Pathology & Laboratory Medicine News Items – June/July 2017

August 4th, 2017 in Uncategorized

Pathology & Laboratory Medicine News Items – June/July 2017

 

  • Announcements:
      • Sandra Cerda MD, was invited as a guest speaker and scientific session Chair and moderator at the “3rd International Conference on Cytopathology & Histopathology” that took place in Philadelphia on June 22-23. Theme “Transforming the Future of Cytopathology & Histopathology”
      • Reyhan Gedik, MD presented a poster at ACLPS 2017 Annual Meeting, June 15-17, 2017 in New Haven, CT. Her poster title was “Computerized Approach to Antibody Identification in Pre-transfusion Testing”
      • Dr. Ivana Delalle has accepted an invitation to become an Associate Editor in Journal of Alzheimer’s Disease
      • Dr. Delalle has also been invited to give a talk on her research at Molecular Pathology seminar series at Johns Hopkins Medical School
      • Dr. Daniel Remick was invited to speak at the Association of Pathology Chairs annual meeting at the new chairs bootcamp. The title of his talk was “The Unique Leadership Challenges in the Pathology Research Mission”
      • Dr. Daniel Remick became the President of the American Society of Investigative Pathology on July 1, 2017. He will serve for a one year term
      • Dr. David Sherr and his team resubmitted their competitive renewal for the BU Superfund Research Center and were awarded a $3,500,000 grant over 2.5 years; http://www.bu.edu/sph/research/research-landing-page/superfund-research-program-at-boston-university/
      • Resident Israa Laklouk, MD submitted abstract entitled  “Predictive accuracy of thyroseq v2 for malignant thyroid nodules among Bethesda-III cytology subcategories: Atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS)” has been accepted as an Oral Presentation and will be part of the Scientific Programme during the  29th European Congress of Pathology to be held in Amsterdam, The Netherlands. The authors list: Israa Laklouk, MDMahmoud Soliman MD, PhD; Dhay Kamel ,MD; Huihong Xu, MD; Sandra Cerda, MD
      • Please Welcome our New Residency Coordinator Daphney Noel! Daphney comes to us via Brigham and Women’s Hospital.  In her recent position as a program coordinator at BWH’s Center for Faculty Development and Diversity Daphney was responsible for planning and arranging programs in support of the faculty and research community. Daphney graduated from Colby-Sawyer College with a BA in History and hopes to get her MS of education in counseling
      • 2017 Graduation Celebration was held this year at Cinquecento Restaurant; Congratulations to All!!

 

n    BU-CTSI Spring 2017 Pilot Awardees

 

Boston University Clinical and Translational Science Institute (BU-CTSI) is pleased to announce the recipients of the Spring 2017 Integrated Pilot Grant Program.  This cycle we received 47 applications, 22 applicants were awarded, including 12 deferred from fall 2016. Each awardee received $20,000 in funding . The CTSI would like to recognize the faculty who reviewed the applicants and offer our sincere thanks for their time and efforts.

 

The purpose of the Integrated Pilot Grant Award mechanism is to stimulate scientific discovery in all areas of basic or translational research related to the prevention, diagnosis, and management of human disease.

 

Nader Rahimi, PhD The purpose of this pilot CTSI grant proposal is to investigate the novel tumor suppressor function of TMIGD1 in renal cancer and possible therapeutic strategy. Renal cell carcinoma is one of the most common and lethal forms of renal cancers and also is a high-risk metastasizing tumor with a poor prognosis. Treatment remains highly challenging as renal cell carcinoma is an intrinsically chemo/radiotherapy-resistant cancer.

 

Joel Henderson, MD, PhD The goal of this study is to evaluate the utility of urine podocyte measurement, or podometrics, in biobanked urine specimens from the Framingham Heart Study. Podocytes are kidney epithelial cells that are critical to the formation and maintenance of the kidney filtration system. Their loss and accumulation in the urine under conditions of stress indicates damage to the kidney filter, and is a critical step in the eventual development of progressive chronic kidney disease (CKD).
Daniel Remick, MD Antibiotic resistance has become an important problem with few new antibiotics approved in the past 10 years. Prior work in the lab has shown that it is possible to stimulate the innate immune system so that the white blood cells eradicate bacteria more effectively. Giving mice a drug that activates the substance P receptor activates the cells so that they are more effective at eliminating bacteria in the lungs. This is essentially a new way of treating pneumonia.

The Department of Pathology and Laboratory Medicine launched a series of initiatives to increase scholarly activity and increase grant funding. These initiatives arose from the strategic planning process. The Department was recently asked to provide information about specific faculty development programs, and we provided the information below.

