Category: Uncategorized

November 2014

December 2nd, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items 

Announcements:

  • Kate Murphy has announced that the Blood Bank had its’ 4th inspection of the year – American Association of Blood Banks (AABB) on November 19th and 20th for an extremely thorough assessment, including nursing competency.  We were successfully accredited for another 2 years!
  • Zach Hunter, PhD Candidate in the Steven Treon’s Lab at Children’s Hospital presented at the following conferences:
    • August 14th in London, UK. At the 8th International Workshop on Waldenstrom’s Macroglobulinemia. His oral presentation was entitled: “Genomic Landscape of WM”
    • August 17th in London, UK, WMUK’s 5th International Doctor Patient Forum “Making Sense of Key Information about your WM: MYD88, CXCR4 and the Genetics of WM”
  • Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st

    LeibowitzParelloDefense.11.21.14

    Caitlin’s Defense

  • Zach Hunter also received a grant in his own name; “Identification of Germline and Somatic Variants Associated with Predisposition to WM” from the International Waldenström’s Macroglobulinemia Foundation
  • Barb Nikolajczyk, PhD presented:
    • “Immunometabolism, Lymphocytes and Obesity” at The Obesity Society annual meeting in Boston, MA on November 6th
    • “Lymphocytes in Human Obesity and Type 2 Diabetes” at the Evans Center/Whitaker mini-symposium on Immune Cells and Metabolism on November 21st
  • David Kindelberger, MD (along with colleague Eric Huang from the University of California, Davis) presented a workshop titled “2012 Updated ASCCP Consensus Management Guidelines for Women with Abnormal Cervical Cancer Screening Tests” at the 62nd Annual American Society of Cytopathology Scientific Meeting on November 17th in Dallas
  • Daniel Remick, MD was given a water pitcher to acknowledge his serving on the Society for Leukocyte Biology Council, and serving as the Program Chair for the 2014 Annual Leukocyte Biology Meeting. The 2014 meeting in Salt Lake City was a joint meeting between Leukocyte Biology and the International Endotoxin and Innate Immune Society.

    Remick Watervase jpg

    Dr. Remick with watervase

  • Mostafa Belghasem, PhD Candidate, Henderson Lab:
    • Presented a poster entitled “Heterozygous Actn4 Mutant Mice are Susceptible to Glomerulopathy when Subjected to Hemodynamic Stress” at American Society of Nephrology (ASN) Kidney Week 2014 in Philadelphia, PA, November 11-16, 2014
    • Mostafa was also selected to participate in the ASN 2014 Kidney STARS program and received a Travel Award from the ASN

 Publications ACCEPTED:

  • Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R.Rifkin and Adam Lerner; “Type 4 cyclic nucleotide phosphodiesterase inhibitors block intracellular Toll-like receptor signaling in chronic lymphocytic leukemia and normal hematopoietic cells”. Journal of Immunology
  • Anastasia Gomez, Nancy S. Miller, and Irina Smolina. Visual detection of bacterial pathogens via PNA-based padlock probe assembly and isothermal amplification of DNAzymes. Analytical Chemistry, Publication Date (Web): 21 Nov 2014

Publications: PUBLISHED:

  • Castillo JJ, Olszewski AJ, Cronin AM, Hunter ZR, Treon SP. Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database. Blood. 2014 Jun 19;123(25):3999–4000. PMID: 24948623
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Patterson CJ, Tsakmaklis N, Kanan S, Rodig S, Castillo JJ, Treon SP. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia. Leukemia. 2014 Jun 10; PMID: 24912431
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. Possible resting metabolic rate modification by the circulating RBP4 in obese subjects. Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Treon SP, Hunter ZR, Castillo JJ, Merlini G. Waldenström Macroglobulinemia. Hematol Oncol Clin North Am. 2014 Oct;28 (5):945–970. PMID: 25212891
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Tsakmaklis N, Kanan S, Castillo JJ, Treon SP. CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells. Br J Haematol. 2014 Nov 5; 
  • Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH (2014) Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genet. 2014 (e-Pub ahead of print) PMID: 25367359

