Toby C. Chai, MD

Chair, Urology

Toby Chai


Toby C. Chai, MD, is Chief of Urology at Boston Medical Center, and Professor and Chair of the Department of Urology at Boston University School of Medicine. He also serves as President of Boston University Medical Center Urologists, Inc.

Dr. Chai was previously Professor of Urology and Obstetrics, Gynecology, and Reproductive Sciences at Yale University School of Medicine. He served as Vice Chair of Research in the Department of Urology and Co-Director of the Female Pelvic Medicine and Reconstructive Surgery Program at Yale New Haven Hospital.

Dr. Chai completed his medical degree at Indiana University School of Medicine, his urology residency at University of Michigan Medical Center, and a fellowship at University of Virginia. Prior to joining Yale, he held the John D. Young Professorship in Urology at the University of Maryland School of Medicine.

Dr. Chai has published 150 papers, reviews, and medical texts. He serves on the editorial board of the American Journal of Physiology – Renal, and is Co-Editor-in-Chief of Bladder and Associate Editor for Journal of Urology. His peers have recognized his significant contributions to the field by honoring him with the American Urological Association’s Victor A. Politano Award for outstanding work in treatment of urinary incontinence and innovations in bladder research and the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction’s Distinguished Service Award for outstanding contributions to urodynamics, female urology and voiding dysfunction, and exemplary service to the Society.

Other Positions

  • Chief, Urology, Boston Medical Center
  • President, Boston University Medical Center Urologists, Inc.
  • Professor, Urology, Boston University School of Medicine


  • Indiana University School of Medicine, MD
  • Yale University, MA
  • Johns Hopkins University, BA


  • Published on 3/19/2020

    Zhu K, Hill WG, Li F, Shi B, Chai TC. Early Increased Urinary IL-2 and IL-10 Levels Were Associated With Development of Chronic UTI in a Murine Model. Urology. 2020 Mar 19. PMID: 32201154.

    Read at: PubMed
  • Published on 1/16/2020

    Rovner E, Chai TC, Jacobs S, Christ G, Andersson KE, Efros M, Nitti V, Davies K, McCullough AR, Melman A. Evaluating the safety and potential activity of URO-902 (hMaxi-K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants with idiopathic (non-neurogenic) overactive bladder syndrome and detrusor overactivity from two double-blind, imbalanced, placebo-controlled randomized phase 1 trials. Neurourol Urodyn. 2020 02; 39(2):744-753. PMID: 31945197.

    Read at: PubMed
  • Published on 11/23/2019

    Ayyagari R, Powell T, Staib L, Chapiro J, Raja A, Bhatia S, Chai T, Schoenberger S, Devito R. Prostatic Artery Embolization Using 100-300-µm Trisacryl Gelatin Microspheres to Treat Lower Urinary Tract Symptoms Attributable to Benign Prostatic Hyperplasia: A Single-Center Outcomes Analysis with Medium-Term Follow-up. J Vasc Interv Radiol. 2020 Jan; 31(1):99-107. PMID: 31771896.

    Read at: PubMed
  • Published on 11/14/2019

    Ayyagari R, Powell T, Staib L, Chapiro J, Perez-Lozada JC, Bhatia S, Chai T, Schoenberger S, Devito R. Prostatic Artery Embolization in Nonindex Benign Prostatic Hyperplasia Patients: Single-center Outcomes for Urinary Retention and Gross Prostatic Hematuria. Urology. 2020 Feb; 136:212-217. PMID: 31734349.

    Read at: PubMed
  • Published on 7/8/2019

    Anger J, Lee U, Ackerman AL, Chou R, Chughtai B, Clemens JQ, Hickling D, Kapoor A, Kenton KS, Kaufman MR, Rondanina MA, Stapleton A, Stothers L, Chai TC. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. J Urol. 2019 08; 202(2):282-289. PMID: 31042112.

    Read at: PubMed
  • Published on 6/26/2019

    Wu Z, Li Y, Liu Q, Liu Y, Chen L, Zhao H, Guo H, Zhu K, Zhou N, Chai TC, Shi B. Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection. Am J Physiol Cell Physiol. 2019 09 01; 317(3):C544-C555. PMID: 31241987.

    Read at: PubMed
  • Published on 3/20/2019

    Lu M, Zhu K, Schulam PG, Chai TC. A non-enzymatic method for dissection of mouse bladder urothelial tissue. Nat Protoc. 2019 04; 14(4):1280-1292. PMID: 30894693.

    Read at: PubMed
  • Published on 1/16/2019

    Yeh J, Lu M, Alvarez-Lugo L, Chai TC. Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis. Am J Physiol Renal Physiol. 2019 04 01; 316(4):F617-F623. PMID: 30648906.

    Read at: PubMed
  • Published on 10/22/2018

    Abelson B, Sun D, Que L, Nebel RA, Baker D, Popiel P, Amundsen CL, Chai T, Close C, DiSanto M, Fraser MO, Kielb SJ, Kuchel G, Mueller ER, Palmer MH, Parker-Autry C, Wolfe AJ, Damaser MS. Sex differences in lower urinary tract biology and physiology. Biol Sex Differ. 2018 10 22; 9(1):45. PMID: 30343668.

    Read at: PubMed
  • Published on 10/13/2018

    Zhao H, Wei Y, Wang J, Chai T. Isolation and expression analysis of cadmium-induced genes from Cd/Mn hyperaccumulator Phytolacca americana in response to high Cd exposure. Plant Biol (Stuttg). 2019 Jan; 21(1):15-24. PMID: 30183121.

    Read at: PubMed

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