Pathology & Laboratory Medicine News Items – November 2016

December 5th, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items – November 2016

  • Announcements:
    • Dr. Shinichiro Kurosawa has been reappointed to the Boston University Laboratory Safety Committee. The term of his appointment is through December 31, 2018
    • Dr. Chris Andry has had his appointment extend as Chair of the Boston University Laboratory Safety Committee. The term of his extension is through December 31, 2018
    • Jacquelyn Sikora Hanson, PhD (Lawreen Connors Lab) successfully defended her Thesis, “Transthyretin gene regulation in wild-type transthyretin amyloidosis” on November 21st, 2016, BRAVO!!
    •   defense3   
    •      
    •  
    •   
    •        
    •                                                           
    • Dr. Sikora Hanson’s Defense Dissertation
    •                                                                                                                                                                                                                        Jacquelyn’s Thesis Committee: Dr. Vickery Trinkaus-Randall,
    • Dr. Lawreen Connors (PI), new Dr. Sikora Hanson and Dr. David Sherr              
    •      committee-trinkaus-randall-connors-hanson-sherr                                                                         

                                                                  

  • dr-hanson-and-family-stephen-brother-ginger-momandray-dad
  •                                                                     Dr. Jacquelyn Sikora Hanson and her proud family
  •  
  • Shark Tank Winners. The Cancer Center held a retreat on November 29th that featured a “Shark Tank” styled competition for research funds. Prior to the retreat faculty were asked to submit brief proposals and the top 4 proposals were selected for presentation. During lunch each group had 5 minutes to make their pitch to the Sharks on the expert panel. David Sherr and Dan Remick submitted a proposal AHR Inhibitors as Novel Immune Checkpoint Inhibitors.  Their idea was selected as the winner. Portions of the funds will be used for processing specimens in the Ex+.

 

     

    Publications ACCEPTED:

    • Hot Off the Presses: The manuscript below has been accepted for publication in Neuropsychiatric Genetics.  While the first four authors worked in Dr. Ivana Delalle’s laboratory, it is really a multi-institutional effort that Dr. Delalle was fortunate to lead.  “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” by Jason L. Choi1, Patricia F. Kao1, Elena Itriago1, Yougen Zhan1, James A. Kozubek2, Andrew G. Hoss3, Meredith G. Banigan4, Charles R. Vanderburg4, Amir H. Rezvani5, Jeanne C. Latourelle3, Howard Cabral6, and Ivana Delalle1#; 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118; 2Broad Institute, Cambridge, MA 02142; Brigham and Women’s Hospital, Boston, MA 02112; 3Department of Neurology, Boston University School of Medicine, Boston, MA 02118; 4Advanced Tissue Resource Center, Harvard NeuroDiscovery Center, Charlestown, MA 02129; 5Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710; 6Department of Biostatistics, Boston University School of Public Health and Boston University Clinical and Translational Science Institute, Boston, MA, 02118

    Publications PUBLISHED:

      The Department has been actively engaged in biobanking initiatives for several years. These important biobanking projects provide specimens to several investigators to help understand the basic mechanisms of disease. Banking these specimens also honors the patients’ wishes to provide tissue for research.On behalf of the patients who donated biospecimens, and investigators who use the biospecimens, thank you. Your efforts ensure that pathology provides high quality biospecimens.Here is the impressive list of current and recent projects, including the pathology personnel that are participating in each project.

      Biobanking grants in Pathology and Laboratory Medicine

      • 2016-2018: Thrombosis in Cancer Patients (TCP). Pre-analytic Variables that May Impact Standardization,
      • NCI. Contract award HHSN261200800001E  – $1.4M total cost
      • PI: Dr. Andry.
      • Co-I: Drs. Stearns-Kurosawa, Kurosawa, Henderson, Sloane, & Ms. Duffy, Sun
      • Other personnel: Cheryl Spencer, Morgan Thompson

       

      •  2016-2017: Boston Medical Center Biospecimen Source Site for the Clinical Proteomic Tumor Analysis Consortium (CPTAC)
      • NCI contract HHSN261201600011I – $89,229.07.
      • PI: Dr. Andry
      • Co-I: Henderson
      • Other personnel: Spencer, Kim, Chen

       

      • 2011-2017: Detection of Early Lung Cancer Among Military Personnel (DE-CAMP), pulmonary
      • Department of Defense W81XWH-11-2-0161 – $2,378,826
      • PI: Avrum Spira, M.D.
      •  Co-I: Remick, Pistey
      • Other personnel: Spencer

       

      • 2016-present: Framingham Heart Study Biospecimen Core
      •  Lab Director – Dr. Henderson

       