October 2014

November 5th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Jessica (Allen) Ritter, PhD Candidate, Genco Lab, presented a poster at XIXth International Pathogenic Neisseria Conference October 12th-17th in Asheville, NC. The poster is entitled; “Neisseria gonorroheae modulates immune cell survival through pyroptosis.” Authors are Jessica Ritter, Kathleen Goodmon, and Caroline Genco.
  • Evan Chiswick, PhD, Remick Lab  was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, October 23rd-25th in Salt Lake City, Utah.  also received a travel award. The title of his talk was “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity” Evan also received a Travel Award, bravo!
  • Daniel Remick, M.D., served as the program chair for the 2014 joint meeting of the Society for Leukocyte Biology and the International Endotoxin and Innate Immunity Society. The meeting had nearly 250 participants from across the world and was held in Salt Lake City, Utah.
  • David Sherr, M.D. has received an award from the Art Because Breast Cancer Foundation. http://www.bostonglobe.com/metro/2014/10/15/team-boston-researchers-will-study-environment-relation-breast-cancer/Bg6nMAlvWIVBNJfBbpat3L/story.html?s_campaign=8315

Publications ACCEPTED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, Clinton T. Baldwin, David C. Seldin, Lawreen H. Connors. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genetics

Publications: PUBLISHED:

  • Tiffany J. Mellott, Sarah M. Pender, Rebecca M. Burke, Erika A. Langley, Jan Krzysztof Blusztajn; “IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and  Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice” PLOS, April 2014. http://www.ncbi.nlm.nih.gov/pubmed/?term=Mellott%20TJ%5Bauth%5D\
  • Erika A. Langley1, Marina Krykbaeva1, Jan Krzysztof Blusztajn, Tiffany J. Mellott; “High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T + Itpr3tf/J mouse model of autism.” Behavioural Brain Research; Volume 278, 1 February 2015, Pages 210–220
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. “Possible resting metabolic rate modification by the circulating RBP4 in obese subjects.” Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. “Targeting receptor tyrosine kinases and their downstream signaling with cell penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.” Chem Biol Drug Des. 2014 Oct 8.
  • O’Brien, MJ, Zhao, Q, Yang, S. “Colorectal Serrated Pathway Cancers And Precursors” Histopathology. 2014 Sep 29. doi: 10.1111/his.12564

 

September 2014

October 7th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • CAP (College of American Pathologists) 2014, September 7-10 in Chicago, Illinois:
    • Resident Yanli Ding, MD presented a poster titled as “Gastroenteric biopsies in patients with rare immunodeficiency syndromes –two case reports and literature review” for the CAP 2014 Annual Meeting

      DingYanli.CAP2014.MicroMsg635457665999840000

      Dr. Yanli Ding with her CAP Poster

    • Resident Dr. Anita Malek’s poster was titled; “Immunohistochemical Approaches to Poorly Differentiated Tumors of Unknown Origins ” Authors: Anita Malek, MD , Qing Zaho, MD, PhD

      Malek.CAP2014.photo

      Dr. Anita Malek with her CAP Poster

    • Resident Dr. Yue Sun also presented a poster entitled “Epithelioid hemangioma of the penis: a case report,” Yue Sun, Qing Zhao

      Sun.CAP2014.(2)

      Dr. Yue Sun with her CAP Poster

  • Post-doc Evan Chiswick, Remick Lab was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, in Salt Lake City, Utah, October 23-25, 2014. Dr. Chiswick also received a Travel Award. The title of his talk is “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity”
  • Dr. Barbara Nikolajczyk has been selected for the 2014 Evans Center Research Collaborator Award. The award will be presented during the Evans Day Gala Dinner,  Oct 16, 2014
  • Brittany Mailhot and Diane Mullen participated in the Jimmy fund Walk with the Dana Farber Facilitating Hope team. Former BMC employees who also participated are Audrey Quinn and Janet Means. Former Patriot’s player Matt Light is the man in the photo with us!

