Departmental Seminar – February 24, 2017

February 19th, 2017 in Spotlight

Seminar Series: Fall 2016 ~~ Friday, February 24, 2017

2:00-3:00 PM

              

Subha Singh, First Year MS Candidate
(D. Anderson Lab)
“Seminal Fluid and its Inflammation Properties on Vaginal Epithelium Cells”

Department of Pathology and Laboratory Medicine
Boston University School of Medicine

 

Rawan Tahboub, First Year MS Candidate
(Rahimi Lab)
“Signal Transduction by Cell Adhesion Molecule, IGPR-1”

Department of Pathology and Laboratory Medicine
Boston University School of Medicine

 

Location & Time:
670 Albany Street
Lobby Level #107/108

2:00-3:00 PM
Friday, February 24, 2017

Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Departmental Seminar – February 17, 2017

February 14th, 2017 in Spotlight

Seminar Series: Fall 2016 ~~ Friday, February 17, 2017

2:00-3:00 PM

              

“Process Improvements in Biobanking, in Partnership with the National Cancer Institute

 

Chris Andry, MPHil, PhD
Vice Chair for Operations and Management
Associate Professor
Director Masters Graduate Program
Department of Pathology and Laboratory Medicine
Boston University School of Medicine

 

Location & Time:
670 Albany Street
Lobby Level #107/108

2:00-3:00 PM
Friday, February 17, 2017

Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Pathology & Laboratory Medicine News Items – December 2016/January 2017

February 1st, 2017 in Uncategorized

Pathology & Laboratory Medicine News Items – December 2016/January 2017

  • Announcements:
      • The Pathology Residency and Cytopathology Fellowship Programs, are proud to announce the ACGME’s decision for the Continued Accreditation for both programs.  Congratulations and thanks to everyone for a job well done!
            •  Rahimi.Cover.2016
        • Dr. Grace Zhao reported; “Congratulations, your Mallory Project is approved with a total budget of $6925. The approved budget is over the budget cap of $5000 because of the potential to expand the IHC list of stains within the Department”
        • Dr. Deborah Stearns-Kurosawa was invited to be a member of the scientific steering committee for the 10th International Symposium on Shiga Toxin (Verocytotoxin) Producing E.coli Infections (VTEC 2018) to be held in Florence, Italy in May 2018
        • Dr. Carmen Sarita-Reyes’s Mallory Proposal has been approved. The Department has provided funds for two medical students to participate in the 8 summer fellowship through the Mallory funds
        • Dr. Barbara Nikolajczyk presented at the following:
          • Endocrinology Grand Rounds, Boston University School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, November 14 2016
          • Endocrinology Grand Rounds, University of Massachusetts School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, December 13, 2016
        • Dr. Daniel  Remick presented in December:
          • Grand Rounds Speaker, Yale School of Medicine, Department of Pathology, “Traumatic Brain Injury Augments Host Defenses”
          • Grand Rounds Speaker, Boston Medical Center, Department of Internal Medicine, “Sepsis: A Moving Target”
        • Dr. Daniel Remick in January:
          • The Houston Methodist Hospital held their first Annual Pathology Research Day on Saturday, January 14th. First year pathology residents presented posters and the upper year residents and fellows each gave 5-7 minute presentation on their projects. Dr. Remick was the Keynote Speaker and gave the talk “Mild Traumatic Brain Injury Augments Innate Immunity”
        • Jason Sutin, PhD (Off-Site at MGH Franceschini Lab) successfully defended his Thesis, “Development of a Novel Diffuse Correlation Spectroscopy Platform for Neuromonitoring Cerebal Blood Flow and Oxygen Metabolism: From Novel Concepts and Devices to Preclinical Live Animal Studies” Fall 2016, BRAVO!!
        • Barbara Nikolajczyk, PhD received a $20,000.00 grant titled “Inflammation in type 1 diabetes” from Boston University CTSI
        • Dr. Nikolajczyk will also be a reviewer on two NIH panels in Feb:
          • Cellular Aspects of Diabetes and Obesity Study Section, Ad-hoc (2017)
          • NIDDK Fellowship and Conflict Study Section, Ad-hoc (2017)
          • New People:
            • The Nikolajczyk Lab has added Joseph Lee, Masters in Nutrition student
      • Publications ACCEPTED:
        • Mahmoud L Soliman, MD PhD, Ashish Tiwari, MD, Grace Zhao MD, PhD “Coexisting tubular adenoma with a high-grade neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin.” The World Journal of Gastroenterology
        • Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH: Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle (accepted for publication)
        • Nicholas DA, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA and Nikolajczyk BS. 2017. Advances in the Quantification of Mitochondrial Function in Primary Human Immune Cells through Extracellular Flux Analysis (Accepted, PLOS ONE)
      • Publications PUBLISHED:
      • The Department’s strategic plan included increasing our academic stature. To achieve this the guidelines for Mallory Research Projects were sent to the faculty. There was an excellent response and the following Mallory proposals were funded in the Fall of 2016.
        1. Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
          1. Drs. Panchenko, O’Brien and Tan
        2. Defining gene programs regulated by Ikaros in T cells
          1. Drs. Winandy and Lee
        3. Validation of Maspin/VHL immunostain for distinguishing carcinoma from reactive atypia in pancreas
          1. Drs. Tan, Yang, and Zha
        4. Local Release of Substance P after mild traumatic brain injury primes the host to survive a subsequent pathogen challenge
          • Drs. Remick and Kim

