August 2014

September 2nd, 2014 in Uncategorized

 

Pathology & Laboratory Medicine News Items

Announcements:

  • New Grant Funding in Pathology:

The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the

period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department

and it would be appropriate to share the specifics of these new grants.

PI Alpaslan Dedeoglu
Co-Investigator Jan Krzysztof Blusztajn
Number 1 I01 BX001875-01
Title Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy
Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.
PI Alpaslan Dedeoglu
Co-Investigator Jan Krzysztof Blusztajn
Number 1 I01 BX002468-01
Title Novel neurotrophic therapies in an optimized mouse model of GWVI
Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.
PI Jan Krzysztof Blusztajn
Co-Investigator Tiffany Mellott, Barbara Slack, Ivana Delalle
Number R01 AG045031-01A1
Title BMP9 as a juvenile protective factor in cognitive aging
Description The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.
PI Shinichiro Kurosawa
Co-Investigator D.J. Stearns-Kurosawa
Number R01 AI102931
Title Development and Treatment of Pre-Clinical EHEC Models with HUS
Description Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children.  There is no treatment available, other than supportive care.  Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.  The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.
PI Vipul Chitalia
Co-investigator Nader Rahimi
Number R01 CA175382
Title Role of c-Cbl in Colon cancer
Description The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase
PI Daniel Remick
Co-Investigator Nader Rahimi
Number R21 AI112887-01
Title Mechanisms of phagocytic cell defects induced by inhibitory IgG
Description We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.
PI Daniel Remick
Number R21 AA022122-01
Title Alcohol Triggered Asthma: Mechanisms of Neuronal Control
Description The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.
PI Susan Winandy
Number R21 CA176811-01
Title Mechanism of Notch-induced leukemogenesis in lymphocytes
Description Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.  This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.

 Welcome to our New Graduate Students:

    • Stephanie Adams, OD/PhD
    • Lois Bayigga, Masters
    • Evan Catudal, Masters
    • Junbo Chen, Masters
    • Yuri Kim, PhD
    • Asha Melo, Masters
    • Tim Norman, PhD
    • Ruoyu Tian, Masters
    • BJ Varian, Masters

 

  • From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
  • Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
  • Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.

Publications: ACCEPTED:

  • Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
  • Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)

Publications: PUBLISHED:

Congratulations Philip Bondzie

August 11th, 2014 in Student Spotlight

  • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014

Congratulations Chad Mayer, MD/PhD

August 11th, 2014 in Student Spotlight

Chad Mayer, from the Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014

July 2014

August 7th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Congratulations to Dr. Manisha Mehta and Dr. Dana Semmel for successfully completing the Anatomic and Clinical Pathology sections of the ABP Board Examination and becoming diplomats of the American Board of Pathology
  • Daniel Remick, M.D., has been selected as the moderator for the Pathology Roundtable. The roundtable has representation by the major pathology societies, such as the College of American Pathology, The United States and Canadian Academy of Pathology, The American Society of Clinical Pathology, The American Board of Pathology, The American Society of Investigative Pathology, the National Association of Medical Examiners, the Association of Directors of Academic Surgical Pathology, the Academy of Clinical Laboratory Physicians and Scientists, The Association of Pathology Informatics, and the American Society of Cytology. The roundtable meets on a regular basis to discuss issues that directly impact our discipline, so that a unified response may be developed. Dr. Remick assumed his duties as moderator in July, 2014 as a representative of the American Society for Investigative Pathology
  • Dr. Remick moderated a session at the 2014 Association of Pathology Chairs Meeting “Academic Pathology 2020: Advancing Research Opportunities,” in Boston, MA; July 8-11, 2014
  • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab, attended the 2014 National Neurotrauma Symposium in San Francisco, late June 2014. Mark presented a poster titled “Pathobiology of Blast-Related Traumatic Brain Injury in a Mouse Model.” Authors: M. Wojnarowicz A. Fisher C. Tagge A. Gaudreau N. Casey J. Moncaster O. Minaeva G. Hall R. Cleveland W. Moss X.L Zhang P. Stanton H. Lu B. Lamb R. Ransohoff A. McKee L. Goldstein
  • Dr. Lawreen Connors received a 1-year grant from the E. Rhodes and Leona B. Carpenter Foundation in support of her study, “Blood Profiling for Biomarkers in Age-related ‘Senile’ Systemic Amyloidosis (SSA)”
  • Chad Mayer, MD/PhD, Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014
  • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014
  • Martin Steffen, PhD has joined the Editorial Board of two new publications:
  • ○     Journal of Bacteriology and Mycology
  • ○     Clinical Journal of Microbiology and Pathology
  • Barb Nikolajczyk, PhD Lab welcomes the following people:
  • ○     Dr. Blanche Ip, Post-doctoral fellow on the Inflammation Training Grant
  • ○     Michel Azer, Masters’ student from the BU Goldman School of Dental Medicine
  • Effective July 1, 2014, Dr. Maria Panchenko will be the new course co-director for our course PA710 “Principles of Applied and Basic Pathology”. The course was originally created by Deborah Stearns-Kurosawa who will be stepping down. I will remain the new course co-director.
    This is a graduate level course which introduces basic concepts of pathology, including some essential histology. Additionally, all graduate students are required to attend our research seminars and prepare a written synopsis of 4 seminars. This allows the students to have their writing formally evaluated. Another major component of the course is to expose all of the new graduate students to the range of research conducted within the Department so that they may select an appropriate lab to do their thesis.  Please join me in welcoming Dr. Panchenko as the new course co-director, and thanking Dr. Stearns-Kurosawa for her efforts to launch and mentor a new course.
  • David Sherr, PhD has been appointed Director of the BU Superfund Research Program
  • Dr. Kazem Azadzoi received the Journal of Urology Best Reviewer in 2013 Award at the American Urological Association 2014 Annual Meeting in Orlando, Florida; May 2014
  • Welcome to our two new Pathology Residents!!!
  • ○  Dr. Reyhan Gedik
  • ○  Dr. Shiva Khoobyari

