Category: Uncategorized

Pathology and Laboratory Medicine New News April 2016

April 29th, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items April 2016

  • Announcements:
    • Congratulations on Three Successful Defenses:
      • Parul Agnihotri PhD, Winandy Lab, successfully defended her thesis The Role of Ikaros in Foxo1-Driven Gene Expression in CD4 T Cells” on Friday, April 8th
      • Parul and Family
      • The new Dr. Agnihotri and her proud family
      • ParulGivingDefense
      • Parul Agnihotri, PhD Defending her Thesis, 4/8/16
      • Melody Lun, MD/PhD, Maria Lehtinen Lab(Off-site at Children’s), successfully defended her thesis Coordination of Cell Intrinsic and Extrinsic Signals in Development of the Mammalian Brain” on Wednesday, April 13th
      • MelodyandMentor2016.IMG_5630
      • The new Dr. Melody Lun and her mentor, Maria Lehtinen (Children’s Hospital)
      • MelodyandCommittee2016.IMG_5631
      • Dr. Lun and her BU Committee Members: Drs. Krzysztof Blusztajn, Barbara Slack and Tarik Haydar
      • Nicole Stauffer Smith , PhD, Mizgerd Lab, successfully defended her thesis Respiratory Infections with Pneumococci Establish Multi-pronged Heterotypic Protection Against Pneumonia” on Wednesday, April 13th
      • NicoleDefenseCelebration
      • Dr. Nicole Stauffer Smith’s Defense Celebration!
    • Tim Norman, PhD Candidate in Alan Fine’s Lab gave an oral presentation and presented a poster at the Gordon Research Conferences on Lymphatics titled “Origins, maturation, and regeneration of the pulmonary lymphatic endothelium” on March 19th in Ventura, California
    • Ivana Delalle is excited to be giving a platform presentation, “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” at the 2nd International Symposium on Microgenomics in Paris, France; June 2016
    • Maria Panchenko was invited to write an expert review about family of JADE genes and corresponding proteins. The review was accepted and will be published in GENE.
    • On the basis of excellent teaching in the first year of the medical school curriculum the following faculty have been selected as Master Educators:
      • Carmen Sarita-Reyes, M.D. (Integrated Problems)
      • Jacqueline Sharon, Ph.D. (Immunology)
      • Deborah Stearns-Kurosawa, Ph.D. (Immunology)
      • Daniel Remick, M.D. (Immunology)
      • Susan Winandy, Ph.D. (Immunology)
    • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab has won a School of Medicine PhD Award from the 2016 Graduate Research Symposium. His poster title was “Blood-Brain Barrier Dysfunction, Neuroinflammation, and Early Chronic Traumatic Encephalopathy-Linked Neuropathology in a Mouse Model of Concussive Impact Neurotrauma.” The Symposium held on April 11th at Metcalf Hall was sponsored by the Office of the Provost
    • Daniel Remick, M.D., received a Certificate of Appreciation for 3 years of service on the Council of the American Society of Investigative Pathology
    • USCAP 2016 – March 12-18, 2016; Seattle, Washington
      • Reyhan Gedik, MD presented the following poster, ““Utility of Next Generation Sequencing (NGS) Cotesting to Recategorize Bethesda-I Thyroid FNAs” : authors 1. Reyhan Gedik MD1, 2. Anita Deshpande MD1, 3. Huihong Xu MD1 and 4. Sandra Cerda, MD
        • USCAP2016.ReyhanGedik
      • Huihong Xu, MD is really happy to report that she has passed the American Board of Pathology Maintenance of Certification (MOC) Part III examination(s) in Anatomic Pathology and Clinical Pathology and Cytopathology; Bravo Huihong!
      • Barb Nikolajczyk, PhD had multiple presentations in April including:
        • Emory University, Woodruff Health Science Center, Atlanta GA, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • Winthrop Hospital, Mineola, NY, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • University of Virginia, Department of Pharmacology, Charlottesville, VA  “Defining Inflammation in Human Obesity and Type 2 Diabetes”
      • Nancy Miller, MD had several events in April also, including:
        • Invited speaker at the American Society for Clinical Laboratory Science-Central New England (ASCLS-CNE) convention, April 26-28, Providence, RI, where she presented cases from the clinical microbiology laboratory entitled:  “From the Bench: A potpourri of challenges, conundrums, and lessons learned”
        • Miller was also the Event co-chair for the 1st joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and the Northeast Branch-American Society for Microbiology (NEB-ASM), April 11-12, Boxborough, MA.
        • Miller is a Laboratory Medical Director for the now-approved Gilead Foundation grant: BMC HCV Screening, Confirmation and Linkage Initiative, (Jonathan Hall, Principal Investigator)
      • Russek Awards 2016:
        • Barbara Slack, Pathology Department Russek Awards Committee, is pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
          • First Prize – Caitlin Miller (Advisor: Rahm Gummuluru)
          • Second Prize – Elizabeth Moses (Advisor: Avrum Spira)
        • Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day will be held on Friday, May 6th in the Hiebert Lounge (L building, 14th floor). The keynote speaker this year will be Dr. James Bradner, the new President of the Biomedical Institutes of Novartis. Posters will be available for viewing throughout the day, and slide presentations by the first prize winners will take place in the afternoon. I hope everyone will be able to attend.
        • More information about this event can be found at the link ((http://www.bumc.bu.edu/gms/students/phd/russek-student-achievement-day-2016/)
      • Daniel Remick, M.D., was given a Certificate of Service in the Advanced Core Program in the Responsible Conduct of Research for Doctoral Candidates by Boston University School of Medicine
      • The Winandy Lab:
        • On April 8th, Parul Agnihotri successfully defended her thesis
        • Caroline Lyon De Ana, a Pathology Masters student, joined our lab
      • PUBLICATIONS PUBLISHED:
        • Wang W, Wang WH, Azadzoi KM et al. Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells. Mol Cell Endocrinol. 2016 May 5;426:91-100. doi: 10.1016/j.mce.2016.02.008. Epub 2016 Feb 15.
        • Wang W, Wang WH, Azadzoi KM et al. Activation of innate antiviral immune response via double-stranded RNA-dependent RLR receptor-mediated necroptosis. Sci Rep. 2016 Mar 3;6:22550. doi: 10.1038/srep22550.

