Fuzhong Qin, MD, PhD

Research Associate Professor, Medicine

Fuzhong Qin
617.638.8051
650 Albany St Evans Biomed Research Ctr

Biography

I have a broad background in cardiovascular physiology, with specific training and expertise in the areas of reactive oxygen species and myocardial remodeling in pacing-induced heart failure, myocardial infarction-induced heart failure, pressure overload-induced myocardial hypertrophy and failure and transgenic mice with heart failure as well as reactive oxygen species in cultured cardiac myocytes. Particularly I have expertise (scientific) in a) oxidative stress, myocyte apoptosis, and apoptosis-related signal transduction pathways, b) oxidative stress, oxidative protein modifications of SERCA2, intracellular calcium transients and myocyte contractile function, c) oxidative stress, myocyte hypertrophy and myocardial diastolic dysfunction. I also have expertise (technical) in the animal models (mice, rats, rabbits and dogs) of myocardial ischemia / reperfusion, coronary artery ligation-induced myocardial infarction and failure, and ascending aortic constriction-induced myocardial hypertrophy and failure, conventional echocardiography, mitral inflow and tissue Doppler echocardiography, in vivo hemodynamics, ex vivo Langendorff isolated heart perfusion, measurements of intracellular calcium concentration and contractile function in isolated myocytes, myocyte culture, assessment of oxidative stress, histological measurements including hematoxylin and eosin staining, Masson trichrome staining, TUNEL staining and immunohistochemical and immunofluorescence staining, biochemical measurements including Western blot, immunoprecipitation, RT-PCR and etc.

Other Positions

  • Boston Medical Center

Education

  • Datong Medical College, MD
  • Shanxi Medical University, PhD

Publications

  • Published on 8/10/2018

    Luptak I, Croteau D, Valentine C, Qin F, Siwik D, Remick D, Colucci WS, Hobai I. Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis. Shock. 2018 Aug 10. PMID: 30102640.

    Read at: PubMed
  • Published on 2/1/2018

    Luptak I, Sverdlov AL, Panagia M, Qin F, Pimentel DR, Croteau D, Siwik DA, Ingwall JS, Bachschmid MM, Balschi JA, Colucci WS. Decreased ATP production and myocardial contractile reserve in metabolic heart disease. J Mol Cell Cardiol. 2018 03; 116:106-114. PMID: 29409987.

    Read at: PubMed
  • Published on 7/24/2017

    Ho JE, Rahban Y, Sandhu H, Hiremath PG, Ayalon N, Qin F, Perez AJ, Downing J, Gopal DM, Cheng S, Colucci WS. Preclinical Alterations in Myocardial Microstructure in People with Metabolic Syndrome. Obesity (Silver Spring). 2017 Sep; 25(9):1516-1522. PMID: 28737258.

    Read at: PubMed
  • Published on 10/20/2016

    Xu XJ, Babo E, Qin F, Croteau D, Colucci WS. Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin. IJC Metab Endocr. 2016 Dec; 13:28-34. PMID: 27942464.

    Read at: PubMed
  • Published on 1/11/2016

    Sverdlov AL, Elezaby A, Qin F, Behring JB, Luptak I, Calamaras TD, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Bachschmid MM, Colucci WS. Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease. J Am Heart Assoc. 2016 Jan 11; 5(1). PMID: 26755553.

    Read at: PubMed
  • Published on 12/31/2015

    Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. J Am Heart Assoc. 2015 Dec 31; 5(1). PMID: 26722122.

    Read at: PubMed
  • Published on 12/9/2014

    Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Wilson S C, Edward J M. Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload. J Mol Cell Cardiol. 2015 Feb; 79:275-83. PMID: 25497302.

    Read at: PubMed
  • Published on 3/14/2014

    Qin F, Siwik DA, Pimentel DR, Morgan RJ, Biolo A, Tu VH, Kang YJ, Cohen RA, Colucci WS. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1453-63. PMID: 24633550.

    Read at: PubMed
  • Published on 8/20/2013

    Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184. PMID: 23963753.

    Read at: PubMed
  • Published on 10/24/2012

    Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236.

    Read at: PubMed

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