Pathology and Laboratory Medicine New News April 2016

April 29th, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items April 2016

  • Announcements:
    • Congratulations on Three Successful Defenses:
      • Parul Agnihotri PhD, Winandy Lab, successfully defended her thesis The Role of Ikaros in Foxo1-Driven Gene Expression in CD4 T Cells” on Friday, April 8th
      • Parul and Family
      • The new Dr. Agnihotri and her proud family
      • ParulGivingDefense
      • Parul Agnihotri, PhD Defending her Thesis, 4/8/16
      • Melody Lun, MD/PhD, Maria Lehtinen Lab(Off-site at Children’s), successfully defended her thesis Coordination of Cell Intrinsic and Extrinsic Signals in Development of the Mammalian Brain” on Wednesday, April 13th
      • MelodyandMentor2016.IMG_5630
      • The new Dr. Melody Lun and her mentor, Maria Lehtinen (Children’s Hospital)
      • MelodyandCommittee2016.IMG_5631
      • Dr. Lun and her BU Committee Members: Drs. Krzysztof Blusztajn, Barbara Slack and Tarik Haydar
      • Nicole Stauffer Smith , PhD, Mizgerd Lab, successfully defended her thesis Respiratory Infections with Pneumococci Establish Multi-pronged Heterotypic Protection Against Pneumonia” on Wednesday, April 13th
      • NicoleDefenseCelebration
      • Dr. Nicole Stauffer Smith’s Defense Celebration!
    • Tim Norman, PhD Candidate in Alan Fine’s Lab gave an oral presentation and presented a poster at the Gordon Research Conferences on Lymphatics titled “Origins, maturation, and regeneration of the pulmonary lymphatic endothelium” on March 19th in Ventura, California
    • Ivana Delalle is excited to be giving a platform presentation, “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” at the 2nd International Symposium on Microgenomics in Paris, France; June 2016
    • Maria Panchenko was invited to write an expert review about family of JADE genes and corresponding proteins. The review was accepted and will be published in GENE.
    • On the basis of excellent teaching in the first year of the medical school curriculum the following faculty have been selected as Master Educators:
      • Carmen Sarita-Reyes, M.D. (Integrated Problems)
      • Jacqueline Sharon, Ph.D. (Immunology)
      • Deborah Stearns-Kurosawa, Ph.D. (Immunology)
      • Daniel Remick, M.D. (Immunology)
      • Susan Winandy, Ph.D. (Immunology)
    • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab has won a School of Medicine PhD Award from the 2016 Graduate Research Symposium. His poster title was “Blood-Brain Barrier Dysfunction, Neuroinflammation, and Early Chronic Traumatic Encephalopathy-Linked Neuropathology in a Mouse Model of Concussive Impact Neurotrauma.” The Symposium held on April 11th at Metcalf Hall was sponsored by the Office of the Provost
    • Daniel Remick, M.D., received a Certificate of Appreciation for 3 years of service on the Council of the American Society of Investigative Pathology
    • USCAP 2016 – March 12-18, 2016; Seattle, Washington
      • Reyhan Gedik, MD presented the following poster, ““Utility of Next Generation Sequencing (NGS) Cotesting to Recategorize Bethesda-I Thyroid FNAs” : authors 1. Reyhan Gedik MD1, 2. Anita Deshpande MD1, 3. Huihong Xu MD1 and 4. Sandra Cerda, MD
        • USCAP2016.ReyhanGedik
      • Huihong Xu, MD is really happy to report that she has passed the American Board of Pathology Maintenance of Certification (MOC) Part III examination(s) in Anatomic Pathology and Clinical Pathology and Cytopathology; Bravo Huihong!
      • Barb Nikolajczyk, PhD had multiple presentations in April including:
        • Emory University, Woodruff Health Science Center, Atlanta GA, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • Winthrop Hospital, Mineola, NY, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • University of Virginia, Department of Pharmacology, Charlottesville, VA  “Defining Inflammation in Human Obesity and Type 2 Diabetes”
      • Nancy Miller, MD had several events in April also, including:
        • Invited speaker at the American Society for Clinical Laboratory Science-Central New England (ASCLS-CNE) convention, April 26-28, Providence, RI, where she presented cases from the clinical microbiology laboratory entitled:  “From the Bench: A potpourri of challenges, conundrums, and lessons learned”
        • Miller was also the Event co-chair for the 1st joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and the Northeast Branch-American Society for Microbiology (NEB-ASM), April 11-12, Boxborough, MA.
        • Miller is a Laboratory Medical Director for the now-approved Gilead Foundation grant: BMC HCV Screening, Confirmation and Linkage Initiative, (Jonathan Hall, Principal Investigator)
      • Russek Awards 2016:
        • Barbara Slack, Pathology Department Russek Awards Committee, is pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
          • First Prize – Caitlin Miller (Advisor: Rahm Gummuluru)
          • Second Prize – Elizabeth Moses (Advisor: Avrum Spira)
        • Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day will be held on Friday, May 6th in the Hiebert Lounge (L building, 14th floor). The keynote speaker this year will be Dr. James Bradner, the new President of the Biomedical Institutes of Novartis. Posters will be available for viewing throughout the day, and slide presentations by the first prize winners will take place in the afternoon. I hope everyone will be able to attend.
        • More information about this event can be found at the link ((http://www.bumc.bu.edu/gms/students/phd/russek-student-achievement-day-2016/)
      • Daniel Remick, M.D., was given a Certificate of Service in the Advanced Core Program in the Responsible Conduct of Research for Doctoral Candidates by Boston University School of Medicine
      • The Winandy Lab:
        • On April 8th, Parul Agnihotri successfully defended her thesis
        • Caroline Lyon De Ana, a Pathology Masters student, joined our lab
      • PUBLICATIONS PUBLISHED:
        • Wang W, Wang WH, Azadzoi KM et al. Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells. Mol Cell Endocrinol. 2016 May 5;426:91-100. doi: 10.1016/j.mce.2016.02.008. Epub 2016 Feb 15.
        • Wang W, Wang WH, Azadzoi KM et al. Activation of innate antiviral immune response via double-stranded RNA-dependent RLR receptor-mediated necroptosis. Sci Rep. 2016 Mar 3;6:22550. doi: 10.1038/srep22550.

