Pathology & Laboratory Medicine News Items – June/July 2017
- One of our recently Defended MD/PhDs, Nisma Mujahid, PhD, first authored paper came out in Cell Reports on Tuesday (6/13/2017) (please find details below), and it’s gotten a press. Nisma’s paper’s been featured in BBC (front page Health News), Time, Science, ScienceMag, Smithsonian…among others. http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30684-8 http://www.bbc.com/news/health-40260029
- Sandra Cerda MD, was invited as a guest speaker and scientific session Chair and moderator at the “3rd International Conference on Cytopathology & Histopathology” that took place in Philadelphia on June 22-23. Theme “Transforming the Future of Cytopathology & Histopathology”
- Reyhan Gedik, MD presented a poster at ACLPS 2017 Annual Meeting, June 15-17, 2017 in New Haven, CT. Her poster title was “Computerized Approach to Antibody Identification in Pre-transfusion Testing”
- Dr. Ivana Delalle has accepted an invitation to become an Associate Editor in Journal of Alzheimer’s Disease
- Dr. Delalle has also been invited to give a talk on her research at Molecular Pathology seminar series at Johns Hopkins Medical School
- Dr. Daniel Remick was invited to speak at the Association of Pathology Chairs annual meeting at the new chairs bootcamp. The title of his talk was “The Unique Leadership Challenges in the Pathology Research Mission”
- Dr. Daniel Remick became the President of the American Society of Investigative Pathology on July 1, 2017. He will serve for a one year term
- Dr. David Sherr and his team resubmitted their competitive renewal for the BU Superfund Research Center and were awarded a $3,500,000 grant over 2.5 years; http://www.bu.edu/sph/research/research-landing-page/superfund-research-program-at-boston-university/
- Resident Israa Laklouk, MD submitted abstract entitled “Predictive accuracy of thyroseq v2 for malignant thyroid nodules among Bethesda-III cytology subcategories: Atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS)” has been accepted as an Oral Presentation and will be part of the Scientific Programme during the 29th European Congress of Pathology to be held in Amsterdam, The Netherlands. The authors list: Israa Laklouk, MD; Mahmoud Soliman MD, PhD; Dhay Kamel ,MD; Huihong Xu, MD; Sandra Cerda, MD
- Please Welcome our New Residency Coordinator Daphney Noel! Daphney comes to us via Brigham and Women’s Hospital. In her recent position as a program coordinator at BWH’s Center for Faculty Development and Diversity Daphney was responsible for planning and arranging programs in support of the faculty and research community. Daphney graduated from Colby-Sawyer College with a BA in History and hopes to get her MS of education in counseling
- 2017 Graduation Celebration was held this year at Cinquecento Restaurant; Congratulations to All!!
|n BU-CTSI Spring 2017 Pilot Awardees|
|Boston University Clinical and Translational Science Institute (BU-CTSI) is pleased to announce the recipients of the Spring 2017 Integrated Pilot Grant Program. This cycle we received 47 applications, 22 applicants were awarded, including 12 deferred from fall 2016. Each awardee received $20,000 in funding . The CTSI would like to recognize the faculty who reviewed the applicants and offer our sincere thanks for their time and efforts.
The purpose of the Integrated Pilot Grant Award mechanism is to stimulate scientific discovery in all areas of basic or translational research related to the prevention, diagnosis, and management of human disease.
The Department of Pathology and Laboratory Medicine launched a series of initiatives to increase scholarly activity and increase grant funding. These initiatives arose from the strategic planning process. The Department was recently asked to provide information about specific faculty development programs, and we provided the information below.
- Writing workshops. A 9 part series of workshops were presented on how to prepare a manuscript. Topics included using bibliography and graphing software, writing an abstract and selecting the most appropriate journal for the manuscript etc. Faculty involved included Daniel Remick, M.D., and Shinichiro Kurosawa, M.D., Ph.D.
- Manuscript accelerator sessions. These sessions are held each week with the intent of accelerating the completion of manuscripts. Participants (grad students, fellows, junior faculty etc.) participate in a 4 part series by bringing different portions of the manuscript to the session. The senior faculty member at the session serves more as an editor than actual reviewer of the manuscript. A 2017 survey of the faculty showed that 82% of the respondents felt these accelerator sessions should be continued. The faculty involved included Drs. Sharon, O’Brien, Kurosawa, Stearns-Kurosawa, Remick, Panchenko and others.
- Internal grant reviews. During each grant review cycle the Department offers internal review of grant submissions. Faculty send in their abstract and specific aims page, and another faculty member is assigned as the reviewer. This initiative has just been started, so it is too early to track success in a systematic manner. However, at least 2 CTSI grants, a Dahoud biobank and Shipley Prostate biobank study have been funded after internal review.
- Publications ACCEPTED:
- Parul Agnihotri, Nicholas M. Robertson, Sarah E. Umetsu, Ksenia Arakcheeva and Susan Winandy; Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells. Accepted for publication in Immunology
- Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, and Delalle I: Methionine sulfoxide reductase-B3 (MsrB3) protein associates with synaptic vesicles and its expression changes in the hippocampi of Alzheimer’s disease patients. Accepted for publication in the Journal of Alzheimer’s Disease
- Agis-Balboa RC, da Silva Pinheiro PC, Rebola N, Kerimoglu C, Benito E, Gertig M, Bahari-Javan S, Jain G, Burkhardt S, Delalle I, Jatzko A, Dettenhofer M, Zunszain P, Schmitt A, Falkai P, Pape J, Binder E, Mulle C, and Sananbenesi F: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk of dementia. Accepted for publication in EMBO Journal, June 27, 2017
- Publications PUBLISHED:
- Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher; A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Reports, Volume 19, Issue 11, p2177–2184, 13 June 2017
- Yang JH, Siroky MB, Yall SV and Azadzoi KM: Mitochondrial Stress and Activation of Phosphoinositol 3 Kinase (PI3K) and Protein Kinase B (Akt) Survival Pathway in Bladder Ischemia. Res Rep Urol 2017, June 10, 9:93-100
- Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging. Comprehensive Physiology (In Press).
- Agrawal, M, Kern, PA, Nikolajczyk BS. The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths. Current Diabetes Reports (In Press
Pathology & Laboratory Medicine News Items – April/May 2017
A Mallory grant “The Utility of Ki-67 and Phosphohistone H3 in the Differentiation Between Classic Papillary Thyroid Carcinoma, Follicular Variant of Papillary Thyroid Carcinoma and Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features” was funded. This will support the work of Drs. Jing Yang, Cerda and Tan.
The T32 training grant, T32GM086308 “Immunobiology of Trauma” was funded for an additional 5 years with a budget of $1,401,170. This grant provides salary support for BMC residents to engage in basic science research full time for two years. Daniel Remick, M.D. is the principal investigator.
