Category: Uncategorized

Pathology and Laboratory Medicine New News – July 2016

August 1st, 2016 in Uncategorized

 Pathology & Laboratory Medicine News Items – July 2016

  • Announcements:
    • Dhay Kamel, one of our recent resident graduates and our new Cytology Fellow, just passed her AP & CP exams successfully! She is now board certified; CONGRATULATIONS Dhay!!
    • Martin Steinbuck, PhD (Susan Winandy Lab) successfully defended his Thesis, “NOVEL T-CELL RECEPTOR MEDIATED MECHANISMS OF NOTCH ACTIVATION AND SIGNALING” on July 18th, 2016, BRAVO!!
    • Martin.Susan.Closer.20160718_115142 (2)
    •      Martin.Cake.Champayne.20160718_150802
    • Newly implemented Departmental Teaching Awards were given at this year’s Castle Graduation Dinner in June, however some recipients were unable to attend the dinner and were presented their awards at alternate times.
    • The committee-driven criteria for the student awards are; collegiality, sharing with fellow-students, knowledge, skills, kindness; Leadership, positive attitude, problem solving, initiatives for improvements; Growth in professional skills, aptitudes and attitudes over the year and being a good team worker, helping others, as well as guiding juniors. The measures for the faculty awards were based on student feedback
    • Bestowed to:
    • On the Research-Side:
      • Mostafa Belghasem, MD, PhD: The Excellence Award 2016 (Student/Resident Award) (given at a Henderson Lab meeting)
      • Krzysztof Blusztajn, PhD: Residents Teaching Award 2016 (Faculty Award) (presented at a recent Faculty Meeting)
    • Tim Norman’s, PhD Candidate (Alan Fine Lab) F31 application from NHLBI titled “Origin, maturation, & regeneration of pulmonary lymphatic endothelium” scored in the 14th percentile. Tim wants to thank Drs. Carter Cornwall, David Atkinson, Andy Henderson, Chris Gable and Chelsea Epler for their help through BU’s Best Grant Writing Seminar
    • Annual Association of Pathology Chairs Meeting, San Diego, CA; July 2016:
      • Daniel Remick, MD gave a talk at the Pathology Leadership Academy in San Diego on July 11, 2016, “Unique Leadership Challenges in the Research Mission”
      • Remick also, organized a workshop at the 2016 Association of Pathology Chairs Meeting in San Diego, “Biorepository Management Workshop”.
      • In addition Remick moderated the Research Committee session at the Association of Pathology Chairs in San Diego, “You Won’t Believe Your Eyes – 21st Century Optics in Pathology”
      • Carmen Sarita-Reyes participated in the course offered by the Association of Pathology Chairs titled “Pathology Leadership Academy” in Coronado, CA July 11-12 2016. This course was offered to only 50 participants selected by their respective Chairs
      • Erin Brooks, MD, University of Wisconsin; David Kindelberger, MD, Boston University; Carmen D. Sarita-Reyes, MD, Boston University presented a Discussion Group titled “Strategies for Maximizing Early Medical Student Exposure to Pathology” at the Association of Pathology Chairs national meeting in San Diego, CA on July 13th 2016.
      • Carmen2.AAPathologists2016.IMG_1318

 

David.AAPathologists2016.IMG_1317

 

 

 

 

 