    • Writing workshops. A 9 part series of workshops were presented on how to prepare a manuscript. Topics included using bibliography and graphing software, writing an abstract and selecting the most appropriate journal for the manuscript etc. Faculty involved included Daniel Remick, M.D., and Shinichiro Kurosawa, M.D., Ph.D.
    • Manuscript accelerator sessions. These sessions are held each week with the intent of accelerating the completion of manuscripts. Participants (grad students, fellows, junior faculty etc.) participate in a 4 part series by bringing different portions of the manuscript to the session. The senior faculty member at the session serves more as an editor than actual reviewer of the manuscript. A 2017 survey of the faculty showed that 82% of the respondents felt these accelerator sessions should be continued. The faculty involved included Drs. Sharon, O’Brien, Kurosawa, Stearns-Kurosawa, Remick, Panchenko and others.
    • Internal grant reviews. During each grant review cycle the Department offers internal review of grant submissions. Faculty send in their abstract and specific aims page, and another faculty member is assigned as the reviewer. This initiative has just been started, so it is too early to track success in a systematic manner. However, at least 2 CTSI grants, a Dahoud biobank and Shipley Prostate biobank study have been funded after internal review.
  • Publications ACCEPTED:
    • Parul Agnihotri, Nicholas M. Robertson, Sarah E. Umetsu, Ksenia Arakcheeva and Susan Winandy; Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells. Accepted for publication in Immunology
    • Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, and Delalle I: Methionine sulfoxide reductase-B3 (MsrB3) protein associates with synaptic vesicles and its expression changes in the hippocampi of Alzheimer’s disease patients. Accepted for publication in the Journal of Alzheimer’s Disease
    • Agis-Balboa RC, da Silva Pinheiro PC, Rebola N, Kerimoglu C, Benito E, Gertig M, Bahari-Javan S, Jain G, Burkhardt S, Delalle I, Jatzko A, Dettenhofer M, Zunszain P, Schmitt A, Falkai P, Pape J, Binder E, Mulle C, and Sananbenesi F: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk of dementia. Accepted for publication in EMBO Journal, June 27, 2017
  • Publications PUBLISHED:
    • Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher; A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Reports, Volume 19, Issue 11, p2177–2184, 13 June 2017
    • Yang JH, Siroky MB, Yall SV and Azadzoi KM: Mitochondrial Stress and Activation of Phosphoinositol 3 Kinase (PI3K) and Protein Kinase B (Akt) Survival Pathway in Bladder Ischemia. Res Rep Urol 2017, June 10, 9:93-100
    • Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging. Comprehensive Physiology (In Press).
    • Agrawal, M, Kern, PA, Nikolajczyk BS. The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths. Current Diabetes Reports (In Press

Pathology & Laboratory Medicine News Items – April/May 2017

June 9th, 2017 in Uncategorized

Pathology & Laboratory Medicine News Items – April/May 2017

Announcements:

    A Mallory grant “The Utility of Ki-67 and Phosphohistone H3 in the Differentiation Between Classic Papillary Thyroid Carcinoma, Follicular Variant of Papillary Thyroid Carcinoma and Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features” was funded. This will support the work of Drs. Jing Yang, Cerda and Tan.

    The T32 training grant, T32GM086308 “Immunobiology of Trauma” was funded for an additional 5 years with a budget of $1,401,170. This grant provides salary support for BMC residents to engage in basic science research full time for two years. Daniel Remick, M.D. is the principal investigator.

    Max Vaickus, graduating Masters student had his abstract accepted for the 40th Annual Conference on SHOCK in June in Fort Lauderdale, Florida. His abstract title is: “Mild traumatic brain injury induces genetic changes in mouse lung to augment Pseudomonas aeruginosa clearance”

    Max also received a Travel Award of $1000 to attend the SHOCK Conference

    On Behalf of Dr. Barbara Slack, Pathology Department Russek Awards Committee

      • I am pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
      • First Prize -Stephanie Adams (Delalle lab)
      • Second Prize – Elizabeth Moses (Spira-Lenburg lab)
      • Third Prize – Nisma Mujahid (Fisher lab, MGH)
      • Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day was held on Friday, April 21st in the Hiebert, The keynote speaker this year was Dr. Carla Shatz, Professor of Biology and Neurobiology at the Stanford Neurosciences Institute https://www.bumc.bu.edu/gms/students/phd/23rd-annual-henry-i-russek-student-achievement-day-april-21/
        • I would also like to thank Dr. Rahimi, Dr. Andry, and Dr. Stearns-Kurosawa, for serving on the departmental Russek committee this year.

       

      Richard Kozak retired April 30th after 38+ years in the Clinical Microbiology Laboratory; thank you!

