April 2015

May 4th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Stephanie Adams, OD/PhD Student and Ivana Delalle have an abstract that has been accepted for a platform presentation at the American Association of Neuropathologists meeting in June in Denver, CO.; “BIN1 Expression In Human Hippocampus During Alzheimer’s Disease Progression,” Authors: Stephanie Adams1, Kathy Tilton1, Sudha Seshadri2, Ivana Delalle1.
  • As part of the new collaboration between Boston University and the University of Damman, Saudi Arabia, Daniel Remick gave two presentations in April in Saudi Arabia :
    • Keynote Address, University of Damman, Saudi Arabia, 1st Annual Scientific Research Update – Traumatic Brain Injury Augments Pulmonary Host Responses to Bacteria: Molecules and Mechanisms
    • Specialized Workshop, King Fahd Hospital University of Damman, Saudi Arabia, Immunopathology of Sepsis – 2015
  • Dr. Remick served as an ad hoc member of the Board of Scientific Review for the National Institutes of Arthritis, Musculoskeletal and Skin Diseases at the National Institutes of Health.
  • Barbara Slack, Pathology Department Russek Awards Committee Member, is pleased to announce that this year’s Russek Award recipients in the Department of Pathology and Laboratory Medicine are:
    • First Prize Recipient – Jacquelyn Sikora Hanson (Advisor: Lawreen Connors); Jacquelyn presented her talk on May 1st entitled; “The transthyretin gene variant G6S may be protective in wild-type transthyretin amyloidosis.”
    • Second Prize Co-Recipients – Caitlin Miller (Advisor: Suryaram Gummuluru) & Nicole Stauffer (Advisor: Joseph P. Mizgerd)
    • Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day was held on May 1st in the Hiebert Lounge (L building, 14th floor). The keynote speaker this year was Dr. David M. Livingston, Emil Frei Professor of Medicine at Harvard Medical School. Posters were available for viewing throughout the day, and slide presentations by the first prize winners took place in the afternoon. More information about this event can be found at the link (http://www.bumc.bu.edu/gms/students/phd/russek-student-achievement-day-2015/)
  • David Sherr, PhD, MD/PHD student, Olga Novikov, won the School of Public Health’s Dean’s Award. See link below. http://www.bu.edu/sph/2015/04/15/olga-novikov-wins-deans-award-at-graduate-research-symposium/
  • Congratulations are in order for Emad Arafa and Jordan Shafran, both graduating Masters students in Nader Rahimi’s Lab. Emad and Jordan have been accepted in BU’s PIBS PhD Program; Bravo!
  • Nisma Mujahid, one of our MD/PhD student has been awarded the Canadian Institutes of Health Research Doctoral Foreign Study Award
  • The department’s biobanking team were represented by Chris Andry, Liz Duffy and Cheryl Spencer at a two day summation meeting for the cancer Human Biobank (caHUB) and Ethical, Legal and Social Implications (ELSI) program at the National Cancer Institute in Bethesda, MD on April 22nd. All four biospecimen source sites involved in the pre-analytic variables study were represented as well as the analytics teams from around the country.  The BMC team presented data regarding biospecimen collection in the pre-analytic variables study as well as on the ELSI enrollment and consent surveys.
    • Analytics data on immunohistochemistry and in situ staining, proteomics and genomics are expected by late Fall.  The ELSI data was synthesized and analyzed by Dr. Teddy Warner, University of New Mexico with very interesting preliminary results
    • BMC’s biobanking efforts were recognized by the NCI leadership, particularly in the areas of quality and collaboration. All pathology faculty and residents were acknowledged for their contributions to the project

Publications PUBLISHED:

  • Eladio Rodriguez-Diaz PhD, Qin Huang MD, Sandra R. Cerda MD, Michael J. O’Brien MD, Irving J. Bigio PhD, Satish K. Singh MD; Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointestinal EndoscopyJjournal. March 2015, Vol.81(3):539547
  • “Systems Biology of Cancer” edited by Sam Thiagalingam, PhD
    • A book edited by Dr. Sam Thiagalingam entitled “Systems Biology of Cancer” was released by the publisher Cambridge University Press on April 9, 2015. It provides a comprehensive account of the current state of the knowledge and a road map to formulate a blueprint for the biological basis of cancer. The emphasis of the book is on the biology with minimal mathematical derivations and computational methods which are still evolving to meet the unprecedented amount of data produced with high-throughput experimentation methods that are continuing to be developed.
    • Readers will be able to get a realistic view of what is known and remaining to be uncovered in the chapters presented by international experts on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health. This will serve as a useful text on cancer suitable for students and researchers in all stages of their careers including the undergraduates. The contents are most suitable and highly recommended for graduate students, medical residents and fellows and experienced researchers. This landmark volume consists of a collection of 32 chapters with contributions from more than 75 international experts which includes 8 chapters by Boston University faculty and trainees. At this time the publisher is providing a 20% discount (see Flyer). Thiagalingam-Flyer-SystemsBiologyof Cancer-2015
    • This link allows you to look at the first few pages of the book in kindle:
  • Witthaus MW, Nipa F, Yang JH, Li Y, Lerner LB, Azadzoi KM. Bladder Oxidative Stress in Sleep Apnea Contributes to Detrusor Instability and Nocturia. J Urol. 2015 May;19 (5):1692-9. PMID: 25463994

