Category: Uncategorized

Pathology & Laboratory Medicine News Items December 2015 – January 2016

February 3rd, 2016 in Uncategorized

  • Announcements:
    • Congratulations are in order to the following Department of Pathology members: BRAVO!
      • Chris Andry, MPhil, PhD; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
      • Abigail Brown, MFS, MLS (ASCP): for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
      • Shinichiro Kurosawa, MD, PhD; for being appointed a Voting Member to the Boston University Laboratory Safety Committee Space / Infrastructure Subcommittee until December 2017, BRAVO!
    • On December 3, 2015 Daniel Remick, MD gave a talk “Mild Traumatic Brain Injury Augments Host Defenses against Pathogens” at the Institute of Neuroscience and Physiology at Sahlgrenska Academy at the University of Gothenburg
    • Daniel Remick, MD was invited to serve as the opponent for Sara Svahn at the University of Gothenburg in Sweden on December 4, 2015. The title of Sara’s thesis was “Effects of dietary fatty acids on the immune system”. Scandinavian countries have a tradition of bringing in an outside expert to ensure that the thesis work has sufficient rigor and depth. This outside member of the committee has the title of opponent. At the two hour defense, the opponent presents background information about the topic of the thesis, in this case sepsis. The student then presents for about 40 minutes, which is then followed by an hour of questioning by the opponent. Sara Syahn, PhD, successfully Defended
    • Chloe Habib and Leah Persky, both students in the Masters in Nutrition Program, joined the Nikolajczyk Lab as of January 2016
    • The Residency Program had an ACGME Site Visit in January to review our program. The Department has been working diligently since last spring to increase the teaching curriculum for the residents. One of the issues identified through the survey in 2015 was lack of scholarly opportunities. The Department will be launching a series of paper writing workshops this spring and all the residents will be invited.
    • The College of American Pathologists (CAP) performed their unannounced Site Visit on January 27, 2016. Seventeen inspectors from the Lifespan System in Rhode Island spent the day thoroughly reviewing both Anatomic Pathology and Laboratory Medicine. The lab inspection went very well with only a few deficiencies identified. This outstanding inspection result was due to the hard work by the pathology faculty and staff in the months leading up to the preparation. BRAVO
  • PUBLICATIONS ACCEPTED:
    • Thurmond P, Yang JH and Azadzoi KM entitled “LUTS in pelvic ischemia: A new concept in voiding dysfunction” — Accepted for publication in AJP – Renal Physiol
    • Ding Y, Francis J, Kalish J, Deshpande A, Quillen K. Recurrent focal segmental glomerulosclerosis resistant to plasma exchange, and improvement after surgical repair of arteriovenous fistula aneurysms. Clinical Kidney Journal [in press]
  • PUBLICATIONS PUBLISHED:
    • Zhifeng Huang, William M. Marsiglia, Upal Basu Roy, Nader Rahimi, Dariush Ilghari, Huiyan Wang, Huaibin Chen, Weiming Gai, Steven Blais, Thomas A. Neubert, Alka Mansukhani, Nathaniel J. Traaseth, Xiaokun Li,  Moosa Mohammadi. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Molecular Cell, December 10, 2015. http://www.sciencedirect.com/science/article/pii/S1097276515009028
    • Lawreen Connors, PhD and Colleagues Publish Findings in ATTRwt Amyloidosis Cohorthttp://www.bu.edu/amyloid/2016/01/22/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort/
      • Data on the largest cohort of ATTRwt amyloidosis patients yet reported (n=121), referred to our institution over a 20-year observational period, were recently reported in the prestigious heart journal, Circulation.  The publication, entitled “Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study,” was authored by Dr. Lawreen H. Connors and colleagues from the Amyloidosis Center at Boston University.  These data establish the natural history of ATTRwt, provide statistical basis for the design of future interventional clinical trials, and highlight the need for more sensitive diagnostic tests and disease-specific treatments for this disease.  For more information, see Circulation, 133:282-290, 2016.
    • Ozturk S, Papageorgis P, Lambert AW, Wong CK, Thiagalingam A, Abdolmaleky HM, Cohen HT, and Thiagalingam S, 2016. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl. Acad. Sci. USA. 113(3): 638-643. http://www.pnas.org/content/113/3/638.full.pdf?with-ds=yes

Departmental Seminar – January 29, 2016

January 25th, 2016 in Uncategorized

 

Seminar Series: Spring 2016 ~~ Friday, January 29, 2016

2:00-3:00 PM

              

“The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention”

 

 

Nisma Mujahid

PhD Candidate, David Fisher Lab (MGH);

Department of Pathology, Boston University School of Medicine

 

Location & Time:
670 Albany Street
Lobby Level #107/108
2:00-3:00 PM
Friday, January 29, 2016
Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

At the conclusion of this activity participants will be able to: 1) recall that ultraviolet-light (UV)-induced tanning is defective in numerous ‘fair-skinned’ individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R); 2) recognize that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blondehaired Mc1re/e mice; and 3) report that ultraviolet (UV) radiation is highly toxic to organisms because it damages cellular constituents such as DNA.

