Category: Uncategorized

March 2015

April 6th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • 104th USCAP Meeting, Boston, MA, March 21-27 2015
    • Cathryn Byrne-Dugan, MD had her abstract accepted:Podocyte Infolding Glomerulopathy – Occurrence of the Disease Entity in the United States, and the Potential Role of an Autoantibody;” Authors:Cathryn J Byrne-Dugan, Pavel Kopach, Laurence H Beck, Vanesa Bijol, Monika Pilichowska, Helmut G Rennke, Masha Bilic
    • Meera Mahalingam will be the Chair/Moderator of “Neoplastic Dermatopathology – Clues and Confounders.” Topic was selected to highlight histopathologically confounding issues in cutaneous neoplasms. Neoplasms selected encompass a spectrum of lineage-unrelated tumors that are commonly encountered some perhaps more than others by a general pathologist both in private practice and in an academic setting. Each speaker will begin with an initial description of the entity and conclude with clues and confounding issues relevant to the entity discussed
    • Qing Zhao, Shi Yang, Cecilia Ponchiardi, and Michael O’Brien had their abstract BRAF/KRAS Mutation, MSI/MSS Status and Tumor Budding in Colorectal Carcinoma” at the Poster Session on Tuesday, March 24th
    •   “Resident Shiva Khoobyari, MD enjoying a Poster at this year’s USCAP in Boston”
      USCAP2015.Shiva.58983127-DSC_624
  • Congratulations to Karen Quillen on her recent promotion to full professor. There is a nice article in BU today about her advancement. http://www.bu.edu/today/2015/med-promotions/
  • Daniel Remick, M.D., has been selected to be a Guest Editor for the Journal of Leukocyte Biology beginning February 2015. Dr. Remick will serve as the Editor for manuscripts solicited from the 2014 joint annual meeting of the Society for Leukocyte Biology and the International Innate Immune and Endotoxin Society.
  • On March 9th 2015 in Boston, MA. Carmen Sarita-Reyes presented at the 2015 Annual Session and Exhibition of the American Dental Education Association (ADEA) a Chair of the ADEA Board of Directors Symposium. The presentation was titled: “IGNITING MINDS THROUGH STUDENT SELF-DIRECTED GROUP LEARNING: Integrated  Problem Sessions (IPS.) Chair of the ADEA Board of Directors Symposium;” Cataldo W. Leone, DMD, DMSc, Carol T. Walsh, MA, PhD, Carmen D. Sarita-Reyes, MD, Monica A. Pessina, MEd, PhD, and Elizabeth R. Whitney, MSPT, PhD
  • Resident Reyhan Gedik, MD volunteers for a non-profit organization called White Tulip Foundation. We organize monthly seminars (called Boston Medical forum http://www.bostonmedicalforum.org/ ) to share our experiences as medical doctors and scientists. In March they invited David Kindelberger to give a talk about “Circulating Tumor Cells; New Tools for Personalized Medicine” and he kindly accepted. Keep an eye out for other interesting topics.
  • Clarissa Koch, PhD, Connors Lab, successfully defended her thesis “Characterizing the Effect of Transthyretin Amyloid on the Heart” on Monday, March 16th
  • “Clarissa Koch, PhD Candidate and her PI Lawreen Connors, about to give her Defense” and “Dr. Koch’s Celebration”
    IMG_4362
    IMG_4380
  • MATCH DAY 2015:
    • Bravo to MD/PhD Graduate David Stepien for successfully being accepted into his First Choice in this year’s Match; Dave will be taking up residence in the University of Michigan Hospital Integrated Plastic and Reconstructive Surgery Residency Program
    • Hooray to 2011 Masters Degree Graduate Nik Bajaj for also getting into his First Choice in this year’s Match; Nik will begin his residency in the University of Illinois – COM – Chicago Neurology Residency Program
  • Kevin Chandler, PhD, a postdoctoral fellow working jointly in the Dr. Cathy Costello and Nader Rahimi laboratories was awarded a three year postdoctoral fellowship from the NIH. The goal of the project is to map the glycosylation of VEGFR-2 and the role of this posttranslational modification in the angiogenic signaling of VEGFR-2
  • David Sherr’s graduate student, Liz Stanford, was selected to be the GMS commencement student speaker
  • Barb Nikolajczyk, PhD is an invited speaker in March 2015 for:
    • Experimental Biology, Diet and Immunometabolism Symposium, Boston, MA, Lymphocyte function in human type 2 diabetes, 2015
    • Immunology Microbiology Program Spring Seminar Series, University of Massachusetts Medical School, Inflammation in human type 2 diabetes, 2015
    • Beth Israel Medical Center,  Inflammation in human type 2 diabetes, 2015
  • Carol Cohen will be presenting at the AATB Quality and Donor Suitability Workshop in Atlanta, Georgia on April 20th. Susan Sharpe MS, MT(ASCP), SBB, CTBS who is the Supervisor of the Tissue and Transfusion Service at Northside Hospital in Atlanta and Carol will be presenting on the FDA’s new ruling that requires medical devices to have unique device identifiers
  • Lawreen Connors, PhD was invited to speak at the EB/ASIP meeting here in Boston on March 31st; the title of her presentation was “The Translational Science of Transthyretin-associated Cardiomyopathies.”
  • Here’s a link to an article in the Chicago Tribune in which David Sherr is quoted/featured: http://www.chicagotribune.com/lifestyles/health/sc-hlth-401-environmental-cancer-20150326-story.html#page=1
  • Remick was recently notified that graduate student, Ms. Erika Langley, was chosen this semester as a Teaching as Research Fellow. As a winner of this fellowship, she will receive an award of $1,000 and partake in a seminar in teaching as research. Teaching-as-Research involves the deliberate, systematic, and reflective use of research methods to develop and implement teaching practices that advance the learning experiences and outcomes of students and teachers. Erika will be in the TAR seminar this spring, and implement a project in a classroom in the summer or fall. Erika’s TAR project has the working title: Improving scientific literacy in undergraduates; she has the support of her faculty advisor for the project Prof. Paul Lipton and her research advisor Prof. Alpaslan Dedeoglu.

