewing articles on sepsis

Masis Parunyan (MED IV) was one of this years recipients of the ASCP Medical Student Award for Pathology

 

 

A review article for Daniel Remick, M.D., reached a milestone when it was read 1000 times.Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry, May 2000, 157: 683-694.

Publications. Published:

  • Kim Vanuytsel, Aditya Mithal, Richard M. Giadone, Anthony K. Yeung, Taylor M. Matte, Todd W. Dowrey, Rhiannon B. Werder, Gregory J. Miller,Nancy S. Miller, Christopher D. Andry, George J. Murphy. Rapid Implementation of a SARS-CoV-2 Diagnostic qRT-PCR Test with Emergency Use Authorization at a Large Academic Safety-Net Hospital. Clinical and Translational Resource and Technology Insights, May 2020 https://doi.org/10.1016/j.medj.2020.05.001
  • Matthew Wolfson,1 Patrick Curtin,2; Emily J. Curry,3; Sandra Cerda,4; Xinning Li1; “Giant cell tumor formation due to metallosis after open latarjet and partial shoulder resurfacing.” Orthopedic Reviews 2020; volume 12:8522

      Publications. Accepted:

  • A recent review article was just accepted in the journal Shock, Yibing Wei, Jiyoun Kim, Harri Ernits and Daniel Remick, “The Septic Neutrophil – Friend or Foe” Yibing Wei recently completed her Masters of Science degree in the Department

 

Department of Pathology & Laboratory Medicine: New News Spring 2020

May 29th, 2020 in Uncategorized

Please find below a summary of reported activities in the department. As Summer approaches we are emerging from a most remarkable experience of dealing with the SARS Cov-2 pandemic.  Our clinical laboratory team: Lab Medicine, Pathology and colleagues in the CReM brought clinical testing forward to support the hospital, in record time.  The group worked tirelessly to ensure we provided the best service possible to our patients and colleagues.  Our Cov autopsy team worked bravely, under challenging circumstances, to perform post-mortem studies and collect important tissue samples for research.  Our department is also actively engaged in archiving biospecimens to be made available for research and future equipment validation.

While these particular efforts have been ongoing, our department has also continued to provide outstanding clinical service, formal teaching, mentorship and research initiatives.

 I wish you all well and thank everyone for their hard work and commitment

– best wishes Chris Andry.

Welcome:

  • Please welcome our new 2020- 2021 residents: Drs. Claire Avillach, Sanket Chosi, Isabela Pereira, Lubna Suaiti and Katie Doonan.
    • Claire Avillach, MD– Faculté de Médecine Paris Descartes (2006)
    • Sanket Chosi, MD-Surat Municipal Institute of Medical Education and Research(2010)
    • Isabela  Pereira, MD - Faculdade da Saúde e Ecologia Humana(2012)
    • Lubna Suaiti, MD –Al-Arab Medical University Faculty of Medicine(2008)
    • Katie Doonan, DO -University of New England College of Osteopathic Medicine(2016)
  • Tao Zuo, MD, PhD joined us from UMass and is a new pathology faculty member in the practice and assistant professor of Pathology & Laboratory Medicine
  • Lan Zhou, MD, PhD is vice chair for research, neurology and professor for Neurology and, Pathology and Laboratory Medicine, she is also a new member of our department and performs subspecialty work on nerve and muscle biopsies
  • Samir Jana, PhD, as a postdoctoral fellow in Dr. Dennis’s lab, beginning May 18th.
  • Weining Lu, MD, MSwas named 2019 Boston University Innovator of the Year:http://www.bu.edu/articles/2019/weining-lu-kidney-researcher-innovator-of-the-year/
  • Dennis Jones, Ph.D., Assistant Professor of Pathology & Laboratory Medicine, has been selected as the inaugural early career representative to the FASEB Board of Directors.  FASEB represents over 130,000 researchers from across the world and has become recognized as the policy voice for biological researchers. Dr. Jones’s selection to serve on the FASEB board recognizes his status as early investigator who will contribute to the direction of scientific studies. https://www.bumc.bu.edu/busm/2020/05/07/dennis-jones-phd-named-to-faseb-board/
  • Daniel Remick, M.D., chaired an NIH study section to review K38 grants. K38 grants are a new mechanism to help create clinician-scientists, Stimulating Access to Research in Residency Transition Scholar (StARRTS)
  • Also Daniel Remick, M.D. was awarded an NIH grant, R21AI 147168 “Mechanisms of improved organ function following sepsis treatment with vitamin c, thiamine and hydrocortisone (triple therapy)”
  • Lan Zhou is excited to share a good news with you, her pathology book "A Case-Based Guide to Neuromuscular Pathology" has been published by Springer! job affiliation. https://www.springer.com/gp/book/9783030256814 A Case-Based Guide to Neuromuscular Pathology: Lan Zhou: Springer   www.springer.com

 

