October – Friday @ 2:00 “Genetic Variation of the Transthyretin Gene May Impact Disease...
- Parul Agnihotri, PhD Candidate in Susan Winandy’s Lab was elected Vice President of the Boston University Graduate Medical Sciences Student Organization (GMSSO) for 2015-2016 effective this month. The GMSSO is a student run organization that works to unite students from all departments and schools on the Medical Campus, to share ideas and address questions or concerns pertaining to student life. Through organizing various social and community service activities, GMSSO is an outlet for students to get involved in the BU Graduate Medical Sciences community, both on and off campus.
- For six weeks, Jason Sutin, Pathology PhD Candidate in Maria Franceschini’s Lab at MGH will be working with the CURE Children’s Hospital of Uganda in Mbale, Uganda, Africa on a collaboration to study the effect of surgical treatment of infant hydrocephalus on cerebral blood flow and oxygen metabolism.
- Nader Rahimi and his Lab’s recent publication on the characterization of a novel adhesion molecule (TMIGD1) was on the news: http://www.sciencedaily.com/releases/2015/09/150902112004.htm
- Several Department of Pathology members participated in the 2015 Boston Heart Walk on Saturday, September 12th sponsored by the American Heart Association. BRAVO!!! The AHA MISSION: Building healthier lives, free of cardiovascular diseases and stroke. Their IMPACT: By 2020, to improve the cardiovascular health of all Americans by 20 percent while reducing deaths from cardiovascular disease and stroke by 20 percent. In 1999, the American Heart Association set a bold 10-year goal: To reduce coronary heart disease, stroke and risk by 25 percent by 2010. We achieved the reduction in deaths ahead of schedule and made substantial progress against three of the six risk factors. Our 2020 Impact Goal focuses on helping people build stronger health and a better quality of life.
- Dequina Nicholas, PhD from Loma Linda Medical School, (2015) has joined the labs of Barbara Nikolajczyk and Gerald Denis as an Inflammation Training Grant-supported post-doctoral full. Welcome Dequina!
- On September 15th the department held a Faculty Meeting that included faculty, residents, postdocs and graduate students devoted to addressing professionalism in the workplace. The meeting will also include professionalism vignettes that were presented at the Association of Pathology Chairs meeting this summer.
Dr. David Kindelberger introduced several vignettes on Professionalism:
Dr. O’Brien spoke on Altruism:
Dr. Chris Andry addressed Accountability:
Dr. Karen Quillen talked about Respect:
Additional comments by Dr. Barbara Slack:
And Dr. Carl O’Hara:
Rally for Research September 16 & 17 2015
The rally for research #rallymedres was held in Washington DC to advocate for increased funding for the National Institutes of Health (NIH). Advocates from 40 states and more than 200 organizations spoke with their Senators and Congressman about the need for robust, predictable and sustainable NIH funding. The key messages that were delivered included the fact that since 2004 there has been a 24% decrease in the dollars available for NIH investigators (adjusted for inflation). In prior years there was a 1 in 3 chance that a grant would be funded, with the current paylines there is a 1 in 7 chance.
The Association of Pathology Chairs was represented at the rally by Daniel Remick, M.D., Chair of Pathology and Laboratory Medicine at Boston University School of Medicine #DanielRemick1 who provided twitter updates throughout the rally.
After orientation on September 16th the 300 rally participants were bused to the Capital for a rally held in the Kennedy Caucus room. Presentations were made by Jerry Moran (R-Kansas), Senator Durbin (D-Illinois), Patti Murray (D-Washington) and Amy Klobuchar (D-Minnesota). Each of these Senators expressed strong bipartisan support to increase NIH funding. Senator Murray talked about the need for NIH funding to maintain American exceptionalism. Senator Klobuchar is such a strong NIH supporter that during the last government shutdown, she donated her salary to the NIH. Francis Collins, the Director of NIH spoke passionately about funding saying we cannot wait for cure and we cannot wait for hope. Patient advocates also spoke about why NIH funding saves lives.
The next morning, September 17th 2015, Representative Tom Cole (R-Oklahoma), the fourth ranking Republican in the House of Representatives addressed participants. He emphasized that Congress is eager to show bipartisan legislation that helps the country, and increased funding for NIH was a clear example of this. The rally participants then met with members of Congress and their staff.
The delegation from Massachusetts consisted of Daniel Remick, M.D., Chair and Professor of Pathology & Lab Medicine, Boston University School of Medicine, Susan Hankinson, Sc.D., Chair of Biostatistics and Epidemiology, Health Sciences University of Massachusetts and Timothy Leshan, Northeastern University Vice President Government Relations. The delegation met with our Senators and Representatives. We met with Ashley Coulombe, Special Assistant to Senator Elizabeth Warren first and relayed specific examples of how decreased NIH funding has hurt research. The next meeting was with Andrew Cohen, Counsel to Senator Edward Markey. Senator Markey has long supported funding for NIH.
The delegation was fortunate to spend 30 minutes with Rep. Joseph Kennedy from the 4th district of Massachusetts (see picture). The day finished with meetings with Jennifer Chandler, Senior Legislative Assistant to Rep. James McGovern and a final meeting the Rep. Capuaon’s Chief of Staff Robert Primus.
All the Massachusetts legislators strongly support increased funding for the mission of NIH but the MA delegates were able to provide several reasons why increased NIH funding is a national imperative.
- Su N, Choi HP, Yang Jing-Hua, Wang F, Su H, Fei Z and Azadzoi KM entitled “Quantitative Proteomic Analysis of Differentially Expressed Proteins and Downstream Signaling Pathways in Chronic Bladder Ischemia” has been accepted for publication in the Journal of Urology.