March 2015

April 6th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • 104th USCAP Meeting, Boston, MA, March 21-27 2015
    • Cathryn Byrne-Dugan, MD had her abstract accepted:Podocyte Infolding Glomerulopathy – Occurrence of the Disease Entity in the United States, and the Potential Role of an Autoantibody;” Authors:Cathryn J Byrne-Dugan, Pavel Kopach, Laurence H Beck, Vanesa Bijol, Monika Pilichowska, Helmut G Rennke, Masha Bilic
    • Meera Mahalingam will be the Chair/Moderator of “Neoplastic Dermatopathology – Clues and Confounders.” Topic was selected to highlight histopathologically confounding issues in cutaneous neoplasms. Neoplasms selected encompass a spectrum of lineage-unrelated tumors that are commonly encountered some perhaps more than others by a general pathologist both in private practice and in an academic setting. Each speaker will begin with an initial description of the entity and conclude with clues and confounding issues relevant to the entity discussed
    • Qing Zhao, Shi Yang, Cecilia Ponchiardi, and Michael O’Brien had their abstract BRAF/KRAS Mutation, MSI/MSS Status and Tumor Budding in Colorectal Carcinoma” at the Poster Session on Tuesday, March 24th
    •   “Resident Shiva Khoobyari, MD enjoying a Poster at this year’s USCAP in Boston”
      USCAP2015.Shiva.58983127-DSC_624
  • Congratulations to Karen Quillen on her recent promotion to full professor. There is a nice article in BU today about her advancement. http://www.bu.edu/today/2015/med-promotions/
  • Daniel Remick, M.D., has been selected to be a Guest Editor for the Journal of Leukocyte Biology beginning February 2015. Dr. Remick will serve as the Editor for manuscripts solicited from the 2014 joint annual meeting of the Society for Leukocyte Biology and the International Innate Immune and Endotoxin Society.
  • On March 9th 2015 in Boston, MA. Carmen Sarita-Reyes presented at the 2015 Annual Session and Exhibition of the American Dental Education Association (ADEA) a Chair of the ADEA Board of Directors Symposium. The presentation was titled: “IGNITING MINDS THROUGH STUDENT SELF-DIRECTED GROUP LEARNING: Integrated  Problem Sessions (IPS.) Chair of the ADEA Board of Directors Symposium;” Cataldo W. Leone, DMD, DMSc, Carol T. Walsh, MA, PhD, Carmen D. Sarita-Reyes, MD, Monica A. Pessina, MEd, PhD, and Elizabeth R. Whitney, MSPT, PhD
  • Resident Reyhan Gedik, MD volunteers for a non-profit organization called White Tulip Foundation. We organize monthly seminars (called Boston Medical forum http://www.bostonmedicalforum.org/ ) to share our experiences as medical doctors and scientists. In March they invited David Kindelberger to give a talk about “Circulating Tumor Cells; New Tools for Personalized Medicine” and he kindly accepted. Keep an eye out for other interesting topics.
  • Clarissa Koch, PhD, Connors Lab, successfully defended her thesis “Characterizing the Effect of Transthyretin Amyloid on the Heart” on Monday, March 16th
  • “Clarissa Koch, PhD Candidate and her PI Lawreen Connors, about to give her Defense” and “Dr. Koch’s Celebration”
    IMG_4362
    IMG_4380
  • MATCH DAY 2015:
    • Bravo to MD/PhD Graduate David Stepien for successfully being accepted into his First Choice in this year’s Match; Dave will be taking up residence in the University of Michigan Hospital Integrated Plastic and Reconstructive Surgery Residency Program
    • Hooray to 2011 Masters Degree Graduate Nik Bajaj for also getting into his First Choice in this year’s Match; Nik will begin his residency in the University of Illinois – COM – Chicago Neurology Residency Program
  • Kevin Chandler, PhD, a postdoctoral fellow working jointly in the Dr. Cathy Costello and Nader Rahimi laboratories was awarded a three year postdoctoral fellowship from the NIH. The goal of the project is to map the glycosylation of VEGFR-2 and the role of this posttranslational modification in the angiogenic signaling of VEGFR-2
  • David Sherr’s graduate student, Liz Stanford, was selected to be the GMS commencement student speaker
  • Barb Nikolajczyk, PhD is an invited speaker in March 2015 for:
    • Experimental Biology, Diet and Immunometabolism Symposium, Boston, MA, Lymphocyte function in human type 2 diabetes, 2015
    • Immunology Microbiology Program Spring Seminar Series, University of Massachusetts Medical School, Inflammation in human type 2 diabetes, 2015
    • Beth Israel Medical Center,  Inflammation in human type 2 diabetes, 2015
  • Carol Cohen will be presenting at the AATB Quality and Donor Suitability Workshop in Atlanta, Georgia on April 20th. Susan Sharpe MS, MT(ASCP), SBB, CTBS who is the Supervisor of the Tissue and Transfusion Service at Northside Hospital in Atlanta and Carol will be presenting on the FDA’s new ruling that requires medical devices to have unique device identifiers
  • Lawreen Connors, PhD was invited to speak at the EB/ASIP meeting here in Boston on March 31st; the title of her presentation was “The Translational Science of Transthyretin-associated Cardiomyopathies.”
  • Here’s a link to an article in the Chicago Tribune in which David Sherr is quoted/featured: http://www.chicagotribune.com/lifestyles/health/sc-hlth-401-environmental-cancer-20150326-story.html#page=1
  • Remick was recently notified that graduate student, Ms. Erika Langley, was chosen this semester as a Teaching as Research Fellow. As a winner of this fellowship, she will receive an award of $1,000 and partake in a seminar in teaching as research. Teaching-as-Research involves the deliberate, systematic, and reflective use of research methods to develop and implement teaching practices that advance the learning experiences and outcomes of students and teachers. Erika will be in the TAR seminar this spring, and implement a project in a classroom in the summer or fall. Erika’s TAR project has the working title: Improving scientific literacy in undergraduates; she has the support of her faculty advisor for the project Prof. Paul Lipton and her research advisor Prof. Alpaslan Dedeoglu.

Publications ACCEPTED:

  • Goldberg, L.J., E. Wise, N. S. Miller. White piedra in a northern climate caused by Trichosporon inkin: A report of two cases. Item of correspondence. Accepted for publication, March 7, 2015. British Journal of Dermatology
  • Chad L Mayer, Caitlin S.L. Parello, Benjamin C Lee, Kiyoshi Itagaki, Shinichiro Kurosawa, DJ Stearns-Kurosawa. “Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns”  Frontiers in Immunology, section Microbial Immunology.