Max Vaickus, graduating Masters student had his abstract accepted for the 40th Annual Conference on SHOCK in June in Fort Lauderdale, Florida. His abstract title is: “Mild traumatic brain injury induces genetic changes in mouse lung to augment Pseudomonas aeruginosa clearance”
Max also received a Travel Award of $1000 to attend the SHOCK Conference
On Behalf of Dr. Barbara Slack, Pathology Department Russek Awards Committee
- I am pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
- First Prize -Stephanie Adams (Delalle lab)
- Second Prize – Elizabeth Moses (Spira-Lenburg lab)
- Third Prize – Nisma Mujahid (Fisher lab, MGH)
- Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day was held on Friday, April 21st in the Hiebert, The keynote speaker this year was Dr. Carla Shatz, Professor of Biology and Neurobiology at the Stanford Neurosciences Institute https://www.bumc.bu.edu/gms/students/phd/23rd-annual-henry-i-russek-student-achievement-day-april-21/
- I would also like to thank Dr. Rahimi, Dr. Andry, and Dr. Stearns-Kurosawa, for serving on the departmental Russek committee this year.
Richard Kozak retired April 30th after 38+ years in the Clinical Microbiology Laboratory; thank you!
For Nancy S. Miller, MD:
- Was an invited speaker at a full-day Medical Mycology Workshop presented at the 2nd joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and Northeast Branch-American Society for Microbiology (NEBASM), April 3, 2017, Wakefield, MA
- An invited guest also for, “Micro meets multiplex: A case-based view of syndromic panel testing”, presented at the Syndromic Testing Symposium, April 6 in Burlington, MA
- Dr. Miller will present a Meet-the-Experts session at ASM Microbe 2017 on June 5th, at the international conference of the American Society for Microbiology June 1-5 in New Orleans. Session Title: “Who knew? And what to do? Tales from the benches and trenches.”
It was Medical Laboratory Professionals Week April 23 -28!! Activities included:
- Some of the Lab Areas had breakfast and lunches for staff throughout the week
- There were two Luncheon Seminar Talks with Pizza
- Cake and Ice Cream on Friday Dessert Day, April 28th for everyone
- Staff were allowed to wear jeans if they donated $2 to a BMC Fund we raised $150 going to pieces of home back pack project at BMC which serves children who are in foster care
- Thank you one & all!!!!
Nisma Mujahid, MD/PhD (Off-Site at MGH, David Fisher Lab) successfully defended her Thesis, “The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention” on May 1st, 2017. HOORAY!!
Stephanie Adams, OD/PhD (Blusztajn/Delalle Lab) successfully defended her Thesis, NEURONAL PHENOTYPES IN HUMAN HIPPOCAMPUS AND NEOCORTEX IN LATE-ONSET ALZHEIMER’S DISEASE: PROTEIN EXPRESSION OF NOVEL GENES IMPLICATED IN PATHOGENESIS” on May 1st, 2017. HOORAY!!
Caitlin Miller, PhD (Gummuluru Lab) successfully defended her Thesis, “Role of viral protein R in infection of human dendritic cells by primate lentiviruses” on May 9th 2017. HOORAY!!
Dr. Daniel Remick was invited to the 9th Wiggers-Bernard Conference at the Ludwig Bolzmann Institute in Vienna, Austria the first week of May. He chaired the working group on defining organ injury in pre-clinical models of sepsis
Dr. Remick also presented a proposal to Wacker Biosolutions in Munich Germany for Boston University. The proposal would potentially fund a student at either the undergraduate or medical campus
Barb Nikolajczyk, PhD participated in the IMMUNOLOGY 2017TM Capitol Hill Day held on May 16 in conjunction with the Annual Meeting of the American Association of Immunologists. She was one of a contingent from MA who met with staff of Representatives from MA Districts 2 and 7 and both Senators to promote a consistent and robust increase in NIH and other science funding “over the long haul”. Check out #AAIHillDay on Twitter to see more.
Daniel Remick was invited to speak at the American Thoracic Society’s annual meeting in Washington DC. His presentation was titled “Heterogeneity in the Septic Inflammatory Response”
Dr. Ivana Delalle is pleased to report that she will give a platform presentation entitled “Expression of MSRB3, Implicated in Decreased Hippocampal Volume, Changes in Alzheimer’s Disease and Associates With Synaptic Vesicles” on June 9 at the Annual Meeting of American Association of Neuropathologists in Orange County, CA.
Dr. Nikolajczyk was invited to give a seminar at East Carolina University, EDCOI Center, Greenville, NC, Mechanisms Driving Inflammation in Human Obesity and Type 2 Diabetes, 2017.
- Masters Degrees:
- Keith Keller, MS
- Denis Kyabaggu, MS
- Carolina Lyon de ana, MS
- Morgan Thompson, MS
- Max Vaickus, MS
- Stephanie Adams, PhD/OD
- Liz Moses, PhD – Liz by the way was the PhD Commencement Speakers, BRAVO LIZ!!!!
- Jessica Ritter, PhD
Pathology Residency Completed: (Photos to come next issue)
- Cecilia Ponchiardi, MD
- Dhay Kamel, MD – from the Cytopathology Program
Nancy L.R> Bucher, MD; Celebration of Life & Legacy
- On Thursday, May 4th the department, friends and family gathered to celebrate and honor the remarkable life and legacy of Professor Nancy L.R. Bucher of Harvard Medical School and Boston University School of Medicine. Dr. Bucher was a pioneer in liver regeneration studies and hepatocyte cultures. Dr. Bucher was a Fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences. She also received The Distinguished Scientific Achievement Award from the American Liver Foundation.
- Miller, C.; Akiyama, H.; Agosto, L.; Emery, A.; Ettinger, C.; Swanstrom, R.; Henderson, A.; Gummuluru, S. Virion associated Vpr alleviates a post-integration block to HIV-1 infection of dendritic cells. Journal of Virology. 2017
- Li, L., A. Gautam and N.S. Miller. Actinomyces neuii, An Uncommon Bacterial Isolate from a Neck Abscess. Accepted for publication April 10, 2017, Internal Medicine Review
- Bi B, Li F, Guo J, Li C, Jing R, Lv X, Chen X, Wang F, Azadzoi KM, Wang L, Liu Y, Yang JH. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. Neuroscience. 2017 Mar 21;351:84-95. doi: 10.1016/j.neuroscience.2017.03.023. [Epub ahead of print] PMID: 28341197
- Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH. Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle. 2017 Apr 3;16(7):649-659. doi: 10.1080/15384101.2017.1281481. Epub 2017 Jan 19. PMID: 28103160
- Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging (In Press, Comprehensive Physiology)
- Sanaz Bahari-Javan, Hristo Varbanov, Rashi Halder, Eva Benito, Lalit Kaurani, Susanne Burkhardt, Heike Anderson-Schmidt, Ion Anghelescu, Monika Budde, Roman M. Stilling, Joan Costa, Juan Medina, Detlef E. Dietrich, Christian Figge, Here Folkerts, Katrin Gade, Urs Heilbronner, Manfred Koller, Carsten Konrad, Sara Y. Nussbeck, Harald Scherk, Carsten Spitzer, Sebastian Stierl, Judith Stöckel, Andreas Thiel, Martin von Hagen, Jörg Zimmermann, Antje Zitzelsberger, Sybille Schulz, Andrea Schmitt, Ivana Delalle, Peter Falkai, Thomas G. Schulze, Alexander Dityatev, Farahnaz Sananbenesi, and André Fischer; “HDAC1 LINKS EARLY LIFE STRESS TO SCHIZOPHRENIA-LIKE PHENOTYPES” PNAS 2017 ; published ahead of print May 22, 2017, doi:10.1073/pnas.1613842114
Pathology & Laboratory Medicine News Items – February/March 2017
- Our Resident, Israa Laklouk, MD had the following abstract ” Diagnostic Implication of ThyroSeq Sequencing Assay on Thyroid Nodules with FNA Cytology Diagnosis of Bethesda III: Atypia of Undetermined Significance versus Follicular Lesion of Undetermined Significance ” authors: Israa Laklouk, Mahmoud L Soliman, Dhay Kamel, Huihong Xu, Sandra Cerda; selected for a Poster Presentation at the United States & Canadian Academy of Pathology’s (USCAP) 106th Annual Meeting, March 4 – 10, 2017 in San Antonio, Texas http://viewer.zmags.com/publication/84c2f7ae#/84c2f7ae/10
- Lawreen H. Connors, PhD and Frederick L. Ruberg, MD presented “Transthyretin-associated (ATTR) cardiomyopathy: A not uncommon, rare disease” at BUSM Department of Medicine Medical Grand Rounds on Feb. 17, 2017 https://echo360.bu.edu:8443/ess/echo/presentation/66b063a7-a6f2-4ef9-8957-81e40ec68bb3
- Carolina Lyon de Ana, a current Masters student in Dr. Susan Winandy’s Lab and Bo Shao, a technician with Dr. Maria Panchenko’s Lab were both accepted into BU’s PhD PIBS Program! Congratulations!!