               

Course Director: Barbara Slack, PhD

Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

10th Annual Nancy Bucher Seminar

January 8th, 2016 in Spotlight, Uncategorized

DUE TO THE INCLEMENT WEATHER WE HAVE DECIDED TO POSTPONE

OUR 10TH ANNUAL NANCY BUCHER SEMINAR; PLEASE STAY TUNE FOR ADDITIONAL DETAILS!

APOLOGIES FOR ANY INCONVENIENCE!!!!

~~~~~~~~~~~

BUSM Pathology & Laboratory Medicine

Seminar Series: Spring 2016 ~~ Friday, February 5th 

2:00 PM; Reception to Follow at 3:00

 

10th Annual Nancy L. R. Bucher, MD Seminar 

 

Unraveling the Complexity of Growth Hormone Regulated Sex Differences in Mouse Liver:

Genomic and Epigenetic Approaches”

 

David Waxman, PhD

Professor of Cell and Molecular Biology, Boston University

Professor of Medicine, Boston University School of Medicine

 

 

Location & Time:

670 Albany Street

Lobby Level #107/108

2:00 PM; Reception to Follow

Friday, February 5, 2016 

Pathology & Laboratory Medicine News Items – November 2015

December 3rd, 2015 in Uncategorized

  • Announcements:
    • Yanli Ding, MD presented a poster at the Annual ASCP 2015 Meeting in Long Beach California, September 28-30, 2015. Title: “Persistent proteinuria in recurrent focal segmental glomerulosclerosis from arterio-venous fistula recirculation, and improvement with aneurysm repair;” Co-authors are Yanli Ding, MD and Karen Quillen, MD
    • Yanli.Ding.2015.ASCP.mmexport1446282806146
    • Atsushi Ebata, PhD, Wolozin Lab, successfully defended his thesis “Development of TDP-43 Granule Inhibitors as Potential Amyotrophic Lateral Sclerosis/Frontotemporal LobarDegeneration Therapies” on Thursday, November 12th
    • Nancy S. Miller, MD presented: “Ebola Dx and the U.S. clinical laboratory: From practical to practice to promise”, at the BUSM Mini-Symposium – Ebola, The Disease and Immune Privilege, on October 29, held in Hiebert Lounge
    • Dr. Miller also convened the symposium: Vibrios Throw Us a Curve: People, Places and Oysters; and presented “Tales from the Trenches – Vibrio Cases from the Clinical Microbiology Laboratory”, at the 50th Annual Region I Meeting of American Society for Microbiology (ASM) branches, October 20, in Randolph, Massachusetts
    • From Lawreen Connors, PhD Lab:
      • Just received notification of research funding from the The Wildflower Foundation, Inc. in support of our study, “Immunoglobulin Light Chain Amyloid Fibril Formation: Structural Determinants as a Platform for Drug Development”
      • She/they also have an approved service agreement, “Fat Pad Analysis – ALN-TTR-NT-002 Discovery Study, with Alnylam Pharmaceuticals, Inc (Cambridge, Massachusetts)
    • Yue Sun presented three posters at the 2015 Annual ASCP Meeting in Long Beach California, September   28-30, 2015:
      • “Extraosseous Chordoma of Retropharyngeal Space: A Case Report;” Yue SunHuihong Xu, and Qing Zhao Zhao 
      • “Periampullary gangliocytic paraganglioma with lymph node involvement: A Case Report;” Yue Sun, David W. KindelbergerHuihong Xu, and Qing Zhao
      • “Lactobacillusgasseri associated with urinary and surgical wound infection in a renal transplant patient;” Yue Sun, Amitabh Gautam, and Nancy S. Miller
      • Yue.Sun.2015.ASCP.chordoma
    •   Yue.Sun.2015.ASCP.Poster3.paraganglioma
    •    Yue.Sun.2015.ASCP.Poster2.lactobacillus
    • Congratulations to Ivana Delalle, she was the honored speaker at the 2015 Annual New England Society of Pathologists Stanley Robbins lecture on November 17th
    • On Behalf of Dr. Chris Andry, Director of our Master of Arts Program: we are pleased to announce that our proposal has been approved and our Masters Graduate Program will now be entitled; MASTER OF SCIENCE IN PATHOLOGY LABORATORY SCIENCES.
    • Michel Azer, a Masters student in Periodontology doing his research in the Nikolajczyk Lab, was a finalist at the American Academy of Periodontology Balint Orban Award Competition for excellence in basic research on periodontal disease.  Congratulations Michel on being included in this prestigious event!
    • Invited presentation by Nikolajczyk in November 2015: The Obesity Society Oral Presentation, Los Angeles CA, “Metformin counters a pro-inflammatory T cell profile, 2015”
    • Ivana Delalle gave a Grand Rounds lecture in the Pathology Department at UC Davis, California on November 23rd