Departmental Seminar – April 29, 2016

April 25th, 2016 in Spotlight

Seminar Series: Spring 2016 ~~ Friday, April 29, 2016

2:00-3:00 PM

              

“Mechanisms and Therapeutic Vulnerabilities of IDH Mutant Biliary Cancer

 

Nabeel Bardeesy, PhD
Associate Professor of Medicine, Harvard Medical School
Assistant Geneticist, Center for Cancer Research
Massachusetts General Hospital

 

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM


Friday, April 29, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) recall that alterations in cell metabolism can drive cancer growth; 2) state that defining such alterations can lead to new therapeutic approaches and; 3) identify that this knowledge will help physicians understand the biological effects of newly discovered mutations in cancer genes that alter cell metabolism and give them insight into how metabolism can be targeted therapeutically.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Departmental Seminar – April 22, 2016

April 21st, 2016 in Spotlight

Seminar Series: Spring 2016 ~~ Friday, April 22, 2016

2:00-3:00 PM

              

“Cellular Stress and Innate Signaling: Integrating Therapeutic Pathways in the Host Defense and Inflammation

 

Pranoti Mandrekar, PhD
Professor of Medicine
Director, Translational Science Graduate Program
University of Massachusetts Medical School

 

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM


Friday, April 22, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) state that binge or moderate alcohol exposure impairs host defense and increases susceptibility to infection because of compromised innate immune responses 2) recall that there is a lack of consensus on the molecular mechanism by which alcohol mediates this immunosuppression; and 3) report that cellular stress proteins HSF1 and hsp70 play a mechanistic role in alcohol-mediated inhibition of the TLR4/MyD88 pathway.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

