Congratulations to Dr. Clarissa Koch

March 31st, 2015 in Student Spotlight

clarissa BU pathology website photo

 

Clarissa Koch, PhD, Connors Lab, successfully defended her thesis Characterizing the Effect of Transthyretin Amyloid on the Hearton Monday, March 16th

February 2015

March 3rd, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • 104th USCAP Meeting, Boston, MA, March 21-27 2015
    • Mostafa Belghasem, PhD Candidate, Henderson Lab has an abstract accepted for poster presentation for the United States & Canadian Academy of Pathology’s (USCAP) 104th Annual Meeting in Boston, MA. The abstract is entitled “Podocyte-Specific Myh9 Deletion in Mice Results in Susceptibility to Glomerular Injury in Response to Subtotal Nephrectomy”
  • From Mark Uva, our Residency Coordinator: We have filled our two vacancies within the residency program.   These positions are in addition to our recruiting through the Match for PGY 1s.  The two physicians come to us with outstanding letters of reference, and thought of very highly in their respective programs.  They will be entering the program as PGY 2s, effective July 1, 2015.
    • Lei Li, MD: Lei is transferring from St. Barnabas Medical Center in Livingston, NJ, where she is currently a PGY 1.  Lei graduated from Xuzhou Medical College, Xuzhou, Jiangsu China in 2000.
    • Ram Al-Sabti, MD: Ram is transferring from University Hospital Case Medical Center, Cleveland, OH, where he is currently a PGY 1.  Ram graduated from the University of Bagdad, Iraq in 2009.

Publications ACCEPTED:

  • Peluso, A. M., B. A. Harnish, N.S. Miller, E. R. Cooper, A. M. Fujii.  Effect of young sibling visitation on respiratory syncytial virus activity in a NICU. The Journal of Perinatology (accepted for publication Feb. 19, 2015)
  • Valencia-Rey P., J. Weinberg, N. Miller, T. Barlam.  Coagulase-negative staphylococcal bloodstream infections: Does vancomycin remain appropriate empiric therapy? Journal of Infection (accepted for publication Feb. 18, 2015)
  • Taimur, S., N.S. Miller, D. Whitney, T. Barlam. Empiric and Targeted Treatment of Enterococcal Infections: Opportunities for Antimicrobial Stewardship. Infectious Diseases in Clinical Practice 2014 Dec; E-published ahead of print: doi:10.1097/IPC.0000000000000193

Departmental Seminar – Mar 27

February 13th, 2015 in Spotlight

“Cerebral Hemodynamics, Vascular Reactivity, and Oxygen Metabolism During Anesthesia-Induced Burst Suppression”

Jason Sutin, PhD Candidate

Department of Pathology and Laboratory Medicine
Boston University School of Medicine
Franceschini Lab (MGH)

Department of Pathology and Laboratory Medicine

Spring 2015 Seminar Series: Friday, March 20, 2:00

Friday, February 20, 2:00 (Refreshments 1:45) 670 Albany Street – Lobby Level #107/108

 

Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914

January 2015

February 9th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Nancy S. Miller, MD was an invited panel member at the Boston Pan African Forum event, “Ebola and other health-related issues in West Africa”, on December 13th in Dorchester, MA
  • Dr. Carmen Sarita-Reyes gave a poster presentation at the SENTAC (Society for Ear, Nose and Throat Advances in Children) meeting on December 6, 2014 in St Louis. “Marsupialization to treat foregut duplication cysts of the oral cavity: a novel technique;” Minyoung Jang; Carmen Sarita-Reyes; Devaki Sundararajan; Jessica Levi
  • Maria Panchenko, PhD has had her BUMC IACUC Appointment extended until June 2015. Thank you for your service Dr. Panchenko!
  • The American Board of Pathology recently nominated Meera Mahalingam, MD, PhD, FRCPath to serve on the Test Development and Advisory Committee on Dermatopathology.  The committees consist of American Board of Pathology trustees, as well as other pathologists and physicians who are recognized as experts in their respective disciplines
  • From Dr. John Lee; “The Hematology Lab has revised and updated the flow cytometry panels using a more sensitive and algorithmic approach.  In addition, a new technique will be employed to determine light chain restriction in plasma cells, which would be useful for myeloma, MGUS, and AL amyloidosis patients.  These changes were put into effect January 5, 2015 by Dina Pelley, MT (flow cytometry assistant supervisor) and John Lee, MD (Hematology Lab Medical Director) with Angel Lui, MT helping from the IT side.”
  • Dr. Ivana Delalle and her Neuropathology Lab have been acknowledged in recognition of her International Research Collaborations by PsyCourse: Pathomechanisms and Signatures of the Longitudinal Course of Psychosis
  • One of our current residents, Cathryn Byrne-Dugan, MD, will be going to University of Michigan for a GI fellowship in 2016-2017