      For Nancy S. Miller, MD:

        • Was an invited speaker at a full-day Medical Mycology Workshop presented at the 2nd joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and Northeast Branch-American Society for Microbiology (NEBASM), April 3, 2017, Wakefield, MA
        • An invited guest also for, “Micro meets multiplex: A case-based view of syndromic panel testing”, presented at the Syndromic Testing Symposium, April 6 in Burlington, MA
        • Dr. Miller will present a Meet-the-Experts session at ASM Microbe 2017 on June 5th, at the international conference of the American Society for Microbiology June 1-5 in New Orleans.  Session Title: “Who knew? And what to do? Tales from the benches and trenches.”

      It was Medical Laboratory Professionals Week April 23 -28!! Activities included:

        • Some of the Lab Areas had breakfast and lunches for staff throughout the week
        • There were two Luncheon Seminar Talks with Pizza
        • Cake and Ice Cream on Friday Dessert Day, April 28th for everyone
        • Staff were allowed to wear jeans if they donated $2 to a BMC Fund we raised $150 going to pieces of home back pack project at BMC which serves children who are in foster care
        • Thank you one & all!!!!

      Nisma Mujahid, MD/PhD (Off-Site at MGH, David Fisher Lab) successfully defended her Thesis, “The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention” on May 1st, 2017. HOORAY!!

      Stephanie Adams, OD/PhD (Blusztajn/Delalle Lab) successfully defended her Thesis, NEURONAL PHENOTYPES IN HUMAN HIPPOCAMPUS AND NEOCORTEX IN LATE-ONSET ALZHEIMER’S DISEASE: PROTEIN EXPRESSION OF NOVEL GENES IMPLICATED IN PATHOGENESIS” on May 1st, 2017. HOORAY!!

      Caitlin Miller, PhD (Gummuluru Lab) successfully defended her Thesis, “Role of viral protein R in infection of human dendritic cells by primate lentiviruses” on May 9th 2017. HOORAY!!

      Dr. Daniel Remick was invited to the 9th Wiggers-Bernard Conference at the Ludwig Bolzmann Institute in Vienna, Austria the first week of May. He chaired the working group on defining organ injury in pre-clinical models of sepsis

      Dr. Remick also presented a proposal to Wacker Biosolutions in Munich Germany for Boston University. The proposal would potentially fund a student at either the undergraduate or medical campus

      Barb Nikolajczyk, PhD participated in the IMMUNOLOGY 2017TM Capitol Hill Day held on May 16 in conjunction with the Annual Meeting of the American Association of Immunologists. She was one of a contingent from MA who met with staff of Representatives from MA Districts 2 and 7 and both Senators to promote a consistent and robust increase in NIH and other science funding “over the long haul”. Check out  #AAIHillDay on Twitter to see more.

      Daniel Remick was invited to speak at the American Thoracic Society’s annual meeting in Washington DC. His presentation was titled “Heterogeneity in the Septic Inflammatory Response”

      Dr. Ivana Delalle is pleased to report that she will give a platform presentation entitled “Expression of MSRB3, Implicated in Decreased Hippocampal Volume, Changes in Alzheimer’s Disease and Associates With Synaptic Vesicles” on June 9 at the Annual Meeting of American Association of Neuropathologists in Orange County, CA.

      Dr. Nikolajczyk was invited to give a seminar at East Carolina University, EDCOI Center, Greenville, NC, Mechanisms Driving Inflammation in Human Obesity and Type 2 Diabetes, 2017.

      CONGRATULATIONS GRADUATES!!!!!

        • Masters Degrees:
          • Keith Keller, MS
          • Denis Kyabaggu, MS
          • Carolina Lyon de ana, MS
          • Morgan Thompson, MS
          • Max Vaickus, MS

      Graduates.Families.PIs.IMG_1454Dr. Andry and Denis Kyabaggu.IMG_1451Keith.Morgan.IMG_0862GraduatesandPIs.IMG_1444b

       

       

       

       

       

       

       

       

       

       

      PhD Degrees:

      • Stephanie Adams, PhD/OD
      • Liz Moses, PhD – Liz by the way was the PhD Commencement Speakers, BRAVO LIZ!!!!
      • Jessica Ritter, PhD

      RemickHoddingLizMoses

       

       

       

      Moses.DefenseTitle

       

      LizMosesandFamily

       

       

      JessRitterDefense

       

       

       

      AdamaDefense.05.01.2017.Blusztajn.Adams.Delalle

       

       

       

       

       

       

      Pathology Residency Completed: (Photos to come next issue)

      • Cecilia Ponchiardi, MD
      • Dhay Kamel, MD – from the Cytopathology Program

      Nancy L.R> Bucher, MD; Celebration of Life & Legacy

      • On Thursday, May 4th the department, friends and family gathered to celebrate and honor the remarkable life and legacy of Professor Nancy L.R. Bucher of Harvard Medical School and Boston University School of Medicine. Dr. Bucher was a pioneer in liver regeneration studies and hepatocyte cultures. Dr. Bucher was a Fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences. She also received The Distinguished Scientific Achievement Award from the American Liver Foundation.