    • The Mid-Career Faculty Leadership Program is a year-long program that uses experiential and project-based learning to engage participants in 360 evaluation, self-reflection, inter-disciplinary collaboration, broad peer and senior mentoring networks, and the enhancement of transformational education, clinical, research, and strategic leadership skills. Two members of our pathology department, both Sandra Cerda and Dr. Debbie Stearns-Kurosawa, have been selected through this competitive application process to participate in this leadership development program.  The selection committee aims yearly to select high potential individuals with clinical and research expertise and demonstrated commitment to BUMC, who are keen on transforming themselves, BUMC, and healthcare. BRAVO!!
    • Effective January 1, 2016 the following changes will occur:
      • David Kindelberger, MD, will become the Residency Director, replacing Daniel Remick, MD This appointment is pending approval by the appropriate BMC committee
      • Qing (Grace) Zhao, MD, PhD, will become the Director of Surgical Pathology, replacing Dr. Kindelberger
      • We are confident that these changes will strengthen our clinical, research and teaching missions by placing dedicated and motivated pathologists in these leadership positions. Please join me in congratulating Drs. Kindelberger and Zhao on their new roles within the Department.
  • PUBLICATIONS ACCEPTED:
    • Connors LH, Sam F, Skinner M, Salinaro F, Sun F, Ruberg FL, Berk JL, and Seldin DC:  Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study.  Circulation,Accepted Nov 11, 2015
    • Miller, N.S. “The new microbiology and vision of faith: When believing isn’t seeing and vice-versa.” Commentary commissioned by Clinical Chemistry for their 2016 special issue, Clinical Mass Spectrometry: Achieving Prominence in Laboratory Medicine”
    • Armin Maghsoudlou, Rosana D. Meyer, Kobra Rezazadeh, Emad Arafa, Jeffrey Pudney, Edward Hartsough, Nader Rahimi.  RNF121 inhibits angiogenic growth factor signaling by restricting cell surface expression of VEGFR-2. Traffic, November 2015 http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291600-0854
  • PUBLICATIONS PUBLISHED:

October 2015

November 6th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items – October 2015

  • Announcements:
    • Daniel Remick was an invited speaker at the Satellite Symposium on Alcohol and Immunology, Society for Leukocyte Biology, Raleigh North Carolina on September 28th: Acute ethanol ingestion triggers asthma
    • Kazem Azadzoi had two recent presentations at the International Continence Society (ICS) meeting in Montreal, Canada, October 6-9, 2015:
      • Zhao Z, Yang J, Li Y, Azadzoi K presented an oral ePoster entitled “Ischemia Survival Signaling Via PI3-K/Akt Pathway mediates Overactive Bladder Progression to Underactive Bladder”
      • Su N, Choi H, Yang J, Azadzoi K presented an oral ePoster entitled “Chronic Ischemia Alters the Bladder Proteomic Profiles and Activates Degenerative Pathways and Survival Signaling” at
    • Barb Nikolajczyk, PhD is organizing a FASEB Scientific Research Conference Entitled “Immunological Aspects of Obesity” July 31-August 5, 2016 in Big Sky, Montana.  Those interested in more information can go to org or contact her directly at bnikol@bu.edu
  • PUBLICATIONS ACCEPTED:
    • Yi-Chien Chang1, Zhenjun Hu1, John Rachlin2, Brian P. Anton3, Simon Kasif1,4*, Richard J. Roberts3*, Martin Steffen4,5 COMBREX-DB: A Database Of Protein Function Prediction Emphasizing Foundational Experimental Data; Nucleic Acids Research

September 2015

October 4th, 2015 in Uncategorized

Announcements:

  • Parul Agnihotri, PhD Candidate in Susan Winandy’s Lab was elected Vice President of the Boston University Graduate Medical Sciences Student Organization (GMSSO) for 2015-2016 effective this month. The GMSSO is a student run organization that works to unite students from all departments and schools on the Medical Campus, to share ideas and address questions or concerns pertaining to student life. Through organizing various social and community service activities, GMSSO is an outlet for students to get involved in the BU Graduate Medical Sciences community, both on and off campus.
  • For six weeks, Jason Sutin, Pathology PhD Candidate in Maria Franceschini’s Lab at MGH will be working with the CURE Children’s Hospital of Uganda in Mbale, Uganda, Africa on a collaboration to study the effect of surgical treatment of infant hydrocephalus on cerebral blood flow and oxygen metabolism.
  • Nader Rahimi and his Lab’s recent publication on the characterization of a novel adhesion molecule (TMIGD1) was on the news: http://www.sciencedaily.com/releases/2015/09/150902112004.htm
    http://www.newsunited.com/newly-discovered-protein-may-news/18305788/
