October 2014

November 5th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items


  • Jessica (Allen) Ritter, PhD Candidate, Genco Lab, presented a poster at XIXth International Pathogenic Neisseria Conference October 12th-17th in Asheville, NC. The poster is entitled; “Neisseria gonorroheae modulates immune cell survival through pyroptosis.” Authors are Jessica Ritter, Kathleen Goodmon, and Caroline Genco.
  • Evan Chiswick, PhD, Remick Lab  was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, October 23rd-25th in Salt Lake City, Utah.  also received a travel award. The title of his talk was “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity” Evan also received a Travel Award, bravo!
  • Daniel Remick, M.D., served as the program chair for the 2014 joint meeting of the Society for Leukocyte Biology and the International Endotoxin and Innate Immunity Society. The meeting had nearly 250 participants from across the world and was held in Salt Lake City, Utah.
  • David Sherr, M.D. has received an award from the Art Because Breast Cancer Foundation. http://www.bostonglobe.com/metro/2014/10/15/team-boston-researchers-will-study-environment-relation-breast-cancer/Bg6nMAlvWIVBNJfBbpat3L/story.html?s_campaign=8315

Publications ACCEPTED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, Clinton T. Baldwin, David C. Seldin, Lawreen H. Connors. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genetics

Publications: PUBLISHED:

  • Tiffany J. Mellott, Sarah M. Pender, Rebecca M. Burke, Erika A. Langley, Jan Krzysztof Blusztajn; “IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and  Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice” PLOS, April 2014. http://www.ncbi.nlm.nih.gov/pubmed/?term=Mellott%20TJ%5Bauth%5D\
  • Erika A. Langley1, Marina Krykbaeva1, Jan Krzysztof Blusztajn, Tiffany J. Mellott; “High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T + Itpr3tf/J mouse model of autism.” Behavioural Brain Research; Volume 278, 1 February 2015, Pages 210–220
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. “Possible resting metabolic rate modification by the circulating RBP4 in obese subjects.” Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. “Targeting receptor tyrosine kinases and their downstream signaling with cell penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.” Chem Biol Drug Des. 2014 Oct 8.
  • O’Brien, MJ, Zhao, Q, Yang, S. “Colorectal Serrated Pathway Cancers And Precursors” Histopathology. 2014 Sep 29. doi: 10.1111/his.12564


NEW COURSE for Spring 2015!

October 21st, 2014 in Spotlight

Human Biospecimens for Research – Information
GMS PA910Rev6

September 2014

October 7th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items


  • CAP (College of American Pathologists) 2014, September 7-10 in Chicago, Illinois:
    • Resident Yanli Ding, MD presented a poster titled as “Gastroenteric biopsies in patients with rare immunodeficiency syndromes –two case reports and literature review” for the CAP 2014 Annual Meeting


      Dr. Yanli Ding with her CAP Poster

    • Resident Dr. Anita Malek’s poster was titled; “Immunohistochemical Approaches to Poorly Differentiated Tumors of Unknown Origins ” Authors: Anita Malek, MD , Qing Zaho, MD, PhD


      Dr. Anita Malek with her CAP Poster

    • Resident Dr. Yue Sun also presented a poster entitled “Epithelioid hemangioma of the penis: a case report,” Yue Sun, Qing Zhao


      Dr. Yue Sun with her CAP Poster

  • Post-doc Evan Chiswick, Remick Lab was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, in Salt Lake City, Utah, October 23-25, 2014. Dr. Chiswick also received a Travel Award. The title of his talk is “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity”
  • Dr. Barbara Nikolajczyk has been selected for the 2014 Evans Center Research Collaborator Award. The award will be presented during the Evans Day Gala Dinner,  Oct 16, 2014
  • Brittany Mailhot and Diane Mullen participated in the Jimmy fund Walk with the Dana Farber Facilitating Hope team. Former BMC employees who also participated are Audrey Quinn and Janet Means. Former Patriot’s player Matt Light is the man in the photo with us!


