News

March 2014

Published: April 2nd, 2014

Pathology & Laboratory Medicine News Items

 Announcements:

          • Nader Rahimi, PhD had recent work in the news and this work was described as a future medicine for cancer treatment (please see link) Rahimi2014.future medicine
          • Huihong Xu, MD was invited to give a lecture of “Frozen Section Diagnosis” at China Shanghai Fudan University Cancer Hospital, Department of Pathology, on January 8th
          • John “Jed” Mahoney , PhD, Cardoso Lab, successfully defended his thesis “The Hippo Pathways Effector Yap Controls Patterning and Differentiation of the Airway Epithelium” on Friday, March 21st   
          • Evan Chiswick , PhD, Remick Lab, successfully defended his thesis “Failure to Kill, Kills: Impaired Bacterial Killing Precedes Death in Polymicrobial Sepsis” on Friday, March 28th   
          • Shinichiro Kurosawa, MD, PhD was invited to give a seminar on March 10th at Harvard Medical School at a joint symposium of the BWH-DFCI Joint Immunology Seminar Series.  The title of his talk was “A pre-clinical animal model of B. anthracis infection:  A new insight into the cause of death.”
          • The Hematology Lab will be providing “Immunofecal Occult Blood Testing” as of 3/17/14, which will be used in screening patients for gastrointestinal bleeding and colorectal cancer. The hematology lab will be using Polymedco’s OC-AUTO Micro 80 platform. This test is more sensitive (one specimen instead of multiple) and more specific (you can eat a hamburger beforehand) than the “Guaic Test”. Melissa Gallinaro, Daoreuang Pongvongkeo, John Lee, Chris Andry, and Carl O’Hara were involved in bringing this test in-house and validating this test.
          • The Hematology Lab will also be providing in-house “Platelet Aggregation Testing” as of 3/17/14, which will be used in assessing baseline platelet function as well as antiplatelet drug efficacy. The hematology lab will be using Chrono-log’s Model 700 Aggregometer platform. This platform uses aggregation impedence methodology, which is favored over the traditional light transmittance methology. Renee Nutting, Daoreuang Pongvongkeo, and John Lee were involved in bringing this test in-house and validating this test.
          • USCAP 2014, United States & Canadian Academy of Pathology’s 103rd  Annual Meeting;         San Diego, California; March 1 – 7, 2014:
            • PhD Candidate, Philip Bondzie, Henderson Lab presented a poster entitled:Glomerular Gene Expression Profiling and Kidney Morphology in Carriers of APOL1 Risk AllelesBondzie P, Norman T, Yang S, Henderson JM
            • Abstracts from our faculty, residents and fellow:
              • “PD-L1 Expression in Stage IV Lung Cancer”. Yue Sun, Huihui Ye, Hao Wu, and Carl O’Hara

                USCAP2014.SunYue.DSC_0479

                Dr. Yue Sun with her poster presentation

              • “Correlation of TWIST Expression in Different Histologic Subtypes of Primary Adenocarcinoma in Lung”. Anita Malek , Hasmeena Kathuria, Carl O’Hara 

                USCAP2014.AnitaMalek.DSC_0477

                Dr. Anita Malek with her poster presentation

              • “The Processing of Surgical Specimens with Forensic Evidence: Lesson’s Learned from the Boston Marathon Bombing”. Cathryn Byrne-Dugan MD, MPH; Anita Deshpande MD, Terra Ceddroth MD, Daniel Remick, MD
              • “HSATII as a Biomarker for Papillary Thyroid Carcinoma”. Anita Deshpande, M.D., Josenia Narcisa M Tan, M.D., Kshitij Arora, M.D.,Vikram Deshpande, M.D.,David Ting, M.D., Antonio de las Morenas M.D., PhD  

                Dr. Anita Despande and Dr. Joy Tan with their poster presentation

                Dr. Anita Despande and Dr. Joy Tan with their poster presentation

              • “Combined Cytology and HPV Testing after Loop Electrosurgical Excision Procedure (LEEP)/Conization of the Cervix Increases the Rate of Detection of Residual Cervical Intraepithelial Neoplasia in Patients with Negative Margins”. Josenia N.M. Tan M.D., Dhay Kamel M.D., Huihong Xu M.D
              • “Papillary Thyroid Carcinoma and Chronic Lymphocytic Thyroiditis, Linked by Severity of Chronic Inflammation or Anti-Thyroid Autoantibodies?” Josenia N.M. Tan M.D.,  Antonio de las Morenas M.D., PhD  