- Dr. Ivana Delalle News:
- On March 24 Dr. Delalle gave an invited lecture at the Croatian Institute for Brain Research (CIBR) on “The brain expression of novel genes implicated in AD and low hippocampal volume”
- She also presented her group’s latest work at AD/PD International Meeting in Vienna, March 29 – April 2: “Protein expression of low hippocampal volume- associated risk allele candidate MSRB3 in AD” by Stephanie L Adams1, Laurent Benayoun1, Jayandra J. Himali2,3, Kathy Tilton1, Sudha Seshadri2,3, and Ivana Delalle1,3. 1Pathology, Boston University School of Medicine; 2Framingham Heart Study, Boston University School of Public Health; 3Neurology, Boston University School of Medicine
- Dr. Delalle has also been invited to give a talk at the 3rd Annual Next Generation Sequencing & Single Cell Analysis Congress, scheduled for 23 – 24 October 2017 in Boston. The title of her talk will be: “Extracellular vesicles microRNA (EV miRNA) as Bipolar Disorder (BD) Biomarkers”, based on her senior author paper published ahead of print on February
- Jessica (Allen) Ritter, PhD (Caroline Genco Lab) successfully defended her Thesis, “Induction of Human Macrophage Cell Death by Neisseria gonorrhoeae” on March 10th, 2017. BRAVO!!
- Elizabeth Moses, PhD (Spira/Lenburg Lab) successfully defended her Thesis, “Characterizing the Airway Epithelium following Chemical Exposure: Molecular Alterations and their Potential Utility in the Treatment of Lung Disease” on March 21st, 2017. HOORAY!!
- News for Dr. Barbara Nikolajczyk:
- Dr. Nikolajczyk gave a talk at the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
- She also presented for The Hormel Institute, University of Minnesota, Austin, MN, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
- Dr. Nikolajczyk also received a Grant Title; “Does salt drive a human immune profile in a mouse model of obesity?” from the Boston University Nutrition and Obesity Research Consortium
- Dr. David Sherr along with Dr. Stefano Monti and presenting work of Amy Li, gave an invited talk at the Clinical and Translational and Sciences Institute Symposium about development of a high throughput genomic platform to identifying which of the 84,000 chemicals in our environment are carcinogens.
- Nancy S. Miller, M.D. – was invited to teach a webinar for Rutgers, The State University of New Jersey, School of Health Professions , Department of Clinical Laboratory Sciences, on March 27 “Improved technology for microbial identification: challenges and lessons learned”
- Welcome New Residents!:
- Marianinha Joanes
- International American University
- Iiyas Yambayev
- Kazakh National Medical University
- FASEB Capitol Hill Day 2017
- On March 9, 2017 scientists from across the country gathered in Washington D.C. to participate in the Federation of American Societies for Experimental Biology (FASEB) Capitol Hill day. The purpose of the day was to advocate for federal funding for research, which includes the National Institutes of Health, National Science Foundation, Centers for Disease Control and other agencies.
- The group met with congressional staff from the offices of our Representatives and Senators. During these meetings we emphasized the importance of research funding that drives scientific discoveries by sharing individual stories. We also emphasized how these scientific advances improve the care of patients and health of the nation. Information was provided about the positive economic impact of NIH and NSF funding for each state and congressional district.
- Our specific request was to have research funded to the full amount in the 2017 budget. Since the federal government currently operates under a continuing resolution, NIH has been withholding 10% from grants until the budget has been finalized.
- The Massachusetts representatives all strongly supported research funding. However, they were also pessimistic given the current political climate in Washington DC, even though there is strong bipartisan support for research.
- This pessimism was justified when the White House released the first version of their budget, which calls for cutting the NIH budget by $5.8 billion, or 18%.
- The Massachusetts delegation included Laura Coleman representing the American Society for Nutrition, Shoumita Dasgupta and Daniel Remick from Boston University School of Medicine and Boston Medical Center, Ming Ming Ning from Massachusetts General Hospital and Hanno Steen from Boston Children’s Hospital and Harvard Medical School. Derek Scholes the Director of Scientific Policy for the American Society of Human Genetics escorted us throughout the day.
- Publications ACCEPTED:
- Leena P. Bharath, Blanche C. Ip, Barbara S. Nikolajczyk Manuscript accepted into: “Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging” Comprehensive Physiology
- Woodworth, M., E.M. Neish, N. S. Miller, Tanvi Dhere, E.M. Burd, Cynthia Carpentieri, K. L. Sitchenko, and C.S. Kraft. Laboratory Testing of Donors and Stool for Fecal Microbiota Transplantation for Recurrent C. difficile Infection. Journal of Clinical Microbiology. Epub ahead of print 2017 Jan 11. doi:10.1128/JCM.02327-16. PMID: 28077694.