Pathology & Laboratory Medicine News Items – August 2015
- Please join me in congratulating Dr. David Kindelberger on his appointment as an Associate Professor of Pathology and Laboratory Medicine. President Brown just approved his appointment. Appointment or promotion to Associate Professor is a significant achievement and acknowledges that Dr. Kindelberger enjoys a national reputation. This national reputation has been demonstrated by his numerous publications as well as many presentations. Dr. Kindelberger has carried a full service load in addition to his teaching to the residents.
- The department had a Visiting Scholar from the University of Dammam, Saudi Arabia:
- Dr. Areej Al Nemer, an anatomic pathologist from University of Dammam was in our department from July 22nd until August 14th. She was involved in several research projects in the Henderson Lab including a study on kidney injury caused by light chain paraproteins, and a collaborative study with the Rahimi Lab investigating IGPR2 expression in human kidney neoplasia. Dr. Al Nemer also learned about the work of our anatomic pathology diagnostic service, and participated in some of the routine activities of the service.
- Dr. Deborah Stearns-Kurosawa has been re-appointed IBC Chair by the Associate Vice President for Research Compliance, bravo!
- Mostafa Belghasem, PhD, Henderson Lab, successfully defended his thesis “Pathological and Molecular Profiling in Hypertension-Induced Glomerular Injury” on Thursday, July 30th
- From Dr. Nader Rahimi’s Lab:
- We welcome Dr. Mehrdad Lavaei and Xueqing Zou to Department of Pathology and Laboratory of Medicine, both recently joined Dr. Rahimi’s laboratory.
- Dr. Lavaei is pathology resident in VU University Medical Center Amsterdam, Nederland and his research is supported by the Dutch government.
- Xueqing Zou is a PhD student at the Shandong University, China. He will be doing his thesis research work with Dr. Rahimi. Xueqing Zou research is supported with a scholarship from China.
- We also welcome Walter Wong and Brad Pearson from BU’s MAMS program, who recently joined Dr. Rahimi’s laboratory.
- Barb Nikolajczyk, PhD has received a new grant; “Roles for B cells in the development of periodontal complications of type 2 diabetes” has been selected for funding. Source of funding: BU Clinical and Translational Science Institute; Funds awarded:$20,000; Budget period: August 31, 2015 – March 31, 2016
- Debbie Stearns-Kurosawa, PhD is an invited to be a speaker at a symposium on the “Molecular Mechanisms of Vascular Disease” at the Mount Desert Biological Laboratory in Bar Harbor, Maine on October 11-15. The symposium is organized by Dr. Hermann Haller, Professor of Medicine at the Hannover Medical School in Germany and includes speakers from the US, Israel, Europe, and Canada. Dr. Stearns-Kurosawa will speak on complement and the hemolytic uremic syndrome.
- From the Kurosawa Lab: Two abstracts were accepted for the 9th Triennial International Symposium on Shiga Toxin (Verocytotoxin) producing Escherichia coli (VTEC) meeting on September 13-16 in Boston:
- 1) DJ Stearns-Kurosawa*, Arthur Fernandezǂ, Denis Garceauǂ, Shinichiro Kurosawa*. “Passive Immunity Strategy For Shiga Toxin-HUS in Non-human Primates”. *Department of Pathology and Laboratory Medicine, Boston University School of Medicine ǂ Thallion Pharmaceuticals, a subsidiary of Bellus Health Inc., 275, boulevard Armand-Frappier Laval (Québec) H7V 4A7 CANADA
- 2) DJ Stearns-Kurosawa, Caitlin S.L. Parello, Shinichiro Kurosawa. “Retrograde Product Development for Treatment of Shiga toxin-HUS”.Department of Pathology and Laboratory Medicine, Boston University School of Medicine
Welcome to our New Graduate Students:
|Ahmad Al Moujahed, PhD Candidate|
|Greg Hall, PhD Candidate|
|Keith Keller, Masters|
|Maya Kim, Masters|
|Denis Kyabaggu, Masters|
|Carolina Lyon de Ana, Masters|
|Morgan Thompson, Masters|
|Max Vaickus, Masters|
Pathology & Laboratory Medicine News Items – July 2015
- A manuscript describing the study from Panchenko Lab was accepted for publication by Cell Cycle without any revision or resubmission. The authors discovered an unexpected role of the component of the histone acetyl trasferase complex, JADE1, in cytokinesis – which is the least described but the most crucial phase of the epithelial cell cycle progression. The study defined JADE1 protein as novel factor of tissue regeneration and a potential player in cancer pathogenesis. By the choice of the Editor-in-Chief this study will be featured in the “News & Views” of the Journal; “The novel function of JADE1 in cytokinesis of epithelial cells” by N.S. Siriwardana, R.D. Meyer, and M.V. Panchenko http://www.ncbi.nlm.nih.gov/pubmed/26151225
- David Sherr and his team just had a R01 score in the 1 percentile. The is the grant, with George Murphy co-PI, which is focused on manipulating AHR activity in differentiating iPSC and resulting in production of unlimited numbers of human red blood cells
- After a long and distinguished career, Tom Christensen has retired! Here are some photos of the luncheon held in his honor:
- Nancy S. Miller, MD presented the Special Session lecture, “Laboratory considerations in an era of improved microbial identification”, at the 4th International Conference and Exhibition on Pathology, July 13-15, 2015 in New Orleans, Louisiana
- Dr. Anita Deshpande successfully passed both the Anatomic Pathology and Clinical Pathology portions of the board, BRAVO!