                Dr. Joy Tan with her poster presentation

                Dr. Joy Tan with her poster presentation

            • PhD Candidate, Mostafa Belghasem’s, Henderson Lab poster was: “Molecular Profiling of Glomeruli in a Glomerular Hypertension Mouse Model” Authors: Mostafa Belghasem, MD, Philip Bondzie, Timothy Norman, Meizhen Cao, Hui Chen, MD, Joel Henderson, MD, PhD.
          • From the Lawreen Connors Lab:
            • PhD candidates, Clarissa Koch and Jacquelyn Sikora as well as a recent grad and new post-doc Michael Greene, PhD have all received Travel Awards from the Amyloidosis Foundation to attend and present at the IXth International Symposium on Amyloidosis. The meeting will be held in Indianapolis from April 27 – May 1
              • Clarissa will be presenting a poster entitles: “Serum and tissue levels of retinol binding protein in patients with TTR-associated forms of amyloidosis”
              • Jacquelyn’s poster presentation will be: “Non-coding genetic variation of the transthyretin gene in senile systemic amyloidosis” on April 30th
            • Dr. Connors will also be attending the meeting and presenting results of “A five year prospective longitudinal study of patients with senile systemic amyloidosis
          • Dr. Daniel Remick has recently been elected to:
            • American Society of Investigative Pathology – elected member of council 2014 – 2017
            • Association of Pathology Chairs — elected Chair of Research Committee 2014 – 2017
          • Dr. Nancy Miller presented at the University of Colorado School of Medicine Office of Continuing Education, “Point-of-Care Meets Microbiology: What We Have, What We Need, What is On the Way? Preparing for the Next Frontier at Point-of-Care” on Friday, March 28th
          • Dr. Barb Nikolajczyk had several invited presentations for March 2014:
            • Loma Linda University, Loma Linda, CA, “B cells support a dominant Th17 cytokine signature in human type 2 diabetes”
            • National Center for Advancing Translational Sciences/NIH, Rockville, MD, “B cells support a dominant Th17 cytokine signature in human type 2 diabetes”
            • American Association of Dental Researchers Annual Meeting, Charlotte, NC, “B cells link periodontal disease and type 2 diabetes”
          • Publications: PUBLISHED:

            • Zhu M1, Nikolajczyk BS; “Immune Cells Link Obesity-associated Type 2 Diabetes and Periodontitis.” Journal of  Dent Res. 2014 Apr;93(4):346-52. doi: 10.1177/0022034513518943. Epub 2014 Jan 6.
            • A 2013 paper in the Proceedings of the National Academy of Sciences raised questions about the value of using mouse models to study human disease. A group of investigators prepared a scientific rebuttal which has just been published: M. F. Osuchowski, D. G. Remick, J. A. Lederer, C. H. Lang, A. O. Aasen, M. Aibiki, L. C. Azevedo, S. Bahrami, M. Boros, R. Cooney, S. Cuzzocrea, Y. Jiang, W. G. Junger, H. Hirasawa, R. S. Hotchkiss, X. A. Li, P. Radermacher, H. Redl, R. Salomao, A. Soebandrio, C. Thiemermann, J. L. Vincent, P. Ward, Y. M. Yao, H. P. Yu, B. Zingarelli and I. H. Chaudry: “Abandon the Mouse Research Ship? Not Just Yet!” Shock, 2014
            • Fulciniti, Mariateresa, Nicola Amodio, Rajya Lakshmi Bandi, Mansa Munshi, Guang Yang, Lian Xu, Zachary Hunter, et al. “MYD88-Independent Growth and Survival Effects of Sp1 Transactivation in Waldenstrom’s Macroglobulinemia.” Blood (March 12, 2014). doi:10.1182/blood-2014-01-550509

            A Day on Capitol Hill:

            FASEB invited a representative from Pathology to attend the annual Capital Hill Day. I participated in the event representing multiple groups. Specifically, as the Chair of the Research Committee of the Association of Pathology Chairs and the Chair of the Public Affairs Working Group of the American Society of Investigative Pathology. My report that I filed with the University is shown below. – Dan Remick, March 7, 2014.

            Advocating For Increased Federal Funding For Basic Science Research

            Every year the Federation of American Societies of Experimental Biologists (FASEB) brings scientists to Washington DC as part of Capital Hill Day. Scientists from across the country meet with Congressional staff to discuss the importance of federal research funding. On March 5, 2014 scientists from 21 states met with their representatives. FASEB’s specific recommendations for funding included $32 billion for the National Institutes of Health and $7.6 billion for the National Science Foundation. The $32 billion recommendation for NIH funding represents fewer actual dollars (not inflation adjusted dollars) compared to 2010. More information about federal funding for basic science research is available on the FASEB website:  http://www.faseb.org/Policy-and-Government-Affairs/Advocacy-on-Capitol-Hill.aspx

            Three scientists from Boston University formed the State of Massachusetts delegation for Capital Hill Day. Shoumita Dasgupta,  Ph.D, from the Department of Medicine,

            Joe, Shoumita, Doug and Dan advocating for science

            Joe, Shoumita, Doug and Dan advocating for science

            Biomedical Genetics Section, Daniel Remick, M.D., from the Department of Pathology and Laboratory Medicine, and Douglas Rosene, Ph.D., from the Department of Anatomy and Neurobiology. They were escorted by Joseph Joseph McInerney, the Executive Vice President of the American Society of  of of Human Genetics. The group visited the offices of Senators Warren and Markey as well as Representatives Tierney and Kennedy.

            At each office the group gave specific information about how reduced funding for science was having multiple negative impacts. Individual stories were told including:

            • Scientists no longer doing research because of lack of funding
            • Increased scientific publications from other countries in the Journal of Immunology compared to publications from the United States
            • International genomic sequencing initiatives (e.g. Beijing Genomics Institute) surpassing efforts at the NIH.
            • Loss of funding for the Framingham Heart studies and missing a generation of data
            • Decreased funding resulting in fewer experiments to examine the devastating effects of aging. These studies require a long term, consistent commitment since aging takes place over decades and it is difficult to start and stop science.