Publications PUBLISHED:

  • Tagne, J.B., Mohtar, O.R., Campbell, J.D., Lakshminarayanan, M., Huang, J., Hinds, A.C., Lu, J., Ramirez, M.I. (2015) Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb Res. 16:22 PMC4335692 http://respiratory-research.com/content/16/1/22
  • Rai A, Nimeh T, Sood A, Thirumavalavan N, Thurmond PE, Azadzoi KM, Lerner LB. Could nocturia be an indicator of an undiagnosed sleep disorder in male veterans? 2015 Mar;85(3):641-7. PMID: 25733279
  • Lei X, Liu C, Azadzoi KM, Li C, Lu F, Xiang A, Sun J, Guo Y, Zhao Q, Yan Z, Yang J,; A novel IgM-H-ficolin complement pathway to attack allogenic cancer cells in vitro. Sci Rep. 2015 Jan 16;5:7824. PMID: 25592840
  • Poutahidis, T., Varian, B. J., Levkovich, T., Lakritz, J. R., Mirabal, S., Kwok, C., & Erdman, S. E. (2015). Dietary microbes modulate transgenerational cancer risk. Cancer research, canres-2732       (BJ Varian is one of our Masters Students; this is with his MIT affiliation)
  • Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. c-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt-mediated phosphorylation. J Biol Chem. 2015 Mar 17J Biol Chem
  • Melody P. Lun, Matthew B. Johnson, Kevin G. Broadbelt, Momoko Watanabe, Young-jin Kang, Kevin F. Chau,Mark W. Springel, Alexandra Malesz, André M.M. Sousa, Mihovil Pletikos, Tais Adelita, Monica L. Calicchio,Yong Zhang, Michael J. Holtzman, Hart G.W. Lidov, Nenad Sestan, Hanno Steen, Edwin S. Monuki, and Maria K. Lehtinen. Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production. The Journal of Neuroscience 25 March 2015, 35(12): 4903-4916
  • Vanesa Bijol, Cathryn J. Byrne-Dugan, and Melanie P. Hoenig. Medical student web-based formative assessment tool for renal pathology. Medical Education Online, Volume 20, 2015; http://med-ed-online.net/index.php/meo/article/view/26765

Congratulations to Dr. Clarissa Koch

March 31st, 2015 in Student Spotlight

clarissa BU pathology website photo

 

Clarissa Koch, PhD, Connors Lab, successfully defended her thesis Characterizing the Effect of Transthyretin Amyloid on the Hearton Monday, March 16th

February 2015

March 3rd, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • 104th USCAP Meeting, Boston, MA, March 21-27 2015
    • Mostafa Belghasem, PhD Candidate, Henderson Lab has an abstract accepted for poster presentation for the United States & Canadian Academy of Pathology’s (USCAP) 104th Annual Meeting in Boston, MA. The abstract is entitled “Podocyte-Specific Myh9 Deletion in Mice Results in Susceptibility to Glomerular Injury in Response to Subtotal Nephrectomy”
  • From Mark Uva, our Residency Coordinator: We have filled our two vacancies within the residency program.   These positions are in addition to our recruiting through the Match for PGY 1s.  The two physicians come to us with outstanding letters of reference, and thought of very highly in their respective programs.  They will be entering the program as PGY 2s, effective July 1, 2015.
    • Lei Li, MD: Lei is transferring from St. Barnabas Medical Center in Livingston, NJ, where she is currently a PGY 1.  Lei graduated from Xuzhou Medical College, Xuzhou, Jiangsu China in 2000.
    • Ram Al-Sabti, MD: Ram is transferring from University Hospital Case Medical Center, Cleveland, OH, where he is currently a PGY 1.  Ram graduated from the University of Bagdad, Iraq in 2009.

Publications ACCEPTED:

  • Peluso, A. M., B. A. Harnish, N.S. Miller, E. R. Cooper, A. M. Fujii.  Effect of young sibling visitation on respiratory syncytial virus activity in a NICU. The Journal of Perinatology (accepted for publication Feb. 19, 2015)
  • Valencia-Rey P., J. Weinberg, N. Miller, T. Barlam.  Coagulase-negative staphylococcal bloodstream infections: Does vancomycin remain appropriate empiric therapy? Journal of Infection (accepted for publication Feb. 18, 2015)
  • Taimur, S., N.S. Miller, D. Whitney, T. Barlam. Empiric and Targeted Treatment of Enterococcal Infections: Opportunities for Antimicrobial Stewardship. Infectious Diseases in Clinical Practice 2014 Dec; E-published ahead of print: doi:10.1097/IPC.0000000000000193