  • Several Department of Pathology members participated in the 2015 Boston Heart Walk on Saturday, September 12th sponsored by the American Heart Association. BRAVO!!! The AHA MISSION: Building healthier lives, free of cardiovascular diseases and stroke. Their IMPACT: By 2020, to improve the cardiovascular health of all Americans by 20 percent while reducing deaths from cardiovascular disease and stroke by 20 percent. In 1999, the American Heart Association set a bold 10-year goal: To reduce coronary heart disease, stroke and risk by 25 percent by 2010. We achieved the reduction in deaths ahead of schedule and made substantial progress against three of the six risk factors. Our 2020 Impact Goal focuses on helping people build stronger health and a better quality of life.
  • Dequina Nicholas, PhD from Loma Linda Medical School, (2015) has joined the labs of Barbara Nikolajczyk and Gerald Denis as an Inflammation Training Grant-supported post-doctoral full. Welcome Dequina!
  • On September 15th the department held a Faculty Meeting that included faculty, residents, postdocs and graduate students devoted to addressing professionalism in the workplace. The meeting will also include professionalism vignettes that were presented at the Association of Pathology Chairs meeting this summer. GroupPhoto2

           Dr. David Kindelberger introduced several vignettes on Professionalism:

Dr.Kindelberger2

           Dr. O’Brien spoke on Altruism:

Dr.O.Brien

           Dr. Chris Andry addressed Accountability:

Dr. Andry

          Dr. Karen Quillen talked about Respect:

Dr. Quillen

Additional comments by Dr. Barbara Slack:

Dr.Slack

And Dr. Carl O’Hara:

Dr. O.Hara

Rally for Research September 16 & 17 2015

The rally for research #rallymedres was held in Washington DC to advocate for increased funding for the National Institutes of Health (NIH). Advocates from 40 states and more than 200 organizations spoke with their Senators and Congressman about the need for robust, predictable and sustainable NIH funding. The key messages that were delivered included the fact that since 2004 there has been a 24% decrease in the dollars available for NIH investigators (adjusted for inflation). In prior years there was a 1 in 3 chance that a grant would be funded, with the current paylines there is a 1 in 7 chance.

The Association of Pathology Chairs was represented at the rally by Daniel Remick, M.D., Chair of Pathology and Laboratory Medicine at Boston University School of Medicine #DanielRemick1 who provided twitter updates throughout the rally.

After orientation on September 16th the 300 rally participants were bused to the Capital for a rally held in the Kennedy Caucus room. Presentations were made by Jerry Moran (R-Kansas), Senator Durbin (D-Illinois), Patti Murray (D-Washington) and Amy Klobuchar (D-Minnesota). Each of these Senators expressed strong bipartisan support to increase NIH funding. Senator Murray talked about the need for NIH funding to maintain American exceptionalism. Senator Klobuchar is such a strong NIH supporter that during the last government shutdown, she donated her salary to the NIH. Francis Collins, the Director of NIH spoke passionately about funding saying we cannot wait for cure and we cannot wait for hope. Patient advocates also spoke about why NIH funding saves lives.

The next morning, September 17th 2015, Representative Tom Cole (R-Oklahoma), the fourth ranking Republican in the House of Representatives addressed participants. He emphasized that Congress is eager to show bipartisan legislation that helps the country, and increased funding for NIH was a clear example of this. The rally participants then met with members of Congress and their staff.

The delegation from Massachusetts consisted of Daniel Remick, M.D., Chair and Professor of Pathology & Lab Medicine, Boston University School of Medicine, Susan Hankinson, Sc.D., Chair of Biostatistics and Epidemiology, Health Sciences University of Massachusetts and Timothy Leshan, Northeastern University Vice President Government Relations. The delegation met with our Senators and Representatives. We met with Ashley Coulombe, Special Assistant to Senator Elizabeth Warren first and relayed specific examples of how decreased NIH funding has hurt research. The next meeting was with Andrew Cohen, Counsel to Senator Edward Markey. Senator Markey has long supported funding for NIH.

The delegation was fortunate to spend 30 minutes with Rep. Joseph Kennedy from the 4th district of Massachusetts (see picture). The day finished with meetings with Jennifer Chandler, Senior Legislative Assistant to Rep. James McGovern and a final meeting the Rep. Capuaon’s Chief of Staff Robert Primus.

Delegation

All the Massachusetts legislators strongly support increased funding for the mission of NIH but the MA delegates were able to provide several reasons why increased NIH funding is a national imperative.