      Dr. Winandy.Bucher ProfessorBucher Family at Table

      Buffet

      Drs. Andry.Blusztajn.MurnaneGuests

       

       

       

       

       

       

       

       

       

       

      Publications ACCEPTED:

        • Miller, C.; Akiyama, H.; Agosto, L.; Emery, A.; Ettinger, C.; Swanstrom, R.; Henderson, A.; Gummuluru, S. Virion associated Vpr alleviates a post-integration block to HIV-1 infection of dendritic cells. Journal of Virology. 2017
        • Li, L., A. Gautam and N.S. Miller. Actinomyces neuii, An Uncommon Bacterial Isolate from a Neck Abscess. Accepted for publication April 10, 2017, Internal Medicine Review

      Publications PUBLISHED:

      • Bi B, Li F, Guo J, Li C, Jing R, Lv X, Chen X, Wang F, Azadzoi KM, Wang L, Liu Y, Yang JH. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. Neuroscience. 2017 Mar 21;351:84-95. doi: 10.1016/j.neuroscience.2017.03.023. [Epub ahead of print] PMID: 28341197
      • Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH. Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle. 2017 Apr 3;16(7):649-659. doi: 10.1080/15384101.2017.1281481. Epub 2017 Jan 19. PMID: 28103160
      • Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging (In Press, Comprehensive Physiology)
      • Sanaz Bahari-Javan, Hristo Varbanov, Rashi Halder, Eva Benito, Lalit Kaurani, Susanne Burkhardt, Heike Anderson-Schmidt, Ion Anghelescu, Monika Budde, Roman M. Stilling, Joan Costa, Juan Medina, Detlef E. Dietrich, Christian Figge, Here Folkerts, Katrin Gade, Urs Heilbronner, Manfred Koller, Carsten Konrad, Sara Y. Nussbeck, Harald Scherk, Carsten Spitzer, Sebastian Stierl, Judith Stöckel, Andreas Thiel, Martin von Hagen, Jörg Zimmermann, Antje Zitzelsberger, Sybille Schulz, Andrea Schmitt, Ivana Delalle, Peter Falkai, Thomas G. Schulze, Alexander Dityatev, Farahnaz Sananbenesi, and André Fischer; “HDAC1 LINKS EARLY LIFE STRESS TO SCHIZOPHRENIA-LIKE PHENOTYPES” PNAS 2017 ; published ahead of print May 22, 2017doi:10.1073/pnas.1613842114

              Pathology & Laboratory Medicine News Items – February/March 2017

              April 4th, 2017 in Uncategorized

              Pathology & Laboratory Medicine News Items – February/March 2017

              Announcements:

              • Our Resident, Israa Laklouk, MD had the following abstract ” Diagnostic Implication of ThyroSeq Sequencing Assay on Thyroid Nodules with FNA Cytology Diagnosis of Bethesda III: Atypia of Undetermined Significance versus Follicular Lesion of Undetermined Significance ” authors: Israa Laklouk, Mahmoud L Soliman, Dhay Kamel, Huihong Xu, Sandra Cerda; selected for a Poster Presentation  at the United States & Canadian Academy of Pathology’s (USCAP) 106th Annual Meeting, March 4 – 10, 2017 in San Antonio, Texas  http://viewer.zmags.com/publication/84c2f7ae#/84c2f7ae/10
              • IsraaLakloud.Poster.USCAP2017-395-IL
              • IsraaLakloudandPoster.USCAP2017.IMG_3527
                • Lawreen H. Connors, PhD and Frederick L. Ruberg, MD presented “Transthyretin-associated (ATTR) cardiomyopathy: A not uncommon, rare disease” at BUSM Department of Medicine Medical Grand Rounds on Feb. 17, 2017 https://echo360.bu.edu:8443/ess/echo/presentation/66b063a7-a6f2-4ef9-8957-81e40ec68bb3
                • Carolina Lyon de Ana, a current Masters student in Dr. Susan Winandy’s Lab and Bo Shao, a technician with Dr. Maria Panchenko’s Lab were both accepted into BU’s PhD PIBS Program! Congratulations!!
                • Dr. Ivana Delalle News:
                  • On March 24 Dr. Delalle gave an invited lecture at the Croatian Institute for Brain Research (CIBR) on “The brain expression of novel genes implicated in AD and low hippocampal volume”
                  • She also presented her group’s latest work at AD/PD International Meeting in Vienna, March 29 – April 2: “Protein expression of low hippocampal volume- associated risk allele candidate MSRB3 in AD” by Stephanie L Adams1, Laurent Benayoun1, Jayandra J. Himali­­2,3, Kathy Tilton1,  Sudha Seshadri2,3, and Ivana Delalle1,31Pathology, Boston University School of Medicine; 2Framingham Heart Study, Boston University School of Public Health; 3Neurology, Boston University School of Medicine
                  • Dr. Delalle has also been invited to give a talk at the 3rd Annual Next Generation Sequencing & Single Cell Analysis Congress, scheduled for 23 – 24 October 2017 in Boston. The title of her talk will be: “Extracellular vesicles microRNA (EV miRNA) as Bipolar Disorder (BD) Biomarkers”, based on her senior author paper published ahead of print on February
                • JessRitterDefense
                • Jessica (Allen) Ritter, PhD (Caroline Genco Lab) successfully defended her Thesis, “Induction of Human Macrophage Cell Death by Neisseria gonorrhoeae” on March 10th, 2017. BRAVO!!
                • Elizabeth Moses, PhD (Spira/Lenburg Lab) successfully defended her Thesis, “Characterizing the Airway Epithelium following Chemical Exposure: Molecular Alterations and their Potential Utility in the Treatment of Lung Disease” on March 21st, 2017. HOORAY!!
                    • Liz andFriends
                    •     LizPresentingandAviWatching
                    •  Moses.DefenseTitle