Publications ACCEPTED:

  • Authors: Caitlin S.L. Parello, Chad L. Mayer, Benjamin C. Lee, Amanda Motomochi, Shinichiro Kurosawa *, Deborah J. Stearns-Kurosawa; Shiga Toxin 2-Induced Endoplasmic Reticulum Stress is Minimized by Activated Protein C but Does Not Correlate With Lethal Kidney Injury; Toxins, in press
  • Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine; (accepted for publication Jan 2014)

Publications: PUBLISHED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, David C. Seldin, Lawreen H. Connors; “Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt);” Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359
  • Cathryn J. Byrne-Dugan, Terra A. Cederroth, Anita Deshpande, and Daniel G. Remick (2014) The Processing of Surgical Specimens With Forensic Evidence: Lessons Learned From the Boston Marathon Bombings. Archives of Pathology & Laboratory Medicine In-Press http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2014-0441-OA
  • Byrne-Dugan, CJ, Collins AB, Lam AQ, Batal I. Membranous Nephropathy as a Manifestation of Graft-Versus-Host Disease: Association With HLA Antigen Typing, Phospholipase A2 Receptor, and C4d. Am J Kidney Dis. 2014 Dec;64(6):987-93. doi: 10.1053/j.ajkd.2014.09.001. Epub 2014 Oct 8
  • Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes
    Obes. 2015 Feb;22(1):1-2. doi: 10.1097/MED.0000000000000130. PubMed; PMID: 25485518
  •  Weber HC. Gastrointestinal peptides and itch sensation. Curr Opin Endocrinol
    Diabetes Obes. 2015 Feb;22(1):29-33. doi: 10.1097/MED.0000000000000122. PubMed;
    PMID: 25485517
  • Hermos JA, Quach L, Gagnon DR, Weber HC, Altincatal A, Cho K, Lawler EV,
    Grotzinger KM. Incident severe thrombocytopenia in veterans treated with
    pegylated interferon plus ribavirin for chronic hepatitis C infection. Pharmacoepidemiol Drug Saf. 2014 May;23(5):480-8. doi: 10.1002/pds.3585. Epub 2014 Feb 20. PubMed PMID: 24677630

9th Annual Nancy L.R. Bucher, MD, Seminar

January 8th, 2015 in Spotlight

 

Department of Pathology and Laboratory Medicine

Spring 2015 Seminar Series: Friday, February 6, 2:00

 

9th Annual Nancy L.R. Bucher, MD, Seminar

“Engineering Liver Tissue at the Microscale”

Friday, February 6, 2:00 (Reception Following) 670 Albany Street – Lobby Level #107/108

Speaker:

Dr. Sangeeta Bhatia, MD, PhD

John J. and Dorothy Wilson Professor of Health Sciences and Technology & Electrical Engineering and Computer Science;
Director, Laboratory for Multiscale Regenerative Technologies;
Massachusetts Institute of Technology

 

Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914

December 2014

January 8th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “Overcoming the resistance to anti-angiogenesis therapy”. The overall of goal of this research is to study the role of posttranslational modifications on VEGFR-2 in colon cancer. Angiogenesis inhibitors targeting the VEGF signaling pathway have been FDA approved for various cancer treatments. Although beneficial, patients inevitably develop resistance and often fail to demonstrate significantly better overall survival. Interfering with the posttranslational modifications of VEGFR-2 may overcome refractoriness and resistance to certain class of anti- cancer drugs.
  • Dr. Daniel Remick was an invited speaker to Loyola University Medical Center in Chicago, December 9/10, 2014:
    • Dr. Remick presented Grand Rounds in the Department of Surgery at Loyola – “Brain Injury Prevents Pneumonia – Who knew?”
    • He also gave a lecture to the Department of Pathology “Physician Scientist Pathway in Pathology”
    • Dr. Remick, as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago presented,  “Inhibitory IgG Increases Sepsis Mortality”
  • Dr. Chris Andry, of Boston University USA, visited Professor Rodger Charlton, and other colleagues in the Division of Primary Care, Nottingham University, United Kingdom on 9th December, 2014 . During his visit, Dr. Andry gave a talk entitled “The Value of a Centralized Hospital Bereavement Office Supporting Multicultural Families in the USA”   

    image

    UK meeting University of Nottingham. Dr. Andry, 2nd from left. Man on his right Professor Rodger Charlton. Man on his left Dean of Srinakharinwirot University, Thailand. First Woman to the right of Professor Charlton, Assistant Professor Nantana Choomchuay, MD. Head, Department of Pathology, Faculty of Medicine, Srinakharinwirot University.

