Department of Pathology and Laboratory Medicine Spring 2015 Seminar Series: Friday, February 6,
Department of Pathology and Laboratory Medicine
Spring 2015 Seminar Series: Friday, February 6, 2:00
9th Annual Nancy L.R. Bucher, MD, Seminar
“Engineering Liver Tissue at the Microscale”
Friday, February 6, 2:00 (Reception Following) 670 Albany Street – Lobby Level #107/108
Dr. Sangeeta Bhatia, MD, PhD
John J. and Dorothy Wilson Professor of Health Sciences and Technology & Electrical Engineering and Computer Science;
Director, Laboratory for Multiscale Regenerative Technologies;
Massachusetts Institute of Technology
Program Director, Barbara Slack, PhD
Program Coordinator: Debra Kiley, 414-7914
Pathology & Laboratory Medicine News Items
- Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “Overcoming the resistance to anti-angiogenesis therapy”. The overall of goal of this research is to study the role of posttranslational modifications on VEGFR-2 in colon cancer. Angiogenesis inhibitors targeting the VEGF signaling pathway have been FDA approved for various cancer treatments. Although beneficial, patients inevitably develop resistance and often fail to demonstrate significantly better overall survival. Interfering with the posttranslational modifications of VEGFR-2 may overcome refractoriness and resistance to certain class of anti- cancer drugs.
- Dr. Daniel Remick was an invited speaker to Loyola University Medical Center in Chicago, December 9/10, 2014:
- Dr. Remick presented Grand Rounds in the Department of Surgery at Loyola – “Brain Injury Prevents Pneumonia – Who knew?”
- He also gave a lecture to the Department of Pathology “Physician Scientist Pathway in Pathology”
- Dr. Remick, as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago presented, “Inhibitory IgG Increases Sepsis Mortality”
- Dr. Chris Andry, of Boston University USA, visited Professor Rodger Charlton, and other colleagues in the Division of Primary Care, Nottingham University, United Kingdom on 9th December, 2014 . During his visit, Dr. Andry gave a talk entitled “The Value of a Centralized Hospital Bereavement Office Supporting Multicultural Families in the USA”
- Jenny McEldoon, BU Undergrad working in the Remick Lab has been awarded funding from UROP for Spring 2015!
- Zachary Hunter, PhD, Steve Treon Lab at Children’s Hospital, successfully defended his thesis “Whole Genome Sequencing Reveals that Recurrent MYD88 and CXCR4 Mutations Underlie the Genomic Landscape of Waldenström’s Macroglobulinemia” on Tuesday, December 2nd
- Inge The, Suzan Ruijtenberg, Benjamin Bouchet, Alba Cristobal, Martine B.W. Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J.R. Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Munoz, and Sander van den Heuvel, Rb and the APC/C co-activator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells. Nature Communications
- Akifumi Fujita, Huihong Xu, Yu-Ming Chang, Scharukh Jalisi, and Osamu Sakai, Best cases from the AIRP: Malignant mixed tumor of the hard plate. RadioGraphics
- Authors: Blanche C. Ip, Andrew E. Hogan, Barbara S. Nikolajczyk; Lymphocyte roles in metabolic dysfunction: of men and mice Trends in Endocrinology and Metabolism
- Michael J. Greene, Elena S. Klimtchuk, David C. Seldin, John L. Berk, and Lawreen H. Connors; “Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal” Biochemistry
- Stevenson EK, Sloan KA, Narsule CK, Kretschman DM, Sarita-Reyes CD, Steiling K, Ebright MI. Catamenial hemothorax in a patient with multiple sclerosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):e69-70
- Zhang Q, Siroky M, Yang JH, Zhao Z and Azadzoi K “Effects of ischemia and oxidative stress on bladder purinoceptors expression” Urology, 2014 Nov;84(5):1249.e1-7. doi: 10.1016/j.urology.2014.07.023
Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st.
Pathology & Laboratory Medicine News Items
- Kate Murphy has announced that the Blood Bank had its’ 4th inspection of the year – American Association of Blood Banks (AABB) on November 19th and 20th for an extremely thorough assessment, including nursing competency. We were successfully accredited for another 2 years!