Publications ACCEPTED:

  • Goldberg, L.J., E. Wise, N. S. Miller. White piedra in a northern climate caused by Trichosporon inkin: A report of two cases. Item of correspondence. Accepted for publication, March 7, 2015. British Journal of Dermatology
  • Chad L Mayer, Caitlin S.L. Parello, Benjamin C Lee, Kiyoshi Itagaki, Shinichiro Kurosawa, DJ Stearns-Kurosawa. “Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga toxins and Host Damage-Associated Molecular Patterns”  Frontiers in Immunology, section Microbial Immunology.

Publications PUBLISHED:

  • Tagne, J.B., Mohtar, O.R., Campbell, J.D., Lakshminarayanan, M., Huang, J., Hinds, A.C., Lu, J., Ramirez, M.I. (2015) Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb Res. 16:22 PMC4335692 http://respiratory-research.com/content/16/1/22
  • Rai A, Nimeh T, Sood A, Thirumavalavan N, Thurmond PE, Azadzoi KM, Lerner LB. Could nocturia be an indicator of an undiagnosed sleep disorder in male veterans? 2015 Mar;85(3):641-7. PMID: 25733279
  • Lei X, Liu C, Azadzoi KM, Li C, Lu F, Xiang A, Sun J, Guo Y, Zhao Q, Yan Z, Yang J,; A novel IgM-H-ficolin complement pathway to attack allogenic cancer cells in vitro. Sci Rep. 2015 Jan 16;5:7824. PMID: 25592840
  • Poutahidis, T., Varian, B. J., Levkovich, T., Lakritz, J. R., Mirabal, S., Kwok, C., & Erdman, S. E. (2015). Dietary microbes modulate transgenerational cancer risk. Cancer research, canres-2732       (BJ Varian is one of our Masters Students; this is with his MIT affiliation)
  • Shivanna S, Harrold I, Shashar M, Meyer R, Kiang C, Francis J, Zhao Q, Feng H, Edelman ER, Rahimi N, Chitalia VC. c-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt-mediated phosphorylation. J Biol Chem. 2015 Mar 17J Biol Chem
  • Melody P. Lun, Matthew B. Johnson, Kevin G. Broadbelt, Momoko Watanabe, Young-jin Kang, Kevin F. Chau,Mark W. Springel, Alexandra Malesz, André M.M. Sousa, Mihovil Pletikos, Tais Adelita, Monica L. Calicchio,Yong Zhang, Michael J. Holtzman, Hart G.W. Lidov, Nenad Sestan, Hanno Steen, Edwin S. Monuki, and Maria K. Lehtinen. Spatially Heterogeneous Choroid Plexus Transcriptomes Encode Positional Identity and Contribute to Regional CSF Production. The Journal of Neuroscience 25 March 2015, 35(12): 4903-4916
  • Vanesa Bijol, Cathryn J. Byrne-Dugan, and Melanie P. Hoenig. Medical student web-based formative assessment tool for renal pathology. Medical Education Online, Volume 20, 2015; http://med-ed-online.net/index.php/meo/article/view/26765

February 2015

March 3rd, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • 104th USCAP Meeting, Boston, MA, March 21-27 2015
    • Mostafa Belghasem, PhD Candidate, Henderson Lab has an abstract accepted for poster presentation for the United States & Canadian Academy of Pathology’s (USCAP) 104th Annual Meeting in Boston, MA. The abstract is entitled “Podocyte-Specific Myh9 Deletion in Mice Results in Susceptibility to Glomerular Injury in Response to Subtotal Nephrectomy”
  • From Mark Uva, our Residency Coordinator: We have filled our two vacancies within the residency program.   These positions are in addition to our recruiting through the Match for PGY 1s.  The two physicians come to us with outstanding letters of reference, and thought of very highly in their respective programs.  They will be entering the program as PGY 2s, effective July 1, 2015.
    • Lei Li, MD: Lei is transferring from St. Barnabas Medical Center in Livingston, NJ, where she is currently a PGY 1.  Lei graduated from Xuzhou Medical College, Xuzhou, Jiangsu China in 2000.
    • Ram Al-Sabti, MD: Ram is transferring from University Hospital Case Medical Center, Cleveland, OH, where he is currently a PGY 1.  Ram graduated from the University of Bagdad, Iraq in 2009.

Publications ACCEPTED:

  • Peluso, A. M., B. A. Harnish, N.S. Miller, E. R. Cooper, A. M. Fujii.  Effect of young sibling visitation on respiratory syncytial virus activity in a NICU. The Journal of Perinatology (accepted for publication Feb. 19, 2015)
  • Valencia-Rey P., J. Weinberg, N. Miller, T. Barlam.  Coagulase-negative staphylococcal bloodstream infections: Does vancomycin remain appropriate empiric therapy? Journal of Infection (accepted for publication Feb. 18, 2015)
  • Taimur, S., N.S. Miller, D. Whitney, T. Barlam. Empiric and Targeted Treatment of Enterococcal Infections: Opportunities for Antimicrobial Stewardship. Infectious Diseases in Clinical Practice 2014 Dec; E-published ahead of print: doi:10.1097/IPC.0000000000000193