            All of the staff assured us that the Senators and Representatives were highly supportive of increased funding for basic science research. Each agreed to submit programmatic requests to the budget committees. This will ensure that funding for basic science will be considered as an integral part of the budget process and not as a separate earmark. They also agreed to sign a “Dear Colleague” letter to be circulated to other Senators and Representatives advocating increased funding for NIH research.  On behalf of Provost Antman, the Boston University faculty invited our Senators, Representatives and their staff to come and visit the basic science labs at Boston University, and thanked them for their continued support.

GMS PA 910 New Course offering

Published: April 2nd, 2014

The objective of this course is to introduce students to the creation, maintenance and efficient use of an indispensible component of translational research in medicine – human tissue and its derivatives. Lectures from invited speakers with extensive experience in human bio-specimens generation, maintenance, and utilization, will provide students with knowledge how to successfully obtain and utilize human bio-specimens. Topics will include logistics and legal aspects of creating and sustaining bio-banks, federal and institutional regulatory and funding mechanisms, and concrete examples of human bio-specimens use to generate break-through data in specific field of biomedical research. Special attention will be given to human biospecimens used in neuroscience as four neuropathologists/neuroscientists from Harvard, Yale, Columbia and Boston University are enlisted as speakers to give comprehensive overview of biospecimens utilized in neurodegenerative diseases and brain tumors.

GMS-PA910Rev6-794x1024

February 2014

Published: March 4th, 2014

Pathology & Laboratory Medicine News Items

Announcements:

  • Nancy Miller, M.D. has been appointed as a member of the Editorial Board for Annals of Clinical and Medical Microbiology. The Annals of Clinical and Medical Microbiology was recently launched and solicited editorial board members. From the journal’s website Annals of Clinical and Medical Microbiology is an international, open access, peer reviewed journal that brings about latest research in all clinical and medical aspects of clinical and medical microbiology. This journal focus upon the most recent research associated with the prognosis, laboratory diagnosis of human and animal infections and understanding the role of the pathogens in both infectious diseases as well as in the exposition of epidemiology of infections.” Dr. Miller’s expertise will be utilized to assure that only papers of the highest quality are accepted for publication. More information about the journal may be found at their website: http://www.jscimedcentral.com/MedicalMicrobiology/
  • Jessica (Allen) Ritter, PhD Candidate in the Genco Lab will be presenting a poster entitled, “Neisseria gonorrhoeae modulates immune cell survival through pyroptosis” at the 2014 Annual Meeting of the Sexually Transmitted Infections Cooperative Research Centers February 19th-21st, 2014 in Cambridge, MA
  • Dr. Huihong Xu was invited to give a lecture on “Frozen Section Diagnosis” at China Shanghai Fudan University Cancer Hospital, Department of Pathology, on January 28th, 2014
  • Nancy S. Miller, M.D. presented “Point of Care Meets Microbiology: Preparing for the next frontier at point-of-care”, at the Department of Laboratory Medicine Seminar Series, Yale University School of Medicine on February 21st
  • Once again on Monday, February 10th the Graduate School of Medical Sciences held another successful PIBS Graduate Program Interview Day. The full day for 53 candidates consisted of a breakfast; an overview of the programs BUSM has to offer (Pathology included); 3-4 interviews with faulty; lunch with Program Directors and Department Chairs; tours and an end-of-day Poster/Interview session. Representatives for Pathology at the Poster/Interview session included: Faculty – Drs. Susan Winandy, New Graduate Program Director, Krzysztof Blusztajn, Daniel Remick, Barbara Slack, and Jackie Sharon as well as current PhD candidates; Parul Agnihotri, Zach Hunter, Caitlin Leibowitz, Caitlin Miller, Jess Ritter and Nicole Stauffer. Thank you all for sharing your time and research!
  • Blood Bank News:
    • CAP was in for a very successful inspection of AP and CP on January 14
    • The Federation for Accreditation of Cellular Therapies (FACT) came for a planned assessment of the complete Stem Cell Transplant Program, including the Blood Bank Stem Cell Processing Lab on January 27. Very successful!
    • While we were still catching our breath, the FDA arrived unannounced on January 30 till February 3 for an extremely thorough inspection of all blood bank functions.  The FDA views Blood Banks as “manufacturers” and all processes that affect the safety, purity and potency of the blood product were scrutinized.  The FDA found no deviations or deficiencies in any of our processes.  All FDA inspections are unannounced and occur roughly every 2 years.
  • Charline Mack has been officially/formally named Manager for Anatomic Pathology. Charline is a wonderful leader for our Anatomic Pathology Department, as well as playing a broader management role within the Department of Pathology & Laboratory Medicine. Please join me in congratulating Charline!

