David L. Coleman, MD

Wade Professor, Medicine

David Coleman
(617) 638-7254
75 E. Newton St Evans Building

Biography

The initial focus of Dr. Coleman’s original scholarship was in the regulation of macrophage activation and proliferation. He identified novel factors that induce macrophage phagocytic function and oxidative metabolism. He went on to characterize the mechanisms by which macrophages are activated, recruited, retained, and induced to proliferate in local tissues. His research team discovered production of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) by non-immunological cell and tissue types such as keratinocytes (skin), glomerular mesangial cells (kidney), and respiratory epithelium (trachea). His team also identified production of other soluble cytokines (Macrophage CSF and Interleukin 6) by local tissues that regulate cell traffic and inflammation, particularly in the skin and kidney – two common sites of inflammation and infection. His later studies focused on the subcellular mechanisms of macrophage activation and proliferation induced by GM-CSF. His further delineated the effect of GM-CSF on intracellular second messenger pathways (e.g., cyclic nucleotides, protein kinase C) and early response genes (e.g., Egr-1) in macrophages. He defined the role of cis-acting 3’ regulatory elements in mediating the transcriptional activation of Egr-1 in macrophages. These studies were designed to characterize paracrine and autocrine signals that regulate cells in local tissues in states of inflammation and infection, and to better understand how therapies might be targeted at the extracellular and intracellular signals that underlie the inflammatory process. His work over the past 15 years has focused on medical and civic professionalism in medical education and clinical practice. He has developed incentive plans that promote physician productivity in an academically affiliated VA Medical Center and at Yale School of Medicine. In addition, he has led efforts at Yale and Boston University Schools of Medicine to develop more effective and rigorous policies for the interactions of clinicians with the pharmaceutical and medical device industries. Dr. Coleman’s clinical responsibilities include serving as an inpatient medical attending and infectious disease consult attending at Boston Medical Center.

Other Positions

  • Chair, Medicine, Boston University School of Medicine

Education

  • University of California, San Francisco, MD
  • Yale University, MA
  • Stanford University, AB

Publications

  • Published on 10/1/2017

    Ravid K, Seta F, Center D, Waters G, Coleman D. Catalyzing Interdisciplinary Research and Training: Initial Outcomes and Evolution of the Affinity Research Collaboratives Model. Acad Med. 2017 Oct; 92(10):1399-1405. PMID: 28445220.

    Read at: PubMed
  • Published on 7/15/2017

    Gordon CE, Chitalia VC, Sloan JM, Salant DJ, Coleman DL, Quillen K, Ravid K, Francis JM. Thrombotic Microangiopathy: A Multidisciplinary Team Approach. Am J Kidney Dis. 2017 Nov; 70(5):715-721. PMID: 28720207.

    Read at: PubMed
  • Published on 1/1/2017

    Coleman DL, Wardrop RM, Levinson WS, Zeidel ML, Parsons PE. Strategies for Developing and Recognizing Faculty Working in Quality Improvement and Patient Safety. Acad Med. 2017 01; 92(1):52-57. PMID: 27191838.

    Read at: PubMed
  • Published on 7/30/2016

    Coleman DL, Johnson DH. The Department of Medicine in 2030: A Look Ahead. Am J Med. 2016 Nov; 129(11):1226-1233. PMID: 27480389.

    Read at: PubMed
  • Published on 2/1/2013

    Ravid K, Faux R, Corkey B, Coleman D. Building interdisciplinary biomedical research using novel collaboratives. Acad Med. 2013 Feb; 88(2):179-84. PMID: 23269301.

    Read at: PubMed
  • Published on 1/1/2013

    Coleman DL, Spira A, Ravid K. Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine. Trans Am Clin Climatol Assoc. 2013; 124:275-82. PMID: 23874035.

    Read at: PubMed
  • Published on 2/1/2012

    Joiner KA, Coleman DL. Perspective: key indicators in academic medicine: a suggested framework for analysis. Acad Med. 2012 Feb; 87(2):230-5. PMID: 22273616.

    Read at: PubMed
  • Published on 10/1/2010

    Coleman DL. A historical perspective on leptin. Nat Med. 2010 Oct; 16(10):1097-9. PMID: 20930752.

    Read at: PubMed
  • Published on 9/1/2008

    Coleman DL. Establishing policies for the relationship between industry and clinicians: lessons learned from two academic health centers. Acad Med. 2008 Sep; 83(9):882-7. PMID: 18728449.

    Read at: PubMed
  • Published on 8/1/2006

    Coleman DL. The impact of the lack of health insurance: how should academic medical centers and medical schools respond? Acad Med. 2006 Aug; 81(8):728-31. PMID: 16868427.

    Read at: PubMed

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