January 2015

February 9th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Nancy S. Miller, MD was an invited panel member at the Boston Pan African Forum event, “Ebola and other health-related issues in West Africa”, on December 13th in Dorchester, MA
  • Dr. Carmen Sarita-Reyes gave a poster presentation at the SENTAC (Society for Ear, Nose and Throat Advances in Children) meeting on December 6, 2014 in St Louis. “Marsupialization to treat foregut duplication cysts of the oral cavity: a novel technique;” Minyoung Jang; Carmen Sarita-Reyes; Devaki Sundararajan; Jessica Levi
  • Maria Panchenko, PhD has had her BUMC IACUC Appointment extended until June 2015. Thank you for your service Dr. Panchenko!
  • The American Board of Pathology recently nominated Meera Mahalingam, MD, PhD, FRCPath to serve on the Test Development and Advisory Committee on Dermatopathology.  The committees consist of American Board of Pathology trustees, as well as other pathologists and physicians who are recognized as experts in their respective disciplines
  • From Dr. John Lee; “The Hematology Lab has revised and updated the flow cytometry panels using a more sensitive and algorithmic approach.  In addition, a new technique will be employed to determine light chain restriction in plasma cells, which would be useful for myeloma, MGUS, and AL amyloidosis patients.  These changes were put into effect January 5, 2015 by Dina Pelley, MT (flow cytometry assistant supervisor) and John Lee, MD (Hematology Lab Medical Director) with Angel Lui, MT helping from the IT side.”
  • Dr. Ivana Delalle and her Neuropathology Lab have been acknowledged in recognition of her International Research Collaborations by PsyCourse: Pathomechanisms and Signatures of the Longitudinal Course of Psychosis
  • One of our current residents, Cathryn Byrne-Dugan, MD, will be going to University of Michigan for a GI fellowship in 2016-2017

Publications ACCEPTED:

  • Authors: Caitlin S.L. Parello, Chad L. Mayer, Benjamin C. Lee, Amanda Motomochi, Shinichiro Kurosawa *, Deborah J. Stearns-Kurosawa; Shiga Toxin 2-Induced Endoplasmic Reticulum Stress is Minimized by Activated Protein C but Does Not Correlate With Lethal Kidney Injury; Toxins, in press
  • Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine; (accepted for publication Jan 2014)

Publications: PUBLISHED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, David C. Seldin, Lawreen H. Connors; “Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt);” Hum Genet. 2015 Jan; 134(1):111-21. PMID: 25367359
  • Cathryn J. Byrne-Dugan, Terra A. Cederroth, Anita Deshpande, and Daniel G. Remick (2014) The Processing of Surgical Specimens With Forensic Evidence: Lessons Learned From the Boston Marathon Bombings. Archives of Pathology & Laboratory Medicine In-Press http://www.archivesofpathology.org/doi/pdf/10.5858/arpa.2014-0441-OA
  • Byrne-Dugan, CJ, Collins AB, Lam AQ, Batal I. Membranous Nephropathy as a Manifestation of Graft-Versus-Host Disease: Association With HLA Antigen Typing, Phospholipase A2 Receptor, and C4d. Am J Kidney Dis. 2014 Dec;64(6):987-93. doi: 10.1053/j.ajkd.2014.09.001. Epub 2014 Oct 8
  • Weber HC. Gastrointestinal regulatory peptides. Curr Opin Endocrinol Diabetes
    Obes. 2015 Feb;22(1):1-2. doi: 10.1097/MED.0000000000000130. PubMed; PMID: 25485518
  •  Weber HC. Gastrointestinal peptides and itch sensation. Curr Opin Endocrinol
    Diabetes Obes. 2015 Feb;22(1):29-33. doi: 10.1097/MED.0000000000000122. PubMed;
    PMID: 25485517
  • Hermos JA, Quach L, Gagnon DR, Weber HC, Altincatal A, Cho K, Lawler EV,
    Grotzinger KM. Incident severe thrombocytopenia in veterans treated with
    pegylated interferon plus ribavirin for chronic hepatitis C infection. Pharmacoepidemiol Drug Saf. 2014 May;23(5):480-8. doi: 10.1002/pds.3585. Epub 2014 Feb 20. PubMed PMID: 24677630

December 2014

January 8th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “Overcoming the resistance to anti-angiogenesis therapy”. The overall of goal of this research is to study the role of posttranslational modifications on VEGFR-2 in colon cancer. Angiogenesis inhibitors targeting the VEGF signaling pathway have been FDA approved for various cancer treatments. Although beneficial, patients inevitably develop resistance and often fail to demonstrate significantly better overall survival. Interfering with the posttranslational modifications of VEGFR-2 may overcome refractoriness and resistance to certain class of anti- cancer drugs.
  • Dr. Daniel Remick was an invited speaker to Loyola University Medical Center in Chicago, December 9/10, 2014:
    • Dr. Remick presented Grand Rounds in the Department of Surgery at Loyola – “Brain Injury Prevents Pneumonia – Who knew?”
    • He also gave a lecture to the Department of Pathology “Physician Scientist Pathway in Pathology”
    • Dr. Remick, as an invited speaker at the Burn and Shock Trauma Research Institute at Loyola University – Chicago presented,  “Inhibitory IgG Increases Sepsis Mortality”
  • Dr. Chris Andry, of Boston University USA, visited Professor Rodger Charlton, and other colleagues in the Division of Primary Care, Nottingham University, United Kingdom on 9th December, 2014 . During his visit, Dr. Andry gave a talk entitled “The Value of a Centralized Hospital Bereavement Office Supporting Multicultural Families in the USA”   

    image

    UK meeting University of Nottingham. Dr. Andry, 2nd from left. Man on his right Professor Rodger Charlton. Man on his left Dean of Srinakharinwirot University, Thailand. First Woman to the right of Professor Charlton, Assistant Professor Nantana Choomchuay, MD. Head, Department of Pathology, Faculty of Medicine, Srinakharinwirot University.