Publications: PUBLISHED:

  • Treon, Steven P, Yang Cao, Lian Xu, Guang Yang, Xia Liu, and Zachary R Hunter. “Somatic Mutations in MYD88 and CXCR4 Are Determinants of Clinical Presentation and Overall Survival in Waldenstrom’s Macroglobulinemia.” Blood (February 19, 2014). doi:10.1182/blood-2014-01-550905
  • Xu, L, Z R Hunter, G Yang, Y Cao, X Liu, R Manning, C Tripsas, et al. “Detection of MYD88 L265P in Peripheral Blood of Patients with Waldenström’s Macroglobulinemia and IgM Monoclonal Gammopathy of Undetermined Significance.” Leukemia (February 10, 2014). doi:10.1038/leu.2014.65

January 2014

Published: January 31st, 2014

Pathology & Laboratory Medicine News Items

 

Announcements:

  • The Department of Pathology and Laboratory Medicine has formed a new Web Site Committee. The purpose of the committee will be to provide advice about the organization, content and structure of our current website. The team will meet monthly towards the goal of ultimately making our site informative, interesting, easily viewed and technologically current! The group is representative of the various components of the department. Committee members are: Chris Andry, Krzysztof Blusztajn, Lindy Joseph, Mary McGovern, Barbara Slack, Celia Slayter, Debbie Stearns-Kurosawa, Mark Wojnarowicz and Grace Zhao.
  • On Friday, January 24th the Graduate School of Medical Sciences held another successful PIBS Graduate Program Interview Day. The full day for 52 candidates consisted of a breakfast; an overview of the programs BUSM has to offer (Pathology included); 3-4 interviews with faculty; lunch with Program Directors and Department Chairs; tours and an end-of-day Poster/Interview session. Representatives for Pathology at the Poster/Interview session included: Faculty – Drs. Susan Winandy, New Graduate Program Director, Krzysztof Blusztajn, Ivana Delalle, Barbara Slack, and Jackie Sharon as well as current PhD candidates; Parul Agnihotri, Zach Hunter, Caitlin Miller, Jess Ritter and Nicole Stauffer. Thank you all for sharing your time and research!

Publications: ACCEPTED:

  • Dr. Ivana Delalle’s funded collaboration with Dr. Li-Huei Tsai at MIT has been accepted for publication in Cell: JJ   Jinsoo Seo1,2,3, Paola Giusti-Rodriguez1,2, Ying Zhou1,2,3, Andrii Rudenko1,2,3, Sukhee Cho1,2, Kristie T. Ota1,2,, Christine Park1,2, Holger Patzke1,2, Ji-Song Guan1,2, Ling Pan1,2,3, Ram Madabhushi1,2,3, Ivana Delalle4, and Li-Huei Tsai1,2,3 : “Activity-dependent p25 Generation Regulates Synaptic Depression and Aß-induced Pathology.” 1The Picower Institute for Learning and Memory, 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 3Howard Hughes Medical Institute, Massachusetts Institute of Technology, 4Department of Pathology and Laboratory Medicine, Boston University School of Medicine

Publications: PUBLISHED:

  • Christopher Dittus and Dana Semmel; “Leishmania amastigotes visualized on bone marrow aspirate in a leishmaniasis and HIV coinfected patient presenting with pancytopenia.” Blood, December 19, 2013 vol. 122 no. 26 4162 http://bloodjournal.hematologylibrary.org/content/122/26/4162.full.pdf+html
  • Azadzoi KM, Yang J, and Siroky M. “Neural regulation of sexual function in men.” WJ Clin Urol 24; 2(3): 32-41, 2013
  • Liu D, Liu C, Li J, Azadzoi KM et al: “Proteomic analysis reveals increased acetylation in human amyotrophic lateral sclerosis spinal cord.” PLOS ONE 8(12):e80779, 2013
  • King EG, Bauza GJ, Mella JR, Remick DG. “Pathophysiologic mechanisms in septic shock.” Lab Invest 2014; 94(1):4-12
  • Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG. “Early murine polymicrobial sepsis predominantly causes renal injury.” Shock 2014; 41(2):97-103
  • Bauza G, Moitra R, Remick D. “Adenosine receptor antagonists effect on plasma-enhanced killing.” Shock 2014; 41(1):62-66
  • Yang SH, Gustafson J, Gangidine M, Stepien D, Schuster R, Pritts TA, et al. “A murine model of mild traumatic brain injury exhibiting cognitive and motor deficits.” J Surg Res 2013; 184(2):981-988
  • Remick D. “Use of animal models for the study of human disease-a shock society debate.” Shock 2013; 40(4):345-346

 

    December 2013

    Published: January 6th, 2014

    Pathology & Laboratory Medicine News Items -

    Announcements:

    • Antonio de las Morenas, M.D., Professor of Pathology and Laboratory Medicine has been recognized by Boston magazine as a Top Doc in Boston. According to BU Today, “To be included in Boston magazine’s Top Doc list, physicians undergo a rigorous screening process by national medical research firm Castle Connolly. The firm gathers nominations online from other licensed physicians, conducts phone interviews with medical professionals to corroborate nominations, and checks the professional qualifications of all nominees . . .”