- Publications PUBLISHED:
- Chan GG, Koch CM, and Connors LH: Blood proteomic profiling in inherited (ATTRm) and acquired (ATTRwt) forms of transthyretin-associated cardiac amyloidosis. J Proteome Res. 2017 Feb 14. doi: 10.1021/acs.jproteome.6b00998. [Epub ahead of print] PMID: 28196416
- Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL: Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Feb 8. doi: 10.1001/jamacardio.2016.5864. [Epub ahead of print] PMID: 28196196
- Wang Z, Monti S, DH S. The diverse and important contributions of the AHR to cancer and cancer immunity. Curr Opinion Toxicol. 2017 ;http://www.sciencedirect.com/science/article/pii/S2468202016300365
- Blandine Bustamante Helfrich, MD, MPH, Nymisha Chilukuri, BSc, Huan He, PhD, MHS, MMgt, Sandra R. Cerda, MD, Xiumei Hong, MD, PhD, Guoying Wang, MD, PhD, Colleen Pearson, BA, Irina Burd, MD, Xiaobin Wang, MD, MPH, ScD. “DOI:Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort” http://dx.doi.org/10.1016/j.placenta.2017.02.016
Pathology & Laboratory Medicine News Items – December 2016/January 2017
- The Pathology Residency and Cytopathology Fellowship Programs, are proud to announce the ACGME’s decision for the Continued Accreditation for both programs. Congratulations and thanks to everyone for a job well done!
- A recently published paper from the Rahimi Lab in the Journal of Molecular Biology was featured on the cover of the journal (http://www.journals.elsevier.com/journal-of-molecular-biology/cover-gallery/cover-of-volume-428-issue-24b). Walter Wang (MAMS Student) and Philip Bondzie (former PhD student & postdoc) were the co-first authors of the paper. The paper was also featured in the F1000prime (http://f1000.com/prime/ext/726966815?referrer=GOOGLE). The papers recommended by the F1000 faculty for biology and medicine are considered the most important papers in the field.
- Dr. Grace Zhao reported; “Congratulations, your Mallory Project is approved with a total budget of $6925. The approved budget is over the budget cap of $5000 because of the potential to expand the IHC list of stains within the Department”
- Dr. Deborah Stearns-Kurosawa was invited to be a member of the scientific steering committee for the 10th International Symposium on Shiga Toxin (Verocytotoxin) Producing E.coli Infections (VTEC 2018) to be held in Florence, Italy in May 2018
- Dr. Carmen Sarita-Reyes’s Mallory Proposal has been approved. The Department has provided funds for two medical students to participate in the 8 summer fellowship through the Mallory funds
- Dr. Barbara Nikolajczyk presented at the following:
- Endocrinology Grand Rounds, Boston University School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, November 14 2016
- Endocrinology Grand Rounds, University of Massachusetts School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, December 13, 2016
- Dr. Daniel Remick presented in December:
- Grand Rounds Speaker, Yale School of Medicine, Department of Pathology, “Traumatic Brain Injury Augments Host Defenses”
- Grand Rounds Speaker, Boston Medical Center, Department of Internal Medicine, “Sepsis: A Moving Target”
- Dr. Daniel Remick in January:
- The Houston Methodist Hospital held their first Annual Pathology Research Day on Saturday, January 14th. First year pathology residents presented posters and the upper year residents and fellows each gave 5-7 minute presentation on their projects. Dr. Remick was the Keynote Speaker and gave the talk “Mild Traumatic Brain Injury Augments Innate Immunity”
- Jason Sutin, PhD (Off-Site at MGH Franceschini Lab) successfully defended his Thesis, “Development of a Novel Diffuse Correlation Spectroscopy Platform for Neuromonitoring Cerebal Blood Flow and Oxygen Metabolism: From Novel Concepts and Devices to Preclinical Live Animal Studies” Fall 2016, BRAVO!!
- Barbara Nikolajczyk, PhD received a $20,000.00 grant titled “Inflammation in type 1 diabetes” from Boston University CTSI
- Dr. Nikolajczyk will also be a reviewer on two NIH panels in Feb:
- Cellular Aspects of Diabetes and Obesity Study Section, Ad-hoc (2017)
- NIDDK Fellowship and Conflict Study Section, Ad-hoc (2017)
- New People:
- The Nikolajczyk Lab has added Joseph Lee, Masters in Nutrition student
- Publications ACCEPTED:
- Mahmoud L Soliman, MD PhD, Ashish Tiwari, MD, Grace Zhao MD, PhD “Coexisting tubular adenoma with a high-grade neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin.” The World Journal of Gastroenterology
- Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH: Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle (accepted for publication)
- Nicholas DA, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA and Nikolajczyk BS. 2017. Advances in the Quantification of Mitochondrial Function in Primary Human Immune Cells through Extracellular Flux Analysis (Accepted, PLOS ONE)
- Publications PUBLISHED:
- Mahmoud L. Soliman, Sandra R. Cerda and Huihong Xu; “Invasive Moderately-Differentiated Mucinous Adenocarcinoma Incidentally Identified in Perforated Acute Diverticulitis With Abscess Formation.” In press in the Pathology and Laboratory Medicine Open Journal
- Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD and Perissi V. 2017. Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell developments (In Press J Biol. Chem).
- The Department’s strategic plan included increasing our academic stature. To achieve this the guidelines for Mallory Research Projects were sent to the faculty. There was an excellent response and the following Mallory proposals were funded in the Fall of 2016.
- Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
- Drs. Panchenko, O’Brien and Tan
- Defining gene programs regulated by Ikaros in T cells
- Drs. Winandy and Lee
- Validation of Maspin/VHL immunostain for distinguishing carcinoma from reactive atypia in pancreas
- Drs. Tan, Yang, and Zha
- Local Release of Substance P after mild traumatic brain injury primes the host to survive a subsequent pathogen challenge
- Drs. Remick and Kim
- Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
Pathology & Laboratory Medicine News Items – November 2016
- Dr. Shinichiro Kurosawa has been reappointed to the Boston University Laboratory Safety Committee. The term of his appointment is through December 31, 2018
- Dr. Chris Andry has had his appointment extend as Chair of the Boston University Laboratory Safety Committee. The term of his extension is through December 31, 2018
- Jacquelyn Sikora Hanson, PhD (Lawreen Connors Lab) successfully defended her Thesis, “Transthyretin gene regulation in wild-type transthyretin amyloidosis” on November 21st, 2016, BRAVO!!
- Dr. Sikora Hanson’s Defense Dissertation
- Jacquelyn’s Thesis Committee: Dr. Vickery Trinkaus-Randall,
- Dr. Lawreen Connors (PI), new Dr. Sikora Hanson and Dr. David Sherr
- Dr. Jacquelyn Sikora Hanson and her proud family
- Shark Tank Winners. The Cancer Center held a retreat on November 29th that featured a “Shark Tank” styled competition for research funds. Prior to the retreat faculty were asked to submit brief proposals and the top 4 proposals were selected for presentation. During lunch each group had 5 minutes to make their pitch to the Sharks on the expert panel. David Sherr and Dan Remick submitted a proposal AHR Inhibitors as Novel Immune Checkpoint Inhibitors. Their idea was selected as the winner. Portions of the funds will be used for processing specimens in the Ex+.
