Scott E. Schaus, PhD

Professor, Chemistry

Scott Schaus
617.353.2489
590 Commonwealth Ave

Biography

Professor Schaus received his Ph.D. in Organic Chemistry with Eric N. Jacobsen at Harvard University in 1999 and did postdoctoral studies in Andy Myers’ laboratory at Harvard University as an NIH fellow.

Research in the Schaus Group is focused in two major areas: enantioselective catalytic synthetic methodologies for chemical synthesis and biomedical research, the latter conducted at the Boston University Center for Molecular Discovery. Catalytic methods developed in the Schaus Research Laboratories include asymmetric Mannich reactions, enantioselective boronate reactions, and metal-promoted condensation reactions.

Asymmetric Mannich Reactions – The use of cinchona amine, acid, and diol catalysis in the synthesis of chiral amines and heterocycles.

Enantioselective Boronate Catalysis – The development of methodologies to construct chiral building blocks and natural products using boronates.

Biomedical Research – In conjunction with the CMD-BU, advance translational science in the treatment of cancer and infectious disease.

Hepatocellular Carcinoma – Taking on liver cancer in the lab.

Neglected Tropical Disease – BU Researchers Work against Deadly, Disfiguring Disease. Pharmaceutical giant GSK chooses team in its new competition.

Techniques & Resources:

Organic Synthesis techniques are used and include modern methods for synthesis, purification, and analysis of organic molecules.

The Center for Molecular Discovery (CMD-BU) is an NIH-funded Center at Boston University which focuses on development of new methodologies for the synthesis of chemical libraries and biomedical research.

Other Positions

  • Assistant Professor, Pharmacology & Experimental Therapeutics, Boston University School of Medicine

Education

  • Harvard University, PhD
  • Boston University, DEng
  • Boston University, BA

Publications

  • Published on 12/26/2018

    Smith MJ, Reichl KD, Escobar RA, Heavey TJ, Coker DF, Schaus SE, Porco JA. Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. J Am Chem Soc. 2019 Jan 09; 141(1):148-153. PMID: 30566336.

    Read at: PubMed
  • Published on 12/17/2018

    Wong CR, Hummel G, Cai Y, Schaus SE, Panek JS. [4 + 2]-Cycloaddition and 1,4-Addition of ortho-Quinone Methides by a Chiral Crotyl Silane. Org Lett. 2019 01 04; 21(1):32-35. PMID: 30557029.

    Read at: PubMed
  • Published on 9/1/2018

    Yang X, Jounaidi Y, Dai JB, Marte-Oquendo F, Halpin ES, Brown LE, Trilles R, Xu W, Daigle R, Yu B, Schaus SE, Porco JA, Forman SA. High-throughput Screening in Larval Zebrafish Identifies Novel Potent Sedative-hypnotics. Anesthesiology. 2018 09; 129(3):459-476. PMID: 29894316.

    Read at: PubMed
  • Published on 4/18/2018

    Christadore L, Grinstaff MW, Schaus SE. Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection. Molecules. 2018 Apr 18; 23(4). PMID: 29669998.

    Read at: PubMed
  • Published on 12/4/2017

    Jiang Y, Thomson RJ, Schaus SE. Asymmetric Traceless Petasis Borono-Mannich Reactions of Enals: Reductive Transposition of Allylic Diazenes. Angew Chem Int Ed Engl. 2017 12 22; 56(52):16631-16635. PMID: 29110383.

    Read at: PubMed
  • Published on 7/12/2017

    Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-Thiones and Clioquinol Synergize To Target ß-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism. ACS Chem Neurosci. 2017 Sep 20; 8(9):2039-2055. PMID: 28628299.

    Read at: PubMed
  • Published on 3/30/2017

    Allen EE, Zhu C, Panek JS, Schaus SE. Multicomponent Condensation Reactions via ortho-Quinone Methides. Org Lett. 2017 04 07; 19(7):1878-1881. PMID: 28357870.

    Read at: PubMed
  • Published on 1/25/2017

    Jiang Y, Diagne AB, Thomson RJ, Schaus SE. Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions. J Am Chem Soc. 2017 02 08; 139(5):1998-2005. PMID: 28121128.

    Read at: PubMed
  • Published on 1/4/2017

    Jiang Y, Schaus SE. Asymmetric Petasis Borono-Mannich Allylation Reactions Catalyzed by Chiral Biphenols. Angew Chem Int Ed Engl. 2017 02 01; 56(6):1544-1548. PMID: 28052567.

    Read at: PubMed
  • Published on 12/13/2016

    Chin HG, Ponnaluri VK, Zhang G, Estève PO, Schaus SE, Hansen U, Pradhan S. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression. Oncotarget. 2016 Dec 13; 7(50):83627-83640. PMID: 27845898.

    Read at: PubMed

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