- Publications ACCEPTED:
- S. Siriwardana, R.D. Meyer, and M.V. Panchenko. “The novel function of JADE1 in cytokinesis of epithelial cells” Cell Cycle
- Brooks CR, Yeung MY, Chen H, Henderson JM, Ichimura T, Bonventre JV. KIM-1/TIM-1-mediated phagocytosis links ATG5/ULK1 dependent clearance of apoptotic cells to antigen presentation. EMBO J. ACCEPTED FOR PUBLICATION
- Ip, B, Cilfone, N, Belkina, AC, DeFuria, J, Jagannathan-Bogdan, M, Zhu, M, Kuchibhatla, R, McDonnell, ME, Xiao, Q, Kepler, TB, Apovian, CM, Lauffenburger, DA, and Nikolajczyk, BS. 2015. Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFa production. Obesity. (In Press)
- Publications PUBLISHED:
- Jeanne Shen MD, Joanna A. Gibson MD, PhD, Stephanie Schulte MD, Hema Khurana MD, Francis A. Farraye MD, MSc; Jonathan Levine MD, Robert Burakoff MD, MPH, Sandra Cerda MD, Taha Qazi MD, Robert D Odze MD, FRCPC. Clinical, Pathologic, and Outcome Study of Hyperplastic and Sessile Serrated Polyps in Inflammatory Bowel Disease. Human Pathology July 2015
- Fujita A, Xu H, Chang Y, Jalisi S, and Sakai O, Best cases from the AIRP: Malignant mixed tumor of the hard palate. RadioGraphics 2015; 35:1186-1190
- Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci. 2015 Aug;16(8):445-57. doi: 10.1038/nrn3921. Epub 2015 Jul 15
- Papageorgis P., Ozturk, Lambert, A.W., S., Tzatsos, A., Neophytou, C.M., Wong, C.K., Thiagalingam, S., and Constantinou, A. I. (2015). Targeting IL13Ralpha2 activates STAT6-p63 pathway to suppress breast cancer metastasis. Breast Cancer Research 17:98.
Pathology & Laboratory Medicine News Items – June 2015
- BMC “Be Exceptional” Awards 2015, which recognize outstanding BMC staff who demonstrate exceptional performance and dedication to fulfilling BMC’s mission and four QUEST goals: Quality, Efficiency, Satisfaction, and Total Revenue. “Chosen by a committee made up of leaders from around the hospital, they were selected for their exceptional performance, initiative and teamwork, and for embodying our RESPECT behavioral attributes. These staffers reflect BMC on its best day, every day. Congratulations to the following individuals and teams!” Two members of the Department of Pathology and Laboratory Medicine are among this year’s recipients which were awarded on June 17th in Hiebert Lounge.:
- Sherri Dagger, one of our Pathology Histotechnologist, for her exceptional performance and dedication to fulfilling BMC’s mission and QUEST goals
- Neil O’Neil, Laboratory Administration Operations, “this appropriately recognizes his outstanding service to BMC”
- Shinichiro Kurosawa has accepted an invitation to serve as a member of the Host Interactions with Bacterial Pathogens Study Section at NIH at the Center for Scientific Review, for the term beginning July 01, 2015 and ending June 30, 2019
- Daniel Remick was in Brazil last month for the 12th Annual Forum on Sepsis at the Latin-American Institute for Sepsis in Sao Paulo, Brazil:
- Remick gave the Keynote Address at the Forum; Pathophysiologic Mechanisms in Septic Shock
- Remick also presented at the Thematic Session – Therapeutic Interventions; Do Inhibitory Immunoglobulins Decrease Pathogen Killing and Increase Sepsis Mortality
- He spoke again at the Thematic Session, Special Situations in Sepsis; Brain Injury and Pneumonia Prevention
- Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “IGPR-1 in colon cancer chemotherapy”. The overall of goal of this research is to study the role of IGPR-1 in colon cancer and chemo treatment. IGPR-1 is a novel protein identified in the Rahimi laboratory. IGPR-1 represents a new class of cell surface receptors involved in cell-cell recognition and mediates tumor angiogenesis, a process by which new blood vessels are recruited to growing tumor.
- Ivana Delalle just presented an abstract at the International Conference on “The long and the short of non-coding RNAs” in Greece, June 14-19, 2015.
- Delalle also presented “Exosomal microRNAs as biomarkers for bipolar disorder and schizophrenia” Jason Choi1, Andre Fischer 2,3, Farahnaz Sananbenesi3, and Ivana Delalle1. 1Boston University School of Medicine, Boston, MA, USA, 2Goettingen University, Goettingen, Germany, 3German Center for Degenerative Diseases (DZNE), Goettingen, Germany.
- New Residents:
- Entering PGY 1s
- Transferring PGY 2s
- Entering PGY 1s
- Kurosawa Lab:
- Annalyn Brown is a STaRS summer student (Summer Training as Research Scholar) in our lab and her project is about how inflammation alters susceptibility of cells to bacterial toxins. Specifically she’ll investigate whether activation of TLR4 increases Gb3 receptor expression for Shiga toxins on endothelial cells. Annalyn is an undergraduate student at the University of the Virgin Islands and we’re pleased to have her in our lab this summer.
- Evan Catudal is a Master’s student in the Pathology program with experience as a medical technologist. His thesis project is a collaborative effort between the Kurosawa and Remick labs to identify contributions of coagulation pathways to enhanced survival of mice after mild traumatic brain injury and pneumoniahasis
- Greg Hall is a licensed veterinarian in the PhD program with interests in animal model development and development of disease pathology. He will be working in the Kurosawa Lab on animal models of thrombotic microangiopathy for his thesis project. joined the Kurosawa Lab coming after his first year in the PIBS Program
- Remick Lab:
- Gina Ellsworth, a science/biology teacher at Haverhill High School is a summer intern with the American Association of Immunologists, where she is learning laboratory techniques in the Remick Lab to create a hands -on activity and curriculum of immunology. This activity will be demonstrated at the National Association of Biology Teachers conference in November and the curriculum will be posted to the AAI website by Spring 2016. Gina is working with postdoc Evan Chiswick, PhD.