  • Erin Norberg has accepted the promotion to Assistant Supervisor in Point of Care
  • Please welcome Brad Couture in his new role of Assistant Supervisor, Microbiology
  • Stacia Cote, was promoted to Assistant Supervisor, Cytology
  • A research publication by Daniel Remick, M.D. reached a milestone in April 2020 when it was cited for the 400th The article: Six at six: Interleukin 6 measured 6 hours after the initiation of sepsis predicts mortality over 3 days was published in the journal Shock in May of 2002.
  • Research Awards from the Massachusetts Consortium on Pathogen Readiness BMC is the recipient of two awards, totaling $619,000, from the Massachusetts Consortium on Pathogen Readiness (MassCPR) to fund research projects focused on COVID-19. George Murphy, PhD, co-director of the Center for Regenerative Medicine (CReM), Chris Andry, MPhil, PhD, chief of pathology and laboratory medicine at BMC, and Nancy Miller, MD, chief and vice chair of laboratory medicine at BMC, in collaboration with CReM faculty researchers, will lead a project aimed at reducing the rates of false negative COVID-19 test results. Using machine learning, the team will develop an algorithm to interpret test results more quickly and accurately than current methods. The team will also develop new methods for pooling samples to increase testing speed.
  • From Weining Lu; our recent publicationhas been selected as an Editor’s Choice article on The American Journal of Pathology (See Editor-in-Chief Dr. Martha Furie’s email below and the article online:https://ajp.amjpathol.org/article/S0002-9440(20)30024-9/fulltext). In addition, there is a news release from BUSM about this work: https://eurekalert.org/pub_releases/2020-05/buso-rsn050420.php
  • Lawreen Connors, PhD, Professor of Pathology & Laboratory Medicine, has been named the Charles J. Brown Research Professor in Amyloidosis, effective July 1, and established by the estate of Charles J. Brown.

Congratulation Class of 2020

  • Residents
    • Shoreh Fazeli, MD; Dr Fazeli will be moving on to the Beth Israel Deaconess Hospital for  a General Surgical Pathology Fellowship
    • Andrey Prilutskiy, MD; Dr Prilutskiy will be at Mass General hospital for a Head and Neck Pathology Fellowship
    • Weiwei Shi, MD: Dr Shi will next be moving to Brigham Women Hospital for the Thoracic Pathology fellowship
  • Masters Graduates
    • Marcela Alvia, MS; is staying on at the VA to finish work for publication
    • Amanda Araujo, MS: Amanda’s future plans include maintaining employment at MGH in the Surgical Pathology department for the near future, and looking forward she is planning on applying to medical school in hopes of becoming a Forensic Pathologist. The only solid plan for now is working at her job and studying for the MCAT
    • Julia Breda Camessola, MS: She is hoping that the Sarah Mazzilli Lab will hire her for a little bit as she has to finish up experiments for a publication that she is co-authoring. After that is done, Julia’s goal is to find a job in clinical research in which allows her to do both bench work but to also have patient contact
    • Kyle de le Cena, MS: Kyle is working at BMC in Pathology as a Research Associate for Biospecimen Science
    • Kunlin Huang, MS: She is moving back home to China over the summer and finding work in a clinical lab
    • Claire Marcus, MS: Unknown at this time
    • Grace Marden, MS: Has been Promoted to Lab Manager in Dr. Maria Trojanowska’s Lab
    • Linzi Sun, MS: Linzi will be moving back home to China over the summer and finding work
    • Hoang Thang, MS: Hoang is applying for a job in Boston as OPT
  • Jessica Kenison-White, PhD Candidate (Sherr Lab) was a recipient of a first prize award at the 26thAnnual H. I. Russek Student Achievement Day. Congratulations!
  • The #ProtectYourCaregiver group hosted a very successful online art auction, raising over $44,000 for BMC frontline staff. Thank you to the group and their committee for putting together such an effort for BMC. The committee included BMC clinician Claire Avillach,  MD, MS Renal fellow, Instructor of Medicine (Incoming Pathology Resident)

Publications. Published:

  • Assessment of minimal residual disease using multiparametric flow cytometry in patients with AL amyloidosis.Staron A, Burks EJ, Lee JC, Sarosiek S, Sloan JM, Sanchorawala V.Blood Adv. 2020 Mar 10;4(5):880-884. doi: 10.1182/bloodadvances.2019001331.PMID
  • Authors: Alexandra Rachel Greenberg*, Bertrand Russel Huber†, David Xianhong Liu‡, James Patrick Logue‡, Amanda Marie Woolsey Hischak‡, Randy Hart, Maureen Abbott‡, Nejra Isic‡, Yohei Michael Hisada, Nigel Mackman§, Richard Scott Bennet‡, Lisa E Hensley‡, John Hazard Connor: entitled “Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: a Longitudinal Study of Zaire Ebolavirus strain Kikwit (EBOV/Kik) The American Journal of Pathology
  • Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS. Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation. Cell Metab. 2020 May 5;. Doi: 10.1016/j.cmet.2020.04.015. [Epub ahead of print] PubMed PMID: 32402267
  • Belkina AC, Azer M, Lee JJ, Elgaali HH, Pihl R, Cleveland M, Carr J, Kim S, Habib C, Hasturk H, Snyder-Cappione JE, Nikolajczyk BS.  Single-Cell Analysis of the Periodontal Immune Niche in Type 2 Diabetes. J Dent Res. 2020 Mar 18;:22034520912188. doi: 10.1177/0022034520912188. [Epub ahead of print] PubMed PMID: 32186942
  • Guillon A, Arafa EI, Barker KA, Belkina AC, Martin I, Shenoy AT, Wooten AK, Lyon De Ana C, Dai A, Labadorf A, Hernandez Escalante J, Dooms H, Blasco H, Traber KE, Jones MR, Quinton LJ, Mizgerd JP.  Pneumonia recovery reprograms the alveolar macrophage pool. JCI Insight. 2020 Feb 27;5(4). doi: 10.1172/jci.insight.133042. PubMed PMID: 31990682; PubMed Central PMCID: PMC7101156
  • Zhang W, Ji T, Lyon S, Mehta M, Zheng Y, Deng X, Liu A, Shagan A, Mizrahi B, Kohane DS. Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Appl Mater interfaces. 2020 Apr 15;12(15):17314-17320
  • Zhang W, Ji T, Li Y, Zheng Y, Mehta M, Zhao C, Liu A, and Kohane DS. Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun. 2020 May 8;11(1):2323

Publication. Accepted:

  • Anna Pisarek-Horowitz, Xueping Fan, Sudhir Kumar, Hila Milo Rasouly, Richa Sharma,Hui Chen, Kathryn Coser, Crystal T. Bluette, Dinesh Hirenallur-Shanthappa, Sarah R. Anderson, Hongying Yang, Laurence H. Beck, Jr, Ramon G. Bonegio, Joel M. Henderson, Stephen P. Berasi, David J. Salant, Weining Lu. Loss of Robo2 in podocytes protects adult mice from glomerular injury by maintaining podocyte foot process structure. The American Journal of Pathology, 2020. in press
  • ThyroSeq v2 Testing: Impact on Cytologic Diagnosis, Management, and Cost of Care in Patients with Thyroid Nodule" was accepted for publication at Authors include: Shoreh R Fazeli, Brad Zehr, Razie Amraei, Gianluca Toraldo, Haixia Guan, David Kindelberger, Stephanie Lee, Sandra Cerda
  • Jones.PhD, Parallels of Resistance between Angiogenesis and Lymphangiogenesis Inhibition in Cancer Therapy: https://www.ncbi.nlm.nih.gov/pubmed/32244922

 

COVID-19 Essential Service: March 23, 2020

March 23rd, 2020 in Uncategorized

COVID-19 ESSENTIAL SERVICES
EXHIBIT A OF THE ORDER OF THE GOVERNOR ASSURING CONTINUED OPERATION OF ESSENTIAL
SERVICES IN THE COMMONWEALTH, CLOSING CERTAIN WORKPLACES AND PROHIBITING GATHERINGS
OF MORE THAN 10 PEOPLE
March 23, 2020