Publications: ACCEPTED:

  • Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG, Lentsch “AB: Substance P Mediates Reduced Pneumonia Rates After Traumatic Brain Injury,” Crit Care Med 2014, PMID: 2501406 (In Press)
  • Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH: “Abandon the Mouse Research Ship? Not Just Yet!”, Shock 2014, PMID: 24569509 (In Press)
  • Mella JR, Chiswick EL, King E, Remick DG: “Location, Location, Location: Cytokine Concentrations are Dependent on Blood Sampling Site,” Shock 2014, PMID: 25004061 (In Press)
  • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. “Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease,” Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press)
  • Gusenleitner, D., S. S. Auerbach, T. Melia, H. F. Gomez, D. H. Sherr, and S. Monti. 2014. “Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.” PLoS One 9:e102579

Congratulations Evan Chiswick!

April 1st, 2014 in Student Spotlight

Evan Chiswick 
 Successfully defended his dissertation:
 
“Failure to Kill, Kills: Impaired Bacterial Killing Precedes Death in Polymicrobial Sepsis”
Here is a short introduction to his Thesis:

Boston University Blackboard Learn

March 23rd, 2014 in See Also

https://learn.bu.edu/webapps/portal/frameset.jsp?tab_tab_group_id=_10_1

Congratulations John Mahoney!

March 23rd, 2014 in Student Spotlight

John “Jed” Mahoney

PhD Candidate

Successfully defend his dissertation:

“The Hippo Pathways Effector Yap Controls Patterning and Differentiation of the Airway Epithelium”

Friday, March 21st, 2014

Top Doc in Boston Antonio de las Morenas!

March 23rd, 2014 in Faculty Highlights

Antonio de las Morenas, M.D., Professor of Pathology and Laboratory Medicine has been recognized by Boston magazine as a Top Doc in Boston. According to BU Today, “To be included in Boston magazine’s Top Doc list, physicians undergo a rigorous screening process by national medical research firm Castle Connolly. The firm gathers nominations online from other licensed physicians, conducts phone interviews with medical professionals to corroborate nominations, and checks the professional qualifications of all nominees . . .”

The list of pathologists in Boston in the top docs may be found here:

http://www.bostonmagazine.com/specialty/pathology/

October 2013

October 28th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –

Announcements:

  • Faculty Appointments and/or Promotions:
    • Dr. Yuriy Alekseyev was promoted to Research Associate Professor
    • Dr. Shinichi Takayama has been appointed as Research Associate ProfessorImmuno Nov 2013
  • Immunology has selected an image from an article authored by Dr. Zhaohua Lu and colleagues, published in this month’s Immunology for the journal cover (see photo and link to article) http://onlinelibrary.wiley.com/doi/10.1111/imm.12150/full
  • The Martin Steffen Lab presented a talk on their work on biomarkers for Prostate Cancer at the 2013 meeting for the New England Section of the American Urological Association in Hartford, Connecticut on September 26 – 28 Towards Reducing the Number of Prostate Biopsies – Biomarkers to Identify Patients with Benign Causes of Elevated PSA LevelsAgnes Bergerat, PhD1, Yi-Chien Chang, MS2, Mark Katz, MD1, David Wang, MD1, Simon Kasif, PhD2, Richard Babayan, MD1Martin Steffen, MD, PhD1
  • Dr. Daniel Remick will be giving a lecture on October 28th at the Brigham & Women’s Hospital entitled, “Mechanisms of Alcohol Triggered Asthma”
  • Dr. Carmen Sarita-Reyes is now Board Certified in Pediatric Pathology

Publications: PUBLISHED:

  • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D.,Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., Jason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary Hunter, M. A. “MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia” New England Journal of Medicine; 367;9 nejm.826 org august 30, 2012
  • Lian Xu,1,2  Zachary R. Hunter,1,2 Guang Yang,1,2 Yangsheng Zhou,1,2 Yang Cao,1,2 Xia Liu,1,2 Enrica Morra,3 Alessandra Trojani,3 Antonino Greco,3 Luca Arcaini,4 Marzia Varettoni,4 Jennifer R. Brown,5 Yu-Tzu Tai,2,6 Kenneth C. Anderson,2,6 Nikhil C. Munshi,2,6 Christopher J. Patterson,1 Robert J. Manning,1 Christina K. Tripsas,1 Neal I. Lindeman,2,7 and Steven P. Treon1,2 “MYD88 L265P in Waldenstr¨om macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction” BLOOD, 14 MARCH 2013 x VOLUME 121, NUMBER 11
  • Steven P. Treon1,2 and Zachary R. Hunter1,2 “A new era for Waldenstrom macroglobulinemia: MYD88 L265P,” BLOOD, 30 MAY 2013 x VOLUME 121, NUMBER 22
  • Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. “The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.” Immunology. 2013 Nov;140(3):374-389. PMID: 23844703

September 2013

September 26th, 2013 in Uncategorized

Pathology & Laboratory Medicine News Items –

 

Announcements:

  • CAP (College of American Pathologist) 2013, Orlando Florida, October 13-16, 2013; Accepted:
    • “Validation Of Pre-transfusion Compatibility Testing In PEG In A Semi-automated Transfusion Service” (Poster No. 98 – p 1371) – Josenia Tan and Karen Quillen – Abstract accepted to CAP 2013, poster presentation
    • “Benign Epithelial Inclusions In Axillary Lymphnodes” (Poster No. 69 – p 1452) - Anita Deshpande, MD; Josenia Tan, MD; Melinda Lerwill, MD; Grace Zhao, MD; selected abstract for poster presentation at CAP ’13.
    • “Utility Of Fetal Tissue Examination in Intrauterine Fetal Demise Autopsies;” (Poster No. 95 – p 1508)
    • Cathryn Byrne-Dugan, MD, et al – Abstract accepted to CAP 2013, poster presentation
    • From Dr. Carmen Sarita-Reyes: on page 166: http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2013-0354-AB; presented by Yue Sun, MD and Antonio de las Morenas, MD; “Anaplastic Thyroid Carcinoma and Potential Therapeutic Target” (Poster No. 152 – p 1525)
  • Dr. Daniel Remick was the Keynote Speaker, 15th Congress of the European Shock Society, Vienna Austria, September 2013; “Sepsis, When you die we want to know why”
  • Dr. Remick also participated in “Meet the Expert, Ludwig Boltzmann Institute of Traumatology,” Vienna Austria in September 2013
  • Daoreuang Pongvongkeo, Angel Lui, Genevieve Matnog, and John Lee from the Hematology Lab have validated a new automated urinalysis platform, the iRICELL Plus, that went live 9/9/13. This new automated platform will improve efficiency in performing and releasing urinalysis results.
  • Dr. Barbara Nikolajczyk presented her teams’ work “Lymphocytes regulate inflammation in human type 2 diabetes” at the Aegean Conference on Immunometabolism in Rhodes, Greece, September 17, 2013
  • Dr. Barb Nikolajczyk also presented her teams’ work “Roles of B cells in type 2 diabetes and T2D-associated periodontal disease” at the Forsyth Institute in Cambridge, MA September 26, 2013
  • Dr. David Sherr was featured in an article in International Innovations in which I discuss the role of the environment in breast cancer progression. See the URL below. http://www.bumc.bu.edu/immunology/files/2006/10/Final-High-resolution-p93-95_David_Sherr.pdf
  • Dr. Daniel Remick was the Keynote Speaker, at the 11th Annual Advances in Inflammation Research, Brown University, September 26th & 27th; “The roles of adenosine and antibodies in sepsis”
  • Daniel Remick, MD is the Chair and invited speaker, 46th Annual Meeting of the Society for Leukocyte Biology, Providence Rhode Island, “Leukocytes and mediators that influence survival”
  • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
  • Resident Manisha Mehta, MD has had her abstract, ‘Vitreous cytology: A diagnostic glimpse into the eye’ Manisha Mehta, MD; Reena Rashid, MD; Stephen Foster, MD; Nora Laver, MD, accepted as a talk at the http://aaoop.org/annual-meetings/2013-aaoop-annual-meeting/” target=”_blank” title=”http://aaoop.org/annual-meetings/2013-aaoop-annual-meeting/”>2013 AAOOP (American Association of Ocular Oncologists and Pathologists) Annual Meeting>, “Memorial Celebration of the Life and Work of Dr. Lorenz E. Zimmerman with Anastasia Zimmerman” on November 15th in New Orleans
  • The Nikolajczyk Lab has received a 1 year Diabetes Complications Consortium Grant from the NIH
  • Welcome to our NEW dedicated Residency Program Coordinator, Mark Uva!