      Pathology & Laboratory Medicine News Items – November 2016

      December 5th, 2016 in Uncategorized

      Pathology & Laboratory Medicine News Items – November 2016

      • Announcements:
        • Dr. Shinichiro Kurosawa has been reappointed to the Boston University Laboratory Safety Committee. The term of his appointment is through December 31, 2018
        • Dr. Chris Andry has had his appointment extend as Chair of the Boston University Laboratory Safety Committee. The term of his extension is through December 31, 2018
        • Jacquelyn Sikora Hanson, PhD (Lawreen Connors Lab) successfully defended her Thesis, “Transthyretin gene regulation in wild-type transthyretin amyloidosis” on November 21st, 2016, BRAVO!!
        •   defense3   
        •      
        •  
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        •        
        •                                                           
        • Dr. Sikora Hanson’s Defense Dissertation
        •                                                                                                                                                                                                                        Jacquelyn’s Thesis Committee: Dr. Vickery Trinkaus-Randall,
        • Dr. Lawreen Connors (PI), new Dr. Sikora Hanson and Dr. David Sherr              
        •      committee-trinkaus-randall-connors-hanson-sherr                                                                         

                                                                      

      • dr-hanson-and-family-stephen-brother-ginger-momandray-dad
      •                                                                     Dr. Jacquelyn Sikora Hanson and her proud family
      •  
      • Shark Tank Winners. The Cancer Center held a retreat on November 29th that featured a “Shark Tank” styled competition for research funds. Prior to the retreat faculty were asked to submit brief proposals and the top 4 proposals were selected for presentation. During lunch each group had 5 minutes to make their pitch to the Sharks on the expert panel. David Sherr and Dan Remick submitted a proposal AHR Inhibitors as Novel Immune Checkpoint Inhibitors.  Their idea was selected as the winner. Portions of the funds will be used for processing specimens in the Ex+.

       

         

        Publications ACCEPTED:

        • Hot Off the Presses: The manuscript below has been accepted for publication in Neuropsychiatric Genetics.  While the first four authors worked in Dr. Ivana Delalle’s laboratory, it is really a multi-institutional effort that Dr. Delalle was fortunate to lead.  “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” by Jason L. Choi1, Patricia F. Kao1, Elena Itriago1, Yougen Zhan1, James A. Kozubek2, Andrew G. Hoss3, Meredith G. Banigan4, Charles R. Vanderburg4, Amir H. Rezvani5, Jeanne C. Latourelle3, Howard Cabral6, and Ivana Delalle1#; 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118; 2Broad Institute, Cambridge, MA 02142; Brigham and Women’s Hospital, Boston, MA 02112; 3Department of Neurology, Boston University School of Medicine, Boston, MA 02118; 4Advanced Tissue Resource Center, Harvard NeuroDiscovery Center, Charlestown, MA 02129; 5Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710; 6Department of Biostatistics, Boston University School of Public Health and Boston University Clinical and Translational Science Institute, Boston, MA, 02118

        Publications PUBLISHED:

          The Department has been actively engaged in biobanking initiatives for several years. These important biobanking projects provide specimens to several investigators to help understand the basic mechanisms of disease. Banking these specimens also honors the patients’ wishes to provide tissue for research.On behalf of the patients who donated biospecimens, and investigators who use the biospecimens, thank you. Your efforts ensure that pathology provides high quality biospecimens.Here is the impressive list of current and recent projects, including the pathology personnel that are participating in each project.