- Alejandro Sanoja is a rising senior from the University of Florida. He is a member of the Summer Training as Research Scholars (STaRS) program at BU. Alejandro’s STaRS internship in the Remick Lab will be with Terry Hsieh, MD/PhD candidate and focuses on investigating immune priming in a mouse model
- Summer Training as Research Scholars Program.
- STaRS is designed to promote access to graduate education for talented undergraduates from minority groups traditionally underrepresented in the biomedical sciences: African-American, Hispanic, Native American/Native Alaskan, and Pacific Islander/Native Hawaiian. STaRS is sponsored by the Division of Graduate Medical Sciences, a recognized leader in graduate education and biomedical research.
- STaRS is a dynamic and focused program that is designed specifically for the enhancement of skills required for successful entrance and completion of a graduate program or an MD/PhD program in the biomedical sciences.
- STaRS offers motivated and academically talented students a valuable opportunity to confirm a strong interest in doctoral studies particularly in the areas of heart, lung and blood research.
- Castle Graduation Dinner Celebration 2015:
- Emad Arafa, Philip Bondzie, Kobra Rezazadeh, Rosana D Meyer, Edward Hartsough, Joel Henderson, John H. Schwartz, Vipul Chitalia, Nader Rahimi. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. American Journal of Pathology, 2015 http://ajp.amjpathol.org/ Emad Arafa & Philip Bondzie are co-primary authors
Pathology & Laboratory Medicine News Items – May 2015
- LAB WEEK was April 20-24 this year, the theme was “was “Not all Heroes Wear Capes, Some Wear Lab Coats!” Events for the week included: a scavenger hunt, door decorating contest, which Chemistry won, for a departmental pizza party, we had games, and we collected $213 for the Cancer Center by allowing employees to wear jeans. We also handed out tumblers as lab week gifts
- Huihong Xu was invited to give a cytology lecture “GI Interesting Cytology Cases” for the pathology residents at Brigham & Women’s Hospital on May 12th, 2015.
- Congratulations; Lee Quinton has been promoted to Associate Professor of Medicine and Pathology & Laboratory Medicine
- Last year Mostafa Belghasem, PhD candidate taught PS701 Immunology/Pathology lectures; these lectures were well-received by the Physician Assistance students and accordingly, he has been invited by the course directors to teach this year as well
- Carmen D. Sarita –Reyes attended, as a member, the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee Meeting from May 11th – 15th 2015 in Chicago, Illinois
- Debbie Stearns-Kurosawa, PhD was an invited featured speaker at the 2015 American Society for Apheresis Annual Conference May 6 – 9 in San Antonio, Texas. Her talk was entitled: The Pathophysiology of E.coli-Mediated Hemolytic Uremic Syndrome
- Mostafa Belghasem, PhD candidate was invited by the Boston University Renal Section to talk about his thesis work. The lecture Mostafa presented was: Pathological and Molecular Profiling in Hypertension-induced Glomerular Injury on April 30, 2015
- A collaborative project between the Kurosawa Lab and Drs. Monica Schaller and Johanna Kremer Hovinga from the University Clinic of Hematology, Central Hematology Laboratory and Department of Clinical Research, University Hospital Berne, Berne, Switzerland was accepted as a poster presentation for the International Society of Thrombosis and Haemostasis (ISTH) meeting in Toronto, Canada (June 20-25). The abstract is entitled: ANTI-IDIOTYPIC DARPINS RESTORE ADAMTS13 ACTIVITY IN BABOONS CHALLENGED WITH HUMAN MONOCLONAL ANTIBODIES: FIRST STEP TOWARDS AN ANIMAL MODEL FOR HUMAN ACQUIRED TTP
- Dave Sherr, PhD and his Lab has received yet another $50k from Avon for breast cancer
- BRAVO is in order:
- Chris Andry has been reappointed as Chair of Boston University’s Safety Committee
- Abigail Brown has been reappointed as a Voting Member of Boston University’s Safety Committee
- Shinichiro Kurosawa has been reappointed as a Voting Member of Boston University’s Safety Committee
- Liz Duffy has been newly appointed as a Voting Member of Boston University’s Safety Committee
- Dave Sherr, PhD and his Lab has received yet another $50k from Avon for breast cancer
- Commencement, May 15, 2015; CONGRATULATIONS GRADUATES:
- Emad Arafa, MA
- Philip Bondzie, PhD
- Patricia Chun, MA
- Zach Hunter, PhD
- Clarissa Koch, PhD
- Caitlin Leibowitz Parello, PhD
- Jordan Shafran, MA
- Nick Woolf, MD/MA
- Publications PUBLISHED:
- Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine. Vol 2, No 2 (2015)
- Publications ACCEPTED:
- Mathew H, Dittus C, Malek A, Negroiu A. Howell-Jolly Bodies on Peripheral Smear Leading to Diagnosis of Congenital Hyposplenism in a Patient with Septic Shock. Clinical Case Report
- Srimathi Srinivasan, Vipul Chitalia, Rosana D Meyer, Edward Hartsough, Manisha Mehta, Itrat Harrold, Nicole Anderson, Hui Feng, Lois E.H. Smith, Yan Jiang, Catherine E. Costello, Nader Rahimi. Hypoxia-induced expression of Phosducin like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis, 2015. http://www.springer.com/biomed/cancer/journal/10456
- Sowmya Shivanna, Kumaran Kolandaivelu, Moshe Shashar, Mostafa Belghasem, Laith Al-Rabadi, Mercedes Balcells, Anqi Zheng, Janice Weinberg, Jean Francis, Michael P. Pollastri, Elazer R. Edelman, David H. Sherr, and Vipul C. Chitalia. “The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia”. Accepted for publication by the Journal of the American Society of Nephrology. May 2015.