PUBLICATIONS ACCEPTED:

  • Su N, Choi HP, Yang Jing-Hua, Wang F, Su H, Fei Z and Azadzoi KM entitled Quantitative Proteomic Analysis of Differentially Expressed Proteins and Downstream Signaling Pathways in Chronic Bladder Ischemia” has been accepted for publication in the Journal of Urology.

August 2015

September 8th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items – August 2015

 

 Announcements:

  • Please join me in congratulating Dr. David Kindelberger on his appointment as an Associate Professor of Pathology and Laboratory Medicine. President Brown just approved his appointment. Appointment or promotion to Associate Professor is a significant achievement and acknowledges that Dr. Kindelberger enjoys a national reputation. This national reputation has been demonstrated by his numerous publications as well as many presentations. Dr. Kindelberger has carried a full service load in addition to his teaching to the residents.
  • The department had a Visiting Scholar from the University of Dammam, Saudi Arabia:
    • Dr. Areej Al Nemer, an anatomic pathologist from University of Dammam was in our department from July 22nd until August 14th.  She was involved in several research projects in the Henderson Lab including a study on kidney injury caused by light chain paraproteins, and a collaborative study with the Rahimi Lab investigating IGPR2 expression in human kidney neoplasia.   Dr. Al Nemer also learned about the work of our anatomic pathology diagnostic service, and participated in some of the routine activities of the service.
  • Dr. Deborah Stearns-Kurosawa has been re-appointed IBC Chair by the Associate Vice President for Research Compliance, bravo!
  • Mostafa Belghasem, PhD, Henderson Lab, successfully defended his thesis “Pathological and Molecular Profiling in Hypertension-Induced Glomerular Injury” on Thursday, July 30th
  • From Dr. Nader Rahimi’s Lab:
    • We welcome Dr. Mehrdad Lavaei and Xueqing Zou to Department of Pathology and Laboratory of Medicine, both recently joined Dr. Rahimi’s laboratory.
    • Dr. Lavaei is pathology resident in VU University Medical Center Amsterdam, Nederland and his research is supported by the Dutch government.
    • Xueqing Zou is a PhD student at the Shandong University, China. He will be doing his thesis research work with Dr. Rahimi. Xueqing Zou research is supported with a scholarship from China.
    • We also welcome Walter Wong and Brad Pearson from BU’s MAMS program, who recently joined Dr. Rahimi’s laboratory.
  •  Barb Nikolajczyk, PhD has received a new grant; “Roles for B cells in the development of periodontal complications of type 2 diabetes” has been selected for funding. Source of funding: BU Clinical and Translational Science Institute; Funds awarded:$20,000; Budget period: August 31, 2015 – March 31, 2016
  • Debbie Stearns-Kurosawa, PhD is an invited to be a speaker at a symposium on the “Molecular Mechanisms of Vascular Disease” at the Mount Desert Biological Laboratory in Bar Harbor, Maine on October 11-15.   The symposium is organized by Dr. Hermann Haller, Professor of Medicine at the Hannover Medical School in Germany and includes speakers from the US, Israel, Europe, and Canada. Dr. Stearns-Kurosawa will speak on complement and the hemolytic uremic syndrome.
  • From the Kurosawa Lab: Two abstracts were accepted for the 9th Triennial International Symposium on Shiga Toxin (Verocytotoxin) producing Escherichia coli (VTEC) meeting on September 13-16 in Boston:
    • 1)  DJ Stearns-Kurosawa*, Arthur Fernandezǂ, Denis Garceauǂ, Shinichiro Kurosawa*.  “Passive Immunity Strategy For Shiga Toxin-HUS in Non-human Primates”.  *Department of Pathology and Laboratory Medicine, Boston University School of Medicine ǂ Thallion Pharmaceuticals, a subsidiary of Bellus Health Inc., 275, boulevard Armand-Frappier Laval (Québec)  H7V 4A7  CANADA
    • 2) DJ Stearns-Kurosawa, Caitlin S.L. Parello, Shinichiro Kurosawa.  “Retrograde Product Development for Treatment of Shiga toxin-HUS”.Department of Pathology and Laboratory Medicine, Boston University School of Medicine

 

Welcome to our New Graduate Students: 

 

Ahmad Al Moujahed, PhD Candidate  Ahmad
Greg Hall, PhD Candidate GregHallPic3
Keith Keller, Masters KeithKeller.FullSizeRender
Maya Kim, Masters maya kim3
Denis Kyabaggu, Masters Denis S  Kyabaggu
Carolina Lyon de Ana, Masters CarolinaLyondeAna..IMG_9601
Morgan Thompson, Masters Morgan Thompson
Max Vaickus, Masters 

 

 

 

July 2015

August 5th, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items – July 2015

  • Announcements:
    • A manuscript describing the study from Panchenko Lab was accepted for publication by Cell Cycle without any revision or resubmission. The authors discovered an unexpected role of the component of the histone acetyl trasferase complex, JADE1, in cytokinesis – which is the least described but the most crucial phase of the epithelial cell cycle progression. The study defined JADE1 protein as novel factor of tissue regeneration and a potential player in cancer pathogenesis. By the choice of the Editor-in-Chief this study will be featured in the “News & Views” of the Journal; “The novel function of JADE1 in cytokinesis of epithelial cells” by N.S. Siriwardana, R.D. Meyer, and M.V. Panchenko  http://www.ncbi.nlm.nih.gov/pubmed/26151225
    • David Sherr and his team just had a R01 score in the 1 percentile. The is the grant, with George Murphy co-PI, which is focused on manipulating AHR activity in differentiating iPSC and resulting in production of unlimited numbers of human red blood cells
    • After a long and distinguished career, Tom Christensen has retired! Here are some photos of the luncheon held in his honor:
    • Cake.cwvDm9asA_Lw9YsGTQNy8vW7ZxwCAVZZH6V
    • Family Looking On. cwvDm9asA_Lw9YsGTQNy8vW7Zxw
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      Young Visitors.cwvDm9asA_Lw9YsGTQNy8vW7ZxwCA5WHC2I
      TomandIvana.cwvDm9asA_Lw9YsGTQNy8vW7Zxw
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      OBrien.OHara.etc.cwvDm9asA_Lw9YsGTQNy8vW7Zxw
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    • Nancy S. Miller, MD presented the Special Session lecture, “Laboratory considerations in an era of improved microbial identification”, at the 4th International Conference and Exhibition on Pathology, July 13-15, 2015 in New Orleans, Louisiana
    • Dr. Anita Deshpande successfully passed both the Anatomic Pathology and Clinical Pathology portions of the board, BRAVO!
  • Publications ACCEPTED:
    • S. Siriwardana, R.D. Meyer, and M.V. Panchenko. “The novel function of JADE1 in cytokinesis of epithelial cells” Cell Cycle 
    • Brooks CR, Yeung MY, Chen H, Henderson JM, Ichimura T, Bonventre JV.  KIM-1/TIM-1-mediated phagocytosis links ATG5/ULK1 dependent clearance of apoptotic cells to antigen presentation.  EMBO J.  ACCEPTED FOR PUBLICATION
    • Ip, B, Cilfone, N, Belkina, AC, DeFuria, J, Jagannathan-Bogdan, M, Zhu, M, Kuchibhatla, R, McDonnell, ME, Xiao, Q, Kepler, TB, Apovian, CM, Lauffenburger, DA, and Nikolajczyk, BS. 2015. Th17 cytokines differentiate obesity from obesity-associated type 2 diabetes and promote TNFa production. Obesity. (In Press)
  • Publications PUBLISHED:

 

 

 

June 2015

July 2nd, 2015 in Uncategorized

 

Pathology & Laboratory Medicine News Items – June 2015

 Announcements:

  • BMC “Be Exceptional” Awards 2015, which recognize outstanding BMC staff who demonstrate exceptional performance and dedication to fulfilling BMC’s mission and four QUEST goals: Quality, Efficiency, Satisfaction, and Total Revenue. “Chosen by a committee made up of leaders from around the hospital, they were selected for their exceptional performance, initiative and teamwork, and for embodying our RESPECT behavioral attributes. These staffers reflect BMC on its best day, every day. Congratulations to the following individuals and teams!” Two members of the Department of Pathology and Laboratory Medicine are among this year’s recipients which were awarded on June 17th in Hiebert Lounge.:
    • Sherri Dagger, one of our Pathology Histotechnologist, for her exceptional performance and dedication to fulfilling BMC’s mission and QUEST goals
    • Neil O’Neil, Laboratory Administration Operations, “this appropriately recognizes his outstanding service to BMC”
  • Shinichiro Kurosawa has accepted an invitation to serve as a member of the Host Interactions with Bacterial Pathogens Study Section at NIH at the Center for Scientific Review, for the term beginning July 01, 2015 and ending June 30, 2019
  • Daniel Remick was in Brazil last month for the 12th Annual Forum on Sepsis at the Latin-American Institute for Sepsis in Sao Paulo, Brazil:
    • Remick gave the Keynote Address at the Forum; Pathophysiologic Mechanisms in Septic Shock
    • Remick also presented at the Thematic Session – Therapeutic Interventions; Do Inhibitory Immunoglobulins Decrease Pathogen Killing and Increase Sepsis Mortality
    • He spoke again at the Thematic Session, Special Situations in Sepsis; Brain Injury and Pneumonia Prevention