                 

                 

                • News for Dr. Barbara Nikolajczyk:
                  • Dr. Nikolajczyk gave a talk at the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
                  • She also presented for The Hormel Institute, University of Minnesota, Austin, MN, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
                  • Dr. Nikolajczyk also received a Grant Title; “Does salt drive a human immune profile in a mouse model of obesity?” from the Boston University Nutrition and Obesity Research Consortium
                • Dr. David Sherr along with Dr. Stefano Monti and presenting work of Amy Li, gave an invited talk at the Clinical and Translational and Sciences Institute Symposium about development of a high throughput genomic platform to identifying which of the 84,000 chemicals in our environment are carcinogens.

                CTSI 2017 BU

                CTSI 2017 – BU

                 

                 

                 

                 

                 

                • Nancy S. Miller, M.D. – was invited to teach a webinar for Rutgers, The State University of New Jersey, School of Health Professions , Department of Clinical Laboratory Sciences, on March 27 “Improved technology for microbial identification: challenges and lessons learned”
                • Welcome New Residents!:              
                •                                                                                                                                                                      Joanes
                • Marianinha Joanes
                • International American University
                • PGY-1
                • Yambayev
                • Iiyas Yambayev
                • Kazakh National Medical University
                •                                                  PGY-1

                 

                • FASEB Capitol Hill Day 2017
                      • On March 9, 2017 scientists from across the country gathered in Washington D.C. to participate in the Federation of American Societies for Experimental Biology (FASEB) Capitol Hill day. The purpose of the day was to advocate for federal funding for research, which includes the National Institutes of Health, National Science Foundation, Centers for Disease Control and other agencies.
                      • The group met with congressional staff from the offices of our Representatives and Senators. During these meetings we emphasized the importance of research funding that drives scientific discoveries by sharing individual stories. We also emphasized how these scientific advances improve the care of patients and health of the nation. Information was provided about the positive economic impact of NIH and NSF funding for each state and congressional district.
                      • Our specific request was to have research funded to the full amount in the 2017 budget. Since the federal government currently operates under a continuing resolution, NIH has been withholding 10% from grants until the budget has been finalized.
                      • The Massachusetts representatives all strongly supported research funding. However, they were also pessimistic given the current political climate in Washington DC, even though there is strong bipartisan support for research.
                      • This pessimism was justified when the White House released the first version of their budget, which calls for cutting the NIH budget by $5.8 billion, or 18%.
                      • The Massachusetts delegation included Laura Coleman representing the American Society for Nutrition, Shoumita Dasgupta and Daniel Remick from Boston University School of Medicine and Boston Medical Center, Ming Ming Ning from Massachusetts General Hospital and Hanno Steen from Boston Children’s Hospital and Harvard Medical School. Derek Scholes the Director of Scientific Policy for the American Society of Human Genetics escorted us throughout the day.