Pathology & Laboratory Medicine News Items – March 2016

April 1st, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items

March 2016

  • Announcements:
    • Please join in congratulating Nancy Miller, M.D. on her promotion to Associate Professor of Pathology and Laboratory Medicine. This promotion recognizes Dr. Miller’s national reputation in the field of pathology, specifically in the area of microbiology. There is amble evidence of her stature, including being an invited participant in preparing the Clinical and Laboratory Standard Institute (CLSI) upcoming international CLSI M-52 Guideline (User Verification/Validation of Microbial Identification and Antimicrobial susceptibility Testing Systems). This panel will establish the national guidelines for the identification of pathogens and antimicrobial testing. Additionally, she was an invited panel member on the nationally and internationally attended 2012 Centers for Disease Control (CDC) forum on Culture-Independent Diagnostics. Dr. Miller was the co-convener for the Symposium: “Fecal microbiota transplants and competing organisms: From practical to practice to promise”, American Society for Microbiology in 2014, and was a faculty participant for workshops (2012, 2014, 2015).
    • Thirty Shades of Red… also known as “Transfusion Medicine in the Hot Seat: A Case-Based Primer” authored by Karen Quillen, MD, MPH out for publication!!! Get your copy!!
    • QuillenPublication2016.FullSizeRender

 