    JimmyFundWalk14

    Jimmy Fund Run

    JimmyFund2014.2.20140921_134330

    Jimmy Fund Run

  • Please welcome the new post-doctoral fellow in the Kurosawa lab, Dr. Ji-Hye (“jee-hay”) Seo. Dr. Seo comes to us from BIDMC where she studied signaling pathways important in development of gastric cancer from chronic Helicobacter pylori infection. She earned her master’s and doctoral degrees from Yonsei University College of Medicine in South Korea (high honors) and lives with her family in Wellesley. Please introduce yourself and lend a hand as she gets settled. 
  • Ivana Delalle, MD, PhD is teaching a new GMS course in the Spring entitled “Human Biospecimens for Research,” PA 910.
    • The objective of this course is to introduce students to the creation, maintenance and efficient use of an indispensable component of translational research in medicine: human biological material (human tissue and bodily fluids)  = human biospecimens and their derivatives. Lectures from faculty from Pathology Departments at Yale, Harvard and Columbia (new York Brain Bank, NYBB), and from Boston University School of Medicine with extensive  experience in human bio-specimens generation, maintenance, and utilization, will instruct how to  successfully obtain and utilize human bio-specimens. ~~~
    • Topics will include logistics and legal aspects of creating and sustaining bio-banks, federal and institutional regulatory and funding mechanisms, and concrete examples of human bio-specimens use to generate break-through data in specific field of biomedical research. Special attention will be given to human biospecimens used in neuroscience as four neuropathologists/neuroscientists from Harvard, Yale, Columbia and Boston University  are enlisted as speakers to give comprehensive overview of biospecimens utilized in neurodegenerative diseases and brain tumors.
  • Karen Quillen, MD is also teaching a new seminar entitled “Blood & Money” in the Kilachand Honors College on the Charles River Campus, with Professor Michael Salinger from the BU School of Management
  • Dr. Nader Rahimi was invited to give a lecture at the Department of Biochemistry, Boston University on September 16. The title of his lecture was “Emerging Roles of Posttranslational Modifications in Receptor Tyrosine Kinase Activation and Signaling”.
  • Dr. Rahimi gave a similar lecture on September 24, 2014 at the University Massachusetts, Lowell.
  • Dr. Rahimi is also invited to give a lecture at the upcoming Boston Angiogenesis Meeting, on November 12, 2014. For additional information, please see the link: (http://lawsonlab.umassmed.edu/BAMspeakersAM.html).   
  • Dr. Lija Joseph recently was awarded the ICPI MSIG Award for her Medical Student Interest Group from the intersociety council for pathology information. Dr. Joseph plans to incorporate our residents in the grand funded program.
  • Publications: PUBLISHED:

    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease, Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press).

    August 2014

    September 2nd, 2014 in Uncategorized

     

    Pathology & Laboratory Medicine News Items

    Announcements:

    • New Grant Funding in Pathology:

    The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the

    period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department

    and it would be appropriate to share the specifics of these new grants.

    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX001875-01
    Title Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.
    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX002468-01
    Title Novel neurotrophic therapies in an optimized mouse model of GWVI
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.
    PI Jan Krzysztof Blusztajn
    Co-Investigator Tiffany Mellott, Barbara Slack, Ivana Delalle
    Number R01 AG045031-01A1
    Title BMP9 as a juvenile protective factor in cognitive aging
    Description The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.
    PI Shinichiro Kurosawa
    Co-Investigator D.J. Stearns-Kurosawa
    Number R01 AI102931
    Title Development and Treatment of Pre-Clinical EHEC Models with HUS
    Description Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children.  There is no treatment available, other than supportive care.  Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.  The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.
    PI Vipul Chitalia
    Co-investigator Nader Rahimi
    Number R01 CA175382
    Title Role of c-Cbl in Colon cancer
    Description The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase
    PI Daniel Remick
    Co-Investigator Nader Rahimi
    Number R21 AI112887-01
    Title Mechanisms of phagocytic cell defects induced by inhibitory IgG
    Description We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.
    PI Daniel Remick
    Number R21 AA022122-01
    Title Alcohol Triggered Asthma: Mechanisms of Neuronal Control
    Description The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.
    PI Susan Winandy
    Number R21 CA176811-01
    Title Mechanism of Notch-induced leukemogenesis in lymphocytes
    Description Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.  This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.

     Welcome to our New Graduate Students:

      • Stephanie Adams, OD/PhD
      • Lois Bayigga, Masters
      • Evan Catudal, Masters
      • Junbo Chen, Masters
      • Yuri Kim, PhD
      • Asha Melo, Masters
      • Tim Norman, PhD
      • Ruoyu Tian, Masters
      • BJ Varian, Masters

     

    • From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
    • Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
    • Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.