  • Dr. Carmen Sarita-Reyes shared that our fellow Brandon Hayse completed our first Boston University School of Medicine Pathology and Laboratory Medicine Fellowship from May 23rd – July 8th 2016 that is offered to 1st year medical students at BUSM. We wanted to thank the department for their support. 
  • Jacquelyn Sikora Hanson, PhD Candidate (Lawreen Connors Lab)presented a poster at the International Symposium on Amyloidosis in Uppsala, Sweden on July 5 entitled “Transthyretin and retinol-binding protein serum concentrations are prognostic and survival indicators in wild-type transthyretin amyloidosis.” The authorship was the following: Jacquelyn LS Hanson, Clarissa M Koch, Marios Arvanitis, Gloria G Chan, Frederick L Ruberg, Tatiana Prokaeva, Lawreen H Connors
  • Jacquelyn Sikora Hanson also received a Travel Award from GMS to attend the International Symposium on Amyloidosis in Sweden
  • Additional Posters/Presentations from the Connors Lab at the XVth Amyloidosis Symposium in Sweden, July 2016, include:
    • ALBase:  an updated and improved platform to study immunoglobulin light chain sequences. A Bhutkar, B Spencer, G Chan, LH Connors, T Prokaeva
    • Proteomic blood profiling in inherited (ATTR-FAC) and acquired (ATTRwt) forms of transthyretin-associated cardiac amyloidosis. GG Chan, CM Koch, LH Connors
    • Serum proteomic variability associated with clinical phenotype in familial transthyretin amyloidosis (ATTRm). LH Connors, CM Koch, GG Chan
    • Retinol-binding protein 4, a natural binding partner of transthyretin, is an indicator of differing pathobiologies in ATTRm and ATTRwt cardiac amyloidosis.  LH Connors, CM Koch, GG Chan
    • Histological characterization of localized amyloidosis tissues.  HL Cui, LH Connors, T Prokaeva, M Skinner, CJ O’Hara
    • Transthyretin and retinol-binding protein serum concentrations are prognostic and survival indicators in wild-type transthyretin amyloidosis (ATTRwt). JLS Hanson, CM Koch, GG Chan, T Prokaeva, LH Connors
    • Quantitation of tissue amyloid by novel Magnetic Resonance Imaging T2 relaxation sequences. N Hua, JE Ward, V Shibad, G Yee, LH Connors, H Jara, DC Seldin, JA Hamilton
    • AL amyloidosis cell model expressing patient-derived immunoglobulin light and heavy chains. ES Klimtchuk, TB Prokaeva, BH Spencer, LH Connors
    • Heavy light chain test quantifies clonal plasma cell disease in patients with AL amyloidosis and low serum free light chain burden.  T Prokaeva, B Spencer, F Sun, N McConnell, RM O’Hara, DC Seldin, LH Connors, V Sanchorawala
    • A new and unusual transthyretin mutant, duplication of TTR codons 51 and 52 (Glu51_Ser52dup), associated with severely aggressive familial amyloidotic polyneuropathy. B Spencer, JL Berk, E Klimtchuk, P SooHoo, T Prokaeva, LH Connors
    • Cytogenetic abnormalities in patients with newly diagnosed AL amyloidosis. H Yameen, JM Sloan, C Varga, JC Lee, CJ O’Hara, V Sanchorawala
    • Familial wild-type transthyretin cardiomyopathy.  MD Benson, JL Berk, LH Connors
  • Barb Nikolajczyk will serve as Lead Organizer for the FASEB Conference “Immunological Aspects of Obesity” held in Big Sky Montana July 31- Aug. 5
  • Barb Nikolajczyk, PhD also presented “Defining Inflammation in Human Obesity and Type 2 Diabetes” at the San Antonio Health Sciences Center Department of Microbiology and Immunology in July 2016.  Dr. Liz Leadbetter, an alum of the BUSM PhD program, hosted the speaker visit
  • Publications: ACCEPTED:
    • Huihong Xu, MD, and Daniel G. Remick MD; “Pathology – A Satisfying Medical Profession” has been recently accepted by Academic Pathology Journal
    • Samar Hafida, Tooraj Mirshahi, and Barbara S. Nikolajczyk,The Impact of Bariatric Surgery on Inflammation: Quenching the Fire of Obesity? In Press at Current Opinion in Endocrinology and Diabetes for Oct. 2016 publication
  • Publications: PUBLISHED:

Pathology and Laboratory Medicine New News – June 2016

June 30th, 2016 in Uncategorized

Pathology & Laboratory Medicine News Items – June 2016

Announcements:

Congratulations to our Graduating Fellow, Residents and Graduate Students:

Fellow/Residents:

  • Anita Deshpande, MD; Moving into a Faculty Position at Melrose-Wakefield – Hallmark Pathology PC
  • Yanli Ding, MD; Going to Renal Path at Brigham & Women’s Hospital
  • Dhay Kamel, MD; Stepping in to our Cytopathology Fellowship – BMC
  • Anita Malek, MD; Moving on to New York Presbyterian – Hematopathology Fellowship
  • Yue Sun, MD; Going on to New York’s Memorial Sloan Kettering Cancer Center, Surg Path Fellowship

Graduate Students:

  • Parul Agnihotri, PhD; Seeking a postdoc position in academia or industry
  • Lois Bayigga, MS; Moved back to Uganda and plans to enter a PhD Program
  • Mostafa Belghasem, PhD, MA; Moved into a position within the department
  • Evan Catudal, MS; Currently employed at the Boston Heart Diagnostics in Framingham, MA as a Medical Technologist. He is working on validating new clinical diagnostic assays for predicting cardiovascular disease risk. Evan is also enrolled as a part-time student in the M.S. in Clinical Investigation program at BUSM beginning in the Fall
  • Atsushi Ebata, PhD; Seeking a postdoc position
  • Terry Hseih, MD/PhD; Gone back to medical school
  • Melody Lun, MD/PhD; Gone back to medical school
  • Nicole Stauffer Smith, PhD; Seeking a postdoc position in academia or industry
  • Martin Steinbuck, PhD; Seeking a postdoc position in academia or industry
  • Ruoyu Tian, MS; Moving on to the Georgia Institute of Technology, PhD Biology Program

Congratulations Graduating Resident, Yanli Ding for receiving the prestigious Robert Foley, MBA, Award. This honor is given annually to a resident or fellow who “demonstrates the qualities that Mr. Foley brought to work every day.”

Newly implemented Departmental Teaching Awards were given at this year’s Castle Graduation Dinner

  • The committee-driven criteria for the student awards are; collegiality, sharing with fellow-students, knowledge, skills, kindness; Leadership, positive attitude, problem solving, initiatives for improvements; Growth in professional skills, aptitudes and attitudes over the year and being a good team worker, helping others, as well as guiding juniors
  • The measures for the faculty awards are based on student feedback
  • Bestowed to:
    • On the Clinical-Side:
      • Yue Sun, MD: The Excellence Award 2016 (Student/Resident Award)
      • Grace Zhao, MD, PhD: Residents Teaching Award 2016 (Faculty Award)
    • For the Research-Side:
      • Not yet awarded, so these will be announced in the next New News Edition!