  • Carmen Sarita-Reyes was recently accepted for a leadership course at the APC meeting. From the APC; “The Association of Pathology Chairs’ Leadership Development and Diversity Committee, it is our pleasure to let you know that your application for the Pathology Leadership Academy (PLA) has been accepted. You will join about 60 colleagues for this special event, which will include lectures and interactive presentations by a host of nationally recognized speakers.” The Leadership Program will take place in July in San Diego, California
  • From Daniel Remick:
    • Daniel Remick, M.D., served as an external reviewer for the Department of Pathology at the University of Iowa. The two day review during the end of March 2016 was conducted as part of the University’s standard 5 year review of the Department
    • The NIH held a one day workshop on the physician scientist workforce on February 19th, 2016. Daniel Remick, M.D. participated as the Chair of the Research Committee for the Association of Pathology Chairs and the Vice President of the American Society of Investigative Pathologists
    • Daniel Remick, M.D. served as an unpaid external reviewer for CBMed, a government – private joint venture in Austria. The company is focusing on developing biomarkers including biobanks. The first review was held in Graz, Austria in February 2016
  • Caitlin Miller, PhD Candidate in Rahm Gummuluru’s Lab attended The Conference on Retroviruses and Opportunistic Infections, February 22-25, 2016 in Boston, MA where she presented a poster entitled, “Essential role of Vpr in HIV-1 infection of dendritic cells”
  • Huihong Xu, M.D., received the “CAPA Member of the Year Award” at the 14th Annual Meeting of Chinese American Pathologists Association on March 12, 2016 in Seattle, Washington
  • USCAP 2016 – March 12-18, 2016; Seattle, Washington
    • Yue Sun, MD presented the following posters:
      • “Analysis of PD-L1 Expression Pattern in Microsatellite Instability Colon Cancer;” Yue Sun, Max Vaickus, Michael O’Brien and Qing Zhao
      • Sun.USCAP.PD,L1.Colon Cancer.IMG_8021
      • “Analysis of PD-L1 Expression Pattern in Advanced Bladder Cancer and Lymph Node Metastasis;” Yue Sun, Max Vaickus, Sandra Cerda and Huihui Ye
      • Sun.USCAP2016.PD.L1Expression...BladderCancer.IMG_8023
    • Anita Deshpande, MD, poster entitled;  “Impact of ThyroSeqv.2 Next-Generation Sequencing Assay on Fine Needle Aspiration Cytology of Thyroid Nodules;” – Anita Deshpande, Xu Huihong, Sandra Cerda
      • Deshpande.USCAP 2016 image 2
        • Deshpande and Dr.Ye Nikiforov who developed and designed the ThyroSeqv.2 test at UPMC
      • From Barbara Nikolajczyk, PhD:
        • Barb Nikolajczyk and Lee Wetzler are hosting the Boston University School of Medicine Inflammation Symposium May 23, 2016 in Bakst Auditorium. All are welcome to join the cross-talk amongst inflammation researchers at BUSM and beyond.  Trainee talks will be selected from submitted abstracts. Please contact the organizers for more details.
        • Barb Nikolajczyk will chair and speak at an “Open Call” Symposium at the 2016 Annual Meeting of The Obesity Society in New Orleans, LA in the Fall of 2016. The Symposium is entitled Complex Data Sets in Obesity: Opportunity over Obfuscation
        • The multi-PI team of Barb Nikolajczyk (BUSM), Caroline Apovian (BMC/BUSM) and Doug Lauffenburger (MIT) were awarded $2.8 million by the NIH/NIDDK for a 4 yr. project entitled “Inflammation in Human Obesity and Type 2 Diabetes”.
        • Gerald Denis and Barb Nikolajczyk will chair “The Obesity Society Guest Symposium” at the American Association of Immunologists Meeting May 13-17, 2016 in Seattle, Washington. The theme this year is Immunometaboism and Cancer.
      • Watch David Sherr, PhD talking on the Science Coalition’s “Super Science Tuesday” about the need for all politicians to know why research investment is so important. This is followed by Dr. Sherr and three other labs discussing “Investing in Prevention at SPH”:
      • The Kurosawa Lab is welcoming new faces:
        • Eriko Morishita, is a Professor of Medicine from Kanazawa University School of Medicine.  Kanazawa is a beautiful city, just north of Kyoto, Japan. She is a trained hematologist, specializing in thrombosis and hemostasis.  Dr. Morishita is visiting our lab for sabbatical for almost a year.  Her interest is in thrombotic microangiopathy (TMA)
        • Takeshi Wada just arrived from Hokkaido University School of Medicine, Sapporo, Japan. Sapporo is famous for its snow festival. We do not expect him to be intimidated by Boston winter. Dr. Wada is a trauma surgeon.  His research interest is in disseminated intravascular coagulation (DIC)
    • PUBLICATIONS PUBLISHED:

     

    Departmental Seminar – March 25, 2016

    March 21st, 2016 in Spotlight, Uncategorized

    Seminar Series: Spring 2016 ~~ Friday, March 25, 2016

    2:00-3:00 PM

                  