    Publications: ACCEPTED:

    • Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
    • Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)

    Publications: PUBLISHED:

    July 2014

    August 7th, 2014 in Uncategorized

    Pathology & Laboratory Medicine News Items

    Announcements:

    • Congratulations to Dr. Manisha Mehta and Dr. Dana Semmel for successfully completing the Anatomic and Clinical Pathology sections of the ABP Board Examination and becoming diplomats of the American Board of Pathology
    • Daniel Remick, M.D., has been selected as the moderator for the Pathology Roundtable. The roundtable has representation by the major pathology societies, such as the College of American Pathology, The United States and Canadian Academy of Pathology, The American Society of Clinical Pathology, The American Board of Pathology, The American Society of Investigative Pathology, the National Association of Medical Examiners, the Association of Directors of Academic Surgical Pathology, the Academy of Clinical Laboratory Physicians and Scientists, The Association of Pathology Informatics, and the American Society of Cytology. The roundtable meets on a regular basis to discuss issues that directly impact our discipline, so that a unified response may be developed. Dr. Remick assumed his duties as moderator in July, 2014 as a representative of the American Society for Investigative Pathology
    • Dr. Remick moderated a session at the 2014 Association of Pathology Chairs Meeting “Academic Pathology 2020: Advancing Research Opportunities,” in Boston, MA; July 8-11, 2014
    • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab, attended the 2014 National Neurotrauma Symposium in San Francisco, late June 2014. Mark presented a poster titled “Pathobiology of Blast-Related Traumatic Brain Injury in a Mouse Model.” Authors: M. Wojnarowicz A. Fisher C. Tagge A. Gaudreau N. Casey J. Moncaster O. Minaeva G. Hall R. Cleveland W. Moss X.L Zhang P. Stanton H. Lu B. Lamb R. Ransohoff A. McKee L. Goldstein
    • Dr. Lawreen Connors received a 1-year grant from the E. Rhodes and Leona B. Carpenter Foundation in support of her study, “Blood Profiling for Biomarkers in Age-related ‘Senile’ Systemic Amyloidosis (SSA)”
    • Chad Mayer, MD/PhD, Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014
    • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014
    • Martin Steffen, PhD has joined the Editorial Board of two new publications:
    • ○     Journal of Bacteriology and Mycology
    • ○     Clinical Journal of Microbiology and Pathology
    • Barb Nikolajczyk, PhD Lab welcomes the following people:
    • ○     Dr. Blanche Ip, Post-doctoral fellow on the Inflammation Training Grant
    • ○     Michel Azer, Masters’ student from the BU Goldman School of Dental Medicine
    • Effective July 1, 2014, Dr. Maria Panchenko will be the new course co-director for our course PA710 “Principles of Applied and Basic Pathology”. The course was originally created by Deborah Stearns-Kurosawa who will be stepping down. I will remain the new course co-director.
      This is a graduate level course which introduces basic concepts of pathology, including some essential histology. Additionally, all graduate students are required to attend our research seminars and prepare a written synopsis of 4 seminars. This allows the students to have their writing formally evaluated. Another major component of the course is to expose all of the new graduate students to the range of research conducted within the Department so that they may select an appropriate lab to do their thesis.  Please join me in welcoming Dr. Panchenko as the new course co-director, and thanking Dr. Stearns-Kurosawa for her efforts to launch and mentor a new course.
    • David Sherr, PhD has been appointed Director of the BU Superfund Research Program
    • Dr. Kazem Azadzoi received the Journal of Urology Best Reviewer in 2013 Award at the American Urological Association 2014 Annual Meeting in Orlando, Florida; May 2014
    • Welcome to our two new Pathology Residents!!!
    • ○  Dr. Reyhan Gedik
    • ○  Dr. Shiva Khoobyari

    Publications: ACCEPTED:

    • Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG, Lentsch “AB: Substance P Mediates Reduced Pneumonia Rates After Traumatic Brain Injury,” Crit Care Med 2014, PMID: 2501406 (In Press)
    • Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH: “Abandon the Mouse Research Ship? Not Just Yet!”, Shock 2014, PMID: 24569509 (In Press)
    • Mella JR, Chiswick EL, King E, Remick DG: “Location, Location, Location: Cytokine Concentrations are Dependent on Blood Sampling Site,” Shock 2014, PMID: 25004061 (In Press)
    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. “Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease,” Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press)
    • Gusenleitner, D., S. S. Auerbach, T. Melia, H. F. Gomez, D. H. Sherr, and S. Monti. 2014. “Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.” PLoS One 9:e102579

    October 2013

    October 28th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items –

    Announcements:

    • Faculty Appointments and/or Promotions:
      • Dr. Yuriy Alekseyev was promoted to Research Associate Professor
      • Dr. Shinichi Takayama has been appointed as Research Associate ProfessorImmuno Nov 2013
    • Immunology has selected an image from an article authored by Dr. Zhaohua Lu and colleagues, published in this month’s Immunology for the journal cover (see photo and link to article) http://onlinelibrary.wiley.com/doi/10.1111/imm.12150/full
    • The Martin Steffen Lab presented a talk on their work on biomarkers for Prostate Cancer at the 2013 meeting for the New England Section of the American Urological Association in Hartford, Connecticut on September 26 – 28 Towards Reducing the Number of Prostate Biopsies – Biomarkers to Identify Patients with Benign Causes of Elevated PSA LevelsAgnes Bergerat, PhD1, Yi-Chien Chang, MS2, Mark Katz, MD1, David Wang, MD1, Simon Kasif, PhD2, Richard Babayan, MD1Martin Steffen, MD, PhD1
    • Dr. Daniel Remick will be giving a lecture on October 28th at the Brigham & Women’s Hospital entitled, “Mechanisms of Alcohol Triggered Asthma”
    • Dr. Carmen Sarita-Reyes is now Board Certified in Pediatric Pathology

    Publications: PUBLISHED:

    • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D.,Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., Jason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary Hunter, M. A. “MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia” New England Journal of Medicine; 367;9 nejm.826 org august 30, 2012
    • Lian Xu,1,2  Zachary R. Hunter,1,2 Guang Yang,1,2 Yangsheng Zhou,1,2 Yang Cao,1,2 Xia Liu,1,2 Enrica Morra,3 Alessandra Trojani,3 Antonino Greco,3 Luca Arcaini,4 Marzia Varettoni,4 Jennifer R. Brown,5 Yu-Tzu Tai,2,6 Kenneth C. Anderson,2,6 Nikhil C. Munshi,2,6 Christopher J. Patterson,1 Robert J. Manning,1 Christina K. Tripsas,1 Neal I. Lindeman,2,7 and Steven P. Treon1,2 “MYD88 L265P in Waldenstr¨om macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction” BLOOD, 14 MARCH 2013 x VOLUME 121, NUMBER 11
    • Steven P. Treon1,2 and Zachary R. Hunter1,2 “A new era for Waldenstrom macroglobulinemia: MYD88 L265P,” BLOOD, 30 MAY 2013 x VOLUME 121, NUMBER 22
    • Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. “The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.” Immunology. 2013 Nov;140(3):374-389. PMID: 23844703

    September 2013

    September 26th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items –

     

    Announcements:

    • CAP (College of American Pathologist) 2013, Orlando Florida, October 13-16, 2013; Accepted:
      • “Validation Of Pre-transfusion Compatibility Testing In PEG In A Semi-automated Transfusion Service” (Poster No. 98 – p 1371) – Josenia Tan and Karen Quillen – Abstract accepted to CAP 2013, poster presentation
      • “Benign Epithelial Inclusions In Axillary Lymphnodes” (Poster No. 69 – p 1452) - Anita Deshpande, MD; Josenia Tan, MD; Melinda Lerwill, MD; Grace Zhao, MD; selected abstract for poster presentation at CAP ’13.
      • “Utility Of Fetal Tissue Examination in Intrauterine Fetal Demise Autopsies;” (Poster No. 95 – p 1508)
      • Cathryn Byrne-Dugan, MD, et al – Abstract accepted to CAP 2013, poster presentation
      • From Dr. Carmen Sarita-Reyes: on page 166: http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2013-0354-AB; presented by Yue Sun, MD and Antonio de las Morenas, MD; “Anaplastic Thyroid Carcinoma and Potential Therapeutic Target” (Poster No. 152 – p 1525)
    • Dr. Daniel Remick was the Keynote Speaker, 15th Congress of the European Shock Society, Vienna Austria, September 2013; “Sepsis, When you die we want to know why”
    • Dr. Remick also participated in “Meet the Expert, Ludwig Boltzmann Institute of Traumatology,” Vienna Austria in September 2013
    • Daoreuang Pongvongkeo, Angel Lui, Genevieve Matnog, and John Lee from the Hematology Lab have validated a new automated urinalysis platform, the iRICELL Plus, that went live 9/9/13. This new automated platform will improve efficiency in performing and releasing urinalysis results.
    • Dr. Barbara Nikolajczyk presented her teams’ work “Lymphocytes regulate inflammation in human type 2 diabetes” at the Aegean Conference on Immunometabolism in Rhodes, Greece, September 17, 2013
    • Dr. Barb Nikolajczyk also presented her teams’ work “Roles of B cells in type 2 diabetes and T2D-associated periodontal disease” at the Forsyth Institute in Cambridge, MA September 26, 2013
    • Dr. David Sherr was featured in an article in International Innovations in which I discuss the role of the environment in breast cancer progression. See the URL below. http://www.bumc.bu.edu/immunology/files/2006/10/Final-High-resolution-p93-95_David_Sherr.pdf
    • Dr. Daniel Remick was the Keynote Speaker, at the 11th Annual Advances in Inflammation Research, Brown University, September 26th & 27th; “The roles of adenosine and antibodies in sepsis”
    • Daniel Remick, MD is the Chair and invited speaker, 46th Annual Meeting of the Society for Leukocyte Biology, Providence Rhode Island, “Leukocytes and mediators that influence survival”
    • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
    • Resident Manisha Mehta, MD has had her abstract, ‘Vitreous cytology: A diagnostic glimpse into the eye’ Manisha Mehta, MD; Reena Rashid, MD; Stephen Foster, MD; Nora Laver, MD, accepted as a talk at the http://aaoop.org/annual-meetings/2013-aaoop-annual-meeting/” target=”_blank” title=”http://aaoop.org/annual-meetings/2013-aaoop-annual-meeting/”>2013 AAOOP (American Association of Ocular Oncologists and Pathologists) Annual Meeting>, “Memorial Celebration of the Life and Work of Dr. Lorenz E. Zimmerman with Anastasia Zimmerman” on November 15th in New Orleans
    • The Nikolajczyk Lab has received a 1 year Diabetes Complications Consortium Grant from the NIH
    • Welcome to our NEW dedicated Residency Program Coordinator, Mark Uva!