    Jimmy Fund Run


    Jimmy Fund Run

  • Please welcome the new post-doctoral fellow in the Kurosawa lab, Dr. Ji-Hye (“jee-hay”) Seo. Dr. Seo comes to us from BIDMC where she studied signaling pathways important in development of gastric cancer from chronic Helicobacter pylori infection. She earned her master’s and doctoral degrees from Yonsei University College of Medicine in South Korea (high honors) and lives with her family in Wellesley. Please introduce yourself and lend a hand as she gets settled. 
  • Ivana Delalle, MD, PhD is teaching a new GMS course in the Spring entitled “Human Biospecimens for Research,” PA 910.
    • The objective of this course is to introduce students to the creation, maintenance and efficient use of an indispensable component of translational research in medicine: human biological material (human tissue and bodily fluids)  = human biospecimens and their derivatives. Lectures from faculty from Pathology Departments at Yale, Harvard and Columbia (new York Brain Bank, NYBB), and from Boston University School of Medicine with extensive  experience in human bio-specimens generation, maintenance, and utilization, will instruct how to  successfully obtain and utilize human bio-specimens. ~~~
    • Topics will include logistics and legal aspects of creating and sustaining bio-banks, federal and institutional regulatory and funding mechanisms, and concrete examples of human bio-specimens use to generate break-through data in specific field of biomedical research. Special attention will be given to human biospecimens used in neuroscience as four neuropathologists/neuroscientists from Harvard, Yale, Columbia and Boston University  are enlisted as speakers to give comprehensive overview of biospecimens utilized in neurodegenerative diseases and brain tumors.
  • Karen Quillen, MD is also teaching a new seminar entitled “Blood & Money” in the Kilachand Honors College on the Charles River Campus, with Professor Michael Salinger from the BU School of Management
  • Dr. Nader Rahimi was invited to give a lecture at the Department of Biochemistry, Boston University on September 16. The title of his lecture was “Emerging Roles of Posttranslational Modifications in Receptor Tyrosine Kinase Activation and Signaling”.
  • Dr. Rahimi gave a similar lecture on September 24, 2014 at the University Massachusetts, Lowell.
  • Dr. Rahimi is also invited to give a lecture at the upcoming Boston Angiogenesis Meeting, on November 12, 2014. For additional information, please see the link: (http://lawsonlab.umassmed.edu/BAMspeakersAM.html).   
  • Dr. Lija Joseph recently was awarded the ICPI MSIG Award for her Medical Student Interest Group from the intersociety council for pathology information. Dr. Joseph plans to incorporate our residents in the grand funded program.
  • Publications: PUBLISHED:

    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease, Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press).

    August 2014

    September 2nd, 2014 in Uncategorized


    Pathology & Laboratory Medicine News Items


    • New Grant Funding in Pathology:

    The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the

    period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department

    and it would be appropriate to share the specifics of these new grants.

    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX001875-01
    Title Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.
    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX002468-01
    Title Novel neurotrophic therapies in an optimized mouse model of GWVI
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.
    PI Jan Krzysztof Blusztajn
    Co-Investigator Tiffany Mellott, Barbara Slack, Ivana Delalle
    Number R01 AG045031-01A1
    Title BMP9 as a juvenile protective factor in cognitive aging
    Description The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.
    PI Shinichiro Kurosawa
    Co-Investigator D.J. Stearns-Kurosawa
    Number R01 AI102931
    Title Development and Treatment of Pre-Clinical EHEC Models with HUS
    Description Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children.  There is no treatment available, other than supportive care.  Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.  The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.
    PI Vipul Chitalia
    Co-investigator Nader Rahimi
    Number R01 CA175382
    Title Role of c-Cbl in Colon cancer
    Description The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase
    PI Daniel Remick
    Co-Investigator Nader Rahimi
    Number R21 AI112887-01
    Title Mechanisms of phagocytic cell defects induced by inhibitory IgG
    Description We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.
    PI Daniel Remick
    Number R21 AA022122-01
    Title Alcohol Triggered Asthma: Mechanisms of Neuronal Control
    Description The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.
    PI Susan Winandy
    Number R21 CA176811-01
    Title Mechanism of Notch-induced leukemogenesis in lymphocytes
    Description Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.  This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.

     Welcome to our New Graduate Students:

      • Stephanie Adams, OD/PhD
      • Lois Bayigga, Masters
      • Evan Catudal, Masters
      • Junbo Chen, Masters
      • Yuri Kim, PhD
      • Asha Melo, Masters
      • Tim Norman, PhD
      • Ruoyu Tian, Masters
      • BJ Varian, Masters


    • From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
    • Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
    • Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.

    Publications: ACCEPTED:

    • Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
    • Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)

    Publications: PUBLISHED:

    Congratulations Philip Bondzie

    August 11th, 2014 in Student Spotlight

    • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014

    Congratulations Chad Mayer, MD/PhD

    August 11th, 2014 in Student Spotlight

    Chad Mayer, from the Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014

    July 2014

    August 7th, 2014 in Uncategorized

    Pathology & Laboratory Medicine News Items


    • Congratulations to Dr. Manisha Mehta and Dr. Dana Semmel for successfully completing the Anatomic and Clinical Pathology sections of the ABP Board Examination and becoming diplomats of the American Board of Pathology
    • Daniel Remick, M.D., has been selected as the moderator for the Pathology Roundtable. The roundtable has representation by the major pathology societies, such as the College of American Pathology, The United States and Canadian Academy of Pathology, The American Society of Clinical Pathology, The American Board of Pathology, The American Society of Investigative Pathology, the National Association of Medical Examiners, the Association of Directors of Academic Surgical Pathology, the Academy of Clinical Laboratory Physicians and Scientists, The Association of Pathology Informatics, and the American Society of Cytology. The roundtable meets on a regular basis to discuss issues that directly impact our discipline, so that a unified response may be developed. Dr. Remick assumed his duties as moderator in July, 2014 as a representative of the American Society for Investigative Pathology
    • Dr. Remick moderated a session at the 2014 Association of Pathology Chairs Meeting “Academic Pathology 2020: Advancing Research Opportunities,” in Boston, MA; July 8-11, 2014
    • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab, attended the 2014 National Neurotrauma Symposium in San Francisco, late June 2014. Mark presented a poster titled “Pathobiology of Blast-Related Traumatic Brain Injury in a Mouse Model.” Authors: M. Wojnarowicz A. Fisher C. Tagge A. Gaudreau N. Casey J. Moncaster O. Minaeva G. Hall R. Cleveland W. Moss X.L Zhang P. Stanton H. Lu B. Lamb R. Ransohoff A. McKee L. Goldstein
    • Dr. Lawreen Connors received a 1-year grant from the E. Rhodes and Leona B. Carpenter Foundation in support of her study, “Blood Profiling for Biomarkers in Age-related ‘Senile’ Systemic Amyloidosis (SSA)”
    • Chad Mayer, MD/PhD, Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014
    • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014
    • Martin Steffen, PhD has joined the Editorial Board of two new publications:
    • ○     Journal of Bacteriology and Mycology
    • ○     Clinical Journal of Microbiology and Pathology
    • Barb Nikolajczyk, PhD Lab welcomes the following people:
    • ○     Dr. Blanche Ip, Post-doctoral fellow on the Inflammation Training Grant
    • ○     Michel Azer, Masters’ student from the BU Goldman School of Dental Medicine
    • Effective July 1, 2014, Dr. Maria Panchenko will be the new course co-director for our course PA710 “Principles of Applied and Basic Pathology”. The course was originally created by Deborah Stearns-Kurosawa who will be stepping down. I will remain the new course co-director.
      This is a graduate level course which introduces basic concepts of pathology, including some essential histology. Additionally, all graduate students are required to attend our research seminars and prepare a written synopsis of 4 seminars. This allows the students to have their writing formally evaluated. Another major component of the course is to expose all of the new graduate students to the range of research conducted within the Department so that they may select an appropriate lab to do their thesis.  Please join me in welcoming Dr. Panchenko as the new course co-director, and thanking Dr. Stearns-Kurosawa for her efforts to launch and mentor a new course.
    • David Sherr, PhD has been appointed Director of the BU Superfund Research Program
    • Dr. Kazem Azadzoi received the Journal of Urology Best Reviewer in 2013 Award at the American Urological Association 2014 Annual Meeting in Orlando, Florida; May 2014
    • Welcome to our two new Pathology Residents!!!
    • ○  Dr. Reyhan Gedik
    • ○  Dr. Shiva Khoobyari

    Publications: ACCEPTED:

    • Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG, Lentsch “AB: Substance P Mediates Reduced Pneumonia Rates After Traumatic Brain Injury,” Crit Care Med 2014, PMID: 2501406 (In Press)
    • Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH: “Abandon the Mouse Research Ship? Not Just Yet!”, Shock 2014, PMID: 24569509 (In Press)
    • Mella JR, Chiswick EL, King E, Remick DG: “Location, Location, Location: Cytokine Concentrations are Dependent on Blood Sampling Site,” Shock 2014, PMID: 25004061 (In Press)
    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. “Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease,” Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press)
    • Gusenleitner, D., S. S. Auerbach, T. Melia, H. F. Gomez, D. H. Sherr, and S. Monti. 2014. “Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.” PLoS One 9:e102579

    Congratulations Evan Chiswick!

    April 1st, 2014 in Student Spotlight

    Evan Chiswick 
     Successfully defended his dissertation:
    “Failure to Kill, Kills: Impaired Bacterial Killing Precedes Death in Polymicrobial Sepsis”
    Here is a short introduction to his Thesis:

    Boston University Blackboard Learn

    March 23rd, 2014 in See Also


    Congratulations John Mahoney!

    March 23rd, 2014 in Student Spotlight

    John “Jed” Mahoney

    PhD Candidate

    Successfully defend his dissertation:

    “The Hippo Pathways Effector Yap Controls Patterning and Differentiation of the Airway Epithelium”

    Friday, March 21st, 2014