- Hot Off the Presses: The manuscript below has been accepted for publication in Neuropsychiatric Genetics. While the first four authors worked in Dr. Ivana Delalle’s laboratory, it is really a multi-institutional effort that Dr. Delalle was fortunate to lead. “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” by Jason L. Choi1, Patricia F. Kao1, Elena Itriago1, Yougen Zhan1, James A. Kozubek2, Andrew G. Hoss3, Meredith G. Banigan4, Charles R. Vanderburg4, Amir H. Rezvani5, Jeanne C. Latourelle3, Howard Cabral6, and Ivana Delalle1#; 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118; 2Broad Institute, Cambridge, MA 02142; Brigham and Women’s Hospital, Boston, MA 02112; 3Department of Neurology, Boston University School of Medicine, Boston, MA 02118; 4Advanced Tissue Resource Center, Harvard NeuroDiscovery Center, Charlestown, MA 02129; 5Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710; 6Department of Biostatistics, Boston University School of Public Health and Boston University Clinical and Translational Science Institute, Boston, MA, 02118
- Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM, Costello CE, Rahimi N. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol. 2016 Nov 9. pii: S0022-2836(16)30472-7. doi: 10.1016/j.jmb.2016.11.003. [Epub ahead of print]
The Department has been actively engaged in biobanking initiatives for several years. These important biobanking projects provide specimens to several investigators to help understand the basic mechanisms of disease. Banking these specimens also honors the patients’ wishes to provide tissue for research.On behalf of the patients who donated biospecimens, and investigators who use the biospecimens, thank you. Your efforts ensure that pathology provides high quality biospecimens.Here is the impressive list of current and recent projects, including the pathology personnel that are participating in each project.
Biobanking grants in Pathology and Laboratory Medicine
- 2016-2018: Thrombosis in Cancer Patients (TCP). Pre-analytic Variables that May Impact Standardization,
- NCI. Contract award HHSN261200800001E – $1.4M total cost
- PI: Dr. Andry.
- Co-I: Drs. Stearns-Kurosawa, Kurosawa, Henderson, Sloane, & Ms. Duffy, Sun
- Other personnel: Cheryl Spencer, Morgan Thompson
- 2016-2017: Boston Medical Center Biospecimen Source Site for the Clinical Proteomic Tumor Analysis Consortium (CPTAC)
- NCI contract HHSN261201600011I – $89,229.07.
- PI: Dr. Andry
- Co-I: Henderson
- Other personnel: Spencer, Kim, Chen
- 2011-2017: Detection of Early Lung Cancer Among Military Personnel (DE-CAMP), pulmonary
- Department of Defense W81XWH-11-2-0161 – $2,378,826
- PI: Avrum Spira, M.D.
- Co-I: Remick, Pistey
- Other personnel: Spencer
- 2016-present: Framingham Heart Study Biospecimen Core
- Lab Director – Dr. Henderson
- 2014-2016: Biospecimen Source Site for Cancer Human Biospecimens (caHUB).
- NCI. Biospecimen Preanalytical Variables Program 11XS1007T1 – $332,508
- Co-I: Drs. Pistey, Henderson
- Other personnel: Spencer, Duffy
- 2014-2015: Biospecimen Source Site for the National Disease Research Interchange (NDRI)
- Biospecimen procurement contract – $14,600
- PI: Dr. Andry
- Other personnel: Bondzie, Spencer
- 2013-2015: Tissue Source Site for The Cancer Genome Atlas Project (TCGA)
- NCI. Initial Task Order 13XS114 – $15,350
- PI: Dr. Andry
- Co-I: Henderson
- Other personnel: Spencer, Mei Cao
Pathology & Laboratory Medicine News Items – October 2016
- Nancy S. Miller, MD led a discussion and tour of the BMC Clinical Microbiology Laboratory for participants of the International Infectious Disease Symposium, October 13, The tour was part of a 3-day BUSM CME conference on Emerging Infectious Diseases that hosted pulmonologists and infectious diseases physicians visiting from the Middle East.
- Miller, MD was the ASM Distinguished Lecturer at the Fall Meeting of the Western New York branch of the American Society for Microbiology, Buffalo, NY, October 25, 2016. Her topic was diagnostic clinical mycology: “Fungal Fest: Challenges, conundrums, and lessons learned.”
- Barb Nikolajczyk, PhD presented her team’s work entitled “Identity and Mechanisms of Inflammation in Human Obesity and Type 2 Diabetes” at Memorial Sloan Kettering Cancer Center, NYC, on October 24, 2016
- Daniel Remick, MD, organized a workshop for the 8th International Congress of the International Federation of Shock Societies held October 3 – 5 in Tokyo, Japan. The workshop was titled: Immunopathology of Traumatic Brain Injury.
- Remick also gave a presentation: “Mild Traumatic Brain Injury but not Tail Trauma Augments Pulmonary Clearance of Substance P”
- Daniel Remick, MD, was also invited to give a presentation at the 8th International Congress of the International Federation of Shock Societies in Tokyo, Japan titled: “Understanding the Heterogeneity of the Host Response to Infection May Direct Therapy”
- Mostafa Belghasem, PhD presented two posters at BU’s Annual Evans Days 2016 Meeting, October 13 & 14, 2016:
- “Aryl Hydrocarbon Receptor signaling is an in vivo targetable antithrombotic pathway and it correlates with thrombosis in humans” Mostafa Belghasem, Moshe Shashar, Jamaica Siwak, Faisal Alousi, Joel Henderson, Anqi Zhang, Jean Francis, Vijaya B. Kolachalama, Vipul Chitalia.
- “CHIP: A Novel Target For Thrombosis” Moshe Shashar, Mostafa Belghasem, Shinobu Matsuura, Faisal Alousi, Keshab Raji, Jean Francis, Vijaya Kolachalama, Joel Henderson, Mercedes Balcells, Kumaran Kolandaivelu, Katya Ravid, Vipul Chitalia
- Keith Keller, Masters Student in the Henderson Lab has been selected to participate in Kidney STARS 2016 program organized by the American Society of Nephrology (ASN). Keith also received a travel grant from ASN to attend Kidney Week 2016
- The Kurosawa Lab welcomes Daniel Buhl a master’s student coming to their lab from the University of Heidelberg in Germany from November – February
- Daniel Remick, MD, just completed a four term of service as a Section Editor for the Journal of Immunology
- Publications: ACCEPTED:
- Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony Coyle, David J. Salant, Stephen Berasi, Weining Lu. “SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion.” Journal of Clinical Investigation Insight; Accepted Oct 2016
Pathology & Laboratory Medicine News Items – September 2016
- Ahmad Al-Moujahed, Pathology PhD Candidate in Dr. Demetrious Vavvas’s Lab (off-site at Massachusetts Eye and Ear Infirmary) has been selected to be a Fall 2016 fellow of the MIT IMPACT program. It is a career development program for post-doctoral and advanced pre-doctoral trainees (here is a good website for the details; http://impactprogram.mit.edu). Ahmad applied last June; he interviewed and was accepted over the Summer. Ahmad started his first session Tuesday, September 13th
- From Sandra Cerda, Cytology Fellowship Director, as of July 2016… “Accordingly, the Residency Review Committee for Pathology, functioning in accordance with the policies and procedures of the Accreditation Council for Graduate Medical Education (ACGME), has removed previous citations for the following program: Cytopathology Boston University Medical Center Program/Boston University Medical Center” Bravo!!!