                    Kennedy picture

                     

                    • Publications ACCEPTED:
                      • Leena P. Bharath, Blanche C. Ip, Barbara S. Nikolajczyk  Manuscript accepted into: “Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging” Comprehensive Physiology
                      • Woodworth, M., E.M. Neish, N. S. Miller, Tanvi Dhere, E.M. Burd, Cynthia Carpentieri, K. L. Sitchenko, and C.S. Kraft. Laboratory Testing of Donors and Stool for Fecal Microbiota Transplantation for Recurrent C. difficile Infection. Journal of Clinical Microbiology. Epub ahead of print 2017 Jan 11. doi:10.1128/JCM.02327-16. PMID: 28077694.
                    • Publications PUBLISHED:
                      • Chan GG, Koch CM, and Connors LH:  Blood proteomic profiling in inherited (ATTRm) and acquired (ATTRwt) forms of transthyretin-associated cardiac amyloidosis. J Proteome Res. 2017 Feb 14. doi: 10.1021/acs.jproteome.6b00998. [Epub ahead of print]  PMID: 28196416
                      • Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL:  Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model.  JAMA Cardiol. 2017 Feb 8. doi: 10.1001/jamacardio.2016.5864. [Epub ahead of print]  PMID: 28196196
                      • Wang Z, Monti S, DH S. The diverse and important contributions of the AHR to cancer and cancer immunity. Curr Opinion Toxicol. 2017 ;http://www.sciencedirect.com/science/article/pii/S2468202016300365
                      • Blandine Bustamante Helfrich, MD, MPH, Nymisha Chilukuri, BSc, Huan He, PhD, MHS, MMgt, Sandra R. Cerda, MD, Xiumei Hong, MD, PhD, Guoying Wang, MD, PhD, Colleen Pearson, BA, Irina Burd, MD, Xiaobin Wang, MD, MPH, ScD. “DOI:Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort” http://dx.doi.org/10.1016/j.placenta.2017.02.016

                     

                     

                     

                    Departmental Seminar – March 24, 2017

                    March 20th, 2017 in Spotlight

                    Seminar Series: Fall 2016 ~~ Friday, February 17, 2017

                    2:00-3:00 PM

                                  

                    “The Relationship of Retina to Brain Pathology in a Mouse Model of Concussive Traumatic Brain Injury

                     

                    Mark Wojnarowicz
                    PhD Candidate, Goldstein Lab
                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Location & Time:
                    670 Albany Street
                    Lobby Level #107/108

                    2:00-3:00 PM
                    Friday, March 24, 2017

                    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

                    Course Director: Barbara Slack, PhD

                    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

                    Dissertation Defense – Tuesday, March 21, 2017

                    March 14th, 2017 in Spotlight

                    Dissertation Defense Seminar ~~ Tuesday, March 21, 2017

                    2:00-3:00 PM

                                  

                    Characterizing the Airway Epithelium following Chemical Exposure:
                    Molecular Alterations and their Potential Utility in the
                    Treatment of Lung Disease

                     

                    Elizabeth Moses
                    PhD Candidate
                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Location & Time:
                    Instructional Building; L-112

                    2:00-3:00 PM
                    Tuesday, March 21, 2017

                    Dissertation Defense – Friday, March 10, 2017

                    March 8th, 2017 in Spotlight

                    Dissertation Defense Seminar ~~ Friday, March 10, 2017

                    10:00-11:00 AM

                                  

                    “Induction of Human Macrophage Cell Death by Neisseria gonorrhoeae

                     

                    Jessica (Allen) Ritter
                    PhD Candidate
                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Location & Time:
                    670 Albany Street
                    Lobby Level #107/108

                    10:00-11:00 AM
                    Friday, March 10, 2017

                     

                    Departmental Seminar – February 24, 2017

                    February 19th, 2017 in Spotlight

                    Seminar Series: Fall 2016 ~~ Friday, February 24, 2017

                    2:00-3:00 PM

                                  

                    Subha Singh, First Year MS Candidate
                    (D. Anderson Lab)
                    “Seminal Fluid and its Inflammation Properties on Vaginal Epithelium Cells”

                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Rawan Tahboub, First Year MS Candidate
                    (Rahimi Lab)
                    “Signal Transduction by Cell Adhesion Molecule, IGPR-1”

                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Location & Time:
                    670 Albany Street
                    Lobby Level #107/108

                    2:00-3:00 PM
                    Friday, February 24, 2017

                    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

                    Course Director: Barbara Slack, PhD

                    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

                    Departmental Seminar – February 17, 2017

                    February 14th, 2017 in Spotlight

                    Seminar Series: Fall 2016 ~~ Friday, February 17, 2017

                    2:00-3:00 PM

                                  

                    “Process Improvements in Biobanking, in Partnership with the National Cancer Institute

                     

                    Chris Andry, MPHil, PhD
                    Vice Chair for Operations and Management
                    Associate Professor
                    Director Masters Graduate Program
                    Department of Pathology and Laboratory Medicine
                    Boston University School of Medicine

                     

                    Location & Time:
                    670 Albany Street
                    Lobby Level #107/108