Departmental Seminar – Apr 24

February 13th, 2015 in Spotlight

Translational Genomics and Precision Cancer Medicine

Nikhil Wagle, MD

Instructor in Medicine
Harvard Medical School
Dana-Farber Cancer Institute
Associate Member, Broad Institute of Harvard and MIT

Department of Pathology and Laboratory Medicine

Spring 2015 Seminar Series: Friday, April 24, 2:00

Friday, February 20, 2:00 (Refreshments 1:45) 670 Albany Street – Lobby Level #107/108

 

Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914

January 2015

February 9th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Nancy S. Miller, MD was an invited panel member at the Boston Pan African Forum event, “Ebola and other health-related issues in West Africa”, on December 13th in Dorchester, MA
  • Dr. Carmen Sarita-Reyes gave a poster presentation at the SENTAC (Society for Ear, Nose and Throat Advances in Children) meeting on December 6, 2014 in St Louis. “Marsupialization to treat foregut duplication cysts of the oral cavity: a novel technique;” Minyoung Jang; Carmen Sarita-Reyes; Devaki Sundararajan; Jessica Levi
  • Maria Panchenko, PhD has had her BUMC IACUC Appointment extended until June 2015. Thank you for your service Dr. Panchenko!
  • The American Board of Pathology recently nominated Meera Mahalingam, MD, PhD, FRCPath to serve on the Test Development and Advisory Committee on Dermatopathology.  The committees consist of American Board of Pathology trustees, as well as other pathologists and physicians who are recognized as experts in their respective disciplines
  • From Dr. John Lee; “The Hematology Lab has revised and updated the flow cytometry panels using a more sensitive and algorithmic approach.  In addition, a new technique will be employed to determine light chain restriction in plasma cells, which would be useful for myeloma, MGUS, and AL amyloidosis patients.  These changes were put into effect January 5, 2015 by Dina Pelley, MT (flow cytometry assistant supervisor) and John Lee, MD (Hematology Lab Medical Director) with Angel Lui, MT helping from the IT side.”
  • Dr. Ivana Delalle and her Neuropathology Lab have been acknowledged in recognition of her International Research Collaborations by PsyCourse: Pathomechanisms and Signatures of the Longitudinal Course of Psychosis
  • One of our current residents, Cathryn Byrne-Dugan, MD, will be going to University of Michigan for a GI fellowship in 2016-2017

Publications ACCEPTED:

  • Authors: Caitlin S.L. Parello, Chad L. Mayer, Benjamin C. Lee, Amanda Motomochi, Shinichiro Kurosawa *, Deborah J. Stearns-Kurosawa; Shiga Toxin 2-Induced Endoplasmic Reticulum Stress is Minimized by Activated Protein C but Does Not Correlate With Lethal Kidney Injury; Toxins, in press
  • Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine; (accepted for publication Jan 2014)

Publications: PUBLISHED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, David C. Seldin, Lawreen H. Connors; “Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt);” Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359
  • Cathryn J. Byrne-Dugan, Terra A. Cederroth, Anita Deshpande, and Daniel G. Remick (2014) The Processing of Surgical Specimens With Forensic Evidence: Lessons Learned From the Boston Marathon Bombings. Archives of Pathology & Laboratory Medicine In-Press http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2014-0441-OA
  • Byrne-Dugan, CJ, Collins AB, Lam AQ, Batal I. Membranous Nephropathy as a Manifestation of Graft-Versus-Host Disease: Association With HLA Antigen Typing, Phospholipase A2 Receptor, and C4d. Am J Kidney Dis. 2014 Dec;64(6):987-93. doi: 10.1053/j.ajkd.2014.09.001. Epub 2014 Oct 8
  • Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes
    Obes. 2015 Feb;22(1):1-2. doi: 10.1097/MED.0000000000000130. PubMed; PMID: 25485518
  •  Weber HC. Gastrointestinal peptides and itch sensation. Curr Opin Endocrinol
    Diabetes Obes. 2015 Feb;22(1):29-33. doi: 10.1097/MED.0000000000000122. PubMed;
    PMID: 25485517
  • Hermos JA, Quach L, Gagnon DR, Weber HC, Altincatal A, Cho K, Lawler EV,
    Grotzinger KM. Incident severe thrombocytopenia in veterans treated with
    pegylated interferon plus ribavirin for chronic hepatitis C infection. Pharmacoepidemiol Drug Saf. 2014 May;23(5):480-8. doi: 10.1002/pds.3585. Epub 2014 Feb 20. PubMed PMID: 24677630