    Daniel Remick, MD was invited to the 39th Annual Shock Society Meeting in Austin, Texas, June 11th -14th to give a presentation: “Interviewing Skills and CV Preparation that Stands Out

    Daniel Remick, MD also organized a debate at the 39th Annual Shock Society Meeting titled “Is Coagulopathy an Appropriate Therapeutic Target During Critical Illness?”

    Congratulations on passing the Qualifying Exams!

    • Ahmad Al-Moujahed
    • Greg Hall
    • Thank you to the faculty members who serve on the Qualifying Exam Committee; Drs. Blusztajn, Delalle, Rahimi, Remick and Slack with a SPECIAL Thank You Barbara Slack, Chair of the Qualifying Exam Committee

    Barb Nikolajczyk, PhD just received word of funding for a $2.95 million 5 year R01 from NIDCR entitled: “Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes”

    Ivana Delalle will be presenting the results of her team’s work at 11thEuropean Congress of Neuropathology (Bordeaux, France, 6-9 July 2016); “Subcellular changes in BIN1 protein expression in human cortex during the progression of Alzheimer’s disease”

    Deborah Stearns-Kurosawa, PhD has received a re-appointment letter for the Boston University Dual Use Research Review Committee through June 30, 2019

    Barb Nikolajczyk, PhD also spoke at the American Association of Diabetes Annual Meeting in New Orleans June 12. Session: Immunobiology of Type 2 Diabetes; Title: T cell Inflammation in Human Obesity and Type 2 Diabetes

    Publications: ACCEPTED:

    • Juan R. Mella M.D., M.P.H., Evan Chiswick Ph.D., David Stepien, M.D., Ph.D., Rituparna Moitra Ph.D., Elizabeth R. Duffy M.A., Arthur Stucchi Ph.D., Daniel Remick M.D. Antagonism of the Neurokinin-1 Receptor Improves Survival in a Mouse Model of Sepsis by Decreasing Inflammation and Increasing Early Cardiovascular Function. Accepted Critical Care Medicine

    Castle Graduation Celebration 2016

        • Charline.Ram.Dan.IMG_0449 AnitaD.Israa.IMG_0453 Clinical Group2.DSC_4220 Cyan.Martin.Parul.Fiancee.IMG_0384 Dahy.HerMom.David.IMG_0635 Carl.DSC_4183 Grace.AnitaM.Husband.IMG_0415 Firefighters.IMG_8233 Joel.Huihong.Debbie.IMG_0413 Yue.Sandra.Yanli.AnitaD.Lei.DSC_4212 Chandelier.DSC_4158 Yue.Award.Clock.IMG_0473 Dinner.DSC_4178 AnitaM.IMG_0433 Cyan.Martin.IMG_0379 Cyan.Martin.Parul.Fiancee.IMG_0384 David.Chris.IMG_0451 GraduatesandCakeSmiling.IMG_5704 Sandra.Carmen.Gail.Grace.DSC_4197 Parul.Diploma.IMG_0463 Yanli.Carl.FoleyAward.IMG_0479 Yue.Husband2.IMG_8279 All Group Photo 2.IMG_0408

    Pathology and Laboratory Medicine New News – May 2016

    June 3rd, 2016 in Uncategorized

    Pathology & Laboratory Medicine News Items  — May 2016

    • Announcements:
      • This year’s Lab Week 2016 was April 25th through 29th celebrating all that our lab people do each and every day!!! Thank you!!
      • Congratulations 2016 Masters Degree Graduates, Lois Bayigga, Evan Catudal and Ruoyu Tian!!!
      • Lois Bayigga, Lindy Joseph and Baby Ava - Graduation 2016
      • Graduate Lois Bayigga with her surrogate Mama/Grandmama, Lindy Joseph, along with Lois’s two-month old Baby Ava, celebrating the occasion!
      •                                                RuoyuTianandDebbieKiley.IMG_0166
      • Masters Graduate Ruoyu Tian and  Program Coordinator, Mrs. Debra Kiley
    • Lois Bayigga with Drs Anderson and Andry at graduation (2) 2016

    Mentor, Dr. Deborah Anderson, Masters Graduate Lois Bayigga and Pathology Masters Program Director, Dr. Chris Andry