- Publications PUBLISHED:
Pathology & Laboratory Medicine News Items
- Stephanie Adams, OD/PhD Student and Ivana Delalle have an abstract that has been accepted for a platform presentation at the American Association of Neuropathologists meeting in June in Denver, CO.; “BIN1 Expression In Human Hippocampus During Alzheimer’s Disease Progression,” Authors: Stephanie Adams1, Kathy Tilton1, Sudha Seshadri2, Ivana Delalle1.
- As part of the new collaboration between Boston University and the University of Damman, Saudi Arabia, Daniel Remick gave two presentations in April in Saudi Arabia :
- Keynote Address, University of Damman, Saudi Arabia, 1st Annual Scientific Research Update – Traumatic Brain Injury Augments Pulmonary Host Responses to Bacteria: Molecules and Mechanisms
- Specialized Workshop, King Fahd Hospital University of Damman, Saudi Arabia, Immunopathology of Sepsis – 2015
- Dr. Remick served as an ad hoc member of the Board of Scientific Review for the National Institutes of Arthritis, Musculoskeletal and Skin Diseases at the National Institutes of Health.
- Barbara Slack, Pathology Department Russek Awards Committee Member, is pleased to announce that this year’s Russek Award recipients in the Department of Pathology and Laboratory Medicine are:
- First Prize Recipient – Jacquelyn Sikora Hanson (Advisor: Lawreen Connors); Jacquelyn presented her talk on May 1st entitled; “The transthyretin gene variant G6S may be protective in wild-type transthyretin amyloidosis.”
- Second Prize Co-Recipients – Caitlin Miller (Advisor: Suryaram Gummuluru) & Nicole Stauffer (Advisor: Joseph P. Mizgerd)
- Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day was held on May 1st in the Hiebert Lounge (L building, 14th floor). The keynote speaker this year was Dr. David M. Livingston, Emil Frei Professor of Medicine at Harvard Medical School. Posters were available for viewing throughout the day, and slide presentations by the first prize winners took place in the afternoon. More information about this event can be found at the link (http://www.bumc.bu.edu/gms/students/phd/russek-student-achievement-day-2015/)
- David Sherr, PhD, MD/PHD student, Olga Novikov, won the School of Public Health’s Dean’s Award. See link below. http://www.bu.edu/sph/2015/04/15/olga-novikov-wins-deans-award-at-graduate-research-symposium/
- Congratulations are in order for Emad Arafa and Jordan Shafran, both graduating Masters students in Nader Rahimi’s Lab. Emad and Jordan have been accepted in BU’s PIBS PhD Program; Bravo!
- Nisma Mujahid, one of our MD/PhD student has been awarded the Canadian Institutes of Health Research Doctoral Foreign Study Award
- The department’s biobanking team were represented by Chris Andry, Liz Duffy and Cheryl Spencer at a two day summation meeting for the cancer Human Biobank (caHUB) and Ethical, Legal and Social Implications (ELSI) program at the National Cancer Institute in Bethesda, MD on April 22nd. All four biospecimen source sites involved in the pre-analytic variables study were represented as well as the analytics teams from around the country. The BMC team presented data regarding biospecimen collection in the pre-analytic variables study as well as on the ELSI enrollment and consent surveys.
- Analytics data on immunohistochemistry and in situ staining, proteomics and genomics are expected by late Fall. The ELSI data was synthesized and analyzed by Dr. Teddy Warner, University of New Mexico with very interesting preliminary results
- BMC’s biobanking efforts were recognized by the NCI leadership, particularly in the areas of quality and collaboration. All pathology faculty and residents were acknowledged for their contributions to the project
- Eladio Rodriguez-Diaz PhD, Qin Huang MD, Sandra R. Cerda MD, Michael J. O’Brien MD, Irving J. Bigio PhD, Satish K. Singh MD; Endoscopic histological assessment of colonic polyps by using elastic scattering spectroscopy. Gastrointestinal EndoscopyJjournal. March 2015, Vol.81(3):539–547
- “Systems Biology of Cancer” edited by Sam Thiagalingam, PhD
- A book edited by Dr. Sam Thiagalingam entitled “Systems Biology of Cancer” was released by the publisher Cambridge University Press on April 9, 2015. It provides a comprehensive account of the current state of the knowledge and a road map to formulate a blueprint for the biological basis of cancer. The emphasis of the book is on the biology with minimal mathematical derivations and computational methods which are still evolving to meet the unprecedented amount of data produced with high-throughput experimentation methods that are continuing to be developed.
