Biochemistry

BIOCHEMISTRY

021.1 Hormone: Cell Interaction – Plasma Membrane Response to Extracellular Signal – Action of Prostaglandins and Catecholamines

Instructor: Dr. Peter Polgar

Location: BUSM, K212
Telephone: 638-4125

Number of Students: One
Period to be Offered: Contact Dr. Polgar

Description of Elective:

The project would involve some aspect of the biochemistry of interaction of the prostaglandins and catecholamines with cells in culture. The hormone-cell relationship would be determined in terms of hormone binding to the cell surface, response of the cyclic AMP and GMP systems and the control of cell division in normal and transformed human fibroblasts.

 

MICROBIOLOGY SECTION

024.1 Growth Control and Cell Transformation

Instructor: Dr. I.N. Chou

Location: BUSM, Dept, of Microbiology, L515A
Telephone: 638-4197

Number of Students per Month: Two
Period to be Offered: September-December, February-April

Description of Elective:

Selected topics in: growth of animal cells in culture, serum and other growth factors, mechanisms of growth regulation, cellular and molecular basis of transformation induced by chemicals, viruses and radiation and the biochemistry of transformed cells, mechanisms of cellular injury by environmental toxic agents and cellular and molecular toxicology.

024.12 Bacterial Physiology

Instructor: Dr. E. R. Kashket

Location: BUSM, Dept. of Microbiology, L520
Telephone: 638-4291

Number of Students per Month: To be arranged
Period to be Offered: Fall semester of odd numbered years.

Description of Elective:

Selected advanced topics in microbial physiology: bioenergetics, transport, and other membrane functions; regulation of metabolism and sporulation, particularly in gram-positive bacteria.

024.14 Virology

Instructor: Drs. Glen B. Zamansky and Paul H. Black

Location: BUSM, Dept. of Microbiology, L502
Telephone: 638-5165

Number of Students per Month: To be arranged
Period to be Offered: Spring semester of even numbered years

Description of Elective:

Evolving concepts of virology will be examined. Topics guided by recent advances in several areas: mechanisms of viral pathogenesis, organization of the viral genome, control of virus replication, viral latency and oncogenesis, immune response to viral infections, and virus models for understanding cellular processes.

024.15 Advanced Immunology

Instructor: Dr. Ann Marshak-Rothstein

Location: BUSM, Dept. of Microbiology, L503
Telephone: 638-4284

Number of Students per Month: To be arranged
Period to be Offered: Spring semester of odd numbered years

Description of Elective:

Directed discussion of classic and current publications in the field of immunology, with emphasis on cellular interactions.

024.16  Molecular and Cellular Changes in Breast Cancer

Instructor: Abdulmaged Traish, Ph.D.

Location: W607
Telephone: 638-4578

Number of Students: 2 per semester
Period to be Offered: Fall and Spring semester

Description of Elective:

This elective will consist of discussions, readings and laboratory work on the receptor levels and other tumor markers in breast cancer and animal tissues. In many patients, breast cancer is a systemic disease at diagnosis, and may not be curable by local treatment alone. A number of therapeutic modalities are used in management of breast cancer patients including adjuvant chemotherapy, radiation therapy, endocrine therapy or a combination of such treatments. These treatments have been shown to prolong disease-free survival (DFS) and overall survival of breast cancer patients. There is a lack of definitive tumor markers which identify those patients in which cancer will likely recur without treatment . While pathological breast cancer staging (tumor size, nodal status, and presence and site of metastasis) remain among the most reliable methods of predicting disease outcome, knowledge of other tumor markers may provide additional prognostic information. There is a critical need for identification of specific tumor markers whose expression directly contributes to the malignant process. Identification of tumor markers may permit their use as targets for therapeutic strategies. We have isolated, partially characterized and cloned the cDNA for a 55 kDa nuclear protein from human breast tumor cells (henceforth referred to as nmt55). We have found that this protein is expressed in most ER+ tumors but not in ER- tumors. We postulate that loss of nmt55 expression is associated with molecular and cellular changes linked to cellular differentiation leading to loss of ER expression, development of hormone-independent tumor growth and metastases.