      • Carmen D. Sarita –Reyes, MD attended, as a member, the National Board of Dental Examiners Microbiology-Pathology Test Construction Committee Meeting  from May 3rd-6th 2016 in Chicago, Illinois
      • Terry Hsieh MD/PhD successfully Defended his Thesis, “Mild Traumatic Brain Injury Augments the Innate Immune Response Through Neurokinin and Cholinergic Signalingon May 11, 2016. BRAVO!!
      •            OLYMPUS DIGITAL CAMERA
      • Newly Terry Hsieh, PhD and his Mentor Daniel Remick, Department Chair
      • OLYMPUS DIGITAL CAMERA
      • Terry Defending His Thesis on May 11,2016
      • Liz Moses, PhD Candidate/Spira Lab presented her research “Molecular Impact of Electronic Cigarette Exposure on Bronchial Airway Epithelium” in an oral presentation at the NIH Tobacco Regulatory Science Conference in Bethesda, MD, May 16-18
      • Caitlin Miller, PhD Candidate/Gummuluru Lab spoke about her research in an oral presentation May 23rd-28th at the Cold Spring Harbor Conference on Retroviruses in Cold Spring Harbor, NY. The title of the talk is, “Vpr enhances HIV-1 infection of dendritic cells by alleviating a post-integration block to virus replication”
      • Stephanie Adams,  OD/PhD Candidate/Delalle Lab was selected to give a platform presentation of the following work at the 92nd Annual 2016 AANP (American Association of Neuropathologists) Meeting in June, in Baltimore, MD: Adams S, Tilton K, Kozubek J, Seshadri S, and I Delalle: “Protein Expression of Low Hippocampal Volume Risk Allele Candidates MSRB3 and LEMD3 in Human CA1 Region During Progression of Alzheimer’s Disease”
      • Barb Nikolajczyk, PhD has had a busy month:
        • She hosted The Obesity Society Guest Symposium at the American Association of Immunologists meeting May 13-17 in Seattle, WA.  The symposium was entitled “Inflammation Fuels Obesity-Associated Cancers”
        • Nikolajczyk was an invited Speaker at Children’s Hospital Los Angeles, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • Barb Nikolajczyk, along with Dr. Lee Wetzler, also successfully organized the BU Inflammation Symposium May 23, held in Bakst Auditorium.  The Symposium, which we hope to be an annual event, included speakers from the Boston area and beyond. The attendance of over 90 participants represented multiple Boston academic institutions and indicated the broad interest in the topic. Sponsors included Thermofisher, Corning, The Training Program in Inflammatory Disorders, The Division of Graduate Medical Sciences, The Dept. of Microbiology, The Evans Foundation ARC Program, and the Sections of Rheumatology, Infectious Diseases and Nephrology in the Dept. of Medicine
        • Hot Off the Presses: Barb Nikolajczyk’s R01 application “Roles for lymphocyte RANKL in periodontal complications of type 2 diabetes” has been approved for funding by the NIDCR
      • Boston Medical Center has released a video to emphasize that some aspects of our care are excellent but that there are still areas of improvement.
        • One portion of the video talks about pathology and the substantial impact of a timely report on the patient. Pathology did a quality improvement project to identify ways to decrease the amount of time necessary to render an accurate diagnosis on breast specimens. While this was a team effort, Charline Mack, David Kindelberger and Mike O’Brien deserve special recognition for their work and initiative on the project.
        • Here is the video: https://vimeo.com/getnovel/review/163603670/686746036e Dan
      • NEW FACES:
        • A BU Undergraduate student, Rebecca Zeng, is working with our Pathology PhD Candidate, Mark Wojnarowicz, the Goldstein Lab through the UROP program for the summer
        • The Department of Pathology and Laboratory Medicine welcomes Brandon Hayse, 1styear medical student at BUSM, as our first fellow in our Summer Clerkship Fellowship in Pathology. Brandon will be rotating with us from May 23rd through July 15th 2016
        • Please join us in welcoming our new residents starting July 1, 2016:
        • Andrey Prilutskiy
    •                    Andrey Prilutskiy
      •          WeiWei (William) Shi
      • WeiWei (William) Shi
      •     Roghayeh Fazeli

    Roghayeh Fazeli

      • Jing Yang
      •        Jing Yang
        • Anna Macklin is a first year undergraduate student majoring in Biological Sciences at the University of Exeter, UK.  Anna will be working with Gail Whitney assisting on a grant while she is here.
        • Erika Banuelos, a sophomore year at Brown University, will be working with Dr. John Kim in the Remick Lab. She is a STaRS (Summer Training Research Scholar): http://www.bumc.bu.edu/gms/admissions/stars/) summer research program student.
        • Ivana Dellala’s Lab will have a student from Cornell (Biological Sciences ’19), Anant Sriram teaming with Stephanie Adams, Pathology OD/PhD Candidate
        • A New Summer Student is joining Maria Panchenko’ s Lab. Justin Cho is currently a junior at Williams College, MA. He was awarded an NIH grant to pursue undergraduate research and is interested in the field of cell cycle regulation.
        • Also in the Panchenko Lab is Bo Shao is a graduate student from Northeastern University. He will be getting his masters in pharmacology degree while continuing to investigate mechanisms of cytokinesis.
        • Please welcome Ksenia (Casey) Arakcheeva, a research technician who has joined the Winandy Lab
      • Nancy S. Miller, M.D. has been selected as a Distinguished Lecturer for the American Society for Microbiology (ASM). The ASM Distinguished Lecturer Program annually selects speakers for a 2-year term to lecture at ASM Branch meetings throughout the country.
      • Dr. Miller has also been accepted to be a Contributor to the Document Development Committee on Quality Management Systems, CLSI QMS01, for the international Clinical and Laboratory Standards Institute
    • PUBLICATIONS ACCEPTED:
      • Just accepted for publication in Journal of Neuropathology and Experimental Neurology (JNEN): Adams SL, Tilton K, Kozubek JA, Seshadri S, and Delalle I: “Subcellular changes in Bridging Integrator 1 (BIN1) protein expression in human cortex during progression of Alzheimer’s disease pathology”
      • “Confirmation of translatability and functionality certifies the dual endothelin1/VEGFsp receptor (DEspR) protein” Victoria LM Herrera; Martin Steffen; Ann Marie Moran; Glaiza A Tan; Khristine A Pasion; Keith Rivera; Darryl J Pappin; Nelson Ruiz-Opazo; BMC Molecular Biology
      • “Non-muscle Myosin-IIA is Critical for Podocyte F-actin Organization, Contractility and Attenuation of Cell Motility.” Philip A. Bondzie, Hui A. Chen, Mei Zhen Cao, Julie A. Tomolonis, Fangfang He, Martin R. Pollak and Joel M. Henderson.  Cytoskeleton (Accepted manuscript online: 27 MAY 2016 06:55PM EST).
    • PUBLICATIONS PUBLISHED:

    Pathology Writing Workshop – 2016

    May 20th, 2016 in Uncategorized

    Pathology Writing Workshop – 2016

    The Department of Pathology and Laboratory Medicine will hold a series of writing workshops. These workshops will help students, residents, and faculty prepare papers for submission to the peer-reviewed literature. This writing workshop is part of the strategic plan to improve the academic stature of the department and individual faculty. Additionally, pathology residents will be required to submit a draft of a manuscript to the attending pathologist based on her/his accepted abstract before being reimbursed for travel expenses. There is an expectation that all graduate students will have at least one first author publication prior to their thesis defense.

    Format: Each writing workshop will be 30 minutes long and will be held from 12:10 to 12:40.

    Target audience: Any member of the department (graduate student, post-doctoral fellow, resident or faculty) who wishes to enhance their scholarly activity will be encouraged to participate.

    Department of Pathology and Laboratory Medicine

    Writing Workshops

    Tuesdays, 12:10-12:40

    670 Albany Street – 3rd Floor Conference Room

    Starting July 19th through September 13th

    • Workshop #1 (7/19): Using Bibliography Software – Endnote (Remick)
    • Workshop #2 (7/26): Pre–writing- preparing the introduction (Remick)
    • Workshop #3 (8/2): Writing the results section (Remick)
    • Workshop #4 (8/9): How to prepare graphics part 1 (Kurosawa)
    • Workshop #5 (8/16): Writing the methods section (Remick)
    • Workshop #6 (8/23): Writing the discussion (Remick)
    • Workshop #7 (8/30): Writing the abstract (Remick)
    • Workshop #8 (9/6): Selecting appropriate journals for submission and reviewers (Remick)
    • Workshop #9 (9/13): Responding to a critique (Remick)

