Pathology & Laboratory Medicine News Items -
- Antonio de las Morenas, M.D., Professor of Pathology and Laboratory Medicine has been recognized by Boston magazine as a Top Doc in Boston. According to BU Today, “To be included in Boston magazine’s Top Doc list, physicians undergo a rigorous screening process by national medical research firm Castle Connolly. The firm gathers nominations online from other licensed physicians, conducts phone interviews with medical professionals to corroborate nominations, and checks the professional qualifications of all nominees . . .”
The list of pathologists in Boston in the top docs may be found here: http://www.bostonmagazine.com/specialty/pathology/
○ From Dr. Daniel Remick, Department Chair: the Department of Pathology and Laboratory Medicine is pleased to announce that Susan Winandy, Ph.D., will become the Director of Graduate Studies in January, 2014. Dr. Winandy is the Nancy Bucher Assistant Professor of Pathology and Laboratory Medicine. She is a member of the Immunology Training Program at Boston University and her work focuses on the study of the protein Ikaros in T cell development and function. The Department thanks Nader Rahimi, Ph.D. for his efforts over the years to the mentoring and growth of our graduate students.
- Dr. Ivana Delalle will be directing a new graduate course, GMS PA-910 “Human Biospecimens for Research” approved by Academic Policy Committee in November
- Also Dr. Ivana Delalle presented a poster entitled “Differential expression of exosomal miR-29c and miR-149 in brain tissue of bipolar disorder patients and rat model of depression” by Zhan Y1, Kozubek J1, Kao P1, Rezvani A2, and Delalle I1, 1Boston Univ. Sch. Of Med., BOSTON, MA, 2Duke University, DURHAM, NC, at the Society for Neuroscience Meeting in San Diego, California on November 11, 2013
- Nancy S. Miller, M.D. directed the “Molecular Micro Grand Slam!” sponsored by the Northeast Branch – American Society for Microbiology, December 6th, at Bristol Community College, Fall River, MA. The all-day seminar featured lectures in molecular theory & laboratory applications, and a hands-on practical workshop emphasizing good molecular techniques. Workshop faculty also included Beverley Orr, MT(ASCP) and Valerie Kosick, M(ASCP)CM from the BMC Clinical Microbiology Laboratory, and Marisa Chattman M.S., SM (ASCP)CM from Tufts Medical Center
- Dr. Ivana Delalle was an invited lecturer at Goettingen University Medical Center, Germany (invitation by Dr. Andre Fischer, Professor at European Neuroscience Institute) on December 19; “Human biospecimens data sharing in NIH- funded international collaborative projects”
- PhD Candidate, Zach Hunter presented the following posters at the American Society of Hematology Annual Meeting, December 7-10; New Orleans, Louisiana:
- “Highly Recurrent Copy Number Alterations and Insight Into The Origins Of 6q Deletions In Waldenström’s Macroglobulinemia Revealed By Whole Genome Sequencing;” Zachary Hunter, Lian Xu, Guang Yang, Xia Liu, Yang Cao, Robert Manning, Christina K Tripsas, Christopher Patterson and Steven Peter Treon
- “Somatic Activating Mutations In CXCR4 Are Common In Patients With Waldenstrom’s Macroglobulinemia, and Their Expression In WM Cells Promotes Resistance To Ibrutinib;” Yang Cao, Zachary Hunter, Xia Liu, Lian Xu, Guang Yang, Christina K Tripsas, Robert Manning, Christopher Patterson and Steven Peter Treon
- “Telomerase Contributes To Repair Of DNA Breaks In Myeloma Cells By Incorporating “TTAGGG” Sequences Within Genome: Biological and Translational Significance;” Jagannath Pal, Jie Ding, Subodh Kumar, Zachary Hunter, Teresa Calimeri, Jianhong Lin, Maria Gkotzamanidou, Giovanni Parmigiani, Steven Treon, Masood Shammas, and Nikhil Munshi
- “Detection Of MYD88 L265P In Peripheral Blood Of Patients With Waldenström’s Macroglobulinemia and IgM Monoclonal Gammopathy Of Undetermined Significance;” Lian Xu, Zachary Hunter, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert Manning, Christopher Patterson, Christina K Tripsas, Sandra Kanan, Jiaji G Chen, Neil I Lindeman, and Steven Peter Treon
- Barbara Nikolajczyk, PhD became an Editor of a new multi-disciplinary journal entitled “Discoveries”
- Zachary R. Hunter , Lian Xu, Guang Yang, Yangsheng Zhou, Xia Liu, Yang Cao, Robert J Manning, Christina K Tripsas, Christopher J Patterson, Patricia Sheehy, and Steven P Treon; MYD88, WHIM-like CXCR4, and Somatic Deletions Associated with B-cell Lymphomagenesis Characterize the Genomic Landscape of Waldenstöm’s Macroglobulinemia. BLOOD
- Zhu, M and Nikolajczyk, BS. 2014. Immune cells define the inter-relationship between obesity and periodontitis Journal of Dental Research (In Press)
- Raval, F, and Nikolajczyk, BS. 2014. The Bidirectional Relationship between Metabolism and Immune Responses. Discoveries (In press)
- Zhu, M and Nikolajczyk, BS. 2014. Immune cells link obesity-associated type 2 diabetes and periodontitis. Journal of Dental Research (In press).