- Readers will be able to get a realistic view of what is known and remaining to be uncovered in the chapters presented by international experts on the aberrations in the fundamental biological processes, deregulation of major signaling networks, alterations in major cancers and the strategies for using the scientific knowledge for effective diagnosis, prognosis and drug discovery to improve public health. This will serve as a useful text on cancer suitable for students and researchers in all stages of their careers including the undergraduates. The contents are most suitable and highly recommended for graduate students, medical residents and fellows and experienced researchers. This landmark volume consists of a collection of 32 chapters with contributions from more than 75 international experts which includes 8 chapters by Boston University faculty and trainees. At this time the publisher is providing a 20% discount (see Flyer). Thiagalingam-Flyer-SystemsBiologyof Cancer-2015
- This link allows you to look at the first few pages of the book in kindle:
- Witthaus MW, Nipa F, Yang JH, Li Y, Lerner LB, Azadzoi KM. Bladder Oxidative Stress in Sleep Apnea Contributes to Detrusor Instability and Nocturia. J Urol. 2015 May;19 (5):1692-9. PMID: 25463994
Pathology & Laboratory Medicine News Items
- 104th USCAP Meeting, Boston, MA, March 21-27 2015
- Cathryn Byrne-Dugan, MD had her abstract accepted: “Podocyte Infolding Glomerulopathy – Occurrence of the Disease Entity in the United States, and the Potential Role of an Autoantibody;” Authors:Cathryn J Byrne-Dugan, Pavel Kopach, Laurence H Beck, Vanesa Bijol, Monika Pilichowska, Helmut G Rennke, Masha Bilic
- Meera Mahalingam will be the Chair/Moderator of “Neoplastic Dermatopathology – Clues and Confounders.” Topic was selected to highlight histopathologically confounding issues in cutaneous neoplasms. Neoplasms selected encompass a spectrum of lineage-unrelated tumors that are commonly encountered some perhaps more than others by a general pathologist both in private practice and in an academic setting. Each speaker will begin with an initial description of the entity and conclude with clues and confounding issues relevant to the entity discussed
- Qing Zhao, Shi Yang, Cecilia Ponchiardi, and Michael O’Brien had their abstract “BRAF/KRAS Mutation, MSI/MSS Status and Tumor Budding in Colorectal Carcinoma” at the Poster Session on Tuesday, March 24th
- “Resident Shiva Khoobyari, MD enjoying a Poster at this year’s USCAP in Boston”
- Congratulations to Karen Quillen on her recent promotion to full professor. There is a nice article in BU today about her advancement. http://www.bu.edu/today/2015/med-promotions/
- Daniel Remick, M.D., has been selected to be a Guest Editor for the Journal of Leukocyte Biology beginning February 2015. Dr. Remick will serve as the Editor for manuscripts solicited from the 2014 joint annual meeting of the Society for Leukocyte Biology and the International Innate Immune and Endotoxin Society.
- On March 9th 2015 in Boston, MA. Carmen Sarita-Reyes presented at the 2015 Annual Session and Exhibition of the American Dental Education Association (ADEA) a Chair of the ADEA Board of Directors Symposium. The presentation was titled: “IGNITING MINDS THROUGH STUDENT SELF-DIRECTED GROUP LEARNING: Integrated Problem Sessions (IPS.) Chair of the ADEA Board of Directors Symposium;” Cataldo W. Leone, DMD, DMSc, Carol T. Walsh, MA, PhD, Carmen D. Sarita-Reyes, MD, Monica A. Pessina, MEd, PhD, and Elizabeth R. Whitney, MSPT, PhD
- Resident Reyhan Gedik, MD volunteers for a non-profit organization called White Tulip Foundation. We organize monthly seminars (called Boston Medical forum http://www.bostonmedicalforum.org/ ) to share our experiences as medical doctors and scientists. In March they invited David Kindelberger to give a talk about “Circulating Tumor Cells; New Tools for Personalized Medicine” and he kindly accepted. Keep an eye out for other interesting topics.
- Clarissa Koch, PhD, Connors Lab, successfully defended her thesis “Characterizing the Effect of Transthyretin Amyloid on the Heart” on Monday, March 16th
- “Clarissa Koch, PhD Candidate and her PI Lawreen Connors, about to give her Defense” and “Dr. Koch’s Celebration”
- MATCH DAY 2015:
- Bravo to MD/PhD Graduate David Stepien for successfully being accepted into his First Choice in this year’s Match; Dave will be taking up residence in the University of Michigan Hospital Integrated Plastic and Reconstructive Surgery Residency Program
- Hooray to 2011 Masters Degree Graduate Nik Bajaj for also getting into his First Choice in this year’s Match; Nik will begin his residency in the University of Illinois – COM – Chicago Neurology Residency Program
- Kevin Chandler, PhD, a postdoctoral fellow working jointly in the Dr. Cathy Costello and Nader Rahimi laboratories was awarded a three year postdoctoral fellowship from the NIH. The goal of the project is to map the glycosylation of VEGFR-2 and the role of this posttranslational modification in the angiogenic signaling of VEGFR-2
- David Sherr’s graduate student, Liz Stanford, was selected to be the GMS commencement student speaker
- Barb Nikolajczyk, PhD is an invited speaker in March 2015 for:
- Experimental Biology, Diet and Immunometabolism Symposium, Boston, MA, Lymphocyte function in human type 2 diabetes, 2015
- Immunology Microbiology Program Spring Seminar Series, University of Massachusetts Medical School, Inflammation in human type 2 diabetes, 2015
- Beth Israel Medical Center, Inflammation in human type 2 diabetes, 2015
- Carol Cohen will be presenting at the AATB Quality and Donor Suitability Workshop in Atlanta, Georgia on April 20th. Susan Sharpe MS, MT(ASCP), SBB, CTBS who is the Supervisor of the Tissue and Transfusion Service at Northside Hospital in Atlanta and Carol will be presenting on the FDA’s new ruling that requires medical devices to have unique device identifiers
- Lawreen Connors, PhD was invited to speak at the EB/ASIP meeting here in Boston on March 31st; the title of her presentation was “The Translational Science of Transthyretin-associated Cardiomyopathies.”
- Here’s a link to an article in the Chicago Tribune in which David Sherr is quoted/featured: http://www.chicagotribune.com/lifestyles/health/sc-hlth-401-environmental-cancer-20150326-story.html#page=1
- Remick was recently notified that graduate student, Ms. Erika Langley, was chosen this semester as a Teaching as Research Fellow. As a winner of this fellowship, she will receive an award of $1,000 and partake in a seminar in teaching as research. Teaching-as-Research involves the deliberate, systematic, and reflective use of research methods to develop and implement teaching practices that advance the learning experiences and outcomes of students and teachers. Erika will be in the TAR seminar this spring, and implement a project in a classroom in the summer or fall. Erika’s TAR project has the working title: Improving scientific literacy in undergraduates; she has the support of her faculty advisor for the project Prof. Paul Lipton and her research advisor Prof. Alpaslan Dedeoglu.