    Pathology and Laboratory Medicine New News April 2016

    April 29th, 2016 in Uncategorized

    Pathology & Laboratory Medicine News Items April 2016

    • Announcements:
      • Congratulations on Three Successful Defenses:
        • Parul Agnihotri PhD, Winandy Lab, successfully defended her thesis The Role of Ikaros in Foxo1-Driven Gene Expression in CD4 T Cells” on Friday, April 8th
        • Parul and Family
        • The new Dr. Agnihotri and her proud family
        • ParulGivingDefense
        • Parul Agnihotri, PhD Defending her Thesis, 4/8/16
        • Melody Lun, MD/PhD, Maria Lehtinen Lab(Off-site at Children’s), successfully defended her thesis Coordination of Cell Intrinsic and Extrinsic Signals in Development of the Mammalian Brain” on Wednesday, April 13th
        • MelodyandMentor2016.IMG_5630
        • The new Dr. Melody Lun and her mentor, Maria Lehtinen (Children’s Hospital)
        • MelodyandCommittee2016.IMG_5631
        • Dr. Lun and her BU Committee Members: Drs. Krzysztof Blusztajn, Barbara Slack and Tarik Haydar
        • Nicole Stauffer Smith , PhD, Mizgerd Lab, successfully defended her thesis Respiratory Infections with Pneumococci Establish Multi-pronged Heterotypic Protection Against Pneumonia” on Wednesday, April 13th
        • NicoleDefenseCelebration
        • Dr. Nicole Stauffer Smith’s Defense Celebration!
      • Tim Norman, PhD Candidate in Alan Fine’s Lab gave an oral presentation and presented a poster at the Gordon Research Conferences on Lymphatics titled “Origins, maturation, and regeneration of the pulmonary lymphatic endothelium” on March 19th in Ventura, California
      • Ivana Delalle is excited to be giving a platform presentation, “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” at the 2nd International Symposium on Microgenomics in Paris, France; June 2016
      • Maria Panchenko was invited to write an expert review about family of JADE genes and corresponding proteins. The review was accepted and will be published in GENE.
      • On the basis of excellent teaching in the first year of the medical school curriculum the following faculty have been selected as Master Educators:
        • Carmen Sarita-Reyes, M.D. (Integrated Problems)
        • Jacqueline Sharon, Ph.D. (Immunology)
        • Deborah Stearns-Kurosawa, Ph.D. (Immunology)
        • Daniel Remick, M.D. (Immunology)
        • Susan Winandy, Ph.D. (Immunology)
      • Mark Wojnarowicz, PhD Candidate in the Goldstein Lab has won a School of Medicine PhD Award from the 2016 Graduate Research Symposium. His poster title was “Blood-Brain Barrier Dysfunction, Neuroinflammation, and Early Chronic Traumatic Encephalopathy-Linked Neuropathology in a Mouse Model of Concussive Impact Neurotrauma.” The Symposium held on April 11th at Metcalf Hall was sponsored by the Office of the Provost
      • Daniel Remick, M.D., received a Certificate of Appreciation for 3 years of service on the Council of the American Society of Investigative Pathology
      • USCAP 2016 – March 12-18, 2016; Seattle, Washington
        • Reyhan Gedik, MD presented the following poster, ““Utility of Next Generation Sequencing (NGS) Cotesting to Recategorize Bethesda-I Thyroid FNAs” : authors 1. Reyhan Gedik MD1, 2. Anita Deshpande MD1, 3. Huihong Xu MD1 and 4. Sandra Cerda, MD
          • USCAP2016.ReyhanGedik
        • Huihong Xu, MD is really happy to report that she has passed the American Board of Pathology Maintenance of Certification (MOC) Part III examination(s) in Anatomic Pathology and Clinical Pathology and Cytopathology; Bravo Huihong!
        • Barb Nikolajczyk, PhD had multiple presentations in April including:
          • Emory University, Woodruff Health Science Center, Atlanta GA, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
          • Winthrop Hospital, Mineola, NY, “Defining Inflammation in Human Obesity and Type 2 Diabetes”
          • University of Virginia, Department of Pharmacology, Charlottesville, VA  “Defining Inflammation in Human Obesity and Type 2 Diabetes”
        • Nancy Miller, MD had several events in April also, including:
          • Invited speaker at the American Society for Clinical Laboratory Science-Central New England (ASCLS-CNE) convention, April 26-28, Providence, RI, where she presented cases from the clinical microbiology laboratory entitled:  “From the Bench: A potpourri of challenges, conundrums, and lessons learned”
          • Miller was also the Event co-chair for the 1st joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and the Northeast Branch-American Society for Microbiology (NEB-ASM), April 11-12, Boxborough, MA.
          • Miller is a Laboratory Medical Director for the now-approved Gilead Foundation grant: BMC HCV Screening, Confirmation and Linkage Initiative, (Jonathan Hall, Principal Investigator)
        • Russek Awards 2016:
          • Barbara Slack, Pathology Department Russek Awards Committee, is pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
            • First Prize – Caitlin Miller (Advisor: Rahm Gummuluru)
            • Second Prize – Elizabeth Moses (Advisor: Avrum Spira)
          • Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day will be held on Friday, May 6th in the Hiebert Lounge (L building, 14th floor). The keynote speaker this year will be Dr. James Bradner, the new President of the Biomedical Institutes of Novartis. Posters will be available for viewing throughout the day, and slide presentations by the first prize winners will take place in the afternoon. I hope everyone will be able to attend.
          • More information about this event can be found at the link ((http://www.bumc.bu.edu/gms/students/phd/russek-student-achievement-day-2016/)
        • Daniel Remick, M.D., was given a Certificate of Service in the Advanced Core Program in the Responsible Conduct of Research for Doctoral Candidates by Boston University School of Medicine
        • The Winandy Lab:
          • On April 8th, Parul Agnihotri successfully defended her thesis
          • Caroline Lyon De Ana, a Pathology Masters student, joined our lab
        • PUBLICATIONS PUBLISHED:
          • Wang W, Wang WH, Azadzoi KM et al. Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells. Mol Cell Endocrinol. 2016 May 5;426:91-100. doi: 10.1016/j.mce.2016.02.008. Epub 2016 Feb 15.
          • Wang W, Wang WH, Azadzoi KM et al. Activation of innate antiviral immune response via double-stranded RNA-dependent RLR receptor-mediated necroptosis. Sci Rep. 2016 Mar 3;6:22550. doi: 10.1038/srep22550.

    Pathology & Laboratory Medicine News Items – March 2016

    April 1st, 2016 in Uncategorized

    Pathology & Laboratory Medicine News Items

    March 2016

    • Announcements:
      • Please join in congratulating Nancy Miller, M.D. on her promotion to Associate Professor of Pathology and Laboratory Medicine. This promotion recognizes Dr. Miller’s national reputation in the field of pathology, specifically in the area of microbiology. There is amble evidence of her stature, including being an invited participant in preparing the Clinical and Laboratory Standard Institute (CLSI) upcoming international CLSI M-52 Guideline (User Verification/Validation of Microbial Identification and Antimicrobial susceptibility Testing Systems). This panel will establish the national guidelines for the identification of pathogens and antimicrobial testing. Additionally, she was an invited panel member on the nationally and internationally attended 2012 Centers for Disease Control (CDC) forum on Culture-Independent Diagnostics. Dr. Miller was the co-convener for the Symposium: “Fecal microbiota transplants and competing organisms: From practical to practice to promise”, American Society for Microbiology in 2014, and was a faculty participant for workshops (2012, 2014, 2015).
      • Thirty Shades of Red… also known as “Transfusion Medicine in the Hot Seat: A Case-Based Primer” authored by Karen Quillen, MD, MPH out for publication!!! Get your copy!!
      • QuillenPublication2016.FullSizeRender

     