    The list of pathologists in Boston in the top docs may be found here: http://www.bostonmagazine.com/specialty/pathology/

    ○      From Dr. Daniel Remick, Department Chair: the Department of Pathology and Laboratory Medicine is pleased to announce that Susan Winandy, Ph.D., will become the Director of Graduate Studies in January, 2014. Dr. Winandy is the Nancy Bucher Assistant Professor of Pathology and Laboratory Medicine. She is a member of the Immunology Training Program at Boston University and her work focuses on the study of the protein Ikaros in T cell development and function. The Department thanks Nader Rahimi, Ph.D. for his efforts over the years to the mentoring and growth of our graduate students.

    • Dr. Ivana Delalle will be directing a new graduate course, GMS PA-910 “Human Biospecimens for Research”  approved by Academic Policy Committee in November
    • Also Dr. Ivana Delalle presented a poster entitled “Differential expression of exosomal miR-29c and miR-149 in brain tissue of bipolar disorder patients and rat model of depression” by Zhan Y1, Kozubek J1, Kao P1, Rezvani A2, and Delalle I1, 1Boston Univ. Sch. Of Med., BOSTON, MA, 2Duke University, DURHAM, NC, at the Society for Neuroscience Meeting in San Diego, California on November 11, 2013
    • Nancy S. Miller, M.D. directed the “Molecular Micro Grand Slam!” sponsored by the Northeast Branch – American Society for Microbiology, December 6th, at Bristol Community College, Fall River, MA. The all-day seminar featured lectures in molecular theory & laboratory applications, and a hands-on practical workshop emphasizing good molecular techniques. Workshop faculty also included Beverley Orr, MT(ASCP) and Valerie Kosick, M(ASCP)CM from the BMC Clinical Microbiology Laboratory, and Marisa Chattman M.S., SM (ASCP)CM from Tufts Medical Center
    • Dr. Ivana Delalle was an invited lecturer at Goettingen University Medical Center, Germany (invitation by Dr. Andre Fischer, Professor at European Neuroscience Institute) on December 19; “Human biospecimens data sharing in NIH-  funded international collaborative projects”
    • PhD Candidate, Zach Hunter presented the following posters at the American Society of Hematology Annual Meeting, December 7-10; New Orleans, Louisiana:
      • “Highly Recurrent Copy Number Alterations and Insight Into The Origins Of 6q Deletions In Waldenström’s Macroglobulinemia Revealed By Whole Genome Sequencing;” Zachary Hunter, Lian Xu, Guang Yang, Xia Liu, Yang Cao, Robert Manning, Christina K Tripsas, Christopher Patterson and Steven Peter Treon
      • “Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib;” Yang Cao, Zachary Hunter, Xia Liu, Lian Xu, Guang Yang, Christina K Tripsas, Robert Manning, Christopher Patterson and Steven Peter Treon
      • “Telomerase Contributes To Repair Of DNA Breaks In Myeloma Cells By Incorporating “TTAGGG” Sequences Within Genome: Biological and Translational Significance;” Jagannath Pal, Jie Ding, Subodh Kumar, Zachary Hunter, Teresa Calimeri, Jianhong Lin, Maria Gkotzamanidou, Giovanni Parmigiani, Steven Treon, Masood Shammas, and Nikhil Munshi
      • “Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström’s Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance;” Lian Xu, Zachary Hunter, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert Manning, Christopher Patterson, Christina K Tripsas, Sandra Kanan, Jiaji G Chen, Neil I Lindeman, and Steven Peter Treon
    • Barbara Nikolajczyk, PhD became an Editor of a new multi-disciplinary journal entitled “Discoveries”

    Publications: ACCEPTED:

    • Zachary R. Hunter , Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert J Manning, Christina K Tripsas, Christopher J Patterson, Patricia Sheehy, and Steven P Treon; MYD88, WHIM-like CXCR4, and Somatic Deletions Associated with B-cell Lymphomagenesis Characterize the Genomic Landscape of Waldenstöm’s Macroglobulinemia. BLOOD
    • Zhu, M and Nikolajczyk, BS.  2014.  Immune cells define the inter-relationship between obesity and periodontitis Journal of Dental Research (In Press)
    • Raval, F, and Nikolajczyk, BS. 2014. The Bidirectional Relationship between Metabolism and Immune Responses. Discoveries (In press)
    • Zhu, M and Nikolajczyk, BS.  2014. Immune cells link obesity-associated type 2 diabetes and periodontitis. Journal of Dental Research (In press).

    Publications: PUBLISHED:

    • Anna Eisenstein, Lev Vaisman, MASc, Hillary Johnston-Cox, Alexander Gallan, MD, Kitt Shaffer, MD, PhD, Deborah Vaughan, PhD, Carl O’Hara, MD, and Lija Joseph, MDIntegration of Basic Science and Clinical Medicine: The Innovative Approach of the Cadaver Biopsy Project at the Boston University School of MedicineThe cadaver biopsy project at Boston University School of Medicine links students’ first basic science experiences in gross anatomy with other basic science courses and later clinical course. The paper on cadaver project is in ePub version (innovation report), and will be in print in the January issue of Academic Medicine
    • Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG: “Early Murine Polymicrobial Sepsis Predominantly Causes Renal Injury,” Shock 2013, PMID: 24300829
    • Bauza G, Moitra R, Remick D: “Adenosine Receptor Antagonists Effect on Plasma Enhanced Killing,” Shock 2013, PMID: 24089004
    • King EG, Bauza GJ, Mella JR, Remick DG: “Pathophysiologic mechanisms in septic shock,” Lab Invest 2013, PMID: 24061288
    • Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG: “Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding,” Physiol Rev 2013, 93:1247-1288, PMID: 23899564
    • Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP: “Roles of STAT3 in protein secretion pathways during the acute-phase response,” Infect Immun 2013, 81:1644-1653, PMID: 23460517