- Goldberg, L.J., E. Wise, N. S. Miller. White piedra in a northern climate caused by Trichosporon inkin: A report of two cases. Item of correspondence. Accepted for publication, March 7, 2015. British Journal of Dermatology
- Chad L Mayer, Caitlin S.L. Parello, Benjamin C Lee, Kiyoshi Itagaki, Shinichiro Kurosawa, DJ Stearns-Kurosawa. “Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns” Frontiers in Immunology, section Microbial Immunology.
- Tagne, J.B., Mohtar, O.R., Campbell, J.D., Lakshminarayanan, M., Huang, J., Hinds, A.C., Lu, J., Ramirez, M.I. (2015) Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb Res. 16:22 PMC4335692 http://respiratory-research.com/content/16/1/22
- Rai A, Nimeh T, Sood A, Thirumavalavan N, Thurmond PE, Azadzoi KM, Lerner LB. Could nocturia be an indicator of an undiagnosed sleep disorder in male veterans? 2015 Mar;85(3):641-7. PMID: 25733279
- Lei X, Liu C, Azadzoi KM, Li C, Lu F, Xiang A, Sun J, Guo Y, Zhao Q, Yan Z, Yang J,; A novel IgM-H-ficolin complement pathway to attack allogenic cancer cells in vitro. Sci Rep. 2015 Jan 16;5:7824. PMID: 25592840
- Poutahidis, T., Varian, B. J., Levkovich, T., Lakritz, J. R., Mirabal, S., Kwok, C., & Erdman, S. E. (2015). Dietary microbes modulate transgenerational cancer risk. Cancer research, canres-2732 (BJ Varian is one of our Masters Students; this is with his MIT affiliation)
- Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. c-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt-mediated phosphorylation. J Biol Chem. 2015 Mar 17J Biol Chem
- Melody P. Lun, Matthew B. Johnson, Kevin G. Broadbelt, Momoko Watanabe, Young-jin Kang, Kevin F. Chau,Mark W. Springel, Alexandra Malesz, André M.M. Sousa, Mihovil Pletikos, Tais Adelita, Monica L. Calicchio,Yong Zhang, Michael J. Holtzman, Hart G.W. Lidov, Nenad Sestan, Hanno Steen, Edwin S. Monuki, and Maria K. Lehtinen. Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production. The Journal of Neuroscience 25 March 2015, 35(12): 4903-4916
- Vanesa Bijol, Cathryn J. Byrne-Dugan, and Melanie P. Hoenig. Medical student web-based formative assessment tool for renal pathology. Medical Education Online, Volume 20, 2015; http://med-ed-online.net/index.php/meo/article/view/26765
Pathology & Laboratory Medicine News Items
- 104th USCAP Meeting, Boston, MA, March 21-27 2015
- Mostafa Belghasem, PhD Candidate, Henderson Lab has an abstract accepted for poster presentation for the United States & Canadian Academy of Pathology’s (USCAP) 104th Annual Meeting in Boston, MA. The abstract is entitled “Podocyte-Specific Myh9 Deletion in Mice Results in Susceptibility to Glomerular Injury in Response to Subtotal Nephrectomy”
- From Mark Uva, our Residency Coordinator: We have filled our two vacancies within the residency program. These positions are in addition to our recruiting through the Match for PGY 1s. The two physicians come to us with outstanding letters of reference, and thought of very highly in their respective programs. They will be entering the program as PGY 2s, effective July 1, 2015.
- Lei Li, MD: Lei is transferring from St. Barnabas Medical Center in Livingston, NJ, where she is currently a PGY 1. Lei graduated from Xuzhou Medical College, Xuzhou, Jiangsu China in 2000.
- Ram Al-Sabti, MD: Ram is transferring from University Hospital Case Medical Center, Cleveland, OH, where he is currently a PGY 1. Ram graduated from the University of Bagdad, Iraq in 2009.
- Peluso, A. M., B. A. Harnish, N.S. Miller, E. R. Cooper, A. M. Fujii. Effect of young sibling visitation on respiratory syncytial virus activity in a NICU. The Journal of Perinatology (accepted for publication Feb. 19, 2015)
- Valencia-Rey P., J. Weinberg, N. Miller, T. Barlam. Coagulase-negative staphylococcal bloodstream infections: Does vancomycin remain appropriate empiric therapy? Journal of Infection (accepted for publication Feb. 18, 2015)
- Taimur, S., N.S. Miller, D. Whitney, T. Barlam. Empiric and Targeted Treatment of Enterococcal Infections: Opportunities for Antimicrobial Stewardship. Infectious Diseases in Clinical Practice 2014 Dec; E-published ahead of print: doi:10.1097/IPC.0000000000000193
Pathology & Laboratory Medicine News Items
- Nancy S. Miller, MD was an invited panel member at the Boston Pan African Forum event, “Ebola and other health-related issues in West Africa”, on December 13th in Dorchester, MA
- Dr. Carmen Sarita-Reyes gave a poster presentation at the SENTAC (Society for Ear, Nose and Throat Advances in Children) meeting on December 6, 2014 in St Louis. “Marsupialization to treat foregut duplication cysts of the oral cavity: a novel technique;” Minyoung Jang; Carmen Sarita-Reyes; Devaki Sundararajan; Jessica Levi
- Maria Panchenko, PhD has had her BUMC IACUC Appointment extended until June 2015. Thank you for your service Dr. Panchenko!
- The American Board of Pathology recently nominated Meera Mahalingam, MD, PhD, FRCPath to serve on the Test Development and Advisory Committee on Dermatopathology. The committees consist of American Board of Pathology trustees, as well as other pathologists and physicians who are recognized as experts in their respective disciplines
- From Dr. John Lee; “The Hematology Lab has revised and updated the flow cytometry panels using a more sensitive and algorithmic approach. In addition, a new technique will be employed to determine light chain restriction in plasma cells, which would be useful for myeloma, MGUS, and AL amyloidosis patients. These changes were put into effect January 5, 2015 by Dina Pelley, MT (flow cytometry assistant supervisor) and John Lee, MD (Hematology Lab Medical Director) with Angel Lui, MT helping from the IT side.”
