My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous pre-clinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues, skeletal tissue cell biology and skeletal tissue transcriptomics. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA and DOD review panels for orthopedic related research and worked on Special Emphasis Review Panels for the FDA. My current work focuses on relating genomic variants that define human bone quality to transcriptomic phenotypes of ostoeblasts and osteoclasts. Other studies in laboratory are focused on developing serum based diagnostics to follow the progression of fracture healing and define delayed and failed healing in humans.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Research Professor, Biochemistry, Boston University School of Medicine
- Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University School of Medicine
- Boston University School of Medicine, PhD
- Pennsylvania State University, BA
- Pennsylvania State University, BS
- Biomedical Research
- GMSBR 730
- GMSMM 707
- GMSMM 710
- GMSMS 971
- SDM OB 763
- Published on 9/13/2018
Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC. Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm. Sci Rep. 2018 Sep 13; 8(1):13756. PMID: 30213970.
- Published on 8/8/2018
Lu D, Tripodis Y, Gerstenfeld L, Demissie S. Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood. Bioinformatics. 2018 Aug 08. PMID: 30101356.
- Published on 3/25/2018
Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol. 2018 Sep; 233(9):7007-7021. PMID: 29380368.
- Published on 11/22/2017
Hussein AI, Mancini C, Lybrand KE, Cooke ME, Matheny HE, Hogue BL, Tornetta P, Gerstenfeld LC. Serum proteomic assessment of the progression of fracture healing. J Orthop Res. 2018 Apr; 36(4):1153-1163. PMID: 28971515.
- Published on 9/20/2017
Cooke ME, Hussein AI, Lybrand KE, Wulff A, Simmons E, Choi JH, Litrenta J, Ricci WM, Nascone JW, O'Toole RV, Morgan EF, Gerstenfeld LC, Tornetta P. Correlation between RUST assessments of fracture healing to structural and biomechanical properties. J Orthop Res. 2018 Mar; 36(3):945-953. PMID: 28833572.
- Published on 9/20/2017
Morgan EF, Pittman J, DeGiacomo A, Cusher D, de Bakker CMJ, Mroszczyk KA, Grinstaff MW, Gerstenfeld LC. Erratum: "BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing" [J Orthop Res. Vol 34, 2096-2105 (2016)]. J Orthop Res. 2018 Mar; 36(3):1040. PMID: 29623681.
- Published on 8/25/2017
Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z. AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation. Biochim Biophys Acta. 2017 12; 1864(12):2369-2377. PMID: 28847510.
- Published on 8/2/2017
Alshenibr W, Tashkandi MM, Alsaqer SF, Alkheriji Y, Wise A, Fulzele S, Mehra P, Goldring MB, Gerstenfeld LC, Bais MV. Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis. Arthritis Res Ther. 2017 Aug 02; 19(1):179. PMID: 28764769.
- Published on 7/1/2017
Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development. Toxicol Sci. 2017 Jul 01; 158(1):63-75. PMID: 28398592.
- Published on 4/12/2017
Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61. PMID: 28412469.
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