    August 2013

    September 5th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items –

     

    Announcements:

    • Chad Mayer, MD/PhD Student in the Kurosawa Lab is the recipient of the 2014, MD/PhD Student Conference Diversity Award from the Medical Sciences Training Program; and he received a check for $500.00
    • MD/PhD candidate Nick Woolf, in the Rahimi Lab, was recently accepted as a fellow in BU’s 2013-2014 Cross-Disciplinary Training in Nanotechnology for Cancer (XTNC) program. This fellowship will fund his research stipend for at least one year (two with a renewal application). It’s a great opportunity for Nick to meet other PhD students in the sciences at BU, and he will be learning the nuances of several techniques with nanobiology applications.
    • Dr. Shinichiro Kurosawa received an NIH/NIAID R01 award to continue his laboratory’s basic and translational research with enterohemorrhagic E.coli and the bacterial toxins
    • Nancy S. Miller, MD will present Grand Rounds at the University of Massachusetts, Lowell, in October
    • Dr. David Sherr’s Lab, along with Stefano Monti’s, was awarded a supplement to their Superfund Research Program to apply computational biology and high throughput genomics to define transcriptional signatures of carcinogenicity
    • Dr. Barbara Nikolajczyk:
      • has been invited to give a Seminar at the 2nd Aegean Conference on Immunometabolism meeting, Rhodes, Greece, September 2013. “Lymphocytes regulate inflammation in human type 2 diabetes”
      • Dr. Nikolajczyk will also serve on the HAI (Hypersensitivity, Allergy and Immune-mediated diseases) study section in October 2013
      • Dr. Barbara Nikolajczyk has also been invited to co-chair and speak in a Major Symposium at the American Association of Immunologists meeting in Pittsburgh, PA in May 2014

    Publications: PUBLISHED:

    • Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ.”NELF coordinates RNA polymerase II pausing, premature termination and chromatin remodeling to regulate HIV transcription.” J Biol Chem. 2013 Jul 24

    July 2013

    August 15th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items

    Announcements:

    • Nancy S. Miller, MD will be President-elect of the Northeast Branch of the American Society for Microbiology, for the one-year term commencing July 1, 2013
    • Daniel Remick, MD was elected to chair the Research Committee of the Association of Pathology Chairs. With this election he will continue as a member of council
    • Parul Agnihotri, PhD Candidate, has been invited to attend the International Graduate Student Immunology Conference in Marseilles, France from August 29-31st. The conference will be take place at the Centre d’Immunologie de Marseille-Luminy (CIML). The title of Parul’s talk will be: “Foxo1: A Potential Target of Ikaros in Regulating Peripheral CD4 T Cell Development”
    • Daniel Remick, MD was an invited speaker at the 2013 Annual Meeting of the Association of Pathology Chairs in the session on Benchmarking Academic Pathologists. His presentation was on using the CARTS methodology to determine budgeting. The APC Meeting was held in Boston this year from July 9 – 12, 2013
    • Cytology Fellow, Josenia Tan, MD, successfully passed her AP and CP Boards; congratulations Joy!