  • Jenny McEldoon, BU Undergrad working in the Remick Lab has been awarded funding from UROP for Spring 2015!
  • Zachary Hunter, PhD, Steve Treon Lab at Children’s Hospital, successfully defended his thesis “Whole Genome Sequencing Reveals that Recurrent MYD88 and CXCR4 Mutations Underlie the Genomic Landscape of Waldenström’s Macroglobulinemia” on Tuesday, December 2nd

Publications ACCEPTED:

  • Inge The, Suzan Ruijtenberg, Benjamin Bouchet, Alba Cristobal, Martine B.W. Prinsen, Tim van Mourik, John Koreth, Huihong Xu, Albert J.R. Heck, Anna Akhmanova, Edwin Cuppen, Mike Boxem, Javier Munoz, and Sander van den Heuvel, Rb and the APC/C co-activator FZR1 determine CDK4/6-Cyclin D requirement in C. elegans and human cancer cells. Nature Communications
  • Akifumi Fujita, Huihong Xu, Yu-Ming Chang, Scharukh Jalisi, and Osamu Sakai, Best cases from the AIRP: Malignant mixed tumor of the hard plate. RadioGraphics
  • Authors: Blanche C. Ip, Andrew E. Hogan, Barbara S. Nikolajczyk; Lymphocyte roles in metabolic dysfunction: of men and mice  Trends in Endocrinology and Metabolism  
  • Michael J. Greene, Elena S. Klimtchuk, David C. Seldin, John L. Berk, and Lawreen H. Connors; “Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal” Biochemistry

Publications: PUBLISHED:

  • Stevenson EK, Sloan KA, Narsule CK, Kretschman DM, Sarita-Reyes CD, Steiling K, Ebright MI. Catamenial hemothorax in a patient with multiple sclerosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):e69-70
  • Zhang QSiroky M, Yang JH, Zhao Z and Azadzoi K “Effects of ischemia and oxidative stress on bladder purinoceptors expression” Urology, 2014 Nov;84(5):1249.e1-7. doi: 10.1016/j.urology.2014.07.023

November 2014

December 2nd, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items 

Announcements:

  • Kate Murphy has announced that the Blood Bank had its’ 4th inspection of the year – American Association of Blood Banks (AABB) on November 19th and 20th for an extremely thorough assessment, including nursing competency.  We were successfully accredited for another 2 years!
  • Zach Hunter, PhD Candidate in the Steven Treon’s Lab at Children’s Hospital presented at the following conferences:
    • August 14th in London, UK. At the 8th International Workshop on Waldenstrom’s Macroglobulinemia. His oral presentation was entitled: “Genomic Landscape of WM”
    • August 17th in London, UK, WMUK’s 5th International Doctor Patient Forum “Making Sense of Key Information about your WM: MYD88, CXCR4 and the Genetics of WM”
  • Caitlin S. Leibowitz Parello, PhD, Kurosawa Lab, successfully defended her thesis “Investigating the Contributions of Leukocyte Responses and Kidney Cell Stress on Shiga- Toxin Pathogenesis” on Friday, November 21st

    LeibowitzParelloDefense.11.21.14

    Caitlin’s Defense

  • Zach Hunter also received a grant in his own name; “Identification of Germline and Somatic Variants Associated with Predisposition to WM” from the International Waldenström’s Macroglobulinemia Foundation
  • Barb Nikolajczyk, PhD presented:
    • “Immunometabolism, Lymphocytes and Obesity” at The Obesity Society annual meeting in Boston, MA on November 6th
    • “Lymphocytes in Human Obesity and Type 2 Diabetes” at the Evans Center/Whitaker mini-symposium on Immune Cells and Metabolism on November 21st
  • David Kindelberger, MD (along with colleague Eric Huang from the University of California, Davis) presented a workshop titled “2012 Updated ASCCP Consensus Management Guidelines for Women with Abnormal Cervical Cancer Screening Tests” at the 62nd Annual American Society of Cytopathology Scientific Meeting on November 17th in Dallas
  • Daniel Remick, MD was given a water pitcher to acknowledge his serving on the Society for Leukocyte Biology Council, and serving as the Program Chair for the 2014 Annual Leukocyte Biology Meeting. The 2014 meeting in Salt Lake City was a joint meeting between Leukocyte Biology and the International Endotoxin and Innate Immune Society.

    Remick Watervase jpg

    Dr. Remick with watervase

  • Mostafa Belghasem, PhD Candidate, Henderson Lab:
    • Presented a poster entitled “Heterozygous Actn4 Mutant Mice are Susceptible to Glomerulopathy when Subjected to Hemodynamic Stress” at American Society of Nephrology (ASN) Kidney Week 2014 in Philadelphia, PA, November 11-16, 2014
    • Mostafa was also selected to participate in the ASN 2014 Kidney STARS program and received a Travel Award from the ASN

 Publications ACCEPTED:

  • Ying Tan, Amanda A. Watkins, Benjamin B. Freeman, John A. Meyers, Ian R.Rifkin and Adam Lerner; “Type 4 cyclic nucleotide phosphodiesterase inhibitors block intracellular Toll-like receptor signaling in chronic lymphocytic leukemia and normal hematopoietic cells”. Journal of Immunology
  • Anastasia Gomez, Nancy S. Miller, and Irina Smolina. Visual detection of bacterial pathogens via PNA-based padlock probe assembly and isothermal amplification of DNAzymes. Analytical Chemistry, Publication Date (Web): 21 Nov 2014

Publications: PUBLISHED:

  • Castillo JJ, Olszewski AJ, Cronin AM, Hunter ZR, Treon SP. Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database. Blood. 2014 Jun 19;123(25):3999–4000. PMID: 24948623
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Patterson CJ, Tsakmaklis N, Kanan S, Rodig S, Castillo JJ, Treon SP. The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom’s Macroglobulinemia. Leukemia. 2014 Jun 10; PMID: 24912431
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. Possible resting metabolic rate modification by the circulating RBP4 in obese subjects. Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Treon SP, Hunter ZR, Castillo JJ, Merlini G. Waldenström Macroglobulinemia. Hematol Oncol Clin North Am. 2014 Oct;28 (5):945–970. PMID: 25212891
  • Cao Y, Hunter ZR, Liu X, Xu L, Yang G, Chen J, Tsakmaklis N, Kanan S, Castillo JJ, Treon SP. CXCR4 WHIM-like frameshift and nonsense mutations promote ibrutinib resistance but do not supplant MYD88(L265P) -directed survival signalling in Waldenström macroglobulinaemia cells. Br J Haematol. 2014 Nov 5; 
  • Sikora JL, Logue MW, Chan GG, Spencer BH, Prokaeva TB, Baldwin CT, Seldin DC, Connors LH (2014) Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genet. 2014 (e-Pub ahead of print) PMID: 25367359

October 2014

November 5th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

Announcements:

  • Jessica (Allen) Ritter, PhD Candidate, Genco Lab, presented a poster at XIXth International Pathogenic Neisseria Conference October 12th-17th in Asheville, NC. The poster is entitled; “Neisseria gonorroheae modulates immune cell survival through pyroptosis.” Authors are Jessica Ritter, Kathleen Goodmon, and Caroline Genco.
  • Evan Chiswick, PhD, Remick Lab  was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, October 23rd-25th in Salt Lake City, Utah.  also received a travel award. The title of his talk was “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity” Evan also received a Travel Award, bravo!
  • Daniel Remick, M.D., served as the program chair for the 2014 joint meeting of the Society for Leukocyte Biology and the International Endotoxin and Innate Immunity Society. The meeting had nearly 250 participants from across the world and was held in Salt Lake City, Utah.
  • David Sherr, M.D. has received an award from the Art Because Breast Cancer Foundation. http://www.bostonglobe.com/metro/2014/10/15/team-boston-researchers-will-study-environment-relation-breast-cancer/Bg6nMAlvWIVBNJfBbpat3L/story.html?s_campaign=8315

Publications ACCEPTED:

  • Jacquelyn L. Sikora, Mark W. Logue, Gloria G. Chan, Brian H. Spencer, Tatiana B. Prokaeva, Clinton T. Baldwin, David C. Seldin, Lawreen H. Connors. Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt). Human Genetics

Publications: PUBLISHED:

  • Tiffany J. Mellott, Sarah M. Pender, Rebecca M. Burke, Erika A. Langley, Jan Krzysztof Blusztajn; “IGF2 Ameliorates Amyloidosis, Increases Cholinergic Marker Expression and Raises BMP9 and  Neurotrophin Levels in the Hippocampus of the APPswePS1dE9 Alzheimer’s Disease Model Mice” PLOS, April 2014. http://www.ncbi.nlm.nih.gov/pubmed/?term=Mellott%20TJ%5Bauth%5D\
  • Erika A. Langley1, Marina Krykbaeva1, Jan Krzysztof Blusztajn, Tiffany J. Mellott; “High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T + Itpr3tf/J mouse model of autism.” Behavioural Brain Research; Volume 278, 1 February 2015, Pages 210–220
  • Ansar H, Mirzaei K, Malek A, Najmafshar A, Hossein-nezhad A. “Possible resting metabolic rate modification by the circulating RBP4 in obese subjects.” Diab Met Syndr: Clin Res Rev (Oct, 2014)
  • Yu J, Rupasinghe C, Wilson JL, Taylor L, Rahimi N, Mierke D, Polgar P. “Targeting receptor tyrosine kinases and their downstream signaling with cell penetrating peptides in human pulmonary artery smooth muscle and endothelial cells.” Chem Biol Drug Des. 2014 Oct 8.
  • O’Brien, MJ, Zhao, Q, Yang, S. “Colorectal Serrated Pathway Cancers And Precursors” Histopathology. 2014 Sep 29. doi: 10.1111/his.12564

 

September 2014

October 7th, 2014 in Uncategorized

Pathology & Laboratory Medicine News Items

 Announcements:

  • CAP (College of American Pathologists) 2014, September 7-10 in Chicago, Illinois:
    • Resident Yanli Ding, MD presented a poster titled as “Gastroenteric biopsies in patients with rare immunodeficiency syndromes –two case reports and literature review” for the CAP 2014 Annual Meeting

      DingYanli.CAP2014.MicroMsg635457665999840000

      Dr. Yanli Ding with her CAP Poster

    • Resident Dr. Anita Malek’s poster was titled; “Immunohistochemical Approaches to Poorly Differentiated Tumors of Unknown Origins ” Authors: Anita Malek, MD , Qing Zaho, MD, PhD

      Malek.CAP2014.photo

      Dr. Anita Malek with her CAP Poster

    • Resident Dr. Yue Sun also presented a poster entitled “Epithelioid hemangioma of the penis: a case report,” Yue Sun, Qing Zhao

      Sun.CAP2014.(2)

      Dr. Yue Sun with her CAP Poster

  • Post-doc Evan Chiswick, Remick Lab was selected to give a talk at this year’s Society of Leukocyte Biology & The International Endotoxin and Innate Immunity Society, in Salt Lake City, Utah, October 23-25, 2014. Dr. Chiswick also received a Travel Award. The title of his talk is “Acute Phase Deaths from Polymicrobial Sepsis are Characterized by Suppression, but Not Exhaustion, of Innate Immunity”
  • Dr. Barbara Nikolajczyk has been selected for the 2014 Evans Center Research Collaborator Award. The award will be presented during the Evans Day Gala Dinner,  Oct 16, 2014
  • Brittany Mailhot and Diane Mullen participated in the Jimmy fund Walk with the Dana Farber Facilitating Hope team. Former BMC employees who also participated are Audrey Quinn and Janet Means. Former Patriot’s player Matt Light is the man in the photo with us!

