Departmental Seminar – February 12, 2016

February 8th, 2016 in Spotlight

Seminar Series: Spring 2016 ~~ Friday, February 12, 2016

2:00-3:00 PM

              

Obese NK Cells Lack Energy to Kill

 

Lydia Lynch, PhD

Assistant Professor of Medicine

Harvard Medical School

Brigham and Women’s Hospital

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM
Friday, February 12, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

 

At the conclusion of this activity participants will be able to: 1) report that immune dysfunction in obese humans, which is associated with their increased cancer and infection susceptibility; 2) state that obesity is now responsible for up to 40% of certain cancers; and 3) recall that cell intrinsic metabolism is altered in obese immune cells, leading to their inability to function.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Pathology & Laboratory Medicine News Items December 2015 – January 2016

February 3rd, 2016 in Uncategorized

  • Announcements:
    • Congratulations are in order to the following Department of Pathology members: BRAVO!
      • Chris Andry, MPhil, PhD; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
      • Abigail Brown, MFS, MLS (ASCP): for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
      • Shinichiro Kurosawa, MD, PhD; for being appointed a Voting Member to the Boston University Laboratory Safety Committee Space / Infrastructure Subcommittee until December 2017, BRAVO!
    • On December 3, 2015 Daniel Remick, MD gave a talk “Mild Traumatic Brain Injury Augments Host Defenses against Pathogens” at the Institute of Neuroscience and Physiology at Sahlgrenska Academy at the University of Gothenburg
    • Daniel Remick, MD was invited to serve as the opponent for Sara Svahn at the University of Gothenburg in Sweden on December 4, 2015. The title of Sara’s thesis was “Effects of dietary fatty acids on the immune system”. Scandinavian countries have a tradition of bringing in an outside expert to ensure that the thesis work has sufficient rigor and depth. This outside member of the committee has the title of opponent. At the two hour defense, the opponent presents background information about the topic of the thesis, in this case sepsis. The student then presents for about 40 minutes, which is then followed by an hour of questioning by the opponent. Sara Syahn, PhD, successfully Defended
    • Chloe Habib and Leah Persky, both students in the Masters in Nutrition Program, joined the Nikolajczyk Lab as of January 2016
    • The Residency Program had an ACGME Site Visit in January to review our program. The Department has been working diligently since last spring to increase the teaching curriculum for the residents. One of the issues identified through the survey in 2015 was lack of scholarly opportunities. The Department will be launching a series of paper writing workshops this spring and all the residents will be invited.
    • The College of American Pathologists (CAP) performed their unannounced Site Visit on January 27, 2016. Seventeen inspectors from the Lifespan System in Rhode Island spent the day thoroughly reviewing both Anatomic Pathology and Laboratory Medicine. The lab inspection went very well with only a few deficiencies identified. This outstanding inspection result was due to the hard work by the pathology faculty and staff in the months leading up to the preparation. BRAVO
  • PUBLICATIONS ACCEPTED:
    • Thurmond P, Yang JH and Azadzoi KM entitled “LUTS in pelvic ischemia: A new concept in voiding dysfunction” — Accepted for publication in AJP – Renal Physiol
    • Ding Y, Francis J, Kalish J, Deshpande A, Quillen K. Recurrent focal segmental glomerulosclerosis resistant to plasma exchange, and improvement after surgical repair of arteriovenous fistula aneurysms. Clinical Kidney Journal [in press]
  • PUBLICATIONS PUBLISHED:
    • Zhifeng Huang, William M. Marsiglia, Upal Basu Roy, Nader Rahimi, Dariush Ilghari, Huiyan Wang, Huaibin Chen, Weiming Gai, Steven Blais, Thomas A. Neubert, Alka Mansukhani, Nathaniel J. Traaseth, Xiaokun Li,  Moosa Mohammadi. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Molecular Cell, December 10, 2015. http://www.sciencedirect.com/science/article/pii/S1097276515009028
    • Lawreen Connors, PhD and Colleagues Publish Findings in ATTRwt Amyloidosis Cohorthttp://www.bu.edu/amyloid/2016/01/22/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort/
      • Data on the largest cohort of ATTRwt amyloidosis patients yet reported (n=121), referred to our institution over a 20-year observational period, were recently reported in the prestigious heart journal, Circulation.  The publication, entitled “Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study,” was authored by Dr. Lawreen H. Connors and colleagues from the Amyloidosis Center at Boston University.  These data establish the natural history of ATTRwt, provide statistical basis for the design of future interventional clinical trials, and highlight the need for more sensitive diagnostic tests and disease-specific treatments for this disease.  For more information, see Circulation, 133:282-290, 2016.
    • Ozturk S, Papageorgis P, Lambert AW, Wong CK, Thiagalingam A, Abdolmaleky HM, Cohen HT, and Thiagalingam S, 2016. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl. Acad. Sci. USA. 113(3): 638-643. http://www.pnas.org/content/113/3/638.full.pdf?with-ds=yes

