Christopher W. Akey, PhD

Professor, Physiology & Biophysics

Christopher Akey
(617) 638-4051
700 Albany St Ctr for Adv Biomed Res

Biography

We are studying the structure and function of macromolecular machines and chaperones. In our work, we use biochemistry and molecular biology coupled with structural electron microscopy, X-ray crystallography and molecular modeling. This hybrid approach allows us to create snapshots of these large assemblies and thus, to infer function from form.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Division of Graduate Medical Sciences

Education

  • Cornell University, PhD
  • University of Richmond, BS

Publications

  • Published on 5/19/2017

    Mendez DL, Akey IV, Akey CW, Kranz RG. Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro. Biochemistry. 2017 Jun 06; 56(22):2766-2769. PMID: 28510448.

    Read at: PubMed
  • Published on 12/1/2016

    Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure. 2017 Jan 03; 25(1):40-52. PMID: 27916517.

    Read at: PubMed
  • Published on 10/4/2016

    Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. A near atomic structure of the active human apoptosome. Elife. 2016 Oct 04; 5. PMID: 27697150.

    Read at: PubMed
  • Published on 10/23/2013

    Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 6; 506(7486):102-6. PMID: 24153188.

    Read at: PubMed
  • Published on 8/1/2013

    D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM. Tango7 directs cellular remodeling by the Drosophila apoptosome. Genes Dev. 2013 Aug 1; 27(15):1650-5. PMID: 23913920.

    Read at: PubMed
  • Published on 7/11/2013

    Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure. 2013 Aug 6; 21(8):1361-73. PMID: 23850453.

    Read at: PubMed
  • Published on 4/2/2013

    Yuan S, Akey CW. Apoptosome structure, assembly, and procaspase activation. Structure. 2013 Apr 2; 21(4):501-15. PMID: 23561633.

    Read at: PubMed
  • Published on 3/22/2013

    Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW. Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry. 2013 Apr 2; 52(13):2319-27. PMID: 23521171.

    Read at: PubMed
  • Published on 8/24/2011

    Platonova O, Akey IV, Head JF, Akey CW. Crystal structure and function of human nucleoplasmin (npm2): a histone chaperone in oocytes and embryos. Biochemistry. 2011 Sep 20; 50(37):8078-89. PMID: 21863821.

    Read at: PubMed
  • Published on 8/10/2011

    Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW. The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure. 2011 Aug 10; 19(8):1084-96. PMID: 21827945.

    Read at: PubMed

View 40 more publications: View full profile at BUMC

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