          Biobanking grants in Pathology and Laboratory Medicine

          • 2016-2018: Thrombosis in Cancer Patients (TCP). Pre-analytic Variables that May Impact Standardization,
          • NCI. Contract award HHSN261200800001E  – $1.4M total cost
          • PI: Dr. Andry.
          • Co-I: Drs. Stearns-Kurosawa, Kurosawa, Henderson, Sloane, & Ms. Duffy, Sun
          • Other personnel: Cheryl Spencer, Morgan Thompson

           

          •  2016-2017: Boston Medical Center Biospecimen Source Site for the Clinical Proteomic Tumor Analysis Consortium (CPTAC)
          • NCI contract HHSN261201600011I – $89,229.07.
          • PI: Dr. Andry
          • Co-I: Henderson
          • Other personnel: Spencer, Kim, Chen

           

          • 2011-2017: Detection of Early Lung Cancer Among Military Personnel (DE-CAMP), pulmonary
          • Department of Defense W81XWH-11-2-0161 – $2,378,826
          • PI: Avrum Spira, M.D.
          •  Co-I: Remick, Pistey
          • Other personnel: Spencer

           

          • 2016-present: Framingham Heart Study Biospecimen Core
          •  Lab Director – Dr. Henderson

           

          • 2014-2016: Biospecimen Source Site for Cancer Human Biospecimens (caHUB).
          • NCI. Biospecimen Preanalytical Variables Program 11XS1007T1 – $332,508
          • Co-I: Drs. Pistey, Henderson
          • Other personnel: Spencer, Duffy

           

          • 2014-2015: Biospecimen Source Site for the National Disease Research Interchange (NDRI)
          • Biospecimen procurement contract – $14,600
          • PI: Dr. Andry
          • Other personnel: Bondzie, Spencer

           

          • 2013-2015: Tissue Source Site for The Cancer Genome Atlas Project (TCGA)
          • NCI. Initial Task Order 13XS114 – $15,350
          • PI: Dr. Andry
          • Co-I: Henderson
          • Other personnel: Spencer, Mei Cao

          Departmental Seminar – November 18, 2016

          November 14th, 2016 in Spotlight

          Seminar Series: Fall 2016 ~~ Friday, November 18, 2016

          2:00-3:00 PM

                        

          “Defining Humoral Correlates of Protection in Infection and Vaccination

           

          Todd Suscovich, PhD
          Staff Scientist
          Ragon Institute of MGH, MIT, and Harvard

           

          Location & Time:
          670 Albany Street
          Lobby Level #107/108

          2:00-3:00 PM
          Friday, November 18, 2016

          Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

          At the conclusion of this activity participants will be able to: 1)  recall that while antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity; 2) report that the authors used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials and 3) state that although over 80 vaccines, covering more than 20 diseases, have been licensed in the United States, vaccine design efforts against persisting infections, including malaria, tuberculosis, and HIV, continue to fail.

          Course Director: Barbara Slack, PhD

          Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

          Departmental Seminar – November 4, 2016

          November 1st, 2016 in Spotlight

          Seminar Series: Fall 2016 ~~ Friday, November 4, 2016

          2:00-3:00 PM

                        

          “Effects of Tumor Evolution On Cancer Genomes

           

          Rameen Beroukhim, MD, PhD
          Assistant Professor of Medical Oncology and Cancer Biology
          Dana-Farber Cancer Institute
          Assistant Professor of Medicine, Harvard Medical School

           

          Location & Time:
          670 Albany Street
          Lobby Level #107/108

          2:00-3:00 PM
          Friday, November 4, 2016

          Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

          At the conclusion of this activity participants will be able to: 1) recall that recent studies have detailed the genomic landscape of primary endometrial cancers, but the evolution of these cancers into metastases has not been characterized; 2) state that endometrial cancer is the most common pelvic gynecological malig­nancy in industrialized countries, partially owing to the obesity epidemic and 3) report that across primary endometrial cancers, 21 new signifi­cantly mutated genes have been identified.