    November 2013

    Published: December 4th, 2013

    Pathology & Laboratory Medicine News Items –

     

    Announcements:

    • Bravo! Bravo! Once again our very own, Dr. Antonio de las Morenas, has made Boston Magazine’s “Top Doctors”List for 2013. Congratulations Dr. de las Morenas!!!
    • Recent PhD graduate, Patricia Kao, now a postdoc at UC Davis, Sacramento, CA,  presented a poster with the current data from the Delalle Lab at the Society of Neuroscience Meeting in San Diego, California on November 11th, 2013; Zhan Y*, Kozubek J*, Kao P*, Rezvani A#, Delalle I*:  Differential expression of exosomal miR-29c and miR-149 in brain tissue of bipolar disorder patients and rat model of depression
    • Jason Sutin, PhD Candidate and his PI Dr. Franceshini from MGH presented a poster at the Society for Neuroscience in San Diego, California on Sunday, Nov 10, 2013. Diffuse optical spectroscopy measurements of cerebral hemodynamic and oxygen metabolism during spontaneous neuronal activity in anesthetized rats. J. Sutin, C. Chang, D. Boas, E. Brown, and M. A. Franceschini 
    • CP Resident, Dr, Dana Semmel represented BMC’s Department of Pathology at the recent 7th Annual Careers in Medicine Fair held in September
    • Dr. Barbara Nikolajczyk has been invited to present at two upcoming events:
      • Vanderbilt Diabetes Center, Vanderbilt University, Nashville, TN, “B cells regulate the dominant Th17 axis in human type 2 diabetes, 2013”
      • University of Massachusetts, Department of Biology, Lowell, MA. “Type 2 diabetes as an inflammatory disease, 2013”
    • Graduate, Edward Hartsough, PhD Methylation Paper is featured in the Science Daily News; http://www.sciencedaily.com/releases/2013/11/131128141410.htm (UPDATED LINK)

    Publications: ACCEPTED:

    • Anna Belkina, Wanda Blanton, Barbara S. Nikolajczyk and Gerald V. Denis. “The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.” Accepted to Journal of Leukocyte Biology
    • Edward J Hartsough, Rosana D Meyer, Vipul Chitalia, Yan Jiang, Victor E. Marquez, Irina V. Zhdanova, Janice Weinberg, Catherine E Costello and Nader Rahimi. “Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis” Science Signaling, Dec. 2013. This paper describes a major breakthrough in the filed of signal transduction. Prior to publication of this work, it was thought that protein phosphorylation is the only mechanism controls activation of receptor tyrosine kinases (RTKs). The work by Edward Hartsough et al., for the first time demonstrates that protein methylation primes RTKs for phosphorylation and subsequent activation which leads to biological responses such as tumor angiogenesis

    Publications: PUBLISHED: 

    • Agbemenyah HY, Agis-Balboa RC, Burkhardt S, Delalle I, Fischer A: “Insulin growth factor binding protein 7 is a novel target to treat dementia” Neurobiol Dis 2013 Sep 25;62C:135-143. doi 10.1016/j.nbd.2013.09.011. PMID: 24075854.
    • Boyd JD, Lee-Armandt JP, Feiler MS, Zauur N, Liu M, Kraemer B, Concannon JB, Ebata A, Wolozin B, Glicksman MA; A High-Content Screen Identifies Novel Compounds That Inhibit Stress-Induced TDP-43 Cellular Aggregation and Associated Cytotoxicity” J Biomol Screen. 2013 Sep 9
    • Amy Leung, Shirley K. Nah, Whitney Reid, Atsushi EbataClarissa M. Koch, Stefano Monti, Joseph C. Genereux, R. Luke Wiseman, Benjamin Wolozin, Lawreen H. Connors, John L. Berk, David C. Seldin, Gustavo Mostoslavsky, Darrell N. Kotton, George J. Murphy “Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis” Stem Cell Reports, 31 October 2013

    October 2013

    Published: October 28th, 2013

    Immuno Nov 2013

    Pathology & Laboratory Medicine News Items –

    Announcements:

    • Faculty Appointments and/or Promotions:
      • Dr. Yuriy Alekseyev was promoted to Research Associate Professor
      • Dr. Shinichi Takayama has been appointed as Research Associate Professor
    • Immunology has selected an image from an article authored by Dr. Zhaohua Lu and colleagues, published in this month’s Immunology for the journal cover (see photo and link to article) http://onlinelibrary.wiley.com/doi/10.1111/imm.12150/full
    • The Martin Steffen Lab presented a talk on their work on biomarkers for Prostate Cancer at the 2013 meeting for the New England Section of the American Urological Association in Hartford, Connecticut on September 26 – 28 Towards Reducing the Number of Prostate Biopsies – Biomarkers to Identify Patients with Benign Causes of Elevated PSA LevelsAgnes Bergerat, PhD1, Yi-Chien Chang, MS2, Mark Katz, MD1, David Wang, MD1, Simon Kasif, PhD2, Richard Babayan, MD1Martin Steffen, MD, PhD1
    • Dr. Daniel Remick will be giving a lecture on October 28th at the Brigham & Women’s Hospital entitled, “Mechanisms of Alcohol Triggered Asthma”
    • Dr. Carmen Sarita-Reyes is now Board Certified in Pediatric Pathology

