My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous preclinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA review panels for skeletal tissue biology and the DOD review panels for orthopedic related research.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences
- Research Professor, Biochemistry, Boston University School of Medicine
- Boston University School of Medicine, PhD
- Pennsylvania State University, BA
- Pennsylvania State University, BS
- Biological Core Tech
- Biomedical Research
- GMS MM707
- GMS MM710
- GMSBR 730
- GMSMM 707
- GMSMM 710
- GMSMS 971
- SDM OB 763
- SDM OB 763
- Published on 10/2/2017
Hussein AI, Mancini C, Lybrand KE, Cooke ME, Matheny HE, Hogue BL, Tornetta P, Gerstenfeld LC. Serum Proteomic Assessment of the Progression of Fracture Healing. J Orthop Res. 2017 Oct 02. PMID: 28971515.
- Published on 8/25/2017
Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z. AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation. Biochim Biophys Acta. 2017 Dec; 1864(12):2369-2377. PMID: 28847510.
- Published on 8/22/2017
Cooke ME, Hussein AI, Lybrand KE, Wulff A, Simmons E, Choi JH, Litrenta J, Ricci WM, Nascone JW, O'Toole RV, Morgan EF, Gerstenfeld LC, Tornetta P. Correlation between RUST assessments of fracture healing to structural and biomechanical properties. J Orthop Res. 2017 Aug 22. PMID: 28833572.
- Published on 8/2/2017
Alshenibr W, Tashkandi MM, Alsaqer SF, Alkheriji Y, Wise A, Fulzele S, Mehra P, Goldring MB, Gerstenfeld LC, Bais MV. Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis. Arthritis Res Ther. 2017 Aug 02; 19(1):179. PMID: 28764769.
- Published on 7/1/2017
Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ. From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development. Toxicol Sci. 2017 Jul 01; 158(1):63-75. PMID: 28398592.
- Published on 4/12/2017
Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017 Aug; 101:49-61. PMID: 28412469.
- Published on 3/8/2017
Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, Sindi H, Li S, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Graves DT. TNFa contributes to diabetes impaired angiogenesis in fracture healing. Bone. 2017 Jun; 99:26-38. PMID: 28285015.
- Published on 11/7/2016
Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016 Dec; 31(12):2204-2214. PMID: 27324177.
- Published on 4/6/2016
Morgan EF, Pittman J, DeGiacomo A, Cusher D, de Bakker CM, Mroszczyk KA, Grinstaff MW, Gerstenfeld LC. BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing. J Orthop Res. 2016 Dec; 34(12):2096-2105. PMID: 26990682.
- Published on 11/5/2015
Alsofi L, Daley E, Hornstra I, Morgan EF, Mason ZD, Acevedo JF, Word RA, Gerstenfeld LC, Trackman PC. Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice. Calcif Tissue Int. 2016 Feb; 98(2):172-85. PMID: 26538021.
View 182 more publications: View full profile at BUMC