    SCARFing Dead Cells and TREMing Inflammation

     

    Terry K. Means, PhD
    Assistant Professor of Medicine, Harvard Medical School
    Associate Immunologist, Massachusetts General Hospital

     

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM


    Friday, March 25, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) recall that the clearance of apoptotic cells is arguably one of the most important processes of the immune system and is necessary for the homeostatic maintenance of healthy tissues and removal of infected or damaged cells; 2) report that defective clearance of apoptotic cells can lead to the development of chronic inflammatory diseases such as systemic lupus erythematosus; and 3) discuss that there are new insights into the regulatory pathways that control Toll-like receptor 7 (TLR7) signaling to prevent loss of tolerance and the development of autoimmunity.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

    Departmental Seminar – March 4, 2016

    February 29th, 2016 in Spotlight, Uncategorized

    Seminar Series: Spring 2016 ~~ Friday, March 4, 2016

    2:00-3:00 PM

                  

    The Role of Epigenetics in the Pathophysiology of Huntington’s Disease

     

    Ghazaleh Sadri-Vakili, PhD
    Assistant Professor of Neurology, Harvard Medical School
    Director, NeuroEpigenetics Laboratory;
    Mass General Institute for Neurodegenerative Disease

     

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM


    Friday, March 4, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) repeat that transcriptional dysregulation has been proposed to play a major role in the pathology of Huntington’s disease; 2) recall that in Huntington’s disease specifically how alterations in transcription and epigenetic regulation can cause pathogenesis and 3) identify novel molecular/epigenetic mechanisms may unveil new therapeutic targets for the treatment of Huntington’s disease.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

    Pathology & Laboratory Medicine News Items December 2015 – January 2016

    February 3rd, 2016 in Uncategorized

    • Announcements:
      • Congratulations are in order to the following Department of Pathology members: BRAVO!
        • Chris Andry, MPhil, PhD; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
        • Abigail Brown, MFS, MLS (ASCP): for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
        • Shinichiro Kurosawa, MD, PhD; for being appointed a Voting Member to the Boston University Laboratory Safety Committee Space / Infrastructure Subcommittee until December 2017, BRAVO!
      • On December 3, 2015 Daniel Remick, MD gave a talk “Mild Traumatic Brain Injury Augments Host Defenses against Pathogens” at the Institute of Neuroscience and Physiology at Sahlgrenska Academy at the University of Gothenburg
      • Daniel Remick, MD was invited to serve as the opponent for Sara Svahn at the University of Gothenburg in Sweden on December 4, 2015. The title of Sara’s thesis was “Effects of dietary fatty acids on the immune system”. Scandinavian countries have a tradition of bringing in an outside expert to ensure that the thesis work has sufficient rigor and depth. This outside member of the committee has the title of opponent. At the two hour defense, the opponent presents background information about the topic of the thesis, in this case sepsis. The student then presents for about 40 minutes, which is then followed by an hour of questioning by the opponent. Sara Syahn, PhD, successfully Defended
      • Chloe Habib and Leah Persky, both students in the Masters in Nutrition Program, joined the Nikolajczyk Lab as of January 2016
      • The Residency Program had an ACGME Site Visit in January to review our program. The Department has been working diligently since last spring to increase the teaching curriculum for the residents. One of the issues identified through the survey in 2015 was lack of scholarly opportunities. The Department will be launching a series of paper writing workshops this spring and all the residents will be invited.
      • The College of American Pathologists (CAP) performed their unannounced Site Visit on January 27, 2016. Seventeen inspectors from the Lifespan System in Rhode Island spent the day thoroughly reviewing both Anatomic Pathology and Laboratory Medicine. The lab inspection went very well with only a few deficiencies identified. This outstanding inspection result was due to the hard work by the pathology faculty and staff in the months leading up to the preparation. BRAVO
    • PUBLICATIONS ACCEPTED:
      • Thurmond P, Yang JH and Azadzoi KM entitled “LUTS in pelvic ischemia: A new concept in voiding dysfunction” — Accepted for publication in AJP – Renal Physiol
      • Ding Y, Francis J, Kalish J, Deshpande A, Quillen K. Recurrent focal segmental glomerulosclerosis resistant to plasma exchange, and improvement after surgical repair of arteriovenous fistula aneurysms. Clinical Kidney Journal [in press]
    • PUBLICATIONS PUBLISHED:
      • Zhifeng Huang, William M. Marsiglia, Upal Basu Roy, Nader Rahimi, Dariush Ilghari, Huiyan Wang, Huaibin Chen, Weiming Gai, Steven Blais, Thomas A. Neubert, Alka Mansukhani, Nathaniel J. Traaseth, Xiaokun Li,  Moosa Mohammadi. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Molecular Cell, December 10, 2015. http://www.sciencedirect.com/science/article/pii/S1097276515009028
      • Lawreen Connors, PhD and Colleagues Publish Findings in ATTRwt Amyloidosis Cohorthttp://www.bu.edu/amyloid/2016/01/22/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort/
        • Data on the largest cohort of ATTRwt amyloidosis patients yet reported (n=121), referred to our institution over a 20-year observational period, were recently reported in the prestigious heart journal, Circulation.  The publication, entitled “Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study,” was authored by Dr. Lawreen H. Connors and colleagues from the Amyloidosis Center at Boston University.  These data establish the natural history of ATTRwt, provide statistical basis for the design of future interventional clinical trials, and highlight the need for more sensitive diagnostic tests and disease-specific treatments for this disease.  For more information, see Circulation, 133:282-290, 2016.
      • Ozturk S, Papageorgis P, Lambert AW, Wong CK, Thiagalingam A, Abdolmaleky HM, Cohen HT, and Thiagalingam S, 2016. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl. Acad. Sci. USA. 113(3): 638-643. http://www.pnas.org/content/113/3/638.full.pdf?with-ds=yes