- Anna Eisenstein, Lev Vaisman, MASc, Hillary Johnston-Cox, Alexander Gallan, MD, Kitt Shaffer, MD, PhD, Deborah Vaughan, PhD, Carl O’Hara, MD, and Lija Joseph, MD “Integration of Basic Science and Clinical Medicine: The Innovative Approach of the Cadaver Biopsy Project at the Boston University School of Medicine” The cadaver biopsy project at Boston University School of Medicine links students’ first basic science experiences in gross anatomy with other basic science courses and later clinical course. The paper on cadaver project is in ePub version (innovation report), and will be in print in the January issue of Academic Medicine
- Craciun FL, Iskander KN, Chiswick EL, Stepien DM, Henderson JM, Remick DG: “Early Murine Polymicrobial Sepsis Predominantly Causes Renal Injury,” Shock 2013, PMID: 24300829
- Bauza G, Moitra R, Remick D: “Adenosine Receptor Antagonists Effect on Plasma Enhanced Killing,” Shock 2013, PMID: 24089004
- King EG, Bauza GJ, Mella JR, Remick DG: “Pathophysiologic mechanisms in septic shock,” Lab Invest 2013, PMID: 24061288
- Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG: “Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding,” Physiol Rev 2013, 93:1247-1288, PMID: 23899564
- Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP: “Roles of STAT3 in protein secretion pathways during the acute-phase response,” Infect Immun 2013, 81:1644-1653, PMID: 23460517
Pathology & Laboratory Medicine News Items –
- 36th ANNUAL CONFERENCE ON SHOCK, June 1 – 4, 2013, San Diego, California:
- PhD Candidates Evan Chiswick, Dominic Beal, and Surgical Resident/Researcher Juan Rodolfo Mella Remick Lab will present a poster; “Too Zealous Too Soon: The Shift from Hyper to Hypo Reactive Phagocytes in Polymicrobial Sepsis”
- Chad Mayer, MD/PhD candidate, Kurosawa Lab, has an abstract accepted for ORAL presentation at the 2013 Shock Society meetings in San Diego. His abstract is entitled” DAMPs and endothelial dysfunction in a mouse model of Stx2 toxemia” by authors CL Mayer, CS Leibowitz, S Kurosawa, DJ Stearns-Kurosawa.
- Caitlin Leibowitz, PhD candidate, Kurosawa Lab, has an abstract accepted for POSTER presentation at the 2013 Shock Society meeting in San Diego. Her abstract is entitled “Neutropenia delays acute kidney injury in a murine Stx2 toxemia model” by authors C.S. Leibowitz, C.L. Mayer, S. Kurosawa, D.J. Stearns-Kurosawa.
- Daniel Remick, M.D. was invited to give talk “Oxidante Regulation of Chemokine Gene Expression”
- Daniel Remick, M.D. helped organize a panel discussion by all 5 level 1 trauma centers in the city of Boston to discuss the trauma center’s experience with the Marathon Day bombings.
- Daniel Remick, M.D., chaired the International Relations Committee and served as a member of council and Past-President of the Society.
- Daniel Remick, M.D., organized the annual fun run, always a highlight of the meeting.