- Zach Hunter, PhD Candidate in the Steven Treon’s Lab at Children’s Hospital presented at the following conferences:
- August 14th in London, UK. At the 8th International Workshop on Waldenstrom’s Macroglobulinemia. His oral presentation was entitled: “Genomic Landscape of WM”
- August 17th in London, UK, WMUK’s 5th International Doctor Patient Forum “Making Sense of Key Information about your WM: MYD88, CXCR4 and the Genetics of WM”
- Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st
- Zach Hunter also received a grant in his own name; “Identification of Germline and Somatic Variants Associated with Predisposition to WM” from the International Waldenström’s Macroglobulinemia Foundation
- Barb Nikolajczyk, PhD presented:
- “Immunometabolism, Lymphocytes and Obesity” at The Obesity Society annual meeting in Boston, MA on November 6th
- “Lymphocytes in Human Obesity and Type 2 Diabetes” at the Evans Center/Whitaker mini-symposium on Immune Cells and Metabolism on November 21st
- David Kindelberger, MD (along with colleague Eric Huang from the University of California, Davis) presented a workshop titled “2012 Updated ASCCP Consensus Management Guidelines for Women with Abnormal Cervical Cancer Screening Tests” at the 62nd Annual American Society of Cytopathology Scientific Meeting on November 17th in Dallas
- Daniel Remick, MD was given a water pitcher to acknowledge his serving on the Society for Leukocyte Biology Council, and serving as the Program Chair for the 2014 Annual Leukocyte Biology Meeting. The 2014 meeting in Salt Lake City was a joint meeting between Leukocyte Biology and the International Endotoxin and Innate Immune Society.
- Mostafa Belghasem, PhD Candidate, Henderson Lab:
- Presented a poster entitled “Heterozygous Actn4 Mutant Mice are Susceptible to Glomerulopathy when Subjected to Hemodynamic Stress” at American Society of Nephrology (ASN) Kidney Week 2014 in Philadelphia, PA, November 11-16, 2014
- Mostafa was also selected to participate in the ASN 2014 Kidney STARS program and received a Travel Award from the ASN
- Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R.Rifkin and Adam Lerner; “Type 4 cyclic nucleotide phosphodiesterase inhibitors block intracellular Toll-like receptor signaling in chronic lymphocytic leukemia and normal hematopoietic cells”. Journal of Immunology
- Anastasia Gomez, Nancy S. Miller, and Irina Smolina. Visual detection of bacterial pathogens via PNA-based padlock probe assembly and isothermal amplification of DNAzymes. Analytical Chemistry, Publication Date (Web): 21 Nov 2014
- Castillo JJ, Olszewski AJ, Cronin AM, Hunter ZR, Treon SP. Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database. Blood. 2014 Jun 19;123(25):3999–4000. PMID: 24948623
- Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Patterson CJ, Tsakmaklis N, Kanan S, Rodig S, Castillo JJ, Treon SP. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia. Leukemia. 2014 Jun 10; PMID: 24912431
- Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. Possible resting metabolic rate modification by the circulating RBP4 in obese subjects. Diab Met Syndr: Clin Res Rev (Oct, 2014)
- Treon SP, Hunter ZR, Castillo JJ, Merlini G. Waldenström Macroglobulinemia. Hematol Oncol Clin North Am. 2014 Oct;28 (5):945–970. PMID: 25212891
- Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Tsakmaklis N, Kanan S, Castillo JJ, Treon SP. CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells. Br J Haematol. 2014 Nov 5;
- Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH (2014) Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genet. 2014 (e-Pub ahead of print) PMID: 25367359
Pathology & Laboratory Medicine News Items
- Jessica (Allen) Ritter, PhD Candidate, Genco Lab, presented a poster at XIXth International Pathogenic Neisseria Conference October 12th-17th in Asheville, NC. The poster is entitled; “Neisseria gonorroheae modulates immune cell survival through pyroptosis.” Authors are Jessica Ritter, Kathleen Goodmon, and Caroline Genco.