                    2:00-3:00 PM
                    Friday, February 17, 2017

                    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

                    Course Director: Barbara Slack, PhD

                    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

                    Pathology & Laboratory Medicine News Items – December 2016/January 2017

                    February 1st, 2017 in Uncategorized

                    Pathology & Laboratory Medicine News Items – December 2016/January 2017

                    • Announcements:
                        • The Pathology Residency and Cytopathology Fellowship Programs, are proud to announce the ACGME’s decision for the Continued Accreditation for both programs.  Congratulations and thanks to everyone for a job well done!
                              •  Rahimi.Cover.2016
                          • Dr. Grace Zhao reported; “Congratulations, your Mallory Project is approved with a total budget of $6925. The approved budget is over the budget cap of $5000 because of the potential to expand the IHC list of stains within the Department”
                          • Dr. Deborah Stearns-Kurosawa was invited to be a member of the scientific steering committee for the 10th International Symposium on Shiga Toxin (Verocytotoxin) Producing E.coli Infections (VTEC 2018) to be held in Florence, Italy in May 2018
                          • Dr. Carmen Sarita-Reyes’s Mallory Proposal has been approved. The Department has provided funds for two medical students to participate in the 8 summer fellowship through the Mallory funds
                          • Dr. Barbara Nikolajczyk presented at the following:
                            • Endocrinology Grand Rounds, Boston University School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, November 14 2016
                            • Endocrinology Grand Rounds, University of Massachusetts School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, December 13, 2016
                          • Dr. Daniel  Remick presented in December:
                            • Grand Rounds Speaker, Yale School of Medicine, Department of Pathology, “Traumatic Brain Injury Augments Host Defenses”
                            • Grand Rounds Speaker, Boston Medical Center, Department of Internal Medicine, “Sepsis: A Moving Target”
                          • Dr. Daniel Remick in January:
                            • The Houston Methodist Hospital held their first Annual Pathology Research Day on Saturday, January 14th. First year pathology residents presented posters and the upper year residents and fellows each gave 5-7 minute presentation on their projects. Dr. Remick was the Keynote Speaker and gave the talk “Mild Traumatic Brain Injury Augments Innate Immunity”
                          • Jason Sutin, PhD (Off-Site at MGH Franceschini Lab) successfully defended his Thesis, “Development of a Novel Diffuse Correlation Spectroscopy Platform for Neuromonitoring Cerebal Blood Flow and Oxygen Metabolism: From Novel Concepts and Devices to Preclinical Live Animal Studies” Fall 2016, BRAVO!!
                          • Barbara Nikolajczyk, PhD received a $20,000.00 grant titled “Inflammation in type 1 diabetes” from Boston University CTSI
                          • Dr. Nikolajczyk will also be a reviewer on two NIH panels in Feb:
                            • Cellular Aspects of Diabetes and Obesity Study Section, Ad-hoc (2017)
                            • NIDDK Fellowship and Conflict Study Section, Ad-hoc (2017)
                            • New People:
                              • The Nikolajczyk Lab has added Joseph Lee, Masters in Nutrition student
                        • Publications ACCEPTED:
                          • Mahmoud L Soliman, MD PhD, Ashish Tiwari, MD, Grace Zhao MD, PhD “Coexisting tubular adenoma with a high-grade neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin.” The World Journal of Gastroenterology
                          • Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH: Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle (accepted for publication)
                          • Nicholas DA, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA and Nikolajczyk BS. 2017. Advances in the Quantification of Mitochondrial Function in Primary Human Immune Cells through Extracellular Flux Analysis (Accepted, PLOS ONE)
                        • Publications PUBLISHED:
                        • The Department’s strategic plan included increasing our academic stature. To achieve this the guidelines for Mallory Research Projects were sent to the faculty. There was an excellent response and the following Mallory proposals were funded in the Fall of 2016.
                          1. Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
                            1. Drs. Panchenko, O’Brien and Tan
                          2. Defining gene programs regulated by Ikaros in T cells
                            1. Drs. Winandy and Lee
                          3. Validation of Maspin/VHL immunostain for distinguishing carcinoma from reactive atypia in pancreas
                            1. Drs. Tan, Yang, and Zha
                          4. Local Release of Substance P after mild traumatic brain injury primes the host to survive a subsequent pathogen challenge
                            • Drs. Remick and Kim

                        Pathology & Laboratory Medicine News Items – November 2016

                        December 5th, 2016 in Uncategorized

                        Pathology & Laboratory Medicine News Items – November 2016

                        • Announcements:
                          • Dr. Shinichiro Kurosawa has been reappointed to the Boston University Laboratory Safety Committee. The term of his appointment is through December 31, 2018
                          • Dr. Chris Andry has had his appointment extend as Chair of the Boston University Laboratory Safety Committee. The term of his extension is through December 31, 2018
                          • Jacquelyn Sikora Hanson, PhD (Lawreen Connors Lab) successfully defended her Thesis, “Transthyretin gene regulation in wild-type transthyretin amyloidosis” on November 21st, 2016, BRAVO!!
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                          • Dr. Sikora Hanson’s Defense Dissertation
                          •                                                                                                                                                                                                                        Jacquelyn’s Thesis Committee: Dr. Vickery Trinkaus-Randall,
                          • Dr. Lawreen Connors (PI), new Dr. Sikora Hanson and Dr. David Sherr              
                          •      committee-trinkaus-randall-connors-hanson-sherr                                                                         