  • Nader Rahimi, PhD was awarded a R21 grant from NIH/NCI entitled “IGPR-1 in colon cancer chemotherapy”. The overall of goal of this research is to study the role of IGPR-1 in colon cancer and chemo treatment. IGPR-1 is a novel protein identified in the Rahimi laboratory. IGPR-1 represents a new class of cell surface receptors involved in cell-cell recognition and mediates tumor angiogenesis, a process by which new blood vessels are recruited to growing tumor.
  • Ivana Delalle just presented an abstract at the International Conference on “The long and the short of non-coding RNAs” in Greece, June 14-19, 2015.
  • Delalle also presented “Exosomal microRNAs as biomarkers for bipolar disorder and schizophrenia” Jason Choi1, Andre Fischer 2,3, Farahnaz Sananbenesi3, and Ivana Delalle1. 1Boston University School of Medicine, Boston, MA, USA, 2Goettingen University, Goettingen, Germany, 3German Center for Degenerative Diseases (DZNE), Goettingen, Germany.  

NEW FACES:

 

  • New Residents:
    • Entering PGY 1s

      • Israa Laklouk, MD   Laklouk
        • Relocating from San Francisco, CA
        • Graduated from University of Tripoli in 2008
      • Mahmoud Soliman, MD  Soliman
        • Relocating from Grand Forks, ND
        • Graduated from University of Cairo in 2004


    • Transferring PGY 2s
      • Lei Li, MD  Li
        • Transferring from residency at Saint Barnabas Medical Center
        • Graduated from Xuzhou Medical College – China in 2000
      • Ram Al-Sabti, MD   Ram Al-Sabti2

        • Transferring from residency at Case Western
        • Graduated from University of Baghdad in 2009
  • Kurosawa Lab:
    • Annalyn Brown is a STaRS summer student (Summer Training as Research Scholar) in our lab and her project is about how inflammation alters susceptibility of cells to bacterial toxins.  Specifically she’ll investigate whether activation of TLR4 increases Gb3 receptor expression for Shiga toxins on endothelial cells.  Annalyn is an undergraduate student at the University of the Virgin Islands and we’re pleased to have her in our lab this summer.
    • Evan Catudal is a Master’s student in the Pathology program with experience as a medical technologist.  His thesis project is a collaborative effort between the Kurosawa and Remick labs to identify contributions of coagulation pathways to enhanced survival of mice after mild traumatic brain injury and pneumoniahasis
    • Greg Hall is a licensed veterinarian in the PhD program with interests in animal model development and development of disease pathology.  He will be working in the Kurosawa Lab on animal models of thrombotic microangiopathy for his thesis project.  joined the Kurosawa Lab coming after his first year in the PIBS Program
  • Remick Lab:
    • Gina Ellsworth, a science/biology teacher at Haverhill High School is a summer intern with the American Association of Immunologists, where she is learning laboratory techniques in the Remick Lab to create a hands -on activity and curriculum of immunology.  This activity will be demonstrated at the National Association of Biology Teachers conference in November and the curriculum will be posted to the AAI website by Spring 2016. Gina is working with postdoc Evan Chiswick, PhD.
    • Alejandro Sanoja is a rising senior from the University of Florida. He is a member of the Summer Training as Research Scholars (STaRS) program at BU. Alejandro’s STaRS internship in the Remick Lab will be with Terry Hsieh, MD/PhD candidate and focuses on investigating immune priming in a mouse model
  • Summer Training as Research Scholars Program.
    • STaRS is designed to promote access to graduate education for talented undergraduates from minority groups traditionally underrepresented in the biomedical sciences:  African-American, Hispanic,  Native American/Native Alaskan, and Pacific Islander/Native Hawaiian.  STaRS is sponsored by the Division of Graduate Medical Sciences, a recognized leader in graduate education and biomedical research.
    • STaRS is a dynamic and focused program that is designed specifically for the enhancement of skills required for successful entrance and completion of a graduate program or an MD/PhD program in the biomedical sciences.
    • STaRS offers motivated and academically talented students a valuable opportunity to confirm a strong interest in doctoral studies particularly in the areas of heart, lung and blood research.

 

  • Castle Graduation Dinner Celebration 2015:

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IMG_0055.Dana.Sandra

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IMG_0066.Shiva.DavidKindelberger

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Publications ACCEPTED:

  • Emad Arafa, Philip Bondzie, Kobra Rezazadeh, Rosana D Meyer, Edward Hartsough, Joel Henderson, John H. Schwartz, Vipul Chitalia, Nader Rahimi. TMIGD1 is a novel adhesion molecule that protects epithelial cells from oxidative cell injury. American Journal of Pathology, 2015 http://ajp.amjpathol.org/ Emad Arafa & Philip Bondzie are co-primary authors

 

 

 

May 2015

June 2nd, 2015 in Uncategorized

Pathology & Laboratory Medicine News Items – May 2015

Announcements:

  • LAB WEEK was April 20-24 this year, the theme was “was “Not all Heroes Wear Capes, Some Wear Lab Coats!” Events for the week included: a scavenger hunt, door decorating contest, which Chemistry won, for a departmental pizza party, we had games, and we collected $213 for the Cancer Center by allowing employees to wear jeans. We also handed out tumblers as lab week gifts

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  • Huihong Xu was invited to give a cytology lecture “GI Interesting Cytology Cases” for the pathology residents at Brigham & Women’s Hospital on May 12th, 2015.
  • Congratulations; Lee Quinton has been promoted to Associate Professor of Medicine and Pathology & Laboratory Medicine
  • Last year Mostafa Belghasem, PhD candidate taught PS701 Immunology/Pathology lectures; these lectures were well-received by the Physician Assistance students and accordingly, he has been invited by the course directors to teach this year as well
  • Carmen D. Sarita –Reyes attended, as a member, the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee Meeting  from May 11th – 15th 2015 in Chicago, Illinois
  • Debbie Stearns-Kurosawa, PhD was an invited featured speaker at the 2015 American Society for Apheresis Annual Conference May 6 – 9 in San Antonio, Texas.  Her talk was entitled: The Pathophysiology of E.coli-Mediated Hemolytic Uremic Syndrome
  • Mostafa Belghasem, PhD candidate was invited by the Boston University Renal Section to talk about his thesis work. The lecture Mostafa presented was: Pathological and Molecular Profiling in Hypertension-induced Glomerular Injury on April 30, 2015
  • A collaborative project between the Kurosawa Lab and Drs. Monica Schaller and Johanna Kremer Hovinga from the University Clinic of Hematology, Central Hematology Laboratory and Department of Clinical Research, University Hospital Berne, Berne, Switzerland was accepted as a poster presentation for the International Society of Thrombosis and Haemostasis (ISTH) meeting in Toronto, Canada (June 20-25).  The abstract is entitled:  ANTI-IDIOTYPIC DARPINS RESTORE ADAMTS13 ACTIVITY IN BABOONS CHALLENGED WITH HUMAN MONOCLONAL ANTIBODIES: FIRST STEP TOWARDS AN ANIMAL MODEL FOR HUMAN ACQUIRED TTP
  • Dave Sherr, PhD and his Lab has received yet another $50k from Avon for breast cancer
  • BRAVO is in order:
    • Chris Andry has been reappointed as Chair of Boston University’s Safety Committee
    • Abigail Brown has been reappointed as a Voting Member of Boston University’s Safety Committee
    • Shinichiro Kurosawa has been reappointed as a Voting Member of Boston University’s Safety Committee
    • Liz Duffy has been newly appointed as a Voting Member of Boston University’s Safety Committee
    • Dave Sherr, PhD and his Lab has received yet another $50k from Avon for breast cancer
    • Commencement, May 15, 2015; CONGRATULATIONS GRADUATES:
      • Emad Arafa, MA
      • Philip Bondzie, PhD
      • Patricia Chun, MA
      • Zach Hunter, PhD
      • Clarissa Koch, PhD
      • Caitlin Leibowitz Parello, PhD
      • Jordan Shafran, MA
      • Nick Woolf, MD/MA

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    • Publications PUBLISHED:
      • Malek A, Lee J.C. Extranodal marginal zone lymphoma of mucosa associated lymphoid tissue arising in the pleura. Annals of Pathology and Laboratory Medicine. Vol 2, No 2 (2015)
    • Publications ACCEPTED:
      • Mathew H, Dittus C, Malek A, Negroiu A. Howell-Jolly Bodies on Peripheral Smear Leading to Diagnosis of Congenital Hyposplenism in a Patient with Septic Shock. Clinical Case Report
      • Srimathi Srinivasan, Vipul Chitalia, Rosana D Meyer, Edward Hartsough, Manisha Mehta, Itrat Harrold, Nicole Anderson, Hui Feng, Lois E.H. Smith, Yan Jiang, Catherine E. Costello, Nader Rahimi. Hypoxia-induced expression of Phosducin like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis, 2015. http://www.springer.com/biomed/cancer/journal/10456
      • Sowmya Shivanna, Kumaran Kolandaivelu, Moshe Shashar, Mostafa Belghasem, Laith Al-Rabadi, Mercedes Balcells, Anqi Zheng, Janice Weinberg, Jean Francis, Michael P. Pollastri, Elazer R. Edelman, David H. Sherr, and Vipul C. Chitalia. “The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia”. Accepted for publication by the Journal of the American Society of Nephrology. May 2015.