- Barb Nikolajczyk, PhD was an invited speaker at the University of Kentucky, Lexington, KY, Department of Pharmacology, “Defining Inflammation in Human Obesity and Type 2 Diabetes,” September 14, 2016
- Dr Sandra Cerda collaborated with the Endocrine Department in an abstract selected for poster presentationat the 86th Annual Meeting of the AMerican Thyroid Association in Denver, Colorado from September 21 – 25, 2016: “Large Independent Prospective Study to Evaluate the Performances of ThyroSeq2 ® Multigene Next Generation Sequencing Panel Analysis on Cancer Diagnosis in Thyroid Nodules with Indeterminate Cytopathology.” Toraldo Gianluca MD, Godley Frederick A MD, Cerda Sandra R MD, Doherty Gerard MD, Braverman Lewis MD, Lee Stephanie MD
- Nader Rahimi, PhD was invited to give a lecture at the Department Pathology, Boston Children Hospital, Harvard Medical School on September 22, 2016. The title of his lecture was “Adhesion signaling in tumor growth and angiogenesis”
- Nancy S. Miller, MD was the invited speaker at the Boston area Microbiology Supervisors Meeting at Faulkner Hospital, Jamaica Plain on September 28th Dr. Miller presented “GPC Potpourri – a collection of pesky staph and streps”
- Dr. Miller will also be the ASM Distinguished Lecturer at the Fall Meeting of the New York City branch of the American Society for Microbiology, NYC, October 7, 2016. Dr. Miller will present “From the bench: Challenges, conundrums, and lessons learned in this era of improved microbial identification”
- CAP 2016:
- Lei Li, Dr. Sandra Cerda, Dr. Reine Gedeon and Dr. Carmen Sarita-Reyes had an abstract accepted for the College of American Pathologists (CAP) in Las Vegas, Nevada from September 25th-28th 2016 titled; “Acrania Without Anencephaly In The Presence Of Amniotic Band Syndrome;” Lei Li, MD, PhD., Sandra Cerda, M.D., Reine Gedeon, M.D., and Carmen Sarita-Reyes, MD
- Dr. Lei Li presenting at CAP 2016
- Also presented at CAP: Israa Laklouk, MD, Mahmoud Soliman, MD, Robert Pistey, MD, and Sandra Cerda, MD; “Primary Unresectable Locally Invasive Right Atrial Paraganglioma Presenting with Chest Pain” Presented in CAP 2106 http://www.archivesofpathology.org/
- Mahmoud Soliman presenting at CAP 2016
- Soliman was quite busy at CAP, he also presented; Mahmoud L Soliman, MD, PhD, Sandra Cerda MD, Huihong Xu MD, “An Invasive Moderately Differentiated Adenocarcinoma incidentally identified in Perforated Diverticulitis with Abscess Formation” Presented in CAP 2106 http://www.archivesofpathology.org/
- Mahmoud Soliman presenting a second poster at CAP 2016
- Welcome to our two new Masters Students:
- Subha Singh joins us directly as a McNair Scholars Fellow from the University of New Hampshire:
- Rawan Tahboub is already an accomplished physician finishing in the top of her class at Jordan University of Science and Technology:
- Publications: ACCEPTED:
- Elizabeth Moses, Teresa Wang, Sean Corbett, George R Jackson, Eduard Drizik, Catalina Perdomo, Claudia Perdomo, Eric Kleerup, Daniel Brooks, George O’Connor, Steven Dubinett, Patrick Hayden, Marc E. Lenburg, and Avrum Spira. “Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium.” Accepted to Toxicological Sciences.
- Publications: PUBLISHED:
- Hafida, S, Mirshahi, T, Nikolajczyk BS. 2016. The impact of bariatric surgery on inflammation: quenching the fire of obesity? Current Opin Endocrinol, Diab and Obesity. 23:373-8. PMID: 27455515
- Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV. 2016. BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci. (In Press). PMID: 27491296
- Moshe S, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 Sep 20. doi: 10.18632/oncotarget.12107
Pathology & Laboratory Medicine News Items – August 2016
- Deborah Stearns-Kurosawa was named as a co-inventor with Dr. Ekinci and co-workers in the BU Mechanical Engineering department on the provisional patent submission entitled METHOD AND DEVICE FOR ANTIBIOTIC SUSCEPTIBILITY TESTING BASED ON FLUCTUATIONS OF ELECTRICAL RESISTANCE IN A MIRCROCHANNEL
- Joel Henderson is now the Laboratory Director for the Framingham Heart Study; he is responsible for the FHS clinical laboratory and the FHS biobank which holds over 1.4 million specimens.
- Israa Lakloud and Dr. Carmen Sarita-Reyes had an abstract presented at the AHR 2016 Conference at the University of Rochester. An AHR-mediated Positive Feedback Loop that Enforces Cell Migration in Triple Negative Human Breast Cancer Cells; Olga Novikov1 , Zhongyan Wang1 , Elizabeth A. Stanford1, Ashley J. Parks1, Alejandra Ramirez- Cardenas1, Esther Landesman1, Israa Laklouk2, Carmen Sarita-Reyes2, Daniel Gusenleitner3, Amy Li3, Stefano Monti3, Sara Manteiga4, Kyongbum Lee4 and David H. Sherr1 1Boston University School of Public Health, 2Boston University School of Medicine, 3Boston University Division of Computational Biomedicine, 4Tufts University School of Engineering
- Tim Norman, PhD Candidate/Fine Lab received a $1500 scholarship from Jackson Labs to attend their 25th Annual Short Course on Experimental Models of Human Cancer – August 20 – 27, 2016. The course included both seminars and hands-on workshops focused on patient-derived xenografts, single cell sequencing, and bioinformatics
- Max Vaickus, second year MS student in the Remick Lab was selected for a Travel Award and a Young Investigator’s Presentation at the 39th Annual Conference on Shock this past June down in Austin, Texas. Max’s talk was titled: “Mild traumatic brain injury mobilizes Mesenchymal Stromal Cells into circulation, role of Substance P?”
- SHOCK President, Dr. Rosemary Kozar, Max Vaickus and Dr. Daniel Remick at the 2016 SHOCK Conference
- Lois Bayigga, MS, one of our recent graduates, has just been awarded the MUII Wellcome Trust Scholarship. The program is Makerere University Infection and Immunity program (MUII). It is funded by Wellcome Trust of the U.K. It offers a 3 year PhD scholarship. It is based at Makerere University in Uganada and allows collaboration with universities in the north. Lois will be collaborating with Dr. Deborah Anderson on her PhD project so she will be returning to Boston to do some of her work. Bravo Lois!
- Susan Winandy has just finished serving on the Institutional Animal Use and Care Committee.
- One of BU STaRs students, Erika Banuelos, under the tutelage of John Kim in the Remick Lab, present her program culmination poster titled “Inhibitory IgG Interferes with Macrophage Killing of Bacteria via the Fc-FcR pathway” on Wednesday, August 11th
- Erika Banuelos and Dr. John Kim the 2016 at STaRs Presentation
- The NIH/NIDDK STEP UP grant awardee Justin Cho, from Williams College, finished his summer internship training in the Panchenko Lab. Justin successfully presented his project at the STEP UP NIH conference in a poster as well as oral presentation on August 1, 2016
- Yazdan Shaik-Dasthagirisaheb, who the BU community knows as Basha, joined the Nikolajczyk Lab on August 15 as a Research Assistant Professor of Microbiology. Welcome Basha!