Departmental Seminar – January 29, 2016

January 25th, 2016 in Uncategorized

 

Seminar Series: Spring 2016 ~~ Friday, January 29, 2016

2:00-3:00 PM

              

“The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention”

 

 

Nisma Mujahid

PhD Candidate, David Fisher Lab (MGH);

Department of Pathology, Boston University School of Medicine

 

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM
Friday, January 29, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) recall that ultraviolet-light (UV)-induced tanning is defective in numerous ‘fair-skinned’ individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R); 2) recognize that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blondehaired Mc1re/e mice; and 3) report that ultraviolet (UV) radiation is highly toxic to organisms because it damages cellular constituents such as DNA.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

10th Annual Nancy Bucher Seminar

January 8th, 2016 in Spotlight, Uncategorized

DUE TO THE INCLEMENT WEATHER WE HAVE DECIDED TO POSTPONE

OUR 10TH ANNUAL NANCY BUCHER SEMINAR; PLEASE STAY TUNE FOR ADDITIONAL DETAILS!

APOLOGIES FOR ANY INCONVENIENCE!!!!

~~~~~~~~~~~

BUSM Pathology & Laboratory Medicine

Seminar Series: Spring 2016 ~~ Friday, February 5th 

2:00 PM; Reception to Follow at 3:00

 

10th Annual Nancy L. R. Bucher, MD Seminar 

 

Unraveling the Complexity of Growth Hormone Regulated Sex Differences in Mouse Liver:

Genomic and Epigenetic Approaches”

 

David Waxman, PhD

Professor of Cell and Molecular Biology, Boston University

Professor of Medicine, Boston University School of Medicine

 

 

Location & Time:

670 Albany Street

Lobby Level #107/108

2:00 PM; Reception to Follow

Friday, February 5, 2016 

Faculty Meeting Notes – November 2015

December 4th, 2015 in Faculty Highlights

 

Please access the presentation by clicking below:

 

Pathology and Laboratory Medicine Faculty meeting Nov 2015

Pathology & Laboratory Medicine News Items – November 2015

December 3rd, 2015 in Uncategorized

  • Announcements:
    • Yanli Ding, MD presented a poster at the Annual ASCP 2015 Meeting in Long Beach California, September 28-30, 2015. Title: “Persistent proteinuria in recurrent focal segmental glomerulosclerosis from arterio-venous fistula recirculation, and improvement with aneurysm repair;” Co-authors are Yanli Ding, MD and Karen Quillen, MD
    • Yanli.Ding.2015.ASCP.mmexport1446282806146
    • Atsushi Ebata, PhD, Wolozin Lab, successfully defended his thesis “Development of TDP-43 Granule Inhibitors as Potential Amyotrophic Lateral Sclerosis/Frontotemporal LobarDegeneration Therapies” on Thursday, November 12th
    • Nancy S. Miller, MD presented: “Ebola Dx and the U.S. clinical laboratory: From practical to practice to promise”, at the BUSM Mini-Symposium – Ebola, The Disease and Immune Privilege, on October 29, held in Hiebert Lounge
    • Dr. Miller also convened the symposium: Vibrios Throw Us a Curve: People, Places and Oysters; and presented “Tales from the Trenches – Vibrio Cases from the Clinical Microbiology Laboratory”, at the 50th Annual Region I Meeting of American Society for Microbiology (ASM) branches, October 20, in Randolph, Massachusetts
    • From Lawreen Connors, PhD Lab:
      • Just received notification of research funding from the The Wildflower Foundation, Inc. in support of our study, “Immunoglobulin Light Chain Amyloid Fibril Formation: Structural Determinants as a Platform for Drug Development”
      • She/they also have an approved service agreement, “Fat Pad Analysis – ALN-TTR-NT-002 Discovery Study, with Alnylam Pharmaceuticals, Inc (Cambridge, Massachusetts)
    • Yue Sun presented three posters at the 2015 Annual ASCP Meeting in Long Beach California, September   28-30, 2015:
      • “Extraosseous Chordoma of Retropharyngeal Space: A Case Report;” Yue SunHuihong Xu, and Qing Zhao Zhao 
      • “Periampullary gangliocytic paraganglioma with lymph node involvement: A Case Report;” Yue Sun, David W. KindelbergerHuihong Xu, and Qing Zhao
      • “Lactobacillusgasseri associated with urinary and surgical wound infection in a renal transplant patient;” Yue Sun, Amitabh Gautam, and Nancy S. Miller
      • Yue.Sun.2015.ASCP.chordoma
    •   Yue.Sun.2015.ASCP.Poster3.paraganglioma
    •    Yue.Sun.2015.ASCP.Poster2.lactobacillus
    • Congratulations to Ivana Delalle, she was the honored speaker at the 2015 Annual New England Society of Pathologists Stanley Robbins lecture on November 17th
    • On Behalf of Dr. Chris Andry, Director of our Master of Arts Program: we are pleased to announce that our proposal has been approved and our Masters Graduate Program will now be entitled; MASTER OF SCIENCE IN PATHOLOGY LABORATORY SCIENCES.
    • Michel Azer, a Masters student in Periodontology doing his research in the Nikolajczyk Lab, was a finalist at the American Academy of Periodontology Balint Orban Award Competition for excellence in basic research on periodontal disease.  Congratulations Michel on being included in this prestigious event!
    • Invited presentation by Nikolajczyk in November 2015: The Obesity Society Oral Presentation, Los Angeles CA, “Metformin counters a pro-inflammatory T cell profile, 2015”
    • Ivana Delalle gave a Grand Rounds lecture in the Pathology Department at UC Davis, California on November 23rd
    • The Mid-Career Faculty Leadership Program is a year-long program that uses experiential and project-based learning to engage participants in 360 evaluation, self-reflection, inter-disciplinary collaboration, broad peer and senior mentoring networks, and the enhancement of transformational education, clinical, research, and strategic leadership skills. Two members of our pathology department, both Sandra Cerda and Dr. Debbie Stearns-Kurosawa, have been selected through this competitive application process to participate in this leadership development program.  The selection committee aims yearly to select high potential individuals with clinical and research expertise and demonstrated commitment to BUMC, who are keen on transforming themselves, BUMC, and healthcare. BRAVO!!
    • Effective January 1, 2016 the following changes will occur:
      • David Kindelberger, MD, will become the Residency Director, replacing Daniel Remick, MD This appointment is pending approval by the appropriate BMC committee
      • Qing (Grace) Zhao, MD, PhD, will become the Director of Surgical Pathology, replacing Dr. Kindelberger
      • We are confident that these changes will strengthen our clinical, research and teaching missions by placing dedicated and motivated pathologists in these leadership positions. Please join me in congratulating Drs. Kindelberger and Zhao on their new roles within the Department.
  • PUBLICATIONS ACCEPTED:
    • Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, and Seldin DC:  Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study.  Circulation,Accepted Nov 11, 2015
    • Miller, N.S. “The new microbiology and vision of faith: When believing isn’t seeing and vice-versa.” Commentary commissioned by Clinical Chemistry for their 2016 special issue, Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”
    • Armin Maghsoudlou, Rosana D. Meyer, Kobra Rezazadeh, Emad Arafa, Jeffrey Pudney, Edward Hartsough, Nader Rahimi.  RNF121 inhibits angiogenic growth factor signaling by restricting cell surface expression of VEGFR-2. Traffic, November 2015 http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291600-0854