9th Annual Nancy L.R. Bucher, MD, Seminar

January 8th, 2015 in Spotlight

 

Department of Pathology and Laboratory Medicine

Spring 2015 Seminar Series: Friday, February 6, 2:00

 

9th Annual Nancy L.R. Bucher, MD, Seminar

“Engineering Liver Tissue at the Microscale”

Friday, February 6, 2:00 (Reception Following) 670 Albany Street – Lobby Level #107/108

Speaker:

Dr. Sangeeta Bhatia, MD, PhD

John J. and Dorothy Wilson Professor of Health Sciences and Technology & Electrical Engineering and Computer Science;
Director, Laboratory for Multiscale Regenerative Technologies;
Massachusetts Institute of Technology

 

Contact:
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914

December 2014

January 8th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “Overcoming the resistance to anti-angiogenesis therapy”. The overall of goal of this research is to study the role of posttranslational modifications on VEGFR-2 in colon cancer. Angiogenesis inhibitors targeting the VEGF signaling pathway have been FDA approved for various cancer treatments. Although beneficial, patients inevitably develop resistance and often fail to demonstrate significantly better overall survival. Interfering with the posttranslational modifications of VEGFR-2 may overcome refractoriness and resistance to certain class of anti- cancer drugs.
  • Dr. Daniel Remick was an invited speaker to Loyola University Medical Center in Chicago, December 9/10, 2014:
    • Dr. Remick presented Grand Rounds in the Department of Surgery at Loyola – “Brain Injury Prevents Pneumonia – Who knew?”
    • He also gave a lecture to the Department of Pathology “Physician Scientist Pathway in Pathology”
    • Dr. Remick, as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago presented,  “Inhibitory IgG Increases Sepsis Mortality”
  • Dr. Chris Andry, of Boston University USA, visited Professor Rodger Charlton, and other colleagues in the Division of Primary Care, Nottingham University, United Kingdom on 9th December, 2014 . During his visit, Dr. Andry gave a talk entitled “The Value of a Centralized Hospital Bereavement Office Supporting Multicultural Families in the USA”   

    image

    UK meeting University of Nottingham. Dr. Andry, 2nd from left. Man on his right Professor Rodger Charlton. Man on his left Dean of Srinakharinwirot University, Thailand. First Woman to the right of Professor Charlton, Assistant Professor Nantana Choomchuay, MD. Head, Department of Pathology, Faculty of Medicine, Srinakharinwirot University.

  • Jenny McEldoon, BU Undergrad working in the Remick Lab has been awarded funding from UROP for Spring 2015!
  • Zachary Hunter, PhD, Steve Treon Lab at Children’s Hospital, successfully defended his thesis “Whole Genome Sequencing Reveals that Recurrent MYD88 and CXCR4 Mutations Underlie the Genomic Landscape of Waldenström’s Macroglobulinemia” on Tuesday, December 2nd

Publications ACCEPTED:

  • Inge The, Suzan Ruijtenberg, Benjamin Bouchet, Alba Cristobal, Martine B.W. Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J.R. Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Munoz, and Sander van den Heuvel, Rb and the APC/C co-activator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells. Nature Communications
  • Akifumi Fujita, Huihong Xu, Yu-Ming Chang, Scharukh Jalisi, and Osamu Sakai, Best cases from the AIRP: Malignant mixed tumor of the hard plate. RadioGraphics
  • Authors: Blanche C. Ip, Andrew E. Hogan, Barbara S. Nikolajczyk; Lymphocyte roles in metabolic dysfunction: of men and mice  Trends in Endocrinology and Metabolism  
  • Michael J. Greene, Elena S. Klimtchuk, David C. Seldin, John L. Berk, and Lawreen H. Connors; “Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal” Biochemistry

Publications: PUBLISHED:

  • Stevenson EK, Sloan KA, Narsule CK, Kretschman DM, Sarita-Reyes CD, Steiling K, Ebright MI. Catamenial hemothorax in a patient with multiple sclerosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):e69-70
  • Zhang QSiroky M, Yang JH, Zhao Z and Azadzoi K “Effects of ischemia and oxidative stress on bladder purinoceptors expression” Urology, 2014 Nov;84(5):1249.e1-7. doi: 10.1016/j.urology.2014.07.023

Congratulations to Dr. Caitlin Leibowitz Parello

December 4th, 2014 in Student Spotlight

Caitlin-Leibowitz thumb

 

Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st.

November 2014

December 2nd, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items 

Announcements:

  • Kate Murphy has announced that the Blood Bank had its’ 4th inspection of the year – American Association of Blood Banks (AABB) on November 19th and 20th for an extremely thorough assessment, including nursing competency.  We were successfully accredited for another 2 years!
  • Zach Hunter, PhD Candidate in the Steven Treon’s Lab at Children’s Hospital presented at the following conferences:
    • August 14th in London, UK. At the 8th International Workshop on Waldenstrom’s Macroglobulinemia. His oral presentation was entitled: “Genomic Landscape of WM”
    • August 17th in London, UK, WMUK’s 5th International Doctor Patient Forum “Making Sense of Key Information about your WM: MYD88, CXCR4 and the Genetics of WM”
  • Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st

    LeibowitzParelloDefense.11.21.14

    Caitlin’s Defense

  • Zach Hunter also received a grant in his own name; “Identification of Germline and Somatic Variants Associated with Predisposition to WM” from the International Waldenström’s Macroglobulinemia Foundation
  • Barb Nikolajczyk, PhD presented:
    • “Immunometabolism, Lymphocytes and Obesity” at The Obesity Society annual meeting in Boston, MA on November 6th
    • “Lymphocytes in Human Obesity and Type 2 Diabetes” at the Evans Center/Whitaker mini-symposium on Immune Cells and Metabolism on November 21st
  • David Kindelberger, MD (along with colleague Eric Huang from the University of California, Davis) presented a workshop titled “2012 Updated ASCCP Consensus Management Guidelines for Women with Abnormal Cervical Cancer Screening Tests” at the 62nd Annual American Society of Cytopathology Scientific Meeting on November 17th in Dallas
  • Daniel Remick, MD was given a water pitcher to acknowledge his serving on the Society for Leukocyte Biology Council, and serving as the Program Chair for the 2014 Annual Leukocyte Biology Meeting. The 2014 meeting in Salt Lake City was a joint meeting between Leukocyte Biology and the International Endotoxin and Innate Immune Society.

    Remick Watervase jpg

    Dr. Remick with watervase

  • Mostafa Belghasem, PhD Candidate, Henderson Lab:
    • Presented a poster entitled “Heterozygous Actn4 Mutant Mice are Susceptible to Glomerulopathy when Subjected to Hemodynamic Stress” at American Society of Nephrology (ASN) Kidney Week 2014 in Philadelphia, PA, November 11-16, 2014
    • Mostafa was also selected to participate in the ASN 2014 Kidney STARS program and received a Travel Award from the ASN

 Publications ACCEPTED:

  • Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R.Rifkin and Adam Lerner; “Type 4 cyclic nucleotide phosphodiesterase inhibitors block intracellular Toll-like receptor signaling in chronic lymphocytic leukemia and normal hematopoietic cells”. Journal of Immunology
  • Anastasia Gomez, Nancy S. Miller, and Irina Smolina. Visual detection of bacterial pathogens via PNA-based padlock probe assembly and isothermal amplification of DNAzymes. Analytical Chemistry, Publication Date (Web): 21 Nov 2014

Publications: PUBLISHED:

  • Castillo JJ, Olszewski AJ, Cronin AM, Hunter ZR, Treon SP. Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database. Blood. 2014 Jun 19;123(25):3999–4000. PMID: 24948623
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Patterson CJ, Tsakmaklis N, Kanan S, Rodig S, Castillo JJ, Treon SP. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia. Leukemia. 2014 Jun 10; PMID: 24912431
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