    JimmyFundWalk14

    Jimmy Fund Run

    JimmyFund2014.2.20140921_134330

    Jimmy Fund Run

  • Please welcome the new post-doctoral fellow in the Kurosawa lab, Dr. Ji-Hye (“jee-hay”) Seo. Dr. Seo comes to us from BIDMC where she studied signaling pathways important in development of gastric cancer from chronic Helicobacter pylori infection. She earned her master’s and doctoral degrees from Yonsei University College of Medicine in South Korea (high honors) and lives with her family in Wellesley. Please introduce yourself and lend a hand as she gets settled. 
  • Ivana Delalle, MD, PhD is teaching a new GMS course in the Spring entitled “Human Biospecimens for Research,” PA 910.
    • The objective of this course is to introduce students to the creation, maintenance and efficient use of an indispensable component of translational research in medicine: human biological material (human tissue and bodily fluids)  = human biospecimens and their derivatives. Lectures from faculty from Pathology Departments at Yale, Harvard and Columbia (new York Brain Bank, NYBB), and from Boston University School of Medicine with extensive  experience in human bio-specimens generation, maintenance, and utilization, will instruct how to  successfully obtain and utilize human bio-specimens. ~~~
    • Topics will include logistics and legal aspects of creating and sustaining bio-banks, federal and institutional regulatory and funding mechanisms, and concrete examples of human bio-specimens use to generate break-through data in specific field of biomedical research. Special attention will be given to human biospecimens used in neuroscience as four neuropathologists/neuroscientists from Harvard, Yale, Columbia and Boston University  are enlisted as speakers to give comprehensive overview of biospecimens utilized in neurodegenerative diseases and brain tumors.
  • Karen Quillen, MD is also teaching a new seminar entitled “Blood & Money” in the Kilachand Honors College on the Charles River Campus, with Professor Michael Salinger from the BU School of Management
  • Dr. Nader Rahimi was invited to give a lecture at the Department of Biochemistry, Boston University on September 16. The title of his lecture was “Emerging Roles of Posttranslational Modifications in Receptor Tyrosine Kinase Activation and Signaling”.
  • Dr. Rahimi gave a similar lecture on September 24, 2014 at the University Massachusetts, Lowell.
  • Dr. Rahimi is also invited to give a lecture at the upcoming Boston Angiogenesis Meeting, on November 12, 2014. For additional information, please see the link: (http://lawsonlab.umassmed.edu/BAMspeakersAM.html).   
  • Dr. Lija Joseph recently was awarded the ICPI MSIG Award for her Medical Student Interest Group from the intersociety council for pathology information. Dr. Joseph plans to incorporate our residents in the grand funded program.
  • Publications: PUBLISHED:

    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease, Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press).

    August 2014

    September 2nd, 2014 in Uncategorized

     

    Pathology & Laboratory Medicine News Items

    Announcements:

    • New Grant Funding in Pathology:

    The Department of Pathology and Laboratory Medicine had a 52% increase in grant funding for the

    period July 2013 to June 2014. This is an exceptional accomplishment on the part of our Department

    and it would be appropriate to share the specifics of these new grants.

    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX001875-01
    Title Cholinergic neurons and memory in GFP-AD mouse: a novel neurotrophic therapy
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone as a treatment of Alzheimer’s disease in a mouse model.
    PI Alpaslan Dedeoglu
    Co-Investigator Jan Krzysztof Blusztajn
    Number 1 I01 BX002468-01
    Title Novel neurotrophic therapies in an optimized mouse model of GWVI
    Description The goal of these studies is to evaluate the efficacy of 7,8-dihydroxyflavone and exercise as a treatment of Gulf War Veterans’ Illness in a mouse model.
    PI Jan Krzysztof Blusztajn
    Co-Investigator Tiffany Mellott, Barbara Slack, Ivana Delalle
    Number R01 AG045031-01A1
    Title BMP9 as a juvenile protective factor in cognitive aging
    Description The goal of these studies is to determine the physiological functions of BMP9 and the potential of BMP9 as a trophic factor for aging brain and a therapeutic target in Alzheimer’s disease.
    PI Shinichiro Kurosawa
    Co-Investigator D.J. Stearns-Kurosawa
    Number R01 AI102931
    Title Development and Treatment of Pre-Clinical EHEC Models with HUS
    Description Hemolytic Uremic Syndrome (HUS) is a potentially lethal complication associated with enterohemorrhagic E. coli (EHEC) infection, mostly seen in children.  There is no treatment available, other than supportive care.  Using our (only) pre-clinical animal model of HUS, we will examine and optimize treatment with 1) passive immunity, using anti-Shiga toxin antibody, 2) a novel cell-permeable peptide-based therapeutic.  The antibody will neutralize extracellular toxin, while the cell-permeable compound will neutralize toxin that is already intracellular.
    PI Vipul Chitalia
    Co-investigator Nader Rahimi
    Number R01 CA175382
    Title Role of c-Cbl in Colon cancer
    Description The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase The goal of these studies is to examine role of c-Cbl ubiquitin E3 ligase
    PI Daniel Remick
    Co-Investigator Nader Rahimi
    Number R21 AI112887-01
    Title Mechanisms of phagocytic cell defects induced by inhibitory IgG
    Description We use an animal model of sepsis with 50% mortality over 28 days. We have been interested why half of the mice die when subjected to the same septic insult. Our preliminary work showed that antibodies present prior to the start of sepsis dictate if the mouse will live or die. It is not the antibody response to the septic challenge, it is the antibodies already present which determine survival. This grant will examine how these antibodies provide protection.
    PI Daniel Remick
    Number R21 AA022122-01
    Title Alcohol Triggered Asthma: Mechanisms of Neuronal Control
    Description The major cause of asthma among inner city children are allergies to cockroach allergens. We have developed a murine model of asthma based on exposure to cockroach allergens. In the past few years there has been an increase in binge drinking among teenagers, as well as an increase in asthma. Our work shows that acute alcohol intoxication will trigger an asthma attack in mice that have been sensitized to cockroach allergens. This grant will study how the ethanol triggers the asthma attack.
    PI Susan Winandy
    Number R21 CA176811-01
    Title Mechanism of Notch-induced leukemogenesis in lymphocytes
    Description Greater than 50% of T-acute lymphoblastic leukemia (T-ALL) display oncogenic activation of Notch. Understanding how Notch activation results in aggressive leukemia is of utmost importance to defining new targets for therapeutic intervention.  This grant is aimed at defining novel nuclear and extranuclear roles for Notch in maintaining proliferation of leukemia cells.

