Tsuneya Ikezu, MD, PhD

Professor, Pharmacology & Experimental Therapeutics

Tsuneya Ikezu
(617) 414-2658
72 E. Concord St Instructional (L)


My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer’s disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer’s disease.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
  • Professor, Neurology, Boston University School of Medicine


  • Tokyo Medical and Dental University, MD
  • Tokyo Medical and Dental University, PhD
  • University of Tokyo, BS

Classes Taught

  • GMS MS 783
  • GMS PM 702
  • GMS PM 800
  • GMS PM820
  • SDM MD 530


  • Published on 9/19/2017

    Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 Sep 19; 47(3):566-581.e9. PMID: 28930663.

    Read at: PubMed
  • Published on 5/10/2017

    Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017 Jun 23; 292(25):10651-10663. PMID: 28490631.

    Read at: PubMed
  • Published on 2/10/2017

    Fujioka S, Curry SE, Kennelly KD, Tacik P, Heckman MG, Tsuboi Y, Strongosky AJ, van Gerpen JA, Uitti RJ, Ross OA, Ikezu T, Wszolek ZK. Occurrence of Crohn's disease with Parkinson's disease. Parkinsonism Relat Disord. 2017 Apr; 37:116-117. PMID: 28215729.

    Read at: PubMed
  • Published on 1/9/2017

    Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017 May; 133(5):785-807. PMID: 28070672.

    Read at: PubMed
  • Published on 12/6/2016

    Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, ß-amyloidosis, and Learning Impairment of APP/PS1 Mice. Mol Ther. 2009 May; 17(5):803-809. PMID: 28189021.

    Read at: PubMed
  • Published on 5/29/2016

    Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. EBioMedicine. 2016 Jun; 8:349. PMID: 27428444.

    Read at: PubMed
  • Published on 1/12/2016

    Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nat Commun. 2016; 7:10332. PMID: 26755131.

    Read at: PubMed
  • Published on 1/1/2016

    Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2016; 51(4):1099-109. PMID: 26890775.

    Read at: PubMed
  • Published on 12/16/2015

    Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar; 356(3):702-11. PMID: 26675679.

    Read at: PubMed
  • Published on 11/10/2015

    Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1. PMID: 26870779.

    Read at: PubMed

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