Governor Charlie Baker issued an emergency order requiring all businesses and organizations that do
not provide “COVID-19 Essential Services” to close their physical workplaces and facilities to workers,
customers and the public as of Tuesday, March 24th at noon until Tuesday, April 7th at noon. These
businesses are encouraged to continue operations remotely.
The Baker-Polito Administration issued a list of designated businesses and other organizations that
provide essential services and workforces related to COVID-19 that shall continue to operate brick and
mortar facilities during this two-week time period. This list is based on federal guidance and amended to
reflect the needs of Massachusetts’ unique economy. While these businesses are designated as
essential, they are urged to follow social distancing protocols for workers in accordance with guidance
from the Department of Public Health.
Businesses and organizations not on the list of essential services are encouraged to continue operations
through remote means that do not require workers, customers, or the public to enter or appear at the
brick-and-mortar premises closed by the order.
Restaurants, bars, and other establishments that sell food and beverage products to the public are
encouraged to continue to offer food for take-out and by delivery if they follow the social distancing
protocols set forth in Department of Public Health guidance continue operations. On-premises
consumption of food or drink is prohibited.
HEALTHCARE / PUBLIC HEALTH / HUMAN SERVICES
• Workers providing COVID-19 testing; Workers that perform critical clinical research needed for
COVID-19 response
• Medical Professionals and caregivers (e.g., physicians, dentists, psychologists, mid-level
practitioners, nurses and assistants, infection control and quality assurance personnel,
pharmacists, physical and occupational therapists and assistants, social workers, speech
pathologists and diagnostic and therapeutic technicians and technologists, other providers of
mental and behavioral health care, personal care attendants, home health aides and home care
workers)
• Hospital and laboratory personnel (including accounting, administrative, admitting and
discharge, engineering, epidemiological, source plasma and blood donation, food service,
housekeeping, medical records, information technology and operational technology,
nutritionists, sanitarians, respiratory therapists, etc.)
• Workers in other medical facilities (including Ambulatory Health and Surgical, Blood Banks,
Medical Clinics, Community Mental Health Centers, Methadone/OBOT Clinics, 24 hour
Diversionary and Residential Behavioral Health Providers, Comprehensive Outpatient
rehabilitation, End Stage Renal Disease, Health Departments, Home Health care, Hospices,
Hospitals, Nursing Facilities, Rest Homes, Assisted Living Residences, Organ Pharmacies,
COVID-19 Essential Services
March 23, 2020
Procurement Organizations, Psychiatric Residential, Residential Treatment Schools, Rural Health
Clinics and Federally Qualified Health Center s and Community Health Centers, State Hospitals,
and licensed medical marijuana retailers)
• Workers in other 24/7 community resident services serving children and youth, and individuals
with developmental, intellectual, physical and/or cognitive disabilities
• Manufacturers, technicians, logistics and warehouse operators, and distributors of or necessary
to the supply chain of medical equipment, personal protective equipment (PPE), medical gases,
pharmaceuticals, blood and blood products, vaccines, testing materials, laboratory supplies,
cleaning, sanitizing, disinfecting or sterilization supplies, and tissue and paper towel products
• Public health / community health workers, including those who compile, model, analyze and
communicate public health information
• Blood and plasma donors and the employees of the organizations that operate and manage
related activities
• Workers that manage health plans, billing, and health information, who cannot practically work
remotely
• Workers who conduct community-based public health functions, conducting epidemiologic
surveillance, compiling, analyzing and communicating public health information, who cannot
practically work remotely
• Workers performing cybersecurity functions at healthcare and public health facilities, who
cannot practically work remotely
• Workers conducting research critical to COVID-19 response
• Workers performing security, incident management, and emergency operations functions at or
on behalf of healthcare entities including healthcare coalitions, who cannot practically work
remotely
• Workers who support food, shelter, and social services, and other necessities of life for
economically disadvantaged or otherwise needy individuals, such as those residing in shelters
• Pharmacy employees necessary for filling prescriptions
• Workers performing mortuary services and workers at funeral homes, crematoriums, and
cemeteries
• Workers who coordinate with other organizations to ensure the proper recovery, handling,
identification, transportation, tracking, storage, and disposal of human remains and personal
effects; certify cause of death; and facilitate access to mental/behavioral health services to the
family members, responders, and survivors of an incident
LAW ENFORCEMENT, PUBLIC SAFETY, FIRST RESPONDERS
• Personnel in emergency management, law enforcement, Emergency Management Systems, fire,
and corrections, including front line and management required to maintain operations
• Emergency Medical Technicians
• 911 call center employees, including telecommunicators, dispatchers and managers
• Fusion Center employees
• Hazardous material responders from government and the private sector.
• Workers – including contracted vendors -- who maintain digital systems infrastructure
supporting law enforcement and emergency service operations.
FOOD AND AGRICULTURE
• Workers supporting groceries, pharmacies and other retail, including farmers markets and farm
stands, that sells food and beverage products, including liquor stores
• Restaurant carry-out and quick serve food operations - Carry-out and delivery food employees
COVID-19 Essential Services
March 23, 2020
• Food manufacturer employees and their supplier employees—to include those employed in
food processing (packers, meat processing, cheese plants, milk plants, produce, etc.) facilities;
livestock, poultry, seafood slaughter facilities; pet and animal feed processing facilities; human
food facilities producing by-products for animal food; beverage production facilities; and the
production of food packaging
• Farm workers to include those employed in animal food, feed, and ingredient production,
packaging, and distribution; manufacturing, packaging, and distribution of veterinary drugs;