    Publications: PUBLISHED:

    • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D.,Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., Jason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary Hunter, M. A. “MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia” New England Journal of Medicine; 367;9 nejm.826 org august 30, 2012
    • Lian Xu,1,2  Zachary R. Hunter,1,2 Guang Yang,1,2 Yangsheng Zhou,1,2 Yang Cao,1,2 Xia Liu,1,2 Enrica Morra,3 Alessandra Trojani,3 Antonino Greco,3 Luca Arcaini,4 Marzia Varettoni,4 Jennifer R. Brown,5 Yu-Tzu Tai,2,6 Kenneth C. Anderson,2,6 Nikhil C. Munshi,2,6 Christopher J. Patterson,1 Robert J. Manning,1 Christina K. Tripsas,1 Neal I. Lindeman,2,7 and Steven P. Treon1,2 “MYD88 L265P in Waldenstr¨om macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction” BLOOD, 14 MARCH 2013 x VOLUME 121, NUMBER 11
    • Steven P. Treon1,2 and Zachary R. Hunter1,2 “A new era for Waldenstrom macroglobulinemia: MYD88 L265P,” BLOOD, 30 MAY 2013 x VOLUME 121, NUMBER 22
    • Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. “The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.” Immunology. 2013 Nov;140(3):374-389. PMID: 23844703

    September 2013

    Published: September 26th, 2013

    Pathology & Laboratory Medicine News Items –

     Announcements:

    • CAP (College of American Pathologist) 2013, Orlando Florida, October 13-16, 2013; Accepted:
      • “Validation Of Pre-transfusion Compatibility Testing In PEG In A Semi-automated Transfusion Service” (Poster No. 98 – p 1371) – Josenia Tan and Karen Quillen – Abstract accepted to CAP 2013, poster presentation
      • “Benign Epithelial Inclusions In Axillary Lymphnodes” (Poster No. 69 – p 1452) - Anita Deshpande, MD; Josenia Tan, MD; Melinda Lerwill, MD; Grace Zhao, MD; selected abstract for poster presentation at CAP ’13.
      • “Utility Of Fetal Tissue Examination in Intrauterine Fetal Demise Autopsies;” (Poster No. 95 – p 1508)
      • Cathryn Byrne-Dugan, MD, et al – Abstract accepted to CAP 2013, poster presentation
      • From Dr. Carmen Sarita-Reyes: on page 166: http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2013-0354-AB; presented by Yue Sun, MD and Antonio de las Morenas, MD; “Anaplastic Thyroid Carcinoma and Potential Therapeutic Target” (Poster No. 152 – p 1525)
    • Dr. Daniel Remick was the Keynote Speaker, 15th Congress of the European Shock Society, Vienna Austria, September 2013; “Sepsis, When you die we want to know why”
    • Dr. Remick also participated in “Meet the Expert, Ludwig Boltzmann Institute of Traumatology,” Vienna Austria in September 2013
    • Daoreuang Pongvongkeo, Angel Lui, Genevieve Matnog, and John Lee from the Hematology Lab have validated a new automated urinalysis platform, the iRICELL Plus, that went live 9/9/13. This new automated platform will improve efficiency in performing and releasing urinalysis results.
    • Dr. Barbara Nikolajczyk presented her teams’ work “Lymphocytes regulate inflammation in human type 2 diabetes” at the Aegean Conference on Immunometabolism in Rhodes, Greece, September 17, 2013
    • Dr. Barb Nikolajczyk also presented her teams’ work “Roles of B cells in type 2 diabetes and T2D-associated periodontal disease” at the Forsyth Institute in Cambridge, MA September 26, 2013
    • Dr. David Sherr was featured in an article in International Innovations in which I discuss the role of the environment in breast cancer progression. See the URL below. http://www.bumc.bu.edu/immunology/files/2006/10/Final-High-resolution-p93-95_David_Sherr.pdf
    • Dr. Daniel Remick was the Keynote Speaker, at the 11th Annual Advances in Inflammation Research, Brown University, September 26th & 27th; “The roles of adenosine and antibodies in sepsis”
    • Daniel Remick, MD is the Chair and invited speaker, 46th Annual Meeting of the Society for Leukocyte Biology, Providence Rhode Island, “Leukocytes and mediators that influence survival”
    • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
    • Resident Manisha Mehta, MD has had her abstract, ‘Vitreous cytology: A diagnostic glimpse into the eye’ Manisha Mehta, MD; Reena Rashid, MD; Stephen Foster, MD; Nora Laver, MD, accepted as a talk at the 2013 AAOOP (American Association of Ocular Oncologists and Pathologists) Annual Meeting, “Memorial Celebration of the Life and Work of Dr. Lorenz E. Zimmerman with Anastasia Zimmerman” on November 15th in New Orleans
    • The Nikolajczyk Lab has received a 1 year Diabetes Complications Consortium Grant from the NIH
    • Welcome to our NEW dedicated Residency Program Coordinator, Mark Uva!