      • 2014-2016: Biospecimen Source Site for Cancer Human Biospecimens (caHUB).
      • NCI. Biospecimen Preanalytical Variables Program 11XS1007T1 – $332,508
      • Co-I: Drs. Pistey, Henderson
      • Other personnel: Spencer, Duffy

       

      • 2014-2015: Biospecimen Source Site for the National Disease Research Interchange (NDRI)
      • Biospecimen procurement contract – $14,600
      • PI: Dr. Andry
      • Other personnel: Bondzie, Spencer

       

      • 2013-2015: Tissue Source Site for The Cancer Genome Atlas Project (TCGA)
      • NCI. Initial Task Order 13XS114 – $15,350
      • PI: Dr. Andry
      • Co-I: Henderson
      • Other personnel: Spencer, Mei Cao

      Departmental Seminar – November 18, 2016

      November 14th, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, November 18, 2016

      2:00-3:00 PM

                    

      “Defining Humoral Correlates of Protection in Infection and Vaccination

       

      Todd Suscovich, PhD
      Staff Scientist
      Ragon Institute of MGH, MIT, and Harvard

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, November 18, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1)  recall that while antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate predictors of protective immunity; 2) report that the authors used an integrative approach termed Systems Serology to analyze relationships among humoral responses elicited in four HIV vaccine trials and 3) state that although over 80 vaccines, covering more than 20 diseases, have been licensed in the United States, vaccine design efforts against persisting infections, including malaria, tuberculosis, and HIV, continue to fail.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Departmental Seminar – November 4, 2016

      November 1st, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, November 4, 2016

      2:00-3:00 PM

                    

      “Effects of Tumor Evolution On Cancer Genomes

       

      Rameen Beroukhim, MD, PhD
      Assistant Professor of Medical Oncology and Cancer Biology
      Dana-Farber Cancer Institute
      Assistant Professor of Medicine, Harvard Medical School

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, November 4, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) recall that recent studies have detailed the genomic landscape of primary endometrial cancers, but the evolution of these cancers into metastases has not been characterized; 2) state that endometrial cancer is the most common pelvic gynecological malig­nancy in industrialized countries, partially owing to the obesity epidemic and 3) report that across primary endometrial cancers, 21 new signifi­cantly mutated genes have been identified.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Pathology & Laboratory Medicine News Items – October 2016

      November 1st, 2016 in Uncategorized

      Pathology & Laboratory Medicine News Items – October 2016

      • Announcements:
        • Nancy S. Miller, MD led a discussion and tour of the BMC Clinical Microbiology Laboratory for participants of the International Infectious Disease Symposium, October 13, The tour was part of a 3-day BUSM CME conference on Emerging Infectious Diseases that hosted pulmonologists and infectious diseases physicians visiting from the Middle East.
        • Miller, MD was the ASM Distinguished Lecturer at the Fall Meeting of the Western New York branch of the American Society for Microbiology, Buffalo, NY, October 25, 2016. Her topic was diagnostic clinical mycology: “Fungal Fest: Challenges, conundrums, and lessons learned.”
        • Barb Nikolajczyk, PhD presented her team’s work entitled “Identity and Mechanisms of Inflammation in Human Obesity and Type 2 Diabetes” at Memorial Sloan Kettering Cancer Center, NYC, on October 24, 2016
        • Daniel Remick, MD, organized a workshop for the 8th International Congress of the International Federation of Shock Societies held October 3 – 5 in Tokyo, Japan. The workshop was titled: Immunopathology of Traumatic Brain Injury.
        • Remick also gave a presentation: “Mild Traumatic Brain Injury but not Tail Trauma Augments Pulmonary Clearance of Substance P”
        • Daniel Remick, MD, was also invited to give a presentation at the 8th International Congress of the International Federation of Shock Societies in Tokyo, Japan titled: “Understanding the Heterogeneity of the Host Response to Infection May Direct Therapy”
        • Mostafa Belghasem, PhD presented two posters at BU’s Annual Evans Days 2016 Meeting, October 13 & 14, 2016:
          • “Aryl Hydrocarbon Receptor signaling is an in vivo targetable antithrombotic pathway and it correlates with thrombosis in humans” Mostafa Belghasem, Moshe Shashar, Jamaica Siwak, Faisal Alousi, Joel Henderson, Anqi Zhang, Jean Francis, Vijaya B. Kolachalama, Vipul Chitalia.
          • “CHIP: A Novel Target For Thrombosis” Moshe Shashar, Mostafa Belghasem, Shinobu Matsuura, Faisal Alousi, Keshab Raji, Jean Francis, Vijaya Kolachalama, Joel Henderson, Mercedes Balcells, Kumaran Kolandaivelu, Katya Ravid, Vipul Chitalia
        • Keith Keller, Masters Student in the Henderson Lab has been selected to participate in Kidney STARS 2016 program organized by the American Society of Nephrology (ASN). Keith also received a travel grant from ASN to attend Kidney Week 2016
        • The Kurosawa Lab welcomes Daniel Buhl a master’s student coming to their lab from the University of Heidelberg in Germany from November – February
        • Daniel Remick, MD, just completed a four term of service as a Section Editor for the Journal of Immunology
      • Publications: ACCEPTED:
        • Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony Coyle, David J. Salant, Stephen Berasi, Weining Lu. “SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion.” Journal of Clinical Investigation Insight; Accepted Oct 2016