     

    Publications: ACCEPTED:

    • Monti, S., and D. Sherr. 2013. The role of the aryl hydrocarbon receptor in normal and malignant B cell development. Seminars in Immunopathology (In Press)
    • Quintana, F., and D. Sherr. 2013. Aryl hydrocarbon receptor ¬control of adaptive immunity Pharm. Rev. (In Pres)
    • Paper accepted in PLoS Biology describing our efforts to build a community of computational and experimental biologists collaborating to experimentally validate gene function: “The COMBREX Project: Design, Methodology, and Initial Results;” Brian P. Anton, Yi-Chien Chang, Peter Brown, Han-Pil Choi, Lina L. Faller, Jyotsna Guleria, Zhenjun Hu, Niels Klitgord, Ami Levy-Moonshine, Almaz Maksad, Varun Mazumdar, Mark McGettrick, Lais Osmani, Revonda Pokrzywa, John Rachlin, Rajeswari Swaminathan, Benjamin Allen, Genevieve Housman, Caitlin Monahan, Krista Rochussen, Kevin Tao, Ashok S. Bhagwat, Steven E. Brenner, Linda Columbus, Valérie de Crécy-Lagard, Donald Ferguson, Alexey Fomenkov, Giovanni Gadda, Richard D. Morgan, Andrei L. Osterman, Dmitry A. Rodionov, Irina A. Rodionova, Kenneth E. Rudd, Dieter Söll, James Spain, Shuang-yong Xu, Alex Bateman, Robert M. Blumenthal, J. Martin Bollinger, Woo-Suk Chang, Manuel Ferrer, Iddo Friedberg, Michael Y. Galperin, Julien Gobeill, Daniel Haft, John Hunt, Peter Karp, William Klimke, Carsten Krebs, Dana Macelis, Ramana Madupu, Maria J. Martin, Jeffrey H. Miller, Claire O’Donovan, Bernhard Palssøn, Patrick Ruch, Aaron Setterdahl, Granger Sutton, John Tate, Alexander Yakunin, Dmitri Tchigvintsev, Russell Greiner, David Horn, Kimmen Sjölander, Steven L. Salzberg, Dennis Vitkup, Stanley Letovsky, Daniel Segrè, Charles DeLisi, Richard J. Roberts, Martin Steffen, Simon Kasif

    June 2013

    July 11th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items

    Announcements:

    • Castle Graduation Celebration 2013

    miller

    Dr. Nancy Miller with Graduate Dr. Yani Toribio, Dr. Grace Zhao and Graduate Dr. Joy Tan

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    First Years; Dr. Yue Sun, Dr. Cathryn Byrne-Dugan, Dr. Dhay Kamel and Dr. Anita Malek

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    Dr. Robert Pistey playing some soft music and resident Dr. Dana Semmel enjoying

     

    • Congratulations Graduating Resident, Dr. Josenia Tan who won the very first Robert Foley, MBA, Award. This honor will be given annually to a resident or fellow who “demonstrates the qualities that Mr. Foley brought to work every day.” This being the inaugural year of the prize Mr. Foley’s family was invited to the Castle Graduation Dinner.

      joyfoley

      Dr. Joy Tan receiving the first Annual Robert Foley, MBA, Award from Department Chair, Dr. Daniel Remick and Dr. Chris Andry cheering her on.