                                                                                        

                        • dr-hanson-and-family-stephen-brother-ginger-momandray-dad
                        •                                                                     Dr. Jacquelyn Sikora Hanson and her proud family
                        •  
                        • Shark Tank Winners. The Cancer Center held a retreat on November 29th that featured a “Shark Tank” styled competition for research funds. Prior to the retreat faculty were asked to submit brief proposals and the top 4 proposals were selected for presentation. During lunch each group had 5 minutes to make their pitch to the Sharks on the expert panel. David Sherr and Dan Remick submitted a proposal AHR Inhibitors as Novel Immune Checkpoint Inhibitors.  Their idea was selected as the winner. Portions of the funds will be used for processing specimens in the Ex+.

                         

                           

                          Publications ACCEPTED:

                          • Hot Off the Presses: The manuscript below has been accepted for publication in Neuropsychiatric Genetics.  While the first four authors worked in Dr. Ivana Delalle’s laboratory, it is really a multi-institutional effort that Dr. Delalle was fortunate to lead.  “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” by Jason L. Choi1, Patricia F. Kao1, Elena Itriago1, Yougen Zhan1, James A. Kozubek2, Andrew G. Hoss3, Meredith G. Banigan4, Charles R. Vanderburg4, Amir H. Rezvani5, Jeanne C. Latourelle3, Howard Cabral6, and Ivana Delalle1#; 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118; 2Broad Institute, Cambridge, MA 02142; Brigham and Women’s Hospital, Boston, MA 02112; 3Department of Neurology, Boston University School of Medicine, Boston, MA 02118; 4Advanced Tissue Resource Center, Harvard NeuroDiscovery Center, Charlestown, MA 02129; 5Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710; 6Department of Biostatistics, Boston University School of Public Health and Boston University Clinical and Translational Science Institute, Boston, MA, 02118

                          Publications PUBLISHED:

                            The Department has been actively engaged in biobanking initiatives for several years. These important biobanking projects provide specimens to several investigators to help understand the basic mechanisms of disease. Banking these specimens also honors the patients’ wishes to provide tissue for research.On behalf of the patients who donated biospecimens, and investigators who use the biospecimens, thank you. Your efforts ensure that pathology provides high quality biospecimens.Here is the impressive list of current and recent projects, including the pathology personnel that are participating in each project.

                            Biobanking grants in Pathology and Laboratory Medicine

                            • 2016-2018: Thrombosis in Cancer Patients (TCP). Pre-analytic Variables that May Impact Standardization,
                            • NCI. Contract award HHSN261200800001E  – $1.4M total cost
                            • PI: Dr. Andry.
                            • Co-I: Drs. Stearns-Kurosawa, Kurosawa, Henderson, Sloane, & Ms. Duffy, Sun
                            • Other personnel: Cheryl Spencer, Morgan Thompson

                             

                            •  2016-2017: Boston Medical Center Biospecimen Source Site for the Clinical Proteomic Tumor Analysis Consortium (CPTAC)
                            • NCI contract HHSN261201600011I – $89,229.07.
                            • PI: Dr. Andry
                            • Co-I: Henderson
                            • Other personnel: Spencer, Kim, Chen

                             

                            • 2011-2017: Detection of Early Lung Cancer Among Military Personnel (DE-CAMP), pulmonary
                            • Department of Defense W81XWH-11-2-0161 – $2,378,826
                            • PI: Avrum Spira, M.D.
                            •  Co-I: Remick, Pistey
                            • Other personnel: Spencer

                             

                            • 2016-present: Framingham Heart Study Biospecimen Core
                            •  Lab Director – Dr. Henderson

                             

                            • 2014-2016: Biospecimen Source Site for Cancer Human Biospecimens (caHUB).
                            • NCI. Biospecimen Preanalytical Variables Program 11XS1007T1 – $332,508
                            • Co-I: Drs. Pistey, Henderson
                            • Other personnel: Spencer, Duffy

                             

                            • 2014-2015: Biospecimen Source Site for the National Disease Research Interchange (NDRI)
                            • Biospecimen procurement contract – $14,600
                            • PI: Dr. Andry
                            • Other personnel: Bondzie, Spencer

                             

                            • 2013-2015: Tissue Source Site for The Cancer Genome Atlas Project (TCGA)
                            • NCI. Initial Task Order 13XS114 – $15,350
                            • PI: Dr. Andry
                            • Co-I: Henderson
                            • Other personnel: Spencer, Mei Cao