- Barb Nikolajczyk, PhD presented her team’s research in a seminar entitled “Defining inflammation in human obesity and type 2 diabetes” at Vanderbilt University August 16
- Publications: ACCEPTED:
- Juan R. Mella, MD, MPH; Evan Chiswick, PhD; David Stepien, MD, PhD; Rituparna Moitra, PhD; Elizabeth R. Duffy, MA; Arthur Stucchi, PhD; Daniel Remick, MD; “Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function”. Accepted to Critical Care Medicine
- Terry Hsieh, Max H. Vaickus, Thor D. Stein, Bethany L. Lussier, Jiyoun Kim, David M. Stepien, Elizabeth R. Duffy, Evan L. Chiswick, Daniel G. Remick; “The Role of Substance P in Pulmonary Clearance of Bacteria in Comparative Injury Models.” Accepted to American Journal of Pathology
- Publications: PUBLISHED:
- Zhao Z, Azad R, Yang JH, Siroky MB, Azadzoi KM. Progressive changes in detrusor function and micturition patterns with chronic bladder ischemia. Investig Clin Urol. 2016 Jul;57(4):249-59
- Panchenko MV. “Structure, function and regulation of jade family PHD finger 1 (JADE1)”. 2016 Sep 1. PMID: 27155521
- Huihong Xu and Daniel G Remick;“Pathology: A Satisfying Medical Profession.” Academic Pathology, Volume 3: 1-4
- Olga Novikov, Zhongyan Wang , Elizabeth A. Stanford, Ashley J. Parks, Alejandra Ramirez- Cardenas, Esther Landesman, Israa Laklouk, Carmen Sarita-Reyes, Daniel Gusenleitner, Amy Li, Stefano Monti, Sara Manteiga, Kyongbum Lee and David H. Sherr; “An Aryl Hydrocarbon Receptor-mediated Amplification Loop that Enforces Cell Migration in ER-/PR-/Her2- Human Breast Cancer Cells”; Molecular Pharmacology Fast Forward. Published on August 29, 2016 as DOI: 10.1124/mol.116.105361
- Dhay Kamel, one of our recent resident graduates and our new Cytology Fellow, just passed her AP & CP exams successfully! She is now board certified; CONGRATULATIONS Dhay!!
- Martin Steinbuck, PhD (Susan Winandy Lab) successfully defended his Thesis, “NOVEL T-CELL RECEPTOR MEDIATED MECHANISMS OF NOTCH ACTIVATION AND SIGNALING” on July 18th, 2016, BRAVO!!
- Newly implemented Departmental Teaching Awards were given at this year’s Castle Graduation Dinner in June, however some recipients were unable to attend the dinner and were presented their awards at alternate times.
- The committee-driven criteria for the student awards are; collegiality, sharing with fellow-students, knowledge, skills, kindness; Leadership, positive attitude, problem solving, initiatives for improvements; Growth in professional skills, aptitudes and attitudes over the year and being a good team worker, helping others, as well as guiding juniors. The measures for the faculty awards were based on student feedback
- Bestowed to:
- On the Research-Side:
- Mostafa Belghasem, MD, PhD: The Excellence Award 2016 (Student/Resident Award) (given at a Henderson Lab meeting)
- Krzysztof Blusztajn, PhD: Residents Teaching Award 2016 (Faculty Award) (presented at a recent Faculty Meeting)
- Tim Norman’s, PhD Candidate (Alan Fine Lab) F31 application from NHLBI titled “Origin, maturation, & regeneration of pulmonary lymphatic endothelium” scored in the 14th percentile. Tim wants to thank Drs. Carter Cornwall, David Atkinson, Andy Henderson, Chris Gable and Chelsea Epler for their help through BU’s Best Grant Writing Seminar
- Annual Association of Pathology Chairs Meeting, San Diego, CA; July 2016:
- Daniel Remick, MD gave a talk at the Pathology Leadership Academy in San Diego on July 11, 2016, “Unique Leadership Challenges in the Research Mission”
- Remick also, organized a workshop at the 2016 Association of Pathology Chairs Meeting in San Diego, “Biorepository Management Workshop”.
- In addition Remick moderated the Research Committee session at the Association of Pathology Chairs in San Diego, “You Won’t Believe Your Eyes – 21st Century Optics in Pathology”
- Carmen Sarita-Reyes participated in the course offered by the Association of Pathology Chairs titled “Pathology Leadership Academy” in Coronado, CA July 11-12 2016. This course was offered to only 50 participants selected by their respective Chairs
- Erin Brooks, MD, University of Wisconsin; David Kindelberger, MD, Boston University; Carmen D. Sarita-Reyes, MD, Boston University presented a Discussion Group titled “Strategies for Maximizing Early Medical Student Exposure to Pathology” at the Association of Pathology Chairs national meeting in San Diego, CA on July 13th 2016.
- Dr. Carmen Sarita-Reyes shared that our fellow Brandon Hayse completed our first Boston University School of Medicine Pathology and Laboratory Medicine Fellowship from May 23rd – July 8th 2016 that is offered to 1st year medical students at BUSM. We wanted to thank the department for their support.
