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Published 6/23/2025
Ikezu T, Bodart-Santos V, Ravula AR, You Y, Abdullah M, Ruan Z, Ellison J, Radhakishun S, Ray NB, Melvin B, Kurti A, Liang Z, Sakai Y, O'Brien D, Nguyen S, Shaffer S, Fiddes L, Butovsky O, Springer W, Ikezu S. P2RX7 regulates tauopathy progression via tau and mitochondria loading in extracellular vesicles. Res Sq. 2025 Jun 23. PMID: 40678243.
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Published 5/30/2025
You Y, Zhang Z, Cortes S, Nguyen SN, Vadakattu P, Melvin BC, Jr Mann SD, Ray NB, Bregendahl M, McLean PJ, Gonzalez-Perez MP, Ikezu S, Ikezu T. Rapid and high-yield recovery of plasma-derived extracellular vesicles using modified chromatography with soluble protein depletion for biomarker discovery. Cell Commun Signal. 2025 May 30; 23(1):253. PMID: 40448170.
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Published 5/26/2025
Ikezu T, Zhang Z, Yu K, Bao H, Ikezu T, Ravula AR, Melvin B, Scholes C, You Y, Ellison J, Kanekiyo T, Wszolek Z, DeTure M, Dickson D, Han X, Peng J, Ikezu S. Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease. Res Sq. 2025 May 26. PMID: 40502793.
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Published 4/1/2025
Yeapuri P, Machhi J, Foster EG, Kadry R, Bhattarai S, Lu Y, Sil S, Sapkota R, Srivastava S, Kumar M, Ikezu T, Poluektova LY, Gendelman HE, Mosley RL. Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal Aß pathology, microgliosis, and extensive neuronal loss. Alzheimers Dement. 2025 Apr; 21(4):e70084. PMID: 40195277.
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Published 1/25/2025
Yeh H, De Cruz MA, You Y, Ikezu S, Ikezu T. Development and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies. Sci Rep. 2025 Jan 25; 15(1):3207. PMID: 39863723.