June 2009
Pathology & Laboratory Medicine News Items
Announcements:
- You can watch our own Dr. Daniel Remick speak about his asthma and cockroach research on http://mms.tveyes.com/MediaCenter/315364.8788/WCVB_05-07-2009_23.15.05.wmv”>Channel 5/WCVB and http://mms.tveyes.com/MediaCenter/316022.6216/WBZ_05-07-2009_23.14.59.wmv”>Channel 4/WBZ (both broadcasts were May 7, 2009)
- Welcome to two New Faculty Members
- Joel Henderson, MD PhD, Assistant Professor
- Catherine Valentine, MD; Assistant Professor
- June is PhD Qualifying Exams Month! This year June 18th will be the written part of the exam and June 25th the oral portion will take place. There are six students who will be taking these exams: Jackie Bouchard, Heather Cohen, Michael Durando, Michael Green, Madhu Jagannathan, and Jillian Richmond. The faculty working with this group of qualifying exam candidates is: Drs. Berse, Burke, Lerner, Murnane, O’Hara, Remick, Sharon and Slack. Good Luck to all!
- Jillian Richmond, PhD student, received Honorable Mention for the 2009 National Science Foundation Graduate Research Fellowship Program Congratulations to you!
- Florin Craciun has won a Travel Grant Award to attend the Thirty-second Annual Conference on Shock, San Antonio, June 6-9, 2009. He will be presenting his abstract also (see below)
PRESS RELEASE: Top Notch choices in the lung: Airways have to cope with tasks as diverse as clearance of environmental particles, detoxification, and air humidification. These tasks are accomplished by a variety of cell types that populate the airways and include ciliated and secretory cells. How these cell fates are established and balanced during development and during injury-repair in the adult is still an open question.
A study from a research team led by Wellington Cardoso, MD, PhD (Pulmonary Center, Dept. of Medicine and Dept. of Pathology) sheds light into the mechanisms that control formation of secretory cells in the lung. They found that when the Notch pathway is inactivated in mouse mutant embryos, airways no longer form the secretory (Clara) cells and the airway epithelium becomes populated almost exclusively by ciliated cells. The unbalance seems to result from the loss of a mechanism of cell fate choice triggered by Notch, called lateral inhibition. These findings not only help to understand how airways develop but they also give insights into how aberrant patterns of differentiation occur in diseases, such as asthma and Chronic Obstructive Pulmonary Disease (COPD). The study is authored by Po-Nien Tsao MD (postdoc) and Michelle Vasconcelos (graduate student). It appears in the current online edition of Development, and is highlighted in the cover. Dr. Cardoso is the Director of the Program in Lung Development and Progenitor Cell Biology, which harbors a multidisciplinary group that studies lung development and its intersection with disease. The Program has been funded by the NIH-NHLBI for 17 years.
|
|
 |
|
Presentations:
- Dr. Karen Quillen spoke on “Safety and complications of therapeutic plasmapheresis” at the PEXIVAS Investigators’ meeting in Cambridge, United Kingdom on April 24, 2009.
|
|
|
- Bryan Belikoff’s, an MD/PhD student, abstract “HYPERBARIC OXYGEN THERAPY PREVENTS LUNG INFLAMMATION IN THE ABSENCE OF ADENOSINE A2A RECEPTOR SIGNALING” has been accepted for an oral and poster presentation at the 2009 Undersea and Hyperbaric Medicine Society Annual Scientific Meeting in Las Vegas, NV, June 24-27.
- Florin Craciun’s abstract was accepted for an oral presentation at the Thirty-second Annual Conference on Shock, San Antonio, June 6-9, 2009. INCREASED LOCAL NEUTROPHIL RECRUITMENT IMPROVES SEPSIS SURVIVAL & BACTERIA CLEARANCE. F. Craciun, M. Osuchowski, B. Belikoff, E. Schuller, and D. Remick.
- Marc Lenburg, PhD gave a talk entitled “Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer” at a symposium entitled Novel Tools for Risk Assessment and Early Detection of Premalignant Lesions and Cancer sponsored by Deutsche Krebshilfe in Bonn, Germany on May 7th.
- Dr. Jianmin Gan’s abstract entitled: “CK 903 and p63 are useful markers in the differential diagnosis of atypical large glandular proliferations of the prostate” has been accepted as a POSTER PRESENTATION at the 22nd European Congress of Pathology to be held in Florence, Italy September 4-9, 2009.
Publications- PUBLISHED:
- A Manuscript by Kazem Azadzoi, MD et al entitled “Oxidative Stress and Molecular Reactions in Arteriogenic Erectile Dysfunction” was published in the April issue of Chonnam Medical Journal 45: 1-8, 2009
- John Cho’s, current Anatomic Pathology Chief Resident, case report has been accepted and published via advance online publication (the print version will come out later).It’s titled “Erythroid/B-cell biphenotypic acute leukemia first case report with the following as citation” Leukemia advance online publication 21 May 2009; doi: 10.1038/leu.2009.105” ()
- Remick DG: : “Old friends: pneumonia and interleukin-6” Critical Care Med 2009, 37:1809-1810
- Osuchowski MF, Connett J, Welch K, Granger J, Remick DG: “Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis” Critical Care Med 2009, 37:1567-1573
- Remick DG: “What’s new in Shock, February 2009?” Shock 2009, 31:111-112
- C Lee, S Yang, Y Zou and L Joseph: “Erythroid/B-cell biphenotypic acute leukemia first case report.” Leukemia advance online publication, 21 May 2009; doi:10.1038/leu.2009.105
Publications- ACCEPTED:
- Jean A. Nemzek DVM, and Jiyoun Kim PhD “Pulmonary Inflammation and Airway Hyperresponsiveness in a Murine Model of Asthma Complicated by Acid Aspiration” Journal of Comparative Medicine
- Noronha, AM, Liang, YM, Hetzel, J, Hasturk, H, Kantarci, A, Stucci , A, Zhang, Y, Nikolajczyk, BS, Farraye, FA, and Ganley-Leal, LM. 2009. Hyper-activated B cells in human inflammatory bowel disease. (Accepted to J. Leukocyte Biol.)
-
Eugen B. Petcu MD, Leonard Berman MD, Maria M. Opris MD, Valentin Ghiorghiu MD, Stanton C. Kessler MD, John Hayes MD, Harrison W. Farber MD, “Severe Pulmonary Hypertension in a Patient with Systemic Lupus Erythematosus complicated by exposure to Dexfenfluramine” has been accepted for publication in the next issue of the Romanian Journal of Legal Medicine (Vol 17, No 2, July 2009)