    • Congratulations on passing the Qualifying Exams!
      • Jessica Allen
      • Mostafa Belghasem
      • Melody Lun
      • Caitlin Miller
      • Jacquelyn Sikora
      • Jason Sutin
      • Thank you to all faculty members who assisted with the qualifying exams, with a SPECIAL Thank You Dr. Barbara Slack and the Qualifying Exam Committee
    • The Scientific Steering Committee of the XXIVth International Society on Thrombosis and Haemostasis (ISTH in Amsterdam, Netherlands; June 29-July 4) has determined that the abstract from the Kurosawa Lab “is likely to have an immediate and important impact on the practice of clinical medicine” and will be included in the ISTH publication with MD Conference Express which is a peer-reviewed meeting highlights report. This late-breaking abstract presented by Dr. Shinichiro Kurosawa is entitled:  “Complement is not activated in nonhuman primates during development of hemolytic uremic syndrome and thrombotic microangiopathy induced by E.coli Shiga toxins” by authors B.C. Lee, C.L. Mayer, C.S. Leibowitz, D.J. Stearns-Kurosawa, S. Kurosawa.
    • Dr. Ivana Delalle gave a platform presentation “Deregulation of Exosomal and Cellular microRNA in Bipolar Disorder,” American Association of Neuropathologists Meeting; Charleston, South Carolina  on June 22, 2013
    • Dominic Beal , PhD, successfully defended his thesis “Role of Macrophages in Cockroach Allergen Induced Asthma” on Tuesday, June 18th
    • The Hematology Lab (Renee Nutting, Daoreuang Pongvongkeo, and John Lee) has validated lupus anticoagulant testing on the in-house automated coagulation platform.  All lupus anticoagulant testing from now on will be performed in-house.
    • Dr. Carmen Sarita-Reyes was the guest lecturer of the “Dr. Manuel Felipe Pimentel Imbert Lecture” at her alma mater Universidad Nacional Pedro Henriquez Ureña School of Medicine on June 18th 2013 in Santo Domingo, Dominican Republic. The title of her lecture was “Pediatric Pathology Clinical and Surgical Management”.

    Sarita.ReyesSpeakingatHerAlmaMater.Spring2013.DSC_0110 (2)

    Sarita.Reyes.AlmaMaterwithPresentation.Spring2013.DSC_0149 (2)

     

    • Nick Woolf, MD/PhD student in Nader Rahimi’s laboratory has been awarded a full fellowship from the Center for Nanoscience and Nanobiotechnology,  Boston University for his project entitled “The Role of IGPR-1 in Tumor Growth and Progression”
    • Zachary Hunter, PhD candidate was an invited speaker at the 2013 International Waldenström’s Macroglobulinemia Foundation Educational Forum; “The Genomic Landscape of WM” May 17-19, San Diego, California
    • Zach Hunter also gave an oral presentation “Recurring Activating Mutations and Somatic Deletions Revealed Through Whole Genome Sequencing in WALDENSTRÖM’S MACROGLOBULINEMIA” at the12th International Conference on Malignant Lymphoma June 19-22, Lugano, Switzerland http://www.lymphcon.ch/
    • Dr. Carmen Sarita-Reyes gave a lecture on “Pediatric Pathology: Clinical-Pathologic Cases” at Robert Reid Cabral Children’s Hospital, Santo Domingo, Dominican Republic on June 25th 2013

    Publications: ACCEPTED:

    • Liling Zeng, Ming Bai, Amit K. Mittal, Wassim El-Jouni, Jing Zhou, David M. Cohen, Mina I. Zhou, Herbert T. Cohen: Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal-cell carcinoma.  Cancer Research 2013 (in press)
    • Srimathi Srinivasan, Rosana D Meyer, Ricardo Lugo, Nader Rahimi. Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGFR-2. Accepted for publication in the Journal of Biological Chemistry

     

    Publications: PUBLISHED:

    • Nicholas J. DeNunzio & Lija Joseph & Roxane Handal & Ankit Agarwal & Divya Ahuja & Ariel E. Hirsch. Devising the Optimal Preclinical Oncology Curriculum for Undergraduate Medical Students in the United States. J Canc Educ (2013) 28:228–236 DOI 10.1007/s13187-012-0442-0
    • Vipul Chitalia, Sowmya Shivanna, Jordi Martorell, Rosana Meyer, Elazer Edelman, and Nader Rahimi.  c-Cbl, a ubiquitin E3 ligase that targets active β-catenin – A novel layer of Wnt regulation Journal of Biol. Chem. jbc.M113.473801. First Published on June 6, 2013, doi:10.1074/jbc.M113.473801
    • Azadzoi KM and Siroky MB. Mechanism of lower urinary tract symptoms in pelvic ischemia. J Biochem & Pharmacol Res: 1: 64-74, 2013, 2013
    • Treon, S. P., & Hunter, Z. R. (2013). A new era for Waldenstrom macroglobulinemia: MYD88 L265P. Blood, 121(22), 4434–4436. doi:10.1182/blood-2013-04-494849