      Departmental Seminar – October 28, 2016

      October 22nd, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, October 28, 2016

      2:00-3:00 PM

                    

      “From Chromatin to the Midbody: Control of Epithelial Cell Cycle by JADE1

       

      Maria Panchenko, PhD
      Assistant Professor of Pathology & Laboratory Medicine
      Boston University School of Medicine

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, October 28, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) recall that the family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3); 2) report that so far JADE1 is the most studied member of the JADE family and 3) state that JADE proteins are encoded by individual genes which are mapped to different chromosomes and designated as PHF17 (JADE1), PHF16 (JADE3), and PHF15 (JADE2).

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Departmental Seminar – October 21, 2016

      October 18th, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, October 21, 2016

      2:00-3:00 PM

                    

      “Mild Traumatic Brain Injury Augments Innate Immune Responses

       

      Daniel Remick, MD
      Chair and Professor of Pathology & Laboratory Medicine
      Boston University School of Medicine

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, October 21, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) report that traumatic brain injury (TBI) results in significant morbidity and mortality and is associated with infectious complications, particularly pneumonia; 2) state that TBI is a major cause of death and disability in both civilian and military populations. and 3) recall that pneumonia is the most common infectious complication associated with TBI, occurring in 20–60% of head-injured patients.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Departmental Seminar – October 14, 2016

      October 10th, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, October 14, 2016

      2:00-3:00 PM

                    

      “Arrhythmogenic Cardiomyopathy: New Insights into Disease Pathogenesis

       

      Jeffrey Saffitz, MD, PhD
      Chair, Department of Pathology
      Beth Israel Deaconess Medical Center
      Mallinckrodt Professor of Pathology
      Harvard Medical School

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, October 14, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) repeat that Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias; 2) state that Arrhythmogenic cardiomyopathy (ACM) is a highly arrhythmic form of human heart disease and a significant cause of sudden death in the young and 3) recall that ACM is caused by mutations in genes that encode proteins in the desmosome, a specialized intercellular-junction complex.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Departmental Seminar – October 7, 2016

      October 3rd, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, October 7, 2016

      2:00-3:00 PM

                    

      “Gene Expression Alterations in Human Bronchial Epithelium Following Electronic Cigarette Exposure

       

      Elizabeth Moses
      PhD Candidate; Spira/Lenburg Lab
      Immunology Training Program
      Boston University School of Medicine

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, October 7, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) state that little evidence is available regarding the physiological effects of exposure to electronic cigarette (ECIG) aerosol.; 2) distinguish that the use of tobacco cigarettes (TCIG) remains the leading preventable cause of death in the United States, responsible for more than 480,000 deaths per year (CDC, 2014); and 3) recognize that the data suggests that ECIG aerosol can induce gene-expression changes in bronchial airway epithelium in vitro, some of which are shared with TCIG smoke.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Pathology & Laboratory Medicine News Items – September 2016