- Jacquelyn Sikora Hanson, PhD Candidate (Lawreen Connors Lab)presented a poster at the International Symposium on Amyloidosis in Uppsala, Sweden on July 5 entitled “Transthyretin and retinol-binding protein serum concentrations are prognostic and survival indicators in wild-type transthyretin amyloidosis.” The authorship was the following: Jacquelyn LS Hanson, Clarissa M Koch, Marios Arvanitis, Gloria G Chan, Frederick L Ruberg, Tatiana Prokaeva, Lawreen H Connors
- Jacquelyn Sikora Hanson also received a Travel Award from GMS to attend the International Symposium on Amyloidosis in Sweden
- Additional Posters/Presentations from the Connors Lab at the XVth Amyloidosis Symposium in Sweden, July 2016, include:
- ALBase: an updated and improved platform to study immunoglobulin light chain sequences. A Bhutkar, B Spencer, G Chan, LH Connors, T Prokaeva
- Proteomic blood profiling in inherited (ATTR-FAC) and acquired (ATTRwt) forms of transthyretin-associated cardiac amyloidosis. GG Chan, CM Koch, LH Connors
- Serum proteomic variability associated with clinical phenotype in familial transthyretin amyloidosis (ATTRm). LH Connors, CM Koch, GG Chan
- Retinol-binding protein 4, a natural binding partner of transthyretin, is an indicator of differing pathobiologies in ATTRm and ATTRwt cardiac amyloidosis. LH Connors, CM Koch, GG Chan
- Histological characterization of localized amyloidosis tissues. HL Cui, LH Connors, T Prokaeva, M Skinner, CJ O’Hara
- Transthyretin and retinol-binding protein serum concentrations are prognostic and survival indicators in wild-type transthyretin amyloidosis (ATTRwt). JLS Hanson, CM Koch, GG Chan, T Prokaeva, LH Connors
- Quantitation of tissue amyloid by novel Magnetic Resonance Imaging T2 relaxation sequences. N Hua, JE Ward, V Shibad, G Yee, LH Connors, H Jara, DC Seldin, JA Hamilton
- AL amyloidosis cell model expressing patient-derived immunoglobulin light and heavy chains. ES Klimtchuk, TB Prokaeva, BH Spencer, LH Connors
- Heavy light chain test quantifies clonal plasma cell disease in patients with AL amyloidosis and low serum free light chain burden. T Prokaeva, B Spencer, F Sun, N McConnell, RM O’Hara, DC Seldin, LH Connors, V Sanchorawala
- A new and unusual transthyretin mutant, duplication of TTR codons 51 and 52 (Glu51_Ser52dup), associated with severely aggressive familial amyloidotic polyneuropathy. B Spencer, JL Berk, E Klimtchuk, P SooHoo, T Prokaeva, LH Connors
- Cytogenetic abnormalities in patients with newly diagnosed AL amyloidosis. H Yameen, JM Sloan, C Varga, JC Lee, CJ O’Hara, V Sanchorawala
- Familial wild-type transthyretin cardiomyopathy. MD Benson, JL Berk, LH Connors
- Barb Nikolajczyk will serve as Lead Organizer for the FASEB Conference “Immunological Aspects of Obesity” held in Big Sky Montana July 31- Aug. 5
- Barb Nikolajczyk, PhD also presented “Defining Inflammation in Human Obesity and Type 2 Diabetes” at the San Antonio Health Sciences Center Department of Microbiology and Immunology in July 2016. Dr. Liz Leadbetter, an alum of the BUSM PhD program, hosted the speaker visit
- Publications: ACCEPTED:
- Huihong Xu, MD, and Daniel G. Remick MD; “Pathology – A Satisfying Medical Profession” has been recently accepted by Academic Pathology Journal
- Samar Hafida, Tooraj Mirshahi, and Barbara S. Nikolajczyk,The Impact of Bariatric Surgery on Inflammation: Quenching the Fire of Obesity? In Press at Current Opinion in Endocrinology and Diabetes for Oct. 2016 publication
- Publications: PUBLISHED:
- Guo J, Wang X, Lü X, Jing R, Li J, Li C, Wang D, Bi B, Chen X, Wang F, Sun S, Azadzoi KM, Yang JH. Unraveling molecular effects of ADAR1 overexpression in HEK294T cells by label-free quantitative proteomics.Cell Cycle. 2016 Jun 17;15(12):1591-601
Pathology & Laboratory Medicine News Items – June 2016
Congratulations to our Graduating Fellow, Residents and Graduate Students:
- Anita Deshpande, MD; Moving into a Faculty Position at Melrose-Wakefield – Hallmark Pathology PC
- Yanli Ding, MD; Going to Renal Path at Brigham & Women’s Hospital
- Dhay Kamel, MD; Stepping in to our Cytopathology Fellowship – BMC
- Anita Malek, MD; Moving on to New York Presbyterian – Hematopathology Fellowship
- Yue Sun, MD; Going on to New York’s Memorial Sloan Kettering Cancer Center, Surg Path Fellowship
- Parul Agnihotri, PhD; Seeking a postdoc position in academia or industry
- Lois Bayigga, MS; Moved back to Uganda and plans to enter a PhD Program
- Mostafa Belghasem, PhD, MA; Moved into a position within the department
- Evan Catudal, MS; Currently employed at the Boston Heart Diagnostics in Framingham, MA as a Medical Technologist. He is working on validating new clinical diagnostic assays for predicting cardiovascular disease risk. Evan is also enrolled as a part-time student in the M.S. in Clinical Investigation program at BUSM beginning in the Fall
- Atsushi Ebata, PhD; Seeking a postdoc position
- Terry Hseih, MD/PhD; Gone back to medical school
- Melody Lun, MD/PhD; Gone back to medical school
- Nicole Stauffer Smith, PhD; Seeking a postdoc position in academia or industry
- Martin Steinbuck, PhD; Seeking a postdoc position in academia or industry
- Ruoyu Tian, MS; Moving on to the Georgia Institute of Technology, PhD Biology Program
Congratulations Graduating Resident, Yanli Ding for receiving the prestigious Robert Foley, MBA, Award. This honor is given annually to a resident or fellow who “demonstrates the qualities that Mr. Foley brought to work every day.”
Newly implemented Departmental Teaching Awards were given at this year’s Castle Graduation Dinner
- The committee-driven criteria for the student awards are; collegiality, sharing with fellow-students, knowledge, skills, kindness; Leadership, positive attitude, problem solving, initiatives for improvements; Growth in professional skills, aptitudes and attitudes over the year and being a good team worker, helping others, as well as guiding juniors
- The measures for the faculty awards are based on student feedback
- Bestowed to:
- On the Clinical-Side:
- Yue Sun, MD: The Excellence Award 2016 (Student/Resident Award)
- Grace Zhao, MD, PhD: Residents Teaching Award 2016 (Faculty Award)
- For the Research-Side:
- Not yet awarded, so these will be announced in the next New News Edition!
- On the Clinical-Side:
Daniel Remick, MD was invited to the 39th Annual Shock Society Meeting in Austin, Texas, June 11th -14th to give a presentation: “Interviewing Skills and CV Preparation that Stands Out
Daniel Remick, MD also organized a debate at the 39th Annual Shock Society Meeting titled “Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness?”
Congratulations on passing the Qualifying Exams!
- Ahmad Al-Moujahed
- Greg Hall
- Thank you to the faculty members who serve on the Qualifying Exam Committee; Drs. Blusztajn, Delalle, Rahimi, Remick and Slack with a SPECIAL Thank You Barbara Slack, Chair of the Qualifying Exam Committee
Barb Nikolajczyk, PhD just received word of funding for a $2.95 million 5 year R01 from NIDCR entitled: “Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes”
Ivana Delalle will be presenting the results of her team’s work at 11thEuropean Congress of Neuropathology (Bordeaux, France, 6-9 July 2016); “Subcellular changes in BIN1 protein expression in human cortex during the progression of Alzheimer’s disease”
Deborah Stearns-Kurosawa, PhD has received a re-appointment letter for the Boston University Dual Use Research Review Committee through June 30, 2019
Barb Nikolajczyk, PhD also spoke at the American Association of Diabetes Annual Meeting in New Orleans June 12. Session: Immunobiology of Type 2 Diabetes; Title: T cell Inflammation in Human Obesity and Type 2 Diabetes
- Juan R. Mella M.D., M.P.H., Evan Chiswick Ph.D., David Stepien, M.D., Ph.D., Rituparna Moitra Ph.D., Elizabeth R. Duffy M.A., Arthur Stucchi Ph.D., Daniel Remick M.D. Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function. Accepted Critical Care Medicine
Castle Graduation Celebration 2016