    • Carmen Sarita-Reyes was recently accepted for a leadership course at the APC meeting. From the APC; “The Association of Pathology Chairs’ Leadership Development and Diversity Committee, it is our pleasure to let you know that your application for the Pathology Leadership Academy (PLA) has been accepted. You will join about 60 colleagues for this special event, which will include lectures and interactive presentations by a host of nationally recognized speakers.” The Leadership Program will take place in July in San Diego, California
    • From Daniel Remick:
      • Daniel Remick, M.D., served as an external reviewer for the Department of Pathology at the University of Iowa. The two day review during the end of March 2016 was conducted as part of the University’s standard 5 year review of the Department
      • The NIH held a one day workshop on the physician scientist workforce on February 19th, 2016. Daniel Remick, M.D. participated as the Chair of the Research Committee for the Association of Pathology Chairs and the Vice President of the American Society of Investigative Pathologists
      • Daniel Remick, M.D. served as an unpaid external reviewer for CBMed, a government – private joint venture in Austria. The company is focusing on developing biomarkers including biobanks. The first review was held in Graz, Austria in February 2016
    • Caitlin Miller, PhD Candidate in Rahm Gummuluru’s Lab attended The Conference on Retroviruses and Opportunistic Infections, February 22-25, 2016 in Boston, MA where she presented a poster entitled, “Essential role of Vpr in HIV-1 infection of dendritic cells”
    • Huihong Xu, M.D., received the “CAPA Member of the Year Award” at the 14th Annual Meeting of Chinese American Pathologists Association on March 12, 2016 in Seattle, Washington
    • USCAP 2016 – March 12-18, 2016; Seattle, Washington
      • Yue Sun, MD presented the following posters:
        • “Analysis of PD-L1 Expression Pattern in Microsatellite Instability Colon Cancer;” Yue Sun, Max Vaickus, Michael O’Brien and Qing Zhao
        • Sun.USCAP.PD,L1.Colon Cancer.IMG_8021
        • “Analysis of PD-L1 Expression Pattern in Advanced Bladder Cancer and Lymph Node Metastasis;” Yue Sun, Max Vaickus, Sandra Cerda and Huihui Ye
        • Sun.USCAP2016.PD.L1Expression...BladderCancer.IMG_8023
      • Anita Deshpande, MD, poster entitled;  “Impact of ThyroSeqv.2 Next-Generation Sequencing Assay on Fine Needle Aspiration Cytology of Thyroid Nodules;” – Anita Deshpande, Xu Huihong, Sandra Cerda
        • Deshpande.USCAP 2016 image 2
          • Deshpande and Dr.Ye Nikiforov who developed and designed the ThyroSeqv.2 test at UPMC
        • From Barbara Nikolajczyk, PhD:
          • Barb Nikolajczyk and Lee Wetzler are hosting the Boston University School of Medicine Inflammation Symposium May 23, 2016 in Bakst Auditorium. All are welcome to join the cross-talk amongst inflammation researchers at BUSM and beyond.  Trainee talks will be selected from submitted abstracts. Please contact the organizers for more details.
          • Barb Nikolajczyk will chair and speak at an “Open Call” Symposium at the 2016 Annual Meeting of The Obesity Society in New Orleans, LA in the Fall of 2016. The Symposium is entitled Complex Data Sets in Obesity: Opportunity over Obfuscation
          • The multi-PI team of Barb Nikolajczyk (BUSM), Caroline Apovian (BMC/BUSM) and Doug Lauffenburger (MIT) were awarded $2.8 million by the NIH/NIDDK for a 4 yr. project entitled “Inflammation in Human Obesity and Type 2 Diabetes”.
          • Gerald Denis and Barb Nikolajczyk will chair “The Obesity Society Guest Symposium” at the American Association of Immunologists Meeting May 13-17, 2016 in Seattle, Washington. The theme this year is Immunometaboism and Cancer.
        • Watch David Sherr, PhD talking on the Science Coalition’s “Super Science Tuesday” about the need for all politicians to know why research investment is so important. This is followed by Dr. Sherr and three other labs discussing “Investing in Prevention at SPH”:
        • The Kurosawa Lab is welcoming new faces:
          • Eriko Morishita, is a Professor of Medicine from Kanazawa University School of Medicine.  Kanazawa is a beautiful city, just north of Kyoto, Japan. She is a trained hematologist, specializing in thrombosis and hemostasis.  Dr. Morishita is visiting our lab for sabbatical for almost a year.  Her interest is in thrombotic microangiopathy (TMA)
          • Takeshi Wada just arrived from Hokkaido University School of Medicine, Sapporo, Japan. Sapporo is famous for its snow festival. We do not expect him to be intimidated by Boston winter. Dr. Wada is a trauma surgeon.  His research interest is in disseminated intravascular coagulation (DIC)
      • PUBLICATIONS PUBLISHED:

       

      Departmental Seminar – March 25, 2016

      March 21st, 2016 in Spotlight, Uncategorized

      Seminar Series: Spring 2016 ~~ Friday, March 25, 2016

      2:00-3:00 PM

                    

      SCARFing Dead Cells and TREMing Inflammation

       

      Terry K. Means, PhD
      Assistant Professor of Medicine, Harvard Medical School
      Associate Immunologist, Massachusetts General Hospital

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108
      2:00-3:00 PM


      Friday, March 25, 2016
      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) recall that the clearance of apoptotic cells is arguably one of the most important processes of the immune system and is necessary for the homeostatic maintenance of healthy tissues and removal of infected or damaged cells; 2) report that defective clearance of apoptotic cells can lead to the development of chronic inflammatory diseases such as systemic lupus erythematosus; and 3) discuss that there are new insights into the regulatory pathways that control Toll-like receptor 7 (TLR7) signaling to prevent loss of tolerance and the development of autoimmunity.