  • Jenny McEldoon, BU Undergrad working in the Remick Lab has been awarded funding from UROP for Spring 2015!
  • Zachary Hunter, PhD, Steve Treon Lab at Children’s Hospital, successfully defended his thesis “Whole Genome Sequencing Reveals that Recurrent MYD88 and CXCR4 Mutations Underlie the Genomic Landscape of Waldenström’s Macroglobulinemia” on Tuesday, December 2nd

Publications ACCEPTED:

  • Inge The, Suzan Ruijtenberg, Benjamin Bouchet, Alba Cristobal, Martine B.W. Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J.R. Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Munoz, and Sander van den Heuvel, Rb and the APC/C co-activator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells. Nature Communications
  • Akifumi Fujita, Huihong Xu, Yu-Ming Chang, Scharukh Jalisi, and Osamu Sakai, Best cases from the AIRP: Malignant mixed tumor of the hard plate. RadioGraphics
  • Authors: Blanche C. Ip, Andrew E. Hogan, Barbara S. Nikolajczyk; Lymphocyte roles in metabolic dysfunction: of men and mice  Trends in Endocrinology and Metabolism  
  • Michael J. Greene, Elena S. Klimtchuk, David C. Seldin, John L. Berk, and Lawreen H. Connors; “Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal” Biochemistry

Publications: PUBLISHED:

  • Stevenson EK, Sloan KA, Narsule CK, Kretschman DM, Sarita-Reyes CD, Steiling K, Ebright MI. Catamenial hemothorax in a patient with multiple sclerosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):e69-70
  • Zhang QSiroky M, Yang JH, Zhao Z and Azadzoi K “Effects of ischemia and oxidative stress on bladder purinoceptors expression” Urology, 2014 Nov;84(5):1249.e1-7. doi: 10.1016/j.urology.2014.07.023

Congratulations to Dr. Caitlin Leibowitz Parello

December 4th, 2014 in Student Spotlight

Caitlin-Leibowitz thumb

 

Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st.

November 2014

December 2nd, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items 

Announcements:

  • Kate Murphy has announced that the Blood Bank had its’ 4th inspection of the year – American Association of Blood Banks (AABB) on November 19th and 20th for an extremely thorough assessment, including nursing competency.  We were successfully accredited for another 2 years!
  • Zach Hunter, PhD Candidate in the Steven Treon’s Lab at Children’s Hospital presented at the following conferences:
    • August 14th in London, UK. At the 8th International Workshop on Waldenstrom’s Macroglobulinemia. His oral presentation was entitled: “Genomic Landscape of WM”
    • August 17th in London, UK, WMUK’s 5th International Doctor Patient Forum “Making Sense of Key Information about your WM: MYD88, CXCR4 and the Genetics of WM”
  • Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st

    LeibowitzParelloDefense.11.21.14

    Caitlin’s Defense

  • Zach Hunter also received a grant in his own name; “Identification of Germline and Somatic Variants Associated with Predisposition to WM” from the International Waldenström’s Macroglobulinemia Foundation
  • Barb Nikolajczyk, PhD presented:
    • “Immunometabolism, Lymphocytes and Obesity” at The Obesity Society annual meeting in Boston, MA on November 6th
    • “Lymphocytes in Human Obesity and Type 2 Diabetes” at the Evans Center/Whitaker mini-symposium on Immune Cells and Metabolism on November 21st
  • David Kindelberger, MD (along with colleague Eric Huang from the University of California, Davis) presented a workshop titled “2012 Updated ASCCP Consensus Management Guidelines for Women with Abnormal Cervical Cancer Screening Tests” at the 62nd Annual American Society of Cytopathology Scientific Meeting on November 17th in Dallas
  • Daniel Remick, MD was given a water pitcher to acknowledge his serving on the Society for Leukocyte Biology Council, and serving as the Program Chair for the 2014 Annual Leukocyte Biology Meeting. The 2014 meeting in Salt Lake City was a joint meeting between Leukocyte Biology and the International Endotoxin and Innate Immune Society.