The 10th Annual Nancy Bucher Seminar

April 15th, 2016 in Spotlight

~~~~~~~~~~~

BUSM Pathology & Laboratory Medicine

Seminar Series: Spring 2016 ~~ Wednesday, April 20th 

Note the time and date change.

11:00 AM Seminar; Reception to Follow at 2:00 PM

 

10th Annual Nancy L. R. Bucher, MD Seminar 

 

Unraveling the Complexity of Growth Hormone Regulated Sex Differences in Mouse Liver: Genomic and Epigenetic Approaches”

 

David Waxman, PhD

Professor of Cell and Molecular Biology, Boston University

Professor of Medicine, Boston University School of Medicine

 

Location & Time:

670 Albany Street

Lobby Level #107/108

11:00 AM; Reception to Follow at 2:00 PM

Wednesday, April 20, 2016 

Departmental Seminar – April 15, 2016

April 12th, 2016 in Spotlight

Seminar Series: Spring 2016 ~~ Friday, April 15, 2016

2:00-3:00 PM

              

“Beyond and Into the Plasma Cell: New Approaches to AL Amyloidosis

 

Raymond Comenzo, MD
Professor of Medicine and Pathology
Director of Blood Bank and Stem Cell Processing Laboratory
Tufts University School of Medicine

 

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM


Friday, April 15, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) report that the current therapeutic landscape for patients with systemic AL amyloidosis has exciting highlights and recurrent valleys of despair; 2) recall that only a minority of patients are eligible for stem cell transplant and a significant fraction of them do not achieve complete hematologic responses; and 3) state that the majority of patients are not eligible for stem cell transplant and, while many benefit from bortezomib-based therapies, 40% of those with advanced heart involvement die within a year of diagnosis.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Departmental Seminar – April 8, 2016

April 4th, 2016 in Spotlight

Seminar Series: Spring 2016 ~~ Friday, April 8, 2016

2:00-3:00 PM

              

“Targeting the Replication of Stress Response in ALT Positive Cancers

 

Rachel Flynn, PhD
Assistant Professor of Pharmacology and Medicine
Boston University School of Medicine

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM


Friday, April 8, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) repeat that the telomere is a repetitive DNA sequence that caps the ends of each human chromosome and acts as a barrier, protecting the genome; 2) state that each time a cell divides, a portion of this barrier is lost and over time our genetic information becomes susceptible to degradation and/or damage; and 3) recall that to avoid this type of damage critically short telomeres send a signal to the cell to induce either growth arrest or cell death. Cancer cells, however, have evolved mechanisms to overcome progressive telomere shortening and bypass this growth arrest.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

Pathology & Laboratory Medicine News Items – March 2016

April 1st, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items

March 2016

  • Announcements:
    • Please join in congratulating Nancy Miller, M.D. on her promotion to Associate Professor of Pathology and Laboratory Medicine. This promotion recognizes Dr. Miller’s national reputation in the field of pathology, specifically in the area of microbiology. There is amble evidence of her stature, including being an invited participant in preparing the Clinical and Laboratory Standard Institute (CLSI) upcoming international CLSI M-52 Guideline (User Verification/Validation of Microbial Identification and Antimicrobial susceptibility Testing Systems). This panel will establish the national guidelines for the identification of pathogens and antimicrobial testing. Additionally, she was an invited panel member on the nationally and internationally attended 2012 Centers for Disease Control (CDC) forum on Culture-Independent Diagnostics. Dr. Miller was the co-convener for the Symposium: “Fecal microbiota transplants and competing organisms: From practical to practice to promise”, American Society for Microbiology in 2014, and was a faculty participant for workshops (2012, 2014, 2015).