                     

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Departmental Seminar – March 4, 2016

      February 29th, 2016 in Spotlight, Uncategorized

      Seminar Series: Spring 2016 ~~ Friday, March 4, 2016

      2:00-3:00 PM

                    

      The Role of Epigenetics in the Pathophysiology of Huntington’s Disease

       

      Ghazaleh Sadri-Vakili, PhD
      Assistant Professor of Neurology, Harvard Medical School
      Director, NeuroEpigenetics Laboratory;
      Mass General Institute for Neurodegenerative Disease

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108
      2:00-3:00 PM


      Friday, March 4, 2016
      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) repeat that transcriptional dysregulation has been proposed to play a major role in the pathology of Huntington’s disease; 2) recall that in Huntington’s disease specifically how alterations in transcription and epigenetic regulation can cause pathogenesis and 3) identify novel molecular/epigenetic mechanisms may unveil new therapeutic targets for the treatment of Huntington’s disease.

                     

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.

      Pathology & Laboratory Medicine News Items December 2015 – January 2016

      February 3rd, 2016 in Uncategorized

      • Announcements:
        • Congratulations are in order to the following Department of Pathology members: BRAVO!
          • Chris Andry, MPhil, PhD; for being appointed Chair of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
          • Abigail Brown, MFS, MLS (ASCP): for being appointed a Voting Member of the Boston University Research and Clinical Connection Subcommittee until December 2017, BRAVO!
          • Shinichiro Kurosawa, MD, PhD; for being appointed a Voting Member to the Boston University Laboratory Safety Committee Space / Infrastructure Subcommittee until December 2017, BRAVO!
        • On December 3, 2015 Daniel Remick, MD gave a talk “Mild Traumatic Brain Injury Augments Host Defenses against Pathogens” at the Institute of Neuroscience and Physiology at Sahlgrenska Academy at the University of Gothenburg
        • Daniel Remick, MD was invited to serve as the opponent for Sara Svahn at the University of Gothenburg in Sweden on December 4, 2015. The title of Sara’s thesis was “Effects of dietary fatty acids on the immune system”. Scandinavian countries have a tradition of bringing in an outside expert to ensure that the thesis work has sufficient rigor and depth. This outside member of the committee has the title of opponent. At the two hour defense, the opponent presents background information about the topic of the thesis, in this case sepsis. The student then presents for about 40 minutes, which is then followed by an hour of questioning by the opponent. Sara Syahn, PhD, successfully Defended
        • Chloe Habib and Leah Persky, both students in the Masters in Nutrition Program, joined the Nikolajczyk Lab as of January 2016
        • The Residency Program had an ACGME Site Visit in January to review our program. The Department has been working diligently since last spring to increase the teaching curriculum for the residents. One of the issues identified through the survey in 2015 was lack of scholarly opportunities. The Department will be launching a series of paper writing workshops this spring and all the residents will be invited.
        • The College of American Pathologists (CAP) performed their unannounced Site Visit on January 27, 2016. Seventeen inspectors from the Lifespan System in Rhode Island spent the day thoroughly reviewing both Anatomic Pathology and Laboratory Medicine. The lab inspection went very well with only a few deficiencies identified. This outstanding inspection result was due to the hard work by the pathology faculty and staff in the months leading up to the preparation. BRAVO
      • PUBLICATIONS ACCEPTED:
        • Thurmond P, Yang JH and Azadzoi KM entitled “LUTS in pelvic ischemia: A new concept in voiding dysfunction” — Accepted for publication in AJP – Renal Physiol
        • Ding Y, Francis J, Kalish J, Deshpande A, Quillen K. Recurrent focal segmental glomerulosclerosis resistant to plasma exchange, and improvement after surgical repair of arteriovenous fistula aneurysms. Clinical Kidney Journal [in press]
      • PUBLICATIONS PUBLISHED:
        • Zhifeng Huang, William M. Marsiglia, Upal Basu Roy, Nader Rahimi, Dariush Ilghari, Huiyan Wang, Huaibin Chen, Weiming Gai, Steven Blais, Thomas A. Neubert, Alka Mansukhani, Nathaniel J. Traaseth, Xiaokun Li,  Moosa Mohammadi. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Molecular Cell, December 10, 2015. http://www.sciencedirect.com/science/article/pii/S1097276515009028
        • Lawreen Connors, PhD and Colleagues Publish Findings in ATTRwt Amyloidosis Cohorthttp://www.bu.edu/amyloid/2016/01/22/connors-and-colleagues-publish-findings-in-attrwt-amyloidosis-cohort/
          • Data on the largest cohort of ATTRwt amyloidosis patients yet reported (n=121), referred to our institution over a 20-year observational period, were recently reported in the prestigious heart journal, Circulation.  The publication, entitled “Heart failure due to age-related cardiac amyloid disease associated with wild-type transthyretin:  a prospective, observational cohort study,” was authored by Dr. Lawreen H. Connors and colleagues from the Amyloidosis Center at Boston University.  These data establish the natural history of ATTRwt, provide statistical basis for the design of future interventional clinical trials, and highlight the need