truck delivery and transport; farm and fishery labor needed to produce our food supply
domestically
• Farm workers and support service workers to include those who field crops; commodity
inspection; fuel ethanol facilities; storage facilities; and other agricultural inputs
• Workers supporting the seafood and fishing industry
• Employees and firms supporting food, feed, and beverage distribution, including warehouse
workers, vendor-managed inventory controllers and blockchain managers
• Workers supporting the sanitation of all food manufacturing processes and operations from
wholesale to retail
• Company cafeterias - in-plant cafeterias used to feed employees; food service workers in
residential schools with students who are unable to leave campus
• Workers in food testing labs in private industries and in institutions of higher education
• Workers essential for assistance programs and government payments
• Employees of companies engaged in the production of chemicals, medicines, vaccines, and
other substances used by the food and agriculture industry, including pesticides, herbicides,
fertilizers, minerals, enrichments, and other agricultural production aids
• Animal agriculture workers to include those employed in veterinary health; manufacturing and
distribution of animal medical materials, animal vaccines, animal drugs, feed ingredients, feed,
and bedding, etc.; transportation of live animals, animal medical materials; transportation of
deceased animals for disposal; raising of animals for food; animal production operations;
slaughter and packing plants and associated regulatory and government workforce
• Organizations and workers responsible for the care and custody of animals, pets and livestock
• Workers who support the manufacture and distribution of forest products, including, but not
limited to timber, paper, and other wood products
• Employees engaged in the manufacture and maintenance of equipment and other infrastructure
necessary to agricultural production and distribution
ENERGY
Electricity industry:
• Workers who maintain, ensure, or restore the reliable generation, transmission, and distribution
of electric power, including call centers, utility workers, reliability engineers and fleet
maintenance technicians
• Workers needed for safe and secure operations at nuclear generation
• Workers at generation, transmission and electric blackstart facilities
• Workers at Reliability Coordinator (RC), Balancing Authorities (BA), and primary and backup
Control Centers (CC), including but not limited to independent system operators, regional
transmission organizations, and balancing authorities
• Mutual assistance personnel
COVID-19 Essential Services
March 23, 2020
• IT and OT technology staff – for EMS (Energy Management Systems) and Supervisory Control
and Data Acquisition (SCADA) systems, and utility data centers; Cybersecurity engineers;
cybersecurity risk management
• Vegetation management crews and traffic workers who support
• Environmental remediation/monitoring technicians
• Instrumentation, protection, and control technicians
Petroleum workers:
• Petroleum product storage, pipeline, marine transport, terminals, rail transport, road transport
• Crude oil storage facilities, pipeline, and marine transport
• Petroleum refinery facilities
• Petroleum security operations center employees and workers who support emergency response
services
• Petroleum operations control rooms/centers
• Petroleum drilling, extraction, production, processing, refining, terminal operations,
transporting, and retail for use as end-use fuels or feedstocks for chemical manufacturing
• Onshore and offshore operations for maintenance and emergency response
• Retail fuel centers such as gas stations and truck stops, and the distribution systems that
support them
Natural and propane gas workers:
• Natural gas transmission and distribution pipelines, including compressor stations, and road
transport
• Underground storage of natural gas
• Natural gas processing plants, and those that deal with natural gas liquids
• Liquefied Natural Gas (LNG) facilities
• Natural gas security operations center, natural gas operations dispatch and control
rooms/centers natural gas emergency response and customer emergencies, including natural
gas leak calls
• Drilling, production, processing, refining, and transporting natural gas for use as end-use fuels,
feedstocks for chemical manufacturing, or use in electricity generation
• Propane gas dispatch and control rooms and emergency response and customer emergencies,
including propane leak calls
• Propane gas service maintenance and restoration, including call centers
• Processing, refining, and transporting natural liquids, including propane gas, for use as end-use
fuels or feedstocks for chemical manufacturing
• Propane gas storage, transmission, and distribution centers
Steam workers:
• Workers who support steam distribution companies’ provision of district heating and any
electric generation
• Workers who support steam distribution companies’ dispatch and control rooms and
emergency response and customer emergencies, including steam leak calls
• Workers who support steam distribution companies’ service maintenance and restoration,
including call centers
• Workers who support steam distribution companies’ storage, transmission, and distribution
centers
COVID-19 Essential Services
March 23, 2020
WATER AND WASTEWATER
Employees needed to operate and maintain public and private drinking water and wastewater/drainage
infrastructure, including:
• Operational staff at water authorities
• Operational staff at community water systems
• Operational staff at wastewater treatment facilities
• Workers repairing water and wastewater conveyances and performing required sampling or
monitoring
• Operational staff for water distribution and testing
• Operational staff at wastewater collection facilities
• Operational staff and technical support for SCADA Control systems
• Chemical disinfectant suppliers for wastewater and personnel protection
• Workers that maintain digital systems infrastructure supporting water and wastewater
operations
TRANSPORTATION AND LOGISTICS
• Employees supporting or enabling transportation functions, including dispatchers, maintenance
and repair technicians, warehouse workers, truck stop and rest area workers, and workers that
maintain and inspect infrastructure (including those that require cross-border travel)
• Employees of firms providing services that enable logistics operations, including cooling, storing,
packaging, and distributing products for wholesale or retail sale or use
• Mass transit and passenger rail workers, including contracted vendors providing transportation
and maintenance services to public transit authorities
• Workers critical to operating rental car companies and Transportation Network Companies