    Remick Watervase jpg

    Dr. Remick with watervase

  • Mostafa Belghasem, PhD Candidate, Henderson Lab:
    • Presented a poster entitled “Heterozygous Actn4 Mutant Mice are Susceptible to Glomerulopathy when Subjected to Hemodynamic Stress” at American Society of Nephrology (ASN) Kidney Week 2014 in Philadelphia, PA, November 11-16, 2014
    • Mostafa was also selected to participate in the ASN 2014 Kidney STARS program and received a Travel Award from the ASN

 Publications ACCEPTED:

  • Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R.Rifkin and Adam Lerner; “Type 4 cyclic nucleotide phosphodiesterase inhibitors block intracellular Toll-like receptor signaling in chronic lymphocytic leukemia and normal hematopoietic cells”. Journal of Immunology
  • Anastasia Gomez, Nancy S. Miller, and Irina Smolina. Visual detection of bacterial pathogens via PNA-based padlock probe assembly and isothermal amplification of DNAzymes. Analytical Chemistry, Publication Date (Web): 21 Nov 2014

Publications: PUBLISHED:

  • Castillo JJ, Olszewski AJ, Cronin AM, Hunter ZR, Treon SP. Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database. Blood. 2014 Jun 19;123(25):3999–4000. PMID: 24948623
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Patterson CJ, Tsakmaklis N, Kanan S, Rodig S, Castillo JJ, Treon SP. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia. Leukemia. 2014 Jun 10; PMID: 24912431
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. Possible resting metabolic rate modification by the circulating RBP4 in obese subjects. Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Treon SP, Hunter ZR, Castillo JJ, Merlini G. Waldenström Macroglobulinemia. Hematol Oncol Clin North Am. 2014 Oct;28 (5):945–970. PMID: 25212891
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Tsakmaklis N, Kanan S, Castillo JJ, Treon SP. CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells. Br J Haematol. 2014 Nov 5; 
  • Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH (2014) Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genet. 2014 (e-Pub ahead of print) PMID: 25367359

October 2014

November 5th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Jessica (Allen) Ritter, PhD Candidate, Genco Lab, presented a poster at XIXth International Pathogenic Neisseria Conference October 12th-17th in Asheville, NC. The poster is entitled; “Neisseria gonorroheae modulates immune cell survival through pyroptosis.” Authors are Jessica Ritter, Kathleen Goodmon, and Caroline Genco.
  • Evan Chiswick, PhD, Remick Lab  was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, October 23rd-25th in Salt Lake City, Utah.  also received a travel award. The title of his talk was “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity” Evan also received a Travel Award, bravo!
  • Daniel Remick, M.D., served as the program chair for the 2014 joint meeting of the Society for Leukocyte Biology and the International Endotoxin and Innate Immunity Society. The meeting had nearly 250 participants from across the world and was held in Salt Lake City, Utah.
  • David Sherr, M.D. has received an award from the Art Because Breast Cancer Foundation. http://www.bostonglobe.com/metro/2014/10/15/team-boston-researchers-will-study-environment-relation-breast-cancer/Bg6nMAlvWIVBNJfBbpat3L/story.html?s_campaign=8315

Publications ACCEPTED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, Clinton T. Baldwin, David C. Seldin, Lawreen H. Connors. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genetics

Publications: PUBLISHED:

  • Tiffany J. Mellott, Sarah M. Pender, Rebecca M. Burke, Erika A. Langley, Jan Krzysztof Blusztajn; “IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and  Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice” PLOS, April 2014. http://www.ncbi.nlm.nih.gov/pubmed/?term=Mellott%20TJ%5Bauth%5D\
  • Erika A. Langley1, Marina Krykbaeva1, Jan Krzysztof Blusztajn, Tiffany J. Mellott; “High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T + Itpr3tf/J mouse model of autism.” Behavioural Brain Research; Volume 278, 1 February 2015, Pages 210–220
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. “Possible resting metabolic rate modification by the circulating RBP4 in obese subjects.” Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. “Targeting receptor tyrosine kinases and their downstream signaling with cell penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.” Chem Biol Drug Des. 2014 Oct 8.
  • O’Brien, MJ, Zhao, Q, Yang, S. “Colorectal Serrated Pathway Cancers And Precursors” Histopathology. 2014 Sep 29. doi: 10.1111/his.12564

 

NEW COURSE for Spring 2015!

October 21st, 2014 in Spotlight

Human Biospecimens for Research – Information
GMS PA910Rev6