- From the Remick Lab: PhD Candidate Evan Chiswick and Surgical Resident Juan Rodolfo Mella each received a Travel Award to attend next month’s SHOCK Conference in San Diego, California
- David Stepien , MD/PhD, successfully defended his thesis “The Immune Response to Bacterial Pneumonia Following Traumatic Brain Injury” on Thursday, May 16th
- MD/PhD Candidate Melody Lun has been awarded a grant from the American Federation for Aging Research (AFAR). The official title of the scholarship is “Glenn/AFAR Scholarship for Research in the Biology of Aging”
- PhD Candidate Mostafa Belghasem received a fellowship (travel award) to attend the Intravital Microscopy Workshop at Indiana University Medical Center; this workshop was the week of May 5th
- Barb Nikolajczyk, PhD was an invited to present at several events for May 2013:
- Childrens Hospital Los Angeles, Childrens Center for Cancer and Blood Diseases, Los Angeles, CA, Human B lymphocytes are master regulators of a pro-inflammatory T cell balance in type 2 diabetes, 2013.
- University of California at Los Angeles, Los Angeles, CA, Human B lymphocytes are master regulators of
- American Association of Immunologists Annual Meeting, Honolulu, HI, Lymphocyte functions in type 2 diabetes, 2013.
- University of Chicago, Department of Pathology. B lymphocytes regulate a pro-inflammatory T cell balance in human type 2 diabetes, 2013.
- A recent manuscript from the Kurosawa and Henderson labs, in collaboration with a group at Texas A&M was discussed in the May issue of the Kidney International Journal Club (Kidney International (2013) 83, 775–776. doi:10.1038/ki.2013.116). This journal highlights the latest research from across a wide spectrum of journals in fields relevant to renal research. The Kurosawa-Henderson manuscript identified differences in renal pathology elicited by toxins from enterohemorrhagic E.coli, a food and water-born pathogen, and supports the notion that therapeutic targeting of both bacterial toxins is of value.
- Nancy S. Miller, MD lead a presentation and audience interactive session at the AACC Trimark Infectious Disease Conference on May 31, 2013 in Randolph, MA. “Point of Care Meets Microbiology: What we have, what we need, what is on the way? Preparing for the next frontier of point-of-care” In collaboration with Jean Ahern, C(ASCP) POC Specialist at BMC.
- Dr. Carmen Sarita –Reyes has been appointed a member of the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee. Dr. Sarita-Reyes will be attending her first meeting from May 28th – 31st 2013 in Chicago, Illinois.
- Dr. Kazem Azadzoi presented a moderated poster entitled “Sleep apnea causes bladder oxidative stress and nocturia in rats” at the American Urological Association (AUA) annual meeting in San Diego
- Dr. Kazem Azadzoi also presented a moderated poster entitled “Upregulation of P2X purinergic receptors in bladder oxidative stress augments smooth muscle contractions” at the American Urological Association (AUA) annual meeting in San Diego
- Han-Pil Choi, Silvia Juarez, Sergio Ciordia, Marisol Fernandez, Rafael Bargiela, Juan P. Albar, Varun Mazumdar, Brian P. Anton, Simon Kasif, Manuel Ferrer, Martin Steffen. “Biochemical Characterization Of Hypothetical Proteins From Helicobacter pylori” PLoS One
In this paper, we present here the biochemical analysis of six proteins from Helicobacter pylori ATCC 26695. The functional characterization of Open Reading Frames (ORFs) from sequenced genomes remains a bottleneck in our effort to understand microbial biology. In particular, the functional characterization of proteins with only remote sequence homology to known proteins can be challenging, as there may be few clues to guide initial experiments. We provide a path towards this problem using affinity enrichment of proteins from cell lysates, and a global perspective of protein function as provided by COMBREX.
- Resident Anita Deshpande, PGY-2, USCAP poster presentation held in Baltimore March 2013 on “Leiomyoma of the Gastrointestinal tract with Interstitial cells of Cajal: A mimic of gastrointestinal stromal tumor” has been accepted by American Journal of Surgical Pathology for publication.
- Smith, B., S. Rozelle, J. Ubellacker, A. Parks, A. Leung, S. Nah, D. French, P. Gadue, S. Monti, D. Chui, M. Steinberg, D. Kotton, G. Mostoslavsky, D. Sherr, and G. Murphy. 2013. The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood In Press
- Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology In Press
- Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. In Press
- Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ*, Kurosawa S.* Quiescent complement in nonhuman primates during E.coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood, 2013. (impact factor 9.8)
- Stearns-Kurosawa DJ, Oh S-Y, Cherla RP, Lee M-S, Tesh VL, Papin J, Henderson J, Kurosawa S. Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic E.coli Shiga toxins in non-human primate models of hemolytic uremic syndrome. American Journal of Pathology, 182(4):1227-38, 2013