(TNCs) that facilitate continuity of operations for essential workforces, and other essential travel
• Workers responsible for operating dispatching passenger, commuter and freight trains and
public transportation and buses and maintaining rail and transit infrastructure and equipment
• Maritime transportation workers - port workers, mariners, equipment operators
• Truck drivers who haul hazardous and waste materials to support critical infrastructure,
capabilities, functions, and services
• Automotive repair and maintenance facilities
• Workers who respond to and clear traffic crashes, including contracted vendors and dispatchers
• Manufacturers and distributors (to include service centers and related operations) of packaging
materials, pallets, crates, containers, and other supplies needed to support manufacturing,
packaging staging and distribution operations
• Postal and shipping workers, to include private companies
• Workers who support moving and storage services
• Employees who repair and maintain vehicles, aircraft, rail equipment, marine vessels, and the
equipment and infrastructure that enables operations that encompass movement of cargo and
passengers
• Air transportation employees, including air traffic controllers, ramp personnel, aviation security,
and aviation management and other workers – including contracted vendors – providing
services for air passengers
• Workers who support the maintenance and operation of cargo by air transportation, including
flight crews, maintenance, airport operations, and other on- and off- airport facilities workers
COVID-19 Essential Services
March 23, 2020
PUBLIC WORKS
• Workers who support the operation, inspection, and maintenance of essential dams, locks and
levees
• Workers who support the operation, inspection, and maintenance of essential public works
facilities and operations, including roads and bridges, water and sewer main breaks, fleet
maintenance personnel, construction of critical or strategic infrastructure, traffic signal
maintenance, emergency location services for buried utilities, maintenance of digital systems
infrastructure supporting public works operations, and other emergent issues
• Workers – including contracted vendors – involved in the construction of critical or strategic
infrastructure including public works construction, airport operations, water, sewer, gas,
electrical, nuclear, oil refining and other critical energy services, roads and highways, public
transportation, solid waste collection and removal, and internet, and telecommunications
systems (including the provision of essential global, national, and local infrastructure for
computing services)
• Workers such as plumbers, electricians, exterminators, inspectors and other service providers
who provide services that are necessary to maintaining the safety, sanitation, and essential
operation of residences, construction sites and projects, and needed facilities
• Support, such as road and line clearing and utility relocation, to ensure the availability of needed
facilities, transportation, energy and communications
• Support to ensure the effective removal, storage, and disposal of residential and commercial
solid waste and hazardous waste
• Licensed site clean-up professionals and other workers addressing hazardous spills, waste sites,
and remediation.
• Workers who support the operation, maintenance and public safety of state parks, forests,
wildlife management areas, water supply protection lands, and other critical natural resources.
• Workers who support storm clean-up operations (e.g., foresters).
COMMUNICATIONS AND INFORMATION TECHNOLOGY
Communications:
• Maintenance of communications infrastructure- including privately owned and maintained
communication systems- supported by technicians, operators, call-centers, wireline and wireless
providers, cable service providers, satellite operations, undersea cable landing stations, Internet
Exchange Points, and manufacturers and distributors of communications equipment
• Workers who support radio, television, and media service, including, but not limited to front line
news reporters, studio, and technicians for newsgathering and reporting
• Workers at Independent System Operators and Regional Transmission Organizations, and
Network Operations staff, engineers and/or technicians to manage the network or operate
facilities
• Engineers, technicians and associated personnel responsible for infrastructure construction and
restoration, including contractors for construction and engineering of fiber optic cables
• Installation, maintenance and repair technicians that establish, support or repair service as
needed
• Central office personnel to maintain and operate central office, data centers, and other network
office facilities
• Customer service and support staff, including managed and professional services as well as
remote providers of support to transitioning employees to set up and maintain home offices,
COVID-19 Essential Services
March 23, 2020
who interface with customers to manage or support service environments and security issues,
including payroll, billing, fraud, and troubleshooting
• Dispatchers involved with service repair and restoration
Information Technology:
• Workers who support command centers, including, but not limited to Network Operations
Command Center, Broadcast Operations Control Center and Security Operations Command
Center
• Data center operators, including system administrators, HVAC & electrical engineers, security
personnel, IT managers, data transfer solutions engineers, software and hardware engineers,
and database administrators
• Client service centers, field engineers, and other technicians supporting critical infrastructure, as
well as manufacturers and supply chain vendors that provide hardware and software, and
information technology equipment (to include microelectronics and semiconductors) for critical
infrastructure
• Workers responding to cyber incidents involving critical infrastructure, including medical
facilities, SLTT governments and federal facilities, energy and utilities, and banks and financial
institutions, and other critical infrastructure categories and personnel
• Workers supporting the provision of essential global, national and local infrastructure for
computing services (incl. cloud computing services), business infrastructure, web-based services,
and critical manufacturing
• Workers supporting communications systems and information technology used by law
enforcement, public safety, medical, energy and other critical industries
• Support required for continuity of services, including janitorial/cleaning personnel
OTHER COMMUNITY-BASED ESSENTIAL FUNCTIONS AND GOVERNMENT OPERATIONS
• Workers to ensure continuity of building functions, including local and state inspectors and