    • Thirty Shades of Red… also known as “Transfusion Medicine in the Hot Seat: A Case-Based Primer” authored by Karen Quillen, MD, MPH out for publication!!! Get your copy!!
    • QuillenPublication2016.FullSizeRender

 

  • Carmen Sarita-Reyes was recently accepted for a leadership course at the APC meeting. From the APC; “The Association of Pathology Chairs’ Leadership Development and Diversity Committee, it is our pleasure to let you know that your application for the Pathology Leadership Academy (PLA) has been accepted. You will join about 60 colleagues for this special event, which will include lectures and interactive presentations by a host of nationally recognized speakers.” The Leadership Program will take place in July in San Diego, California
  • From Daniel Remick:
    • Daniel Remick, M.D., served as an external reviewer for the Department of Pathology at the University of Iowa. The two day review during the end of March 2016 was conducted as part of the University’s standard 5 year review of the Department
    • The NIH held a one day workshop on the physician scientist workforce on February 19th, 2016. Daniel Remick, M.D. participated as the Chair of the Research Committee for the Association of Pathology Chairs and the Vice President of the American Society of Investigative Pathologists
    • Daniel Remick, M.D. served as an unpaid external reviewer for CBMed, a government – private joint venture in Austria. The company is focusing on developing biomarkers including biobanks. The first review was held in Graz, Austria in February 2016
  • Caitlin Miller, PhD Candidate in Rahm Gummuluru’s Lab attended The Conference on Retroviruses and Opportunistic Infections, February 22-25, 2016 in Boston, MA where she presented a poster entitled, “Essential role of Vpr in HIV-1 infection of dendritic cells”
  • Huihong Xu, M.D., received the “CAPA Member of the Year Award” at the 14th Annual Meeting of Chinese American Pathologists Association on March 12, 2016 in Seattle, Washington
  • USCAP 2016 – March 12-18, 2016; Seattle, Washington
    • Yue Sun, MD presented the following posters:
      • “Analysis of PD-L1 Expression Pattern in Microsatellite Instability Colon Cancer;” Yue Sun, Max Vaickus, Michael O’Brien and Qing Zhao
      • Sun.USCAP.PD,L1.Colon Cancer.IMG_8021
      • “Analysis of PD-L1 Expression Pattern in Advanced Bladder Cancer and Lymph Node Metastasis;” Yue Sun, Max Vaickus, Sandra Cerda and Huihui Ye
      • Sun.USCAP2016.PD.L1Expression...BladderCancer.IMG_8023
    • Anita Deshpande, MD, poster entitled;  “Impact of ThyroSeqv.2 Next-Generation Sequencing Assay on Fine Needle Aspiration Cytology of Thyroid Nodules;” – Anita Deshpande, Xu Huihong, Sandra Cerda
      • Deshpande.USCAP 2016 image 2
        • Deshpande and Dr.Ye Nikiforov who developed and designed the ThyroSeqv.2 test at UPMC
      • From Barbara Nikolajczyk, PhD:
        • Barb Nikolajczyk and Lee Wetzler are hosting the Boston University School of Medicine Inflammation Symposium May 23, 2016 in Bakst Auditorium. All are welcome to join the cross-talk amongst inflammation researchers at BUSM and beyond.  Trainee talks will be selected from submitted abstracts. Please contact the organizers for more details.
        • Barb Nikolajczyk will chair and speak at an “Open Call” Symposium at the 2016 Annual Meeting of The Obesity Society in New Orleans, LA in the Fall of 2016. The Symposium is entitled Complex Data Sets in Obesity: Opportunity over Obfuscation
        • The multi-PI team of Barb Nikolajczyk (BUSM), Caroline Apovian (BMC/BUSM) and Doug Lauffenburger (MIT) were awarded $2.8 million by the NIH/NIDDK for a 4 yr. project entitled “Inflammation in Human Obesity and Type 2 Diabetes”.
        • Gerald Denis and Barb Nikolajczyk will chair “The Obesity Society Guest Symposium” at the American Association of Immunologists Meeting May 13-17, 2016 in Seattle, Washington. The theme this year is Immunometaboism and Cancer.
      • Watch David Sherr, PhD talking on the Science Coalition’s “Super Science Tuesday” about the need for all politicians to know why research investment is so important. This is followed by Dr. Sherr and three other labs discussing “Investing in Prevention at SPH”:
      • The Kurosawa Lab is welcoming new faces:
        • Eriko Morishita, is a Professor of Medicine from Kanazawa University School of Medicine.  Kanazawa is a beautiful city, just north of Kyoto, Japan. She is a trained hematologist, specializing in thrombosis and hemostasis.  Dr. Morishita is visiting our lab for sabbatical for almost a year.  Her interest is in thrombotic microangiopathy (TMA)
        • Takeshi Wada just arrived from Hokkaido University School of Medicine, Sapporo, Japan. Sapporo is famous for its snow festival. We do not expect him to be intimidated by Boston winter. Dr. Wada is a trauma surgeon.  His research interest is in disseminated intravascular coagulation (DIC)
    • PUBLICATIONS PUBLISHED:

     

    Departmental Seminar – April 1, 2016

    March 28th, 2016 in Spotlight

    Seminar Series: Spring 2016 ~~ Friday, April 1, 2016

    2:00-3:00 PM

                  

    “Complement C3-Deficiency Protects the Mouse Hippocampus Against Aging and Alzheimer’s Disease

     

    Cynthia Lemere, PhD
    Principal Investigator, Ann Romney Center for Neurological Diseases, Brigham and Women’s Hospital
    Associate Professor of Neurology, Harvard Medical School

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM


    Friday, April 1, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) state that inflammation and innate immunity have been implicated in Alzheimer’s disease; 2) recall that similar to brain development, we found that complement signaling appears to play an important role in synaptic and neuronal health and function during aging and Alzheimer’s disease; and 3) report that  more data is needed to better understand how immunity and inflammation contribute to neurodegeneration and/or rate of progression and to identify new therapies targeting these pathways.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

    Departmental Seminar – March 25, 2016

    March 21st, 2016 in Spotlight, Uncategorized

    Seminar Series: Spring 2016 ~~ Friday, March 25, 2016

    2:00-3:00 PM

                  

    SCARFing Dead Cells and TREMing Inflammation

     

    Terry K. Means, PhD
    Assistant Professor of Medicine, Harvard Medical School
    Associate Immunologist, Massachusetts General Hospital

     

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM


    Friday, March 25, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) recall that the clearance of apoptotic cells is arguably one of the most important processes of the immune system and is necessary for the homeostatic maintenance of healthy tissues and removal of infected or damaged cells; 2) report that defective clearance of apoptotic cells can lead to the development of chronic inflammatory diseases such as systemic lupus erythematosus; and 3) discuss that there are new insights into the regulatory pathways that control Toll-like receptor 7 (TLR7) signaling to prevent loss of tolerance and the development of autoimmunity.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

    Departmental Seminar – March 18, 2016

    March 14th, 2016 in Spotlight

    Seminar Series: Spring 2016 ~~ Friday, March 18, 2016

    2:00-3:00 PM

                  

    Regionalized Cerebrospinal Fluid Factors in Development of the Cerebral Cortex

     

    Melody Lun, MD/PhD Candidate
    Department of Pathology and Laboratory Medicine
    Boston University School of Medicine; M. Lehtinen Lab (MGH)

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM


    Friday, March 18, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) state that the choroid plexus is the major source of cerebrospinal fluid (CSF) in the vertebrate brain; 2) report that previous studies have demonstrated that choroid plexus-derived CSF signaling factors play an important role in regulating cerebral cortical development, yet the choroid plexus-CSF system is still an understudied area of neurobiology; and 3) recall the contributions of the choroid plexus transcriptome and secretome in the composition of the CSF from embryonic development into adulthood. These findings suggest the potential for improving diagnostic and prognostic markers in choroid plexus tumors.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.