          Course Director: Barbara Slack, PhD

          Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

          Pathology & Laboratory Medicine News Items – October 2016

          November 1st, 2016 in Uncategorized

          Pathology & Laboratory Medicine News Items – October 2016

          • Announcements:
            • Nancy S. Miller, MD led a discussion and tour of the BMC Clinical Microbiology Laboratory for participants of the International Infectious Disease Symposium, October 13, The tour was part of a 3-day BUSM CME conference on Emerging Infectious Diseases that hosted pulmonologists and infectious diseases physicians visiting from the Middle East.
            • Miller, MD was the ASM Distinguished Lecturer at the Fall Meeting of the Western New York branch of the American Society for Microbiology, Buffalo, NY, October 25, 2016. Her topic was diagnostic clinical mycology: “Fungal Fest: Challenges, conundrums, and lessons learned.”
            • Barb Nikolajczyk, PhD presented her team’s work entitled “Identity and Mechanisms of Inflammation in Human Obesity and Type 2 Diabetes” at Memorial Sloan Kettering Cancer Center, NYC, on October 24, 2016
            • Daniel Remick, MD, organized a workshop for the 8th International Congress of the International Federation of Shock Societies held October 3 – 5 in Tokyo, Japan. The workshop was titled: Immunopathology of Traumatic Brain Injury.
            • Remick also gave a presentation: “Mild Traumatic Brain Injury but not Tail Trauma Augments Pulmonary Clearance of Substance P”
            • Daniel Remick, MD, was also invited to give a presentation at the 8th International Congress of the International Federation of Shock Societies in Tokyo, Japan titled: “Understanding the Heterogeneity of the Host Response to Infection May Direct Therapy”
            • Mostafa Belghasem, PhD presented two posters at BU’s Annual Evans Days 2016 Meeting, October 13 & 14, 2016:
              • “Aryl Hydrocarbon Receptor signaling is an in vivo targetable antithrombotic pathway and it correlates with thrombosis in humans” Mostafa Belghasem, Moshe Shashar, Jamaica Siwak, Faisal Alousi, Joel Henderson, Anqi Zhang, Jean Francis, Vijaya B. Kolachalama, Vipul Chitalia.
              • “CHIP: A Novel Target For Thrombosis” Moshe Shashar, Mostafa Belghasem, Shinobu Matsuura, Faisal Alousi, Keshab Raji, Jean Francis, Vijaya Kolachalama, Joel Henderson, Mercedes Balcells, Kumaran Kolandaivelu, Katya Ravid, Vipul Chitalia
            • Keith Keller, Masters Student in the Henderson Lab has been selected to participate in Kidney STARS 2016 program organized by the American Society of Nephrology (ASN). Keith also received a travel grant from ASN to attend Kidney Week 2016
            • The Kurosawa Lab welcomes Daniel Buhl a master’s student coming to their lab from the University of Heidelberg in Germany from November – February
            • Daniel Remick, MD, just completed a four term of service as a Section Editor for the Journal of Immunology
          • Publications: ACCEPTED:
            • Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony Coyle, David J. Salant, Stephen Berasi, Weining Lu. “SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion.” Journal of Clinical Investigation Insight; Accepted Oct 2016

          Departmental Seminar – October 28, 2016

          October 22nd, 2016 in Spotlight

          Seminar Series: Fall 2016 ~~ Friday, October 28, 2016

          2:00-3:00 PM

                        

          “From Chromatin to the Midbody: Control of Epithelial Cell Cycle by JADE1

           

          Maria Panchenko, PhD
          Assistant Professor of Pathology & Laboratory Medicine
          Boston University School of Medicine

           

          Location & Time:
          670 Albany Street
          Lobby Level #107/108

          2:00-3:00 PM
          Friday, October 28, 2016

          Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

          At the conclusion of this activity participants will be able to: 1) recall that the family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3); 2) report that so far JADE1 is the most studied member of the JADE family and 3) state that JADE proteins are encoded by individual genes which are mapped to different chromosomes and designated as PHF17 (JADE1), PHF16 (JADE3), and PHF15 (JADE2).

          Course Director: Barbara Slack, PhD

          Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

          Departmental Seminar – October 21, 2016

          October 18th, 2016 in Spotlight

          Seminar Series: Fall 2016 ~~ Friday, October 21, 2016

          2:00-3:00 PM

                        

          “Mild Traumatic Brain Injury Augments Innate Immune Responses

           

          Daniel Remick, MD
          Chair and Professor of Pathology & Laboratory Medicine
          Boston University School of Medicine

           

          Location & Time:
          670 Albany Street
          Lobby Level #107/108

          2:00-3:00 PM
          Friday, October 21, 2016

          Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

          At the conclusion of this activity participants will be able to: 1) report that traumatic brain injury (TBI) results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia; 2) state that TBI is a major cause of death and disability in both civilian and military populations. and 3) recall that pneumonia is the most common infectious complication associated with TBI, occurring in 20–60% of head-injured patients.

          Course Director: Barbara Slack, PhD

          Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

          Departmental Seminar – October 14, 2016

          October 10th, 2016 in Spotlight

          Seminar Series: Fall 2016 ~~ Friday, October 14, 2016

          2:00-3:00 PM

                        

          “Arrhythmogenic Cardiomyopathy: New Insights into Disease Pathogenesis

           

          Jeffrey Saffitz, MD, PhD
          Chair, Department of Pathology
          Beth Israel Deaconess Medical Center
          Mallinckrodt Professor of Pathology
          Harvard Medical School

           

          Location & Time:
          670 Albany Street
          Lobby Level #107/108

          2:00-3:00 PM
          Friday, October 14, 2016

          Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

          At the conclusion of this activity participants will be able to: 1) repeat that Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias; 2) state that Arrhythmogenic cardiomyopathy (ACM) is a highly arrhythmic form of human heart disease and a significant cause of sudden death in the young and 3) recall that ACM is caused by mutations in genes that encode proteins in the desmosome, a specialized intercellular-junction complex.

          Course Director: Barbara Slack, PhD

          Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.