administrative support of inspection services who are responsible for the inspection of
elevators, escalators, lifts, buildings, plumbing and gas fitting, electrical work, and other safety
related professional work
• Security staff to maintain building access control and physical security measures
• Elections personnel
• Federal, State, and Local, Tribal, and Territorial employees who support Mission Essential
Functions and communications networks
• Trade Officials (FTA negotiators; international data flow administrators)
• Weather forecasters
• Workers that maintain digital systems infrastructure supporting other critical government
operations
• Workers at operations centers necessary to maintain other essential functions
• Workers who support necessary credentialing, vetting and licensing operations for
transportation workers including holders of Commercial Drivers Licenses
• Workers who are critical to facilitating trade in support of the national, state and local
emergency response supply chain
• Educators and staff supporting public and private emergency childcare programs, residential
schools for students with disabilities, K-12 schools, colleges, and universities for purposes of
facilitating distance learning, provision of school meals, or performing other essential student
support functions, if operating under rules for social distancing
COVID-19 Essential Services
March 23, 2020
• Hotel workers
• Critical government workers, as defined by the employer and consistent with Continuity of
Operations Plans
• Construction Workers who support the construction, operation, inspection, and maintenance of
construction sites and construction projects (including housing construction)
• Workers that provide services for or determine eligibility for public benefits such as subsidized
health care, food and feeding programs, residential and congregate care programs, shelter, inhome
supportive services, child welfare, juvenile justice programs, adult protective services and
social services, and other necessities of life for economically disadvantaged or otherwise needy
individuals (including family members)
• Workers in sober homes
• Professional services (such as legal and accounting services) and payroll and employee benefit
services, when necessary to assist in compliance with legally mandated activities and critical
sector services or where failure to provide such services during the time of the order would
result in significant prejudice
• Commercial retail stores that supply essential sectors, including convenience stores, pet supply
stores, auto supplies and repair, hardware and home improvement, and home appliance
retailers
• Laundromats and laundry services
• Workers and instructors supporting academies and training facilities and courses for the
purpose of graduating students and cadets that comprise the essential workforce for all
identified critical sectors
• Workers at places of worship
CRITICAL MANUFACTURING
• Workers necessary for the manufacturing of materials and products needed for medical supply
chains including personal protective equipment and hygiene products, transportation, energy,
communications, food and agriculture, chemical manufacturing, nuclear facilities, the operation
of dams, water and wastewater treatment, emergency services, and the defense industrial base.
HAZARDOUS MATERIALS
• Workers at nuclear facilities, workers managing medical waste, workers managing waste from
pharmaceuticals and medical material production, and workers at laboratories processing test
kits
• Workers who support hazardous materials response and cleanup
• Workers who maintain digital systems infrastructure supporting hazardous materials
management operations
FINANCIAL SERVICES
• Workers who are needed to process and maintain systems for processing financial transactions
and services (e.g., payment, clearing, and settlement; wholesale funding; insurance services; and
capital markets activities)
• Workers who are needed to provide consumer access to banking and lending services, including
ATMs, and to move currency and payments (e.g., armored cash carriers)
• Workers who support financial operations, such as those staffing data and security operations
centers
COVID-19 Essential Services
March 23, 2020
CHEMICAL
• Workers supporting the chemical and industrial gas supply chains, including workers at chemical
manufacturing plants, workers in laboratories, workers at distribution facilities, workers who
transport basic raw chemical materials to the producers of industrial and consumer goods,
including hand sanitizers, food and food additives, pharmaceuticals, textiles, and paper
products.
• Workers supporting the safe transportation of chemicals, including those supporting tank truck
cleaning facilities and workers who manufacture packaging items
• Workers supporting the production of protective cleaning and medical solutions, personal
protective equipment, and packaging that prevents the contamination of food, water, medicine,
among others essential products
• Workers supporting the operation and maintenance of facilities (particularly those with high risk
chemicals and/or sites that cannot be shut down) whose work cannot be done remotely and
requires the presence of highly trained personnel to ensure safe operations, including plant
contract workers who provide inspections
• Workers who support the production and transportation of chlorine and alkali manufacturing,
single-use plastics, and packaging that prevents the contamination or supports the continued
manufacture of food, water, medicine, and other essential products, including glass container
manufacturing
DEFENSE INDUSTRIAL BASE
• Workers who support the essential services required to meet national security commitments to
the federal government and U.S. Military. These individuals, include but are not limited to,
aerospace; mechanical and software engineers, manufacturing/production workers; IT support;
security staff; security personnel; intelligence support, aircraft and weapon system mechanics
and maintainers
• Personnel working for companies, and their subcontractors, who perform under contract to the
Department of Defense providing materials and services to the Department of Defense, and
government-owned/contractor-operated and government-owned/government-operated
facilities
If the function of your business is not listed above, but you believe that it is essential or it is an entity
providing essential services or functions, you may request designation as an essential business.
Requests by businesses to be designated an essential function should only be made if they are NOT
covered by the guidance.
To request designation as an essential business, please click here:
https://www.mass.gov/forms/essential-service-designation-request
Any questions can be directed to covid19.biz@mass.gov.

