Yuriy O. Alekseyev, PhD
Research Associate Professor, Pathology & Laboratory Medicine
Biography
Yuriy serves as director of BU Microarray Core Resource facility since 2007. Prior to joining BU, Yuriy was a post-doctoral associate with Dr. John Essigmann at MIT where he used animal models to study transcriptional networks affected by a human hepatocarcinogen Aflatoxin B1 and by chemoprevention agents that suppress aflatoxin-induced carcinogenesis.
Yuriy earned a Ph.D. in Biochemistry from the Department of Chemistry at Wayne State University in the laboratory of Dr. Romano, where he studied mechanisms of DNA replication, mutagenesis and repair of carcinogenic lesions. Prior to that he received a M.S. in biotechnology from Moscow Academy of Fine Chemical Technology and worked in Moscow State Scientific Center GNIIGenetica where he studied plant toxins and took part in development of immunotoxins for potential use in cancer therapy and organ transplantation.
Other Positions
- Director, Microarray Resource Core, Boston University School of Medicine
Education
- Wayne State University, PhD
- Moscow State University of Fine Chemical Technologies, MS
- Moscow State University of Fine Chemical Technologies, BS
Publications
- Published on 5/6/2019
Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 May 06; 9(1):6978. PMID: 31061400.
Read at: PubMed - Published on 4/25/2019
Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M. Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD. Eur Respir J. 2019 Apr; 53(4). PMID: 30846474.
Read at: PubMed - Published on 6/22/2018
Billatos E, Faiz A, Gesthalter Y, LeClerc A, Alekseyev YO, Xiao X, Liu G, Ten Hacken NHT, Heijink IH, Timens W, Brandsma CA, Postma DS, van den Berge M, Spira A, Lenburg ME. Impact of acute exposure to cigarette smoke on airway gene expression. Physiol Genomics. 2018 09 01; 50(9):705-713. PMID: 29932825.
Read at: PubMed - Published on 5/6/2018
Alekseyev YO, Fazeli R, Yang S, Basran R, Maher T, Miller NS, Remick D. A Next-Generation Sequencing Primer-How Does It Work and What Can It Do? Acad Pathol. 2018 Jan-Dec; 5:2374289518766521. PMID: 29761157.
Read at: PubMed - Published on 3/15/2018
Herbert ZT, Kershner JP, Butty VL, Thimmapuram J, Choudhari S, Alekseyev YO, Fan J, Podnar JW, Wilcox E, Gipson J, Gillaspy A, Jepsen K, BonDurant SS, Morris K, Berkeley M, LeClerc A, Simpson SD, Sommerville G, Grimmett L, Adams M, Levine SS. Cross-site comparison of ribosomal depletion kits for Illumina RNAseq library construction. BMC Genomics. 2018 Mar 15; 19(1):199. PMID: 29703133.
Read at: PubMed - Published on 3/14/2016
Colletti NJ, Liu H, Gower AC, Alekseyev YO, Arendt CW, Shaw MH. TLR3 Signaling Promotes the Induction of Unique Human BDCA-3 Dendritic Cell Populations. Front Immunol. 2016; 7:88. PMID: 27014268.
Read at: PubMed - Published on 2/2/2016
Huang D, He X, Zou J, Guo P, Jiang S, Lv N, Alekseyev Y, Luo L, Luo Z. Negative regulation of Bmi-1 by AMPK and implication in cancer progression. Oncotarget. 2016 Feb 02; 7(5):6188-200. PMID: 26717043.
Read at: PubMed - Published on 10/27/2015
Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13. PMID: 26507575.
Read at: PubMed - Published on 10/14/2015
Wang TW, Vermeulen RC, Hu W, Liu G, Xiao X, Alekseyev Y, Xu J, Reiss B, Steiling K, Downward GS, Silverman DT, Wei F, Wu G, Li J, Lenburg ME, Rothman N, Spira A, Lan Q. Gene-expression profiling of buccal epithelium among non-smoking women exposed to household air pollution from smoky coal. Carcinogenesis. 2015 Dec; 36(12):1494-501. PMID: 26468118.
Read at: PubMed - Published on 9/25/2015
Coleman MA, Sasi SP, Onufrak J, Natarajan M, Manickam K, Schwab J, Muralidharan S, Peterson LE, Alekseyev YO, Yan X, Goukassian DA. Low-dose radiation affects cardiac physiology: gene networks and molecular signaling in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Dec 1; 309(11):H1947-63. PMID: 26408534.
Read at: PubMed
View 24 more publications: View full profile at BUMC