  • PUBLICATIONS PUBLISHED:

Congratulations to Dr. Atsushi Ebata!

November 24th, 2015 in Student Spotlight

Atsushi Ebata, PhD   aebata

 

successfully defended his thesis:

“Development of TDP-43 Granule Inhibitors as Potential Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration Therapies”

 on Thursday, November, 15th, 2015!

 

Departmental Seminar – December 4, 2015

November 24th, 2015 in Spotlight

2:00-3:00 PM; Friday, December 4, 2015

 

“Neisseria gonorrhoeae Induces non-canonical Pyroptosis in Human Macrophages”

 

Jessica Ritter, PhD Candidate

Department of Pathology, Genco Lab

Boston University School of Medicine

 

Location & Time:

670 Albany Street; Lobby Level #107/108

2:00-3:00 PM; Friday, December 4, 2015

Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to:1) state that infection and disease associated with Neisseria gonorrhoeae, the gonococcus, continue to be a global health problem; 2) repeat that asymptomatic and subclinical gonococcal infections occur at a high frequency in females; thus, the true incidence of N. gonorrhoeae infections are presumed to be severely underestimated. and 3) discuss that Inherent to this asymptomatic/subclinical diseased state is the continued prevalence of this organism within the general population, as well as the medical, economic, and social burden equated with the observed chronic, disease sequelae

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

October 2015

November 6th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items – October 2015

  • Announcements:
    • Daniel Remick was an invited speaker at the Satellite Symposium on Alcohol and Immunology, Society for Leukocyte Biology, Raleigh North Carolina on September 28th: Acute ethanol ingestion triggers asthma
    • Kazem Azadzoi had two recent presentations at the International Continence Society (ICS) meeting in Montreal, Canada, October 6-9, 2015:
      • Zhao Z, Yang J, Li Y, Azadzoi K presented an oral ePoster entitled “Ischemia Survival Signaling Via PI3-K/Akt Pathway mediates Overactive Bladder Progression to Underactive Bladder”
      • Su N, Choi H, Yang J, Azadzoi K presented an oral ePoster entitled “Chronic Ischemia Alters the Bladder Proteomic Profiles and Activates Degenerative Pathways and Survival Signaling” at
    • Barb Nikolajczyk, PhD is organizing a FASEB Scientific Research Conference Entitled “Immunological Aspects of Obesity” July 31-August 5, 2016 in Big Sky, Montana.  Those interested in more information can go to org or contact her directly at bnikol@bu.edu
  • PUBLICATIONS ACCEPTED:
    • Yi-Chien Chang1, Zhenjun Hu1, John Rachlin2, Brian P. Anton3, Simon Kasif1,4*, Richard J. Roberts3*, Martin Steffen4,5 COMBREX-DB: A Database Of Protein Function Prediction Emphasizing Foundational Experimental Data; Nucleic Acids Research

Departmental Seminar – November 13, 2015

November 6th, 2015 in Spotlight

2:00-3:00 PM; Friday, November 13, 2015

“Astroglia-Mediated Pathogenic Mechanisms in

Fragile X Syndrome (FXS)”

 

Yongjie Yang, PhD

Assistant Professor of Neuroscience

Sackler School of Graduate Biomedical Sciences; Tufts University

Location & Time:

670 Albany Street; Lobby Level #107/108

2:00-3:00 PM; Friday, November 13, 2015

     Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

     At the conclusion of this activity participants will be able to: 1) report that Astroglial cells are the most abundant glial cells in the mammalian central nervous system (CNS); 2) recall that recently, astroglial cells have been more and more implicated in the pathogenesis of various neurological diseases and injuries and 3) discuss how selective deletion of astroglial FMRP affects typical FXS phenotypes

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.