    Departmental Seminar – January 29, 2016

    January 25th, 2016 in Uncategorized

     

    Seminar Series: Spring 2016 ~~ Friday, January 29, 2016

    2:00-3:00 PM

                  

    “The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention”

     

     

    Nisma Mujahid

    PhD Candidate, David Fisher Lab (MGH);

    Department of Pathology, Boston University School of Medicine

     

    Location & Time:
    670 Albany Street
    Lobby Level #107/108
    2:00-3:00 PM
    Friday, January 29, 2016
    Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

    At the conclusion of this activity participants will be able to: 1) recall that ultraviolet-light (UV)-induced tanning is defective in numerous ‘fair-skinned’ individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R); 2) recognize that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blondehaired Mc1re/e mice; and 3) report that ultraviolet (UV) radiation is highly toxic to organisms because it damages cellular constituents such as DNA.

                   

    Course Director: Barbara Slack, PhD

    Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

    10th Annual Nancy Bucher Seminar

    January 8th, 2016 in Spotlight, Uncategorized

    DUE TO THE INCLEMENT WEATHER WE HAVE DECIDED TO POSTPONE

    OUR 10TH ANNUAL NANCY BUCHER SEMINAR; PLEASE STAY TUNE FOR ADDITIONAL DETAILS!

    APOLOGIES FOR ANY INCONVENIENCE!!!!

    ~~~~~~~~~~~

    BUSM Pathology & Laboratory Medicine

    Seminar Series: Spring 2016 ~~ Friday, February 5th 

    2:00 PM; Reception to Follow at 3:00

     

    10th Annual Nancy L. R. Bucher, MD Seminar 

     

    Unraveling the Complexity of Growth Hormone Regulated Sex Differences in Mouse Liver:

    Genomic and Epigenetic Approaches”

     

    David Waxman, PhD

    Professor of Cell and Molecular Biology, Boston University

    Professor of Medicine, Boston University School of Medicine

     

     

    Location & Time:

    670 Albany Street

    Lobby Level #107/108

    2:00 PM; Reception to Follow

    Friday, February 5, 2016 

    Pathology & Laboratory Medicine News Items – November 2015

    December 3rd, 2015 in Uncategorized

    • Announcements:
      • Yanli Ding, MD presented a poster at the Annual ASCP 2015 Meeting in Long Beach California, September 28-30, 2015. Title: “Persistent proteinuria in recurrent focal segmental glomerulosclerosis from arterio-venous fistula recirculation, and improvement with aneurysm repair;” Co-authors are Yanli Ding, MD and Karen Quillen, MD
      • Yanli.Ding.2015.ASCP.mmexport1446282806146
      • Atsushi Ebata, PhD, Wolozin Lab, successfully defended his thesis “Development of TDP-43 Granule Inhibitors as Potential Amyotrophic Lateral Sclerosis/Frontotemporal LobarDegeneration Therapies” on Thursday, November 12th
      • Nancy S. Miller, MD presented: “Ebola Dx and the U.S. clinical laboratory: From practical to practice to promise”, at the BUSM Mini-Symposium – Ebola, The Disease and Immune Privilege, on October 29, held in Hiebert Lounge
      • Dr. Miller also convened the symposium: Vibrios Throw Us a Curve: People, Places and Oysters; and presented “Tales from the Trenches – Vibrio Cases from the Clinical Microbiology Laboratory”, at the 50th Annual Region I Meeting of American Society for Microbiology (ASM) branches, October 20, in Randolph, Massachusetts
      • From Lawreen Connors, PhD Lab:
        • Just received notification of research funding from the The Wildflower Foundation, Inc. in support of our study, “Immunoglobulin Light Chain Amyloid Fibril Formation: Structural Determinants as a Platform for Drug Development”
        • She/they also have an approved service agreement, “Fat Pad Analysis – ALN-TTR-NT-002 Discovery Study, with Alnylam Pharmaceuticals, Inc (Cambridge, Massachusetts)
      • Yue Sun presented three posters at the 2015 Annual ASCP Meeting in Long Beach California, September   28-30, 2015:
        • “Extraosseous Chordoma of Retropharyngeal Space: A Case Report;” Yue SunHuihong Xu, and Qing Zhao Zhao 
        • “Periampullary gangliocytic paraganglioma with lymph node involvement: A Case Report;” Yue Sun, David W. KindelbergerHuihong Xu, and Qing Zhao
        • “Lactobacillusgasseri associated with urinary and surgical wound infection in a renal transplant patient;” Yue Sun, Amitabh Gautam, and Nancy S. Miller
        • Yue.Sun.2015.ASCP.chordoma
      •   Yue.Sun.2015.ASCP.Poster3.paraganglioma
      •    Yue.Sun.2015.ASCP.Poster2.lactobacillus
      • Congratulations to Ivana Delalle, she was the honored speaker at the 2015 Annual New England Society of Pathologists Stanley Robbins lecture on November 17th
      • On Behalf of Dr. Chris Andry, Director of our Master of Arts Program: we are pleased to announce that our proposal has been approved and our Masters Graduate Program will now be entitled; MASTER OF SCIENCE IN PATHOLOGY LABORATORY SCIENCES.
      • Michel Azer, a Masters student in Periodontology doing his research in the Nikolajczyk Lab, was a finalist at the American Academy of Periodontology Balint Orban Award Competition for excellence in basic research on periodontal disease.  Congratulations Michel on being included in this prestigious event!
      • Invited presentation by Nikolajczyk in November 2015: The Obesity Society Oral Presentation, Los Angeles CA, “Metformin counters a pro-inflammatory T cell profile, 2015”
      • Ivana Delalle gave a Grand Rounds lecture in the Pathology Department at UC Davis, California on November 23rd
      • The Mid-Career Faculty Leadership Program is a year-long program that uses experiential and project-based learning to engage participants in 360 evaluation, self-reflection, inter-disciplinary collaboration, broad peer and senior mentoring networks, and the enhancement of transformational education, clinical, research, and strategic leadership skills. Two members of our pathology department, both Sandra Cerda and Dr. Debbie Stearns-Kurosawa, have been selected through this competitive application process to participate in this leadership development program.  The selection committee aims yearly to select high potential individuals with clinical and research expertise and demonstrated commitment to BUMC, who are keen on transforming themselves, BUMC, and healthcare. BRAVO!!
      • Effective January 1, 2016 the following changes will occur:
        • David Kindelberger, MD, will become the Residency Director, replacing Daniel Remick, MD This appointment is pending approval by the appropriate BMC committee
        • Qing (Grace) Zhao, MD, PhD, will become the Director of Surgical Pathology, replacing Dr. Kindelberger
        • We are confident that these changes will strengthen our clinical, research and teaching missions by placing dedicated and motivated pathologists in these leadership positions. Please join me in congratulating Drs. Kindelberger and Zhao on their new roles within the Department.
    • PUBLICATIONS ACCEPTED:
      • Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, and Seldin DC:  Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study.  Circulation,Accepted Nov 11, 2015
      • Miller, N.S. “The new microbiology and vision of faith: When believing isn’t seeing and vice-versa.” Commentary commissioned by Clinical Chemistry for their 2016 special issue, Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”
      • Armin Maghsoudlou, Rosana D. Meyer, Kobra Rezazadeh, Emad Arafa, Jeffrey Pudney, Edward Hartsough, Nader Rahimi.  RNF121 inhibits angiogenic growth factor signaling by restricting cell surface expression of VEGFR-2. Traffic, November 2015 http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291600-0854
    • PUBLICATIONS PUBLISHED:

    October 2015

    November 6th, 2015 in Uncategorized

    Pathology & Laboratory Medicine News Items – October 2015

    • Announcements:
      • Daniel Remick was an invited speaker at the Satellite Symposium on Alcohol and Immunology, Society for Leukocyte Biology, Raleigh North Carolina on September 28th: Acute ethanol ingestion triggers asthma
      • Kazem Azadzoi had two recent presentations at the International Continence Society (ICS) meeting in Montreal, Canada, October 6-9, 2015:
        • Zhao Z, Yang J, Li Y, Azadzoi K presented an oral ePoster entitled “Ischemia Survival Signaling Via PI3-K/Akt Pathway mediates Overactive Bladder Progression to Underactive Bladder”
        • Su N, Choi H, Yang J, Azadzoi K presented an oral ePoster entitled “Chronic Ischemia Alters the Bladder Proteomic Profiles and Activates Degenerative Pathways and Survival Signaling” at
      • Barb Nikolajczyk, PhD is organizing a FASEB Scientific Research Conference Entitled “Immunological Aspects of Obesity” July 31-August 5, 2016 in Big Sky, Montana.  Those interested in more information can go to org or contact her directly at bnikol@bu.edu
    • PUBLICATIONS ACCEPTED:
      • Yi-Chien Chang1, Zhenjun Hu1, John Rachlin2, Brian P. Anton3, Simon Kasif1,4*, Richard J. Roberts3*, Martin Steffen4,5 COMBREX-DB: A Database Of Protein Function Prediction Emphasizing Foundational Experimental Data; Nucleic Acids Research

    September 2015

    October 4th, 2015 in Uncategorized

    Announcements:

    • Parul Agnihotri, PhD Candidate in Susan Winandy’s Lab was elected Vice President of the Boston University Graduate Medical Sciences Student Organization (GMSSO) for 2015-2016 effective this month. The GMSSO is a student run organization that works to unite students from all departments and schools on the Medical Campus, to share ideas and address questions or concerns pertaining to student life. Through organizing various social and community service activities, GMSSO is an outlet for students to get involved in the BU Graduate Medical Sciences community, both on and off campus.
    • For six weeks, Jason Sutin, Pathology PhD Candidate in Maria Franceschini’s Lab at MGH will be working with the CURE Children’s Hospital of Uganda in Mbale, Uganda, Africa on a collaboration to study the effect of surgical treatment of infant hydrocephalus on cerebral blood flow and oxygen metabolism.
    • Nader Rahimi and his Lab’s recent publication on the characterization of a novel adhesion molecule (TMIGD1) was on the news: http://www.sciencedaily.com/releases/2015/09/150902112004.htm
      http://www.newsunited.com/newly-discovered-protein-may-news/18305788/
    • Several Department of Pathology members participated in the 2015 Boston Heart Walk on Saturday, September 12th sponsored by the American Heart Association. BRAVO!!! The AHA MISSION: Building healthier lives, free of cardiovascular diseases and stroke. Their IMPACT: By 2020, to improve the cardiovascular health of all Americans by 20 percent while reducing deaths from cardiovascular disease and stroke by 20 percent. In 1999, the American Heart Association set a bold 10-year goal: To reduce coronary heart disease, stroke and risk by 25 percent by 2010. We achieved the reduction in deaths ahead of schedule and made substantial progress against three of the six risk factors. Our 2020 Impact Goal focuses on helping people build stronger health and a better quality of life.
    • Dequina Nicholas, PhD from Loma Linda Medical School, (2015) has joined the labs of Barbara Nikolajczyk and Gerald Denis as an Inflammation Training Grant-supported post-doctoral full. Welcome Dequina!
    • On September 15th the department held a Faculty Meeting that included faculty, residents, postdocs and graduate students devoted to addressing professionalism in the workplace. The meeting will also include professionalism vignettes that were presented at the Association of Pathology Chairs meeting this summer. GroupPhoto2