     Welcome to our New Graduate Students:

      • Stephanie Adams, OD/PhD
      • Lois Bayigga, Masters
      • Evan Catudal, Masters
      • Junbo Chen, Masters
      • Yuri Kim, PhD
      • Asha Melo, Masters
      • Tim Norman, PhD
      • Ruoyu Tian, Masters
      • BJ Varian, Masters

     

    • From Dr. David Sherr; The Immunology Training Program (ITP) T32 Grant was renewed for 5 more years
    • Dr. Ivana Delalle will be presenting novel data at the XVIII International Congress of Neuropathology in Rio de Janeiro, Brazil, September 14-18, 2014: Protein Expression of Alzheimer’s disease- and Reduced Hippocampal Volume- Risk Genetic Loci in Human Hippocampus. Stephanie Adams 1, Tim Norman1, Kathy Tilton1, Sudha Seshadri2, and Ivana Delalle1
    • Daniel Remick, MD was invited to discuss the creation of a physician scientist pathway at the American Board of Pathology Annual Retreat in Santa Fe, New Mexico in late July. The proposal would establish a board sanctioned physician scientist pathway in pathology, similar to pathways in other disciplines such as Internal Medicine and Pediatrics. The Association of Pathology Chairs has been advocating for this pathway for more than 10 years. The Trustees of the American Board of Pathology voted to approve the pathway.

    Publications: ACCEPTED:

    • Rahimi Nader & Catherine E Costello. Emerging Roles of Posttranslational Modifications in Signal Transduction and Angiogenesis. PROTEOMICS, 2014
    • Mathew H., Dittus C., Malek A., Negroiu A. “Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma.” Journal of Gastrointestinal Oncology; (accepted for publication August 2014)

    Publications: PUBLISHED:

    July 2014

    August 7th, 2014 in Uncategorized

    Pathology & Laboratory Medicine News Items

    Announcements:

    • Congratulations to Dr. Manisha Mehta and Dr. Dana Semmel for successfully completing the Anatomic and Clinical Pathology sections of the ABP Board Examination and becoming diplomats of the American Board of Pathology
    • Daniel Remick, M.D., has been selected as the moderator for the Pathology Roundtable. The roundtable has representation by the major pathology societies, such as the College of American Pathology, The United States and Canadian Academy of Pathology, The American Society of Clinical Pathology, The American Board of Pathology, The American Society of Investigative Pathology, the National Association of Medical Examiners, the Association of Directors of Academic Surgical Pathology, the Academy of Clinical Laboratory Physicians and Scientists, The Association of Pathology Informatics, and the American Society of Cytology. The roundtable meets on a regular basis to discuss issues that directly impact our discipline, so that a unified response may be developed. Dr. Remick assumed his duties as moderator in July, 2014 as a representative of the American Society for Investigative Pathology
    • Dr. Remick moderated a session at the 2014 Association of Pathology Chairs Meeting “Academic Pathology 2020: Advancing Research Opportunities,” in Boston, MA; July 8-11, 2014
    • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab, attended the 2014 National Neurotrauma Symposium in San Francisco, late June 2014. Mark presented a poster titled “Pathobiology of Blast-Related Traumatic Brain Injury in a Mouse Model.” Authors: M. Wojnarowicz A. Fisher C. Tagge A. Gaudreau N. Casey J. Moncaster O. Minaeva G. Hall R. Cleveland W. Moss X.L Zhang P. Stanton H. Lu B. Lamb R. Ransohoff A. McKee L. Goldstein
    • Dr. Lawreen Connors received a 1-year grant from the E. Rhodes and Leona B. Carpenter Foundation in support of her study, “Blood Profiling for Biomarkers in Age-related ‘Senile’ Systemic Amyloidosis (SSA)”
    • Chad Mayer, MD/PhD, Kurosawa Lab successfully Defended his thesis: “An Inside Job: Shiga Toxins, DAMPs, and a Tale of Endothelial Dysfunction” on Friday, May 9th, 2014
    • Philip Bondzie, PhD, Henderson Lab successfully Defended his thesis; “Out of Africa; The Role of APOL1 and MYH9 in Chronic Kidney Disease on Wednesday, July 16, 2014
    • Martin Steffen, PhD has joined the Editorial Board of two new publications:
    • ○     Journal of Bacteriology and Mycology
    • ○     Clinical Journal of Microbiology and Pathology
    • Barb Nikolajczyk, PhD Lab welcomes the following people:
    • ○     Dr. Blanche Ip, Post-doctoral fellow on the Inflammation Training Grant
    • ○     Michel Azer, Masters’ student from the BU Goldman School of Dental Medicine
    • Effective July 1, 2014, Dr. Maria Panchenko will be the new course co-director for our course PA710 “Principles of Applied and Basic Pathology”. The course was originally created by Deborah Stearns-Kurosawa who will be stepping down. I will remain the new course co-director.
      This is a graduate level course which introduces basic concepts of pathology, including some essential histology. Additionally, all graduate students are required to attend our research seminars and prepare a written synopsis of 4 seminars. This allows the students to have their writing formally evaluated. Another major component of the course is to expose all of the new graduate students to the range of research conducted within the Department so that they may select an appropriate lab to do their thesis.  Please join me in welcoming Dr. Panchenko as the new course co-director, and thanking Dr. Stearns-Kurosawa for her efforts to launch and mentor a new course.
    • David Sherr, PhD has been appointed Director of the BU Superfund Research Program
    • Dr. Kazem Azadzoi received the Journal of Urology Best Reviewer in 2013 Award at the American Urological Association 2014 Annual Meeting in Orlando, Florida; May 2014
    • Welcome to our two new Pathology Residents!!!
    • ○  Dr. Reyhan Gedik
    • ○  Dr. Shiva Khoobyari