A Message from Kate Walsh

March 13th, 2020 in Uncategorized

Dear Colleagues,

Over the past week, the COVID-19 situation has progressed rapidly, with the World Health Organization officially declaring it a pandemic and Governor Baker declaring a state of emergency in Massachusetts. We’ve already felt this significant change, not just on our BMC Health System, but in each of our lives and communities.

Across BMCHS, staff have stepped up to prepare for this unprecedented challenge that will place enormous strain on the entire health care system. As we ramp up our work, our teams have been performing at their very best. Colleagues across the system have come together to develop the best possible responses to a range of tough challenges, guided by a commitment to the safety and well-being of our staff, patients, visitors, members, and community.

March marks 10 years that I have worked with all of you. Since my earliest days here, I have time and again been so impressed and proud of the resiliency and creativity of our staff, even in the most difficult situations. As we look out to the days and weeks ahead, we will be relying more than ever on each of you for your flexibility and your continued creativity and commitment. Even as we make changes to our daily routines, how we do our work, and what we ask of our patients and their loved ones, I’m asking all of us to remain focused on carrying out our mission and living our values. Never have each of you, whatever role you play, been more important to the work that we do.

I appreciate that the volume of work, combined with the rapidly changing situation, is causing understandable anxiety both here at work and at home. I’m committed to making sure we’re doing all that we can to support you, even as you’re supporting our patients and members. We’re working hard to put those supports in place, with more to come in the days ahead. Meanwhile, it’s important that you make time for your own personal preparedness to keep yourself and your families safe and healthy. That means following our own advice about getting enough sleep, eating nutritiously, staying home with respiratory and flu-like symptoms, washing our hands, not touching our faces, avoiding international travel and large gatherings, and following social distancing protocols.

My deepest appreciation to all of you for working so hard to ensure our hospital and health plan operations are able to meet the needs of our patients and members. And most of all, thank you for being caring and supportive colleagues to one another as we meet this challenge head on.

Kate Walsh
President and CEO

From BMC Communications: COVID-19 Updates; 3/13 @ 8:09 AM

March 13th, 2020 in Uncategorized

FROM BMC COMMUNICATION:

Dear Colleagues,
Please read below for today’s updates.

A Note about Mask Usage and Conservation
No employee should have a mask on as they walk through the hospital unless they are caring for a patient on precautions in that patient’s room, or are transporting a patient on precautions. We need everyone’s help to conserve our supplies.
Updated Visitor Policy and Hospital Access Changes for Patients, Visitors, and Staff
An earlier update<http://s2.bl-1.com/h/cNMKMLKW?url=https://internal.bmc.org/sites/default/files/docs/2020-03/visitor%20policy_access%20restrictions_3.12.20.pdf> outlined our updated visitor policy (one visitor per patient at a time, no visitors under 18, no PACU visitors) as well as our plan to limit access points to the hospital.
NEW: Guidance for Care and Placement of Patients with Viral Respiratory Illnesses
In light of new guidance<http://s2.bl-1.com/h/cNMKMRkY?url=https://www.cdc.gov/coronavirus/2019-ncov/infection-control/control-recommendations.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Finfection-control.html> from the CDC, effective immediately BMC has updated its own infection control recommendations surrounding the care of patients with COVID-19. These new guidelines are designed to protect the safety of our employees, while ensuring we are able to continue to provide excellent care to our patients during an ongoing epidemic. It will also ensure staff are protected from unsuspected initial presentations of COVID-19 patients. They are consistent with what other academic medical centers have adopted.

Below is a summary of the changes. More detailed procedures will be shared as they are developed.

1) All patients with symptoms consistent with any viral respiratory illnesses (including suspected or confirmed COVID-19 cases)

COVID-19 Information; 3/12/2020 @ 6:56 AM

March 12th, 2020 in Uncategorized

Boston University Medical Campus
Office of the Associate Provost GMS

Dear GMS Faculty, Staff, and Students,

Today’s letters from President Brown is the university’s response to the COVID-19 pandemic and how we will make adjustments in the interests of all our BU community members. The change to remote teaching will begin next Monday (March 16th) and I applaud all of you who planned ahead for this transition. Note that EdMedia is a continuing resource and GMS has staff who can assist with Zoom as well. Contacts are on the GMS web page and feel free to reach out to us for help.

There are some points in President Brown’s communications that are under discussion and many people are asking questions. I do not have all the answers now. Generally, keep academic activities to groups of 10 people or less. If it is not essential, either cancel or do it remotely. However, the campus is still “open” so faculty and staff are expected to come to work as usual.

Research Graduate Students and Postdoctoral Scholars: Research activities will continue normally. Research graduate students should report to their research laboratories for rotations or thesis research, but do so with common sense. Talk with your PI to see if you can shift hours so you avoid rush hour on public transportation, freeze down cells, back up your data, try not to schedule long-term experiments with animals. You should follow the decisions and recommendations of your research PI. PhD thesis defenses can go on as scheduled, but limit attendance to 10 or fewer people. Avoid inviting family and plan your (anticipated) celebration at an off campus site to accommodate well-wishers.

Clinical Graduate Students: We hope that the status of clinical rotations will be resolved tomorrow morning at a meeting of BU deans. There is universal understanding of the potential impact on accreditation and graduation requirements and we are doing everything possible on behalf of our students. This is evolving very rapidly and I will keep you updated as soon as possible.

I appreciate your concerns and forbearance as we work through these changes. We still have a few days until the changes come into effect and I am very optimistic that matters will be worked out in time. These are extraordinary times and we are extraordinarily resilient.

With best regards,
Debbie

Deborah Stearns-Kurosawa, PhD
Associate Provost ad interim
Graduate Medical Sciences
Make a Difference at GMS<http://www.bumc.bu.edu/gms