- Evan Chiswick, PhD, Remick Lab was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, October 23rd-25th in Salt Lake City, Utah. also received a travel award. The title of his talk was “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity” Evan also received a Travel Award, bravo!
- Daniel Remick, M.D., served as the program chair for the 2014 joint meeting of the Society for Leukocyte Biology and the International Endotoxin and Innate Immunity Society. The meeting had nearly 250 participants from across the world and was held in Salt Lake City, Utah.
- David Sherr, M.D. has received an award from the Art Because Breast Cancer Foundation. http://www.bostonglobe.com/metro/2014/10/15/team-boston-researchers-will-study-environment-relation-breast-cancer/Bg6nMAlvWIVBNJfBbpat3L/story.html?s_campaign=8315
- Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, Clinton T. Baldwin, David C. Seldin, Lawreen H. Connors. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genetics
- Tiffany J. Mellott, Sarah M. Pender, Rebecca M. Burke, Erika A. Langley, Jan Krzysztof Blusztajn; “IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice” PLOS, April 2014. http://www.ncbi.nlm.nih.gov/pubmed/?term=Mellott%20TJ%5Bauth%5D\
- Erika A. Langley1, Marina Krykbaeva1, Jan Krzysztof Blusztajn, Tiffany J. Mellott; “High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T + Itpr3tf/J mouse model of autism.” Behavioural Brain Research; Volume 278, 1 February 2015, Pages 210–220
- Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. “Possible resting metabolic rate modification by the circulating RBP4 in obese subjects.” Diab Met Syndr: Clin Res Rev (Oct, 2014)
- Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. “Targeting receptor tyrosine kinases and their downstream signaling with cell penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.” Chem Biol Drug Des. 2014 Oct 8.
- O’Brien, MJ, Zhao, Q, Yang, S. “Colorectal Serrated Pathway Cancers And Precursors” Histopathology. 2014 Sep 29. doi: 10.1111/his.12564
Pathology & Laboratory Medicine News Items
- CAP (College of American Pathologists) 2014, September 7-10 in Chicago, Illinois:
- Resident Yanli Ding, MD presented a poster titled as “Gastroenteric biopsies in patients with rare immunodeficiency syndromes –two case reports and literature review” for the CAP 2014 Annual Meeting
- Resident Dr. Anita Malek’s poster was titled; “Immunohistochemical Approaches to Poorly Differentiated Tumors of Unknown Origins ” Authors: Anita Malek, MD , Qing Zaho, MD, PhD
- Resident Dr. Yue Sun also presented a poster entitled “Epithelioid hemangioma of the penis: a case report,” Yue Sun, Qing Zhao
- Post-doc Evan Chiswick, Remick Lab was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, in Salt Lake City, Utah, October 23-25, 2014. Dr. Chiswick also received a Travel Award. The title of his talk is “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity”
- Dr. Barbara Nikolajczyk has been selected for the 2014 Evans Center Research Collaborator Award. The award will be presented during the Evans Day Gala Dinner, Oct 16, 2014
- Brittany Mailhot and Diane Mullen participated in the Jimmy fund Walk with the Dana Farber Facilitating Hope team. Former BMC employees who also participated are Audrey Quinn and Janet Means. Former Patriot’s player Matt Light is the man in the photo with us!
- Please welcome the new post-doctoral fellow in the Kurosawa lab, Dr. Ji-Hye (“jee-hay”) Seo. Dr. Seo comes to us from BIDMC where she studied signaling pathways important in development of gastric cancer from chronic Helicobacter pylori infection. She earned her master’s and doctoral degrees from Yonsei University College of Medicine in South Korea (high honors) and lives with her family in Wellesley. Please introduce yourself and lend a hand as she gets settled.
- Ivana Delalle, MD, PhD is teaching a new GMS course in the Spring entitled “Human Biospecimens for Research,” PA 910.
