August 2014

 

Pathology & Laboratory Medicine News Items

Announcements:

  • New Grant Funding in Pathology:

The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the

period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department

and it would be appropriate to share the specifics of these new grants.

PI Alpaslan Dedeoglu
Co-Investigator Jan Krzysztof Blusztajn
Number 1 I01 BX001875-01
Title Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy
Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.
PI Alpaslan Dedeoglu
Co-Investigator Jan Krzysztof Blusztajn
Number 1 I01 BX002468-01
Title Novel neurotrophic therapies in an optimized mouse model of GWVI
Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.
PI Jan Krzysztof Blusztajn
Co-Investigator Tiffany Mellott, Barbara Slack, Ivana Delalle
Number R01 AG045031-01A1
Title BMP9 as a juvenile protective factor in cognitive aging
Description The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.
PI Shinichiro Kurosawa
Co-Investigator D.J. Stearns-Kurosawa
Number R01 AI102931
Title Development and Treatment of Pre-Clinical EHEC Models with HUS
Description Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children.  There is no treatment available, other than supportive care.  Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.  The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.
PI Vipul Chitalia
Co-investigator Nader Rahimi
Number R01 CA175382
Title Role of c-Cbl in Colon cancer
Description The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase
PI Daniel Remick
Co-Investigator Nader Rahimi
Number R21 AI112887-01
Title Mechanisms of phagocytic cell defects induced by inhibitory IgG
Description We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.
PI Daniel Remick
Number R21 AA022122-01
Title Alcohol Triggered Asthma: Mechanisms of Neuronal Control
Description The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.
PI Susan Winandy
Number R21 CA176811-01
Title Mechanism of Notch-induced leukemogenesis in lymphocytes
Description Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.  This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.

 Welcome to our New Graduate Students:

    • Stephanie Adams, OD/PhD
    • Lois Bayigga, Masters
    • Evan Catudal, Masters
    • Junbo Chen, Masters
    • Yuri Kim, PhD
    • Asha Melo, Masters
    • Tim Norman, PhD
    • Ruoyu Tian, Masters
    • BJ Varian, Masters

 

  • From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
  • Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
  • Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.

Publications: ACCEPTED:

  • Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
  • Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)

Publications: PUBLISHED:

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