      September 30th, 2016 in Uncategorized

      Pathology & Laboratory Medicine News Items – September 2016

      • Announcements:
        • Ahmad Al-Moujahed, Pathology PhD Candidate in Dr. Demetrious Vavvas’s Lab (off-site at Massachusetts Eye and Ear Infirmary) has been selected to be a Fall 2016 fellow of the MIT IMPACT program. It is  a career development program for post-doctoral and advanced pre-doctoral trainees (here is a good website for the details; http://impactprogram.mit.edu). Ahmad applied last June; he interviewed and was accepted over the Summer. Ahmad started his first session Tuesday, September 13th
        • From Sandra Cerda, Cytology Fellowship Director, as of July 2016… “Accordingly, the Residency Review Committee for Pathology, functioning in accordance with the policies and procedures of the Accreditation Council for Graduate Medical Education (ACGME), has removed previous citations for the following program: Cytopathology Boston University Medical Center Program/Boston University Medical Center” Bravo!!!
        • Barb Nikolajczyk, PhD was an invited speaker at the University of Kentucky, Lexington, KY, Department of Pharmacology, “Defining Inflammation in Human Obesity and Type 2 Diabetes,” September 14, 2016
        • Dr Sandra Cerda collaborated with the Endocrine Department in an abstract selected for poster presentationat the 86th Annual Meeting of the AMerican Thyroid Association in Denver, Colorado from September 21 – 25, 2016: “Large Independent Prospective Study to Evaluate the Performances of ThyroSeq2 ® Multigene Next Generation Sequencing Panel Analysis on Cancer Diagnosis in Thyroid Nodules with Indeterminate Cytopathology.” Toraldo Gianluca MD, Godley Frederick A MD, Cerda Sandra  R MD, Doherty Gerard MD, Braverman Lewis MD, Lee Stephanie MD
        • Nader Rahimi, PhD was invited to give a lecture at the Department Pathology, Boston Children Hospital, Harvard Medical School on September 22, 2016. The title of his lecture was “Adhesion signaling in tumor growth and angiogenesis”
        • Nancy S. Miller, MD was the invited speaker at the Boston area Microbiology Supervisors Meeting at Faulkner Hospital, Jamaica Plain on September 28th Dr. Miller presented “GPC Potpourri – a collection of pesky staph and streps”
        • Dr. Miller will also be the ASM Distinguished Lecturer at the Fall Meeting of the New York City branch of the American Society for Microbiology, NYC, October 7, 2016. Dr. Miller will present “From the bench: Challenges, conundrums, and lessons learned in this era of improved microbial identification”
        • CAP 2016:
          • Lei Li, Dr. Sandra Cerda, Dr. Reine Gedeon and Dr. Carmen Sarita-Reyes had an abstract accepted for the College of American Pathologists (CAP) in Las Vegas, Nevada from September 25th-28th 2016 titled; “Acrania Without Anencephaly In The Presence Of Amniotic Band Syndrome;” Lei Li, MD, PhD., Sandra Cerda, M.D., Reine Gedeon, M.D., and Carmen Sarita-Reyes, MD
          • Lei.CAP2016.image1.SECOND TRYDr. Lei Li presenting at CAP 2016
          • Also presented at CAP: Israa Laklouk, MD, Mahmoud Soliman, MDRobert Pistey, MD, and Sandra Cerda, MD; “Primary Unresectable Locally Invasive Right Atrial Paraganglioma Presenting with Chest Pain”  Presented in CAP 2106 http://www.archivesofpathology.org/
          • Mahmoud.CAP2016.IMG_2132Mahmoud Soliman presenting at CAP 2016
          • Soliman was quite busy at CAP, he also presented; Mahmoud L Soliman, MD, PhD, Sandra Cerda MD, Huihong Xu MD, “An Invasive Moderately Differentiated Adenocarcinoma incidentally identified in Perforated Diverticulitis with Abscess Formation”  Presented in CAP 2106 http://www.archivesofpathology.org/
          • Mahmoud.CAP2016.Poster2.Mahmoud Soliman presenting a second poster at CAP 2016
        • Welcome to our two new Masters Students:
        • SubhaSinghSubha Singh joins us directly as a McNair Scholars Fellow from the University of New Hampshire:
        • Rawan picRawan Tahboub is already an accomplished physician finishing in the top of her class at Jordan University of Science and Technology:
      • Publications: ACCEPTED:
        • Elizabeth Moses, Teresa Wang, Sean Corbett, George R Jackson, Eduard Drizik, Catalina Perdomo, Claudia Perdomo, Eric Kleerup, Daniel Brooks, George O’Connor, Steven Dubinett, Patrick Hayden, Marc E. Lenburg, and Avrum Spira. “Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium.” Accepted to Toxicological Sciences.
      • Publications: PUBLISHED:
        • Hafida, S, Mirshahi, T, Nikolajczyk BS. 2016. The impact of bariatric surgery on inflammation: quenching the fire of obesity? Current Opin Endocrinol, Diab and Obesity. 23:373-8. PMID: 27455515
        • Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV. 2016. BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci. (In Press). PMID: 27491296
        • Moshe S, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 Sep 20. doi: 10.18632/oncotarget.12107

      Departmental Seminar – September 30, 2016

      September 26th, 2016 in Spotlight

      Seminar Series: Fall 2016 ~~ Friday, September 30, 2016

      2:00-3:00 PM

                    

      Effective Filtration Area – A Novel Indicator of Aqueous Outflow Resistance and Structural Changes

       

      Haiyan Gong, MD, PhD
      Professor of Ophthalmology and Anatomy & Neurobiology
      Sackler School of Graduate Biomedical Sciences
      Boston University School of Medicine

      Location & Time:
      670 Albany Street
      Lobby Level #107/108

      2:00-3:00 PM
      Friday, September 30, 2016

      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) state that the primary open angle glaucoma is a leading cause of blindness worldwide; 2) identify that the primary risk factor associated with POAG is elevated IOP, consequent  of high levels of aqueous humor outflow resistance and 3) recall that the mechanism regulating outflow resistance remains elusive.

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.