- Dr. Ivana Delalle and her Neuropathology Lab have been acknowledged in recognition of her International Research Collaborations by PsyCourse: Pathomechanisms and Signatures of the Longitudinal Course of Psychosis
- One of our current residents, Cathryn Byrne-Dugan, MD, will be going to University of Michigan for a GI fellowship in 2016-2017
- Authors: Caitlin S.L. Parello, Chad L. Mayer, Benjamin C. Lee, Amanda Motomochi, Shinichiro Kurosawa *, Deborah J. Stearns-Kurosawa; Shiga Toxin 2-Induced Endoplasmic Reticulum Stress is Minimized by Activated Protein C but Does Not Correlate With Lethal Kidney Injury; Toxins, in press
- Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine; (accepted for publication Jan 2014)
- Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, David C. Seldin, Lawreen H. Connors; “Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt);” Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359
- Cathryn J. Byrne-Dugan, Terra A. Cederroth, Anita Deshpande, and Daniel G. Remick (2014) The Processing of Surgical Specimens With Forensic Evidence: Lessons Learned From the Boston Marathon Bombings. Archives of Pathology & Laboratory Medicine In-Press http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2014-0441-OA
- Byrne-Dugan, CJ, Collins AB, Lam AQ, Batal I. Membranous Nephropathy as a Manifestation of Graft-Versus-Host Disease: Association With HLA Antigen Typing, Phospholipase A2 Receptor, and C4d. Am J Kidney Dis. 2014 Dec;64(6):987-93. doi: 10.1053/j.ajkd.2014.09.001. Epub 2014 Oct 8
- Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes
Obes. 2015 Feb;22(1):1-2. doi: 10.1097/MED.0000000000000130. PubMed; PMID: 25485518
- Weber HC. Gastrointestinal peptides and itch sensation. Curr Opin Endocrinol
Diabetes Obes. 2015 Feb;22(1):29-33. doi: 10.1097/MED.0000000000000122. PubMed;
- Hermos JA, Quach L, Gagnon DR, Weber HC, Altincatal A, Cho K, Lawler EV,
Grotzinger KM. Incident severe thrombocytopenia in veterans treated with
pegylated interferon plus ribavirin for chronic hepatitis C infection. Pharmacoepidemiol Drug Saf. 2014 May;23(5):480-8. doi: 10.1002/pds.3585. Epub 2014 Feb 20. PubMed PMID: 24677630
Pathology & Laboratory Medicine News Items
- Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “Overcoming the resistance to anti-angiogenesis therapy”. The overall of goal of this research is to study the role of posttranslational modifications on VEGFR-2 in colon cancer. Angiogenesis inhibitors targeting the VEGF signaling pathway have been FDA approved for various cancer treatments. Although beneficial, patients inevitably develop resistance and often fail to demonstrate significantly better overall survival. Interfering with the posttranslational modifications of VEGFR-2 may overcome refractoriness and resistance to certain class of anti- cancer drugs.
- Dr. Daniel Remick was an invited speaker to Loyola University Medical Center in Chicago, December 9/10, 2014:
- Dr. Remick presented Grand Rounds in the Department of Surgery at Loyola – “Brain Injury Prevents Pneumonia – Who knew?”
- He also gave a lecture to the Department of Pathology “Physician Scientist Pathway in Pathology”
- Dr. Remick, as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago presented, “Inhibitory IgG Increases Sepsis Mortality”
- Dr. Chris Andry, of Boston University USA, visited Professor Rodger Charlton, and other colleagues in the Division of Primary Care, Nottingham University, United Kingdom on 9th December, 2014 . During his visit, Dr. Andry gave a talk entitled “The Value of a Centralized Hospital Bereavement Office Supporting Multicultural Families in the USA”
- Jenny McEldoon, BU Undergrad working in the Remick Lab has been awarded funding from UROP for Spring 2015!
- Zachary Hunter, PhD, Steve Treon Lab at Children’s Hospital, successfully defended his thesis “Whole Genome Sequencing Reveals that Recurrent MYD88 and CXCR4 Mutations Underlie the Genomic Landscape of Waldenström’s Macroglobulinemia” on Tuesday, December 2nd
- Inge The, Suzan Ruijtenberg, Benjamin Bouchet, Alba Cristobal, Martine B.W. Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J.R. Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Munoz, and Sander van den Heuvel, Rb and the APC/C co-activator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells. Nature Communications
- Akifumi Fujita, Huihong Xu, Yu-Ming Chang, Scharukh Jalisi, and Osamu Sakai, Best cases from the AIRP: Malignant mixed tumor of the hard plate. RadioGraphics
- Authors: Blanche C. Ip, Andrew E. Hogan, Barbara S. Nikolajczyk; Lymphocyte roles in metabolic dysfunction: of men and mice Trends in Endocrinology and Metabolism
- Michael J. Greene, Elena S. Klimtchuk, David C. Seldin, John L. Berk, and Lawreen H. Connors; “Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal” Biochemistry
- Stevenson EK, Sloan KA, Narsule CK, Kretschman DM, Sarita-Reyes CD, Steiling K, Ebright MI. Catamenial hemothorax in a patient with multiple sclerosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):e69-70
- Zhang Q, Siroky M, Yang JH, Zhao Z and Azadzoi K “Effects of ischemia and oxidative stress on bladder purinoceptors expression” Urology, 2014 Nov;84(5):1249.e1-7. doi: 10.1016/j.urology.2014.07.023