September 2008

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Two pathologists successfully passed their Anatomic Pathology Boards:

    • Carmen Sarita-Reyes, M.D.
    • Rachel Factor, M.D.

Successful Ph.D. Dissertations:

    • Kristen Ross
    • Sri Sridhar

Awards:

  • Alyson Mangini won First Prize for Henry Russek Day this year for Pathology with the following abstract: A.J. Mangini, J.A. Meyers, T. Nagai, A. Ozonoff, M.J. Fritzler, R. Lafyatis, G. van Seventer and J. Maguire van Seventer (2008) Type I Interferons inhibit inflammatory T helper cell responses. H.I Russek Student Achievement Day, Boston University School of Medicine, Boston, MA.
  • L Liou, M.D.’s poster won Best in Session (Basic Science Poster session 2) at the Annual Urology Meeting in Orlando this past May 2008. 262] MicroRNA EXPRESSION PROFILE IN CLEAR-CELL KIDNEY CANCER. Authors: David Juan*, Boston, MA, Gabriela Alexe, Travis Antes, Mountain View, CA, David Foran, Anant Madabhushi, Gyan Bhanot, Piscataway, NJ, Charles Delisi, Shridar Ganesan, New Brunswick, NJ, Louis Liou, Boston, MA

Presentations:

    • Antonio de las Moranes was invited to give the Grand Round presentation “Fine Needle Aspiration of Unusual Tumors. Differential Diagnosis” at New England Medical Center on August 20th 2008.
    • Louis Liou, M.D. has been invited to give Urology Grand Rounds at the Medical College of Wisconsin in September, 2008.

Publications:

  • Reiner, AP, Carty CL, Jenny NS, Nievergelt C, Cushman M, Stearns-Kurosawa DJ, Kurosawa S, Kuller LH, Lange LA. PROC, PROCR, and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. J Thromb Haemost, in press, 2008. (published on-line 1 August 2008) The study shows that a variant of the protein C receptor, part of a molecular network that regulates coagulation and inflammation, is associated with increased risk of stroke, all-cause mortality and decreased healthy survival in aging adults.
  • Thampi P, Stewarta BW, Joseph L, Melnyck SB, Jennings LJ, Nagarajan S Dietary homocysteine promotes atherosclerosis in apoE-deficient mice by inducing scavenger receptors expression. Atherosclerosis 2008:197, http://www.atherosclerosis-journal.com/issues/contents?issue_key=S0021-9150(08)X0004-8(2) 620-629
  • Vita JA, Holbrook M, Palmisano J, Shenouda SM, Chung WB, Hamburg NM, Eskenazi BR, Joseph L, Shapira OM. Flow-induced arterial remodeling relates to endothelial function in the human forearm. Circulation 2008; 117:3126-3133.
  • Apovian CM, Bigornia S, Mott M, Meyers MR, Ulloor J, Gagua M, McDonnell M, Hess D, Joseph L, Gokce N. Adipose Macrophage Infiltration is Associated with Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects Arterioscler Thromb Vasc Biol. 2008 Jun 19. [Epub ahead of print]
  • Effects of Ischemia on Tachykinin-Containing Nerves and Neurokinin Receptors in the Bladder Published in UROLOGY 71: 979 –983, 2008 Authors: Kazem Azadzoi, Ziv M. Radisavljevic, and Mike B. Siroky
  • Zhang, Y, Saccani, S Shin, H, and Nikolajczyk, BS. 2008. Dynamic protein associations define two phases of IL-1b transcriptional activation. J. Immunol. 181:503-512
  • L Liou just published a paper in J. Urol this month on hypermethylation of kidney cancer. I have been invited to give Urology grand rounds at Medical College of Wisconsin this September.

Student Publication:

  • Alyson J. Mangini, Robert Lafyatis, and Jean Maguire van Seventer. (2007) Type I Interferons Inhibition of Inflammatory T helper Cell Responses in Systemic Lupus Erythematosus. Ann. N.Y. Acad. Sci. 1108: 11-23.
  • Karen Quillen’s and Kate Murphy’s article, “Quality improvement to decrease specimen mislabeling in transfusion medicine (Arch Pathol Lab Med 2006;130:1196-1198) was recently cited in the Joint Commission DRAFT of Blood Management Candidate Measure Profile (BM-17).

Abstracts:

  • Oxidative Stress-Responsive genes Regulate Ultrastructural Changes of the Overactive Bladder Authors: Kazem Azadzoi, Ziv Radisavljevic, Bingguan Chen, and Mike Siroky To be presented at the International Continence Society (ICS) annual meeting in Cairo, Egypt on October 22-25, 2008
  • Abstract accepted for poster presentation at CAP meeting, September 2008: Ochrobactrum anthropi Bacteremia in a Patient Treated with Intravenous Treprostinil for Pulmonary Hypertension Bethany J. Tierno, MD; Paschalis Vergidis, MD; Jason Konter, MD; Harrison W. Farber, MD; Nancy S. Miller, MD
  • Abstract accepted for poster presentation at AABB meeting, October 2008: Validation of the VersaTREK® automated blood culture system for detection of microbial contamination in hematopoietic progenitor cells SC KOENIG, BL ORR, A SCHWARZMANN, K QUILLEN, NS MILLER Boston Medical Center, Department of Laboratory Medicine, Boston, MA
  • Accepted Abstract for 2008 CAP meeting in September. Use of multiple patient analyte samples to enhance detection of changing clinical status. SC Koenig, MH Kroll
  • Accepted Abstract for 2008 CAP meeting in September Incorporation of a periodic function: an alternate approach to insulin monitoring. SC Koenig, MH Kroll

Student Abstracts:

    • T. Nagai, A. Mangini, M. York, A. Ozonoff , R. Lafyatis and J.M. van Seventer (2008) Serum from a subset of SLE patients inhibits inflammatory cytokine IFN-γ and IL-17 secretion in a type I IFN-dependent manner. Conference of Japan Immunology Society, Kyoto, Japan.

Grants:

    • Kazem Azadzoi, M.D., M.A. just got funding notification by VA Merit Review for “Oxidative Stress and Neurodegeneration in the Overactive Bladder” for 4 years starting October 08

Resident News:

    • Sara Koenig was accepted at UNC for their transfusion medicine fellowship
    • John Lee is presenting at the CAP Conference. John Lee’s Title “Myocardial Mast Cell Distribution in Cardiovascular Disease”

Announcements:

    • The integrated disease and therapy course for the second year medical students in underway as of August 18th, 2008. The course is the result of over two years of planning and discussions initiated by Dr.Adrianne Rogers. The course “horizontally” integrates microbiology, pharmacology, pathology and biology of disease into one course. It has a thread of health law and policy weaved throughout. The course also “vertically” integrates anatomy, histology, biochemistry and physiology content from the first year. The Integrated problems and introduction to clinical medicine courses are now aligned to this course content so that organ based concept is emphasized to the students. Many of the pathology faculty have been integral and extremely helpful in the process and we are always looking for faculty who would like to develop their educational portfolio on campus. If you are interested in being part of this effort, please contact Dr. Joseph at lija.joseph@bmc.org or Dr. O’Hara at Carl.Ohara@bmc.org

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