- The objective of this course is to introduce students to the creation, maintenance and efficient use of an indispensable component of translational research in medicine: human biological material (human tissue and bodily fluids) = human biospecimens and their derivatives. Lectures from faculty from Pathology Departments at Yale, Harvard and Columbia (new York Brain Bank, NYBB), and from Boston University School of Medicine with extensive experience in human bio-specimens generation, maintenance, and utilization, will instruct how to successfully obtain and utilize human bio-specimens. ~~~
- Topics will include logistics and legal aspects of creating and sustaining bio-banks, federal and institutional regulatory and funding mechanisms, and concrete examples of human bio-specimens use to generate break-through data in specific field of biomedical research. Special attention will be given to human biospecimens used in neuroscience as four neuropathologists/neuroscientists from Harvard, Yale, Columbia and Boston University are enlisted as speakers to give comprehensive overview of biospecimens utilized in neurodegenerative diseases and brain tumors.
- Karen Quillen, MD is also teaching a new seminar entitled “Blood & Money” in the Kilachand Honors College on the Charles River Campus, with Professor Michael Salinger from the BU School of Management
- Dr. Nader Rahimi was invited to give a lecture at the Department of Biochemistry, Boston University on September 16. The title of his lecture was “Emerging Roles of Posttranslational Modifications in Receptor Tyrosine Kinase Activation and Signaling”.
- Dr. Rahimi gave a similar lecture on September 24, 2014 at the University Massachusetts, Lowell.
- Dr. Rahimi is also invited to give a lecture at the upcoming Boston Angiogenesis Meeting, on November 12, 2014. For additional information, please see the link: (http://lawsonlab.umassmed.edu/BAMspeakersAM.html).
- Dr. Lija Joseph recently was awarded the ICPI MSIG Award for her Medical Student Interest Group from the intersociety council for pathology information. Dr. Joseph plans to incorporate our residents in the grand funded program.
- Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease, Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press).
Pathology & Laboratory Medicine News Items
- New Grant Funding in Pathology:
The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the
period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department
and it would be appropriate to share the specifics of these new grants.
|Co-Investigator||Jan Krzysztof Blusztajn|
|Number||1 I01 BX001875-01|
|Title||Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy|
|Description||The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.|
|Co-Investigator||Jan Krzysztof Blusztajn|
|Number||1 I01 BX002468-01|
|Title||Novel neurotrophic therapies in an optimized mouse model of GWVI|
|Description||The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.|
|PI||Jan Krzysztof Blusztajn|
|Co-Investigator||Tiffany Mellott, Barbara Slack, Ivana Delalle|
|Title||BMP9 as a juvenile protective factor in cognitive aging|
|Description||The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.|
|Title||Development and Treatment of Pre-Clinical EHEC Models with HUS|
|Description||Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children. There is no treatment available, other than supportive care. Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic. The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.|
|Title||Role of c-Cbl in Colon cancer|
|Description||The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase|
|Title||Mechanisms of phagocytic cell defects induced by inhibitory IgG|
|Description||We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.|
|Title||Alcohol Triggered Asthma: Mechanisms of Neuronal Control|
|Description||The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.|
|Title||Mechanism of Notch-induced leukemogenesis in lymphocytes|
|Description||Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention. This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.|
Welcome to our New Graduate Students:
- Stephanie Adams, OD/PhD
- Lois Bayigga, Masters
- Evan Catudal, Masters
- Junbo Chen, Masters
- Yuri Kim, PhD
- Asha Melo, Masters
- Tim Norman, PhD
- Ruoyu Tian, Masters
- BJ Varian, Masters
- From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
- Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
- Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.
- Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
- Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)
- Recent publication from Panchenko Lab (by Siriwardana et al, “Cell cycle-dependent chromatin shuttling of HBO1–JADE1 histone acetyl transferase (HAT) complex” https://www.landesbioscience.com/journals/cc/article/28759/) has been featured in the News & Views section of the Journal: “HBO1:JADE1 at the cell cycle chromatin crossroads” Comment on: Siriwardana NS, et al. Cell Cycle 2014; 13: 1885-1901; PMID: 24739512; by Brian R Calvi; Department of Biology; Indiana University; Bloomington, IN USA; https://www.landesbioscience.com/journals/cc/article/29832/
- Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of
Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease” on Wednesday, July 16, 2014
Chad Mayer, from the Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014