               Dr. David Kindelberger introduced several vignettes on Professionalism:

    Dr.Kindelberger2

               Dr. O’Brien spoke on Altruism:

    Dr.O.Brien

               Dr. Chris Andry addressed Accountability:

    Dr. Andry

              Dr. Karen Quillen talked about Respect:

    Dr. Quillen

    Additional comments by Dr. Barbara Slack:

    Dr.Slack

    And Dr. Carl O’Hara:

    Dr. O.Hara

    Rally for Research September 16 & 17 2015

    The rally for research #rallymedres was held in Washington DC to advocate for increased funding for the National Institutes of Health (NIH). Advocates from 40 states and more than 200 organizations spoke with their Senators and Congressman about the need for robust, predictable and sustainable NIH funding. The key messages that were delivered included the fact that since 2004 there has been a 24% decrease in the dollars available for NIH investigators (adjusted for inflation). In prior years there was a 1 in 3 chance that a grant would be funded, with the current paylines there is a 1 in 7 chance.

    The Association of Pathology Chairs was represented at the rally by Daniel Remick, M.D., Chair of Pathology and Laboratory Medicine at Boston University School of Medicine #DanielRemick1 who provided twitter updates throughout the rally.

    After orientation on September 16th the 300 rally participants were bused to the Capital for a rally held in the Kennedy Caucus room. Presentations were made by Jerry Moran (R-Kansas), Senator Durbin (D-Illinois), Patti Murray (D-Washington) and Amy Klobuchar (D-Minnesota). Each of these Senators expressed strong bipartisan support to increase NIH funding. Senator Murray talked about the need for NIH funding to maintain American exceptionalism. Senator Klobuchar is such a strong NIH supporter that during the last government shutdown, she donated her salary to the NIH. Francis Collins, the Director of NIH spoke passionately about funding saying we cannot wait for cure and we cannot wait for hope. Patient advocates also spoke about why NIH funding saves lives.

    The next morning, September 17th 2015, Representative Tom Cole (R-Oklahoma), the fourth ranking Republican in the House of Representatives addressed participants. He emphasized that Congress is eager to show bipartisan legislation that helps the country, and increased funding for NIH was a clear example of this. The rally participants then met with members of Congress and their staff.

    The delegation from Massachusetts consisted of Daniel Remick, M.D., Chair and Professor of Pathology & Lab Medicine, Boston University School of Medicine, Susan Hankinson, Sc.D., Chair of Biostatistics and Epidemiology, Health Sciences University of Massachusetts and Timothy Leshan, Northeastern University Vice President Government Relations. The delegation met with our Senators and Representatives. We met with Ashley Coulombe, Special Assistant to Senator Elizabeth Warren first and relayed specific examples of how decreased NIH funding has hurt research. The next meeting was with Andrew Cohen, Counsel to Senator Edward Markey. Senator Markey has long supported funding for NIH.

    The delegation was fortunate to spend 30 minutes with Rep. Joseph Kennedy from the 4th district of Massachusetts (see picture). The day finished with meetings with Jennifer Chandler, Senior Legislative Assistant to Rep. James McGovern and a final meeting the Rep. Capuaon’s Chief of Staff Robert Primus.

    Delegation

    All the Massachusetts legislators strongly support increased funding for the mission of NIH but the MA delegates were able to provide several reasons why increased NIH funding is a national imperative.

    PUBLICATIONS ACCEPTED:

    • Su N, Choi HP, Yang Jing-Hua, Wang F, Su H, Fei Z and Azadzoi KM entitled Quantitative Proteomic Analysis of Differentially Expressed Proteins and Downstream Signaling Pathways in Chronic Bladder Ischemia” has been accepted for publication in the Journal of Urology.