    August 2013

    Published: September 5th, 2013

    Pathology & Laboratory Medicine News Items –

     

    Announcements:

    • Chad Mayer, MD/PhD Student in the Kurosawa Lab is the recipient of the 2014, MD/PhD Student Conference Diversity Award from the Medical Sciences Training Program; and he received a check for $500.00
    • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
    • Dr. Shinichiro Kurosawa received an NIH/NIAID R01 award to continue his laboratory’s basic and translational research with enterohemorrhagic E.coli and the bacterial toxins
    • Nancy S. Miller, MD will present Grand Rounds at the University of Massachusetts, Lowell, in October
    • Dr. David Sherr’s Lab, along with Stefano Monti’s, was awarded a supplement to their Superfund Research Program to apply computational biology and high throughput genomics to define transcriptional signatures of carcinogenicity
    • Dr. Barbara Nikolajczyk:
      • has been invited to give a Seminar at the 2nd Aegean Conference on Immunometabolism meeting, Rhodes, Greece, September 2013. “Lymphocytes regulate inflammation in human type 2 diabetes”
      • Dr. Nikolajczyk will also serve on the HAI (Hypersensitivity, Allergy and Immune-mediated diseases) study section in October 2013
      • Dr. Barbara Nikolajczyk has also been invited to co-chair and speak in a Major Symposium at the American Association of Immunologists meeting in Pittsburgh, PA in May 2014

    Publications: PUBLISHED:

    • Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ.”NELF coordinates RNA polymerase II pausing, premature termination and chromatin remodeling to regulate HIV transcription.” J Biol Chem. 2013 Jul 24

    July 2013

    Published: August 15th, 2013

    Pathology & Laboratory Medicine News Items

    Announcements:

    • Nancy S. Miller, MD will be President-elect of the Northeast Branch of the American Society for Microbiology, for the one-year term commencing July 1, 2013
    • Daniel Remick, MD was elected to chair the Research Committee of the Association of Pathology Chairs. With this election he will continue as a member of council
    • Parul Agnihotri, PhD Candidate, has been invited to attend the International Graduate Student Immunology Conference in Marseilles, France from August 29-31st. The conference will be take place at the Centre d’Immunologie de Marseille-Luminy (CIML). The title of Parul’s talk will be: “Foxo1: A Potential Target of Ikaros in Regulating Peripheral CD4 T Cell Development”
    • Daniel Remick, MD was an invited speaker at the 2013 Annual Meeting of the Association of Pathology Chairs in the session on Benchmarking Academic Pathologists. His presentation was on using the CARTS methodology to determine budgeting. The APC Meeting was held in Boston this year from July 9 – 12, 2013
    • Cytology Fellow, Josenia Tan, MD, successfully passed her AP and CP Boards; congratulations Joy!

     

    Publications: ACCEPTED:

    • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology (In Press)
    • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. (In Pres)
    • Paper accepted in PLoS Biology describing our efforts to build a community of computational and experimental biologists collaborating to experimentally validate gene function: “The COMBREX Project: Design, Methodology, and Initial Results;” Brian P. Anton, Yi-Chien Chang, Peter Brown, Han-Pil Choi, Lina L. Faller, Jyotsna Guleria, Zhenjun Hu, Niels Klitgord, Ami Levy-Moonshine, Almaz Maksad, Varun Mazumdar, Mark McGettrick, Lais Osmani, Revonda Pokrzywa, John Rachlin, Rajeswari Swaminathan, Benjamin Allen, Genevieve Housman, Caitlin Monahan, Krista Rochussen, Kevin Tao, Ashok S. Bhagwat, Steven E. Brenner, Linda Columbus, Valérie de Crécy-Lagard, Donald Ferguson, Alexey Fomenkov, Giovanni Gadda, Richard D. Morgan, Andrei L. Osterman, Dmitry A. Rodionov, Irina A. Rodionova, Kenneth E. Rudd, Dieter Söll, James Spain, Shuang-yong Xu, Alex Bateman, Robert M. Blumenthal, J. Martin Bollinger, Woo-Suk Chang, Manuel Ferrer, Iddo Friedberg, Michael Y. Galperin, Julien Gobeill, Daniel Haft, John Hunt, Peter Karp, William Klimke, Carsten Krebs, Dana Macelis, Ramana Madupu, Maria J. Martin, Jeffrey H. Miller, Claire O’Donovan, Bernhard Palssøn, Patrick Ruch, Aaron Setterdahl, Granger Sutton, John Tate, Alexander Yakunin, Dmitri Tchigvintsev, Russell Greiner, David Horn, Kimmen Sjölander, Steven L. Salzberg, Dennis Vitkup, Stanley Letovsky, Daniel Segrè, Charles DeLisi, Richard J. Roberts, Martin Steffen, Simon Kasif