    Publications: ACCEPTED:

    • Yang S, Stepien D, Hanseman D, Robinson B, Goodman MD, Pritts TA, Caldwell CC, Remick DG, Lentsch “AB: Substance P Mediates Reduced Pneumonia Rates After Traumatic Brain Injury,” Crit Care Med 2014, PMID: 2501406 (In Press)
    • Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH: “Abandon the Mouse Research Ship? Not Just Yet!”, Shock 2014, PMID: 24569509 (In Press)
    • Mella JR, Chiswick EL, King E, Remick DG: “Location, Location, Location: Cytokine Concentrations are Dependent on Blood Sampling Site,” Shock 2014, PMID: 25004061 (In Press)
    • Strissel, KJ, Denis, GV, and Nikolajczyk, BS. 2014. “Immune Regulators of Inflammation in Obesity-Associated Type 2 Diabetes and Coronary Artery Disease,” Current Opin Endocrinol and Diab- Obesity and Nutr. (In Press)
    • Gusenleitner, D., S. S. Auerbach, T. Melia, H. F. Gomez, D. H. Sherr, and S. Monti. 2014. “Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.” PLoS One 9:e102579

    October 2013

    October 28th, 2013 in Uncategorized

    Pathology & Laboratory Medicine News Items –

    Announcements:

    • Faculty Appointments and/or Promotions:
      • Dr. Yuriy Alekseyev was promoted to Research Associate Professor
      • Dr. Shinichi Takayama has been appointed as Research Associate ProfessorImmuno Nov 2013
    • Immunology has selected an image from an article authored by Dr. Zhaohua Lu and colleagues, published in this month’s Immunology for the journal cover (see photo and link to article) http://onlinelibrary.wiley.com/doi/10.1111/imm.12150/full
    • The Martin Steffen Lab presented a talk on their work on biomarkers for Prostate Cancer at the 2013 meeting for the New England Section of the American Urological Association in Hartford, Connecticut on September 26 – 28 Towards Reducing the Number of Prostate Biopsies – Biomarkers to Identify Patients with Benign Causes of Elevated PSA LevelsAgnes Bergerat, PhD1, Yi-Chien Chang, MS2, Mark Katz, MD1, David Wang, MD1, Simon Kasif, PhD2, Richard Babayan, MD1Martin Steffen, MD, PhD1
    • Dr. Daniel Remick will be giving a lecture on October 28th at the Brigham & Women’s Hospital entitled, “Mechanisms of Alcohol Triggered Asthma”
    • Dr. Carmen Sarita-Reyes is now Board Certified in Pediatric Pathology

    Publications: PUBLISHED:

    • Steven P. Treon, M.D., Ph.D., Lian Xu, M.S., Guang Yang, Ph.D., Yangsheng Zhou, M.D., Ph.D., Xia Liu, M.D., Yang Cao, M.D., Patricia Sheehy, N.P., Robert J. Manning, B.S., Christopher J. Patterson, M.A., Christina Tripsas, M.A., Luca Arcaini, M.D., Geraldine S. Pinkus, M.D.,Scott J. Rodig, M.D., Ph.D., Aliyah R. Sohani, M.D., Nancy Lee Harris, M.D., Jason M. Laramie, Ph.D., Donald A. Skifter, Ph.D., Stephen E. Lincoln, Ph.D., and Zachary Hunter, M. A. “MYD88 L265P Somatic Mutation in Waldenstrom’s Macroglobulinemia” New England Journal of Medicine; 367;9 nejm.826 org august 30, 2012
    • Lian Xu,1,2  Zachary R. Hunter,1,2 Guang Yang,1,2 Yangsheng Zhou,1,2 Yang Cao,1,2 Xia Liu,1,2 Enrica Morra,3 Alessandra Trojani,3 Antonino Greco,3 Luca Arcaini,4 Marzia Varettoni,4 Jennifer R. Brown,5 Yu-Tzu Tai,2,6 Kenneth C. Anderson,2,6 Nikhil C. Munshi,2,6 Christopher J. Patterson,1 Robert J. Manning,1 Christina K. Tripsas,1 Neal I. Lindeman,2,7 and Steven P. Treon1,2 “MYD88 L265P in Waldenstr¨om macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction” BLOOD, 14 MARCH 2013 x VOLUME 121, NUMBER 11
    • Steven P. Treon1,2 and Zachary R. Hunter1,2 “A new era for Waldenstrom macroglobulinemia: MYD88 L265P,” BLOOD, 30 MAY 2013 x VOLUME 121, NUMBER 22
    • Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. “The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide.” Immunology. 2013 Nov;140(3):374-389. PMID: 23844703