The major focus of research in the laboratory is the study of molecular mechanisms utilized by ocular antigen presenting cells (APCs) to regulate inflammatory ocular immune responses. Particular focus is on elucidating the role of thrombospondin-1 (TSP-1) in regulating ocular inflammation.
Resident ocular APCs in the posterior and anterior segment of the eye depend on TSP-1 for maintaining an anti-inflammatory phenotype. In the absence of TSP-1 these APCs acquire more immunogenic phenotype. These observations are examined further to determine their role in ocular inflammation.
Induction of regulatory T cells (Treg) subset by ocular APCs is known to be a key component of ocular immune privilege. The ability of ocular APCs to induce Treg and its correlation with their expression of TSP-1 is examined in the laboratory at the level of molecular mechanisms.
The laboratory has identified spontaneous development of autoimmune Sjögren’s syndrome and related ocular inflammation in TSP-1 deficient mice that closely resembles clinical symptoms in human Sjögren’s patients. Different projects in the laboratory address immunologic mechanisms underlying disease development in these mice.
- Northeastern University, PhD
- Northeastern University, MS
- University of Bombay, BSc
- Published on 12/20/2018
Soriano-Romaní L, Contreras-Ruiz L, López-García A, Diebold Y, Masli S. Topical Application of TGF-ß-Activating Peptide, KRFK, Prevents Inflammatory Manifestations in the TSP-1-Deficient Mouse Model of Chronic Ocular Inflammation. Int J Mol Sci. 2018 Dec 20; 20(1). PMID: 30577496.
- Published on 10/16/2018
Tatematsu Y, Khan Q, Blanco T, Bair JA, Hodges RR, Masli S, Dartt DA. Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves. Int J Mol Sci. 2018 Oct 16; 19(10). PMID: 30332778.
- Published on 10/11/2018
Singh N, Chin I, Gabriel P, Blaum E, Masli S. Dysregulated Marginal Zone B Cell Compartment in a Mouse Model of Sjögren's Syndrome with Ocular Inflammation. Int J Mol Sci. 2018 Oct 11; 19(10). PMID: 30314337.
- Published on 2/14/2018
Bhattacharya S, García-Posadas L, Hodges RR, Makarenkova HP, Masli S, Dartt DA. Alteration in nerves and neurotransmitter stimulation of lacrimal gland secretion in the TSP-1-/- mouse model of aqueous deficiency dry eye. Mucosal Immunol. 2018 07; 11(4):1138-1148. PMID: 29445135.
- Published on 8/9/2017
Wakshull E, Quarmby V, Mahler HC, Rivers H, Jere D, Ramos M, Szczesny P, Bechtold-Peters K, Masli S, Gupta S. Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space. AAPS J. 2017 Nov; 19(6):1656-1668. PMID: 28795351.
- Published on 1/31/2017
Contreras Ruiz L, Mir FA, Turpie B, Masli S. Thrombospondin-derived peptide attenuates Sjögren's syndrome-associated ocular surface inflammation in mice. Clin Exp Immunol. 2017 Apr; 188(1):86-95. PMID: 28033649.
- Published on 9/30/2016
Shatos MA, Hodges RR, Morinaga M, McNay DE, Islam R, Bhattacharya S, Li D, Turpie B, Makarenkova HP, Masli S, Utheim TP, Dartt DA. Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1-/- mice, a model of dry eye. Exp Eye Res. 2016 Dec; 153:27-41. PMID: 27697548.
- Published on 2/8/2016
Smith RE, Reyes NJ, Khandelwal P, Schlereth SL, Lee HS, Masli S, Saban DR. Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. J Leukoc Biol. 2016 Aug; 100(2):371-80. PMID: 26856994.
- Published on 10/14/2015
Contreras-Ruiz L, Mir FA, Turpie B, Krauss AH, Masli S. Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin a4 antagonist GW559090. Exp Eye Res. 2016 Feb; 143:1-8. PMID: 26463157.
- Published on 10/12/2015
Mir FA, Contreras-Ruiz L, Masli S. Thrombospondin-1-dependent immune regulation by transforming growth factor-ß2-exposed antigen-presenting cells. Immunology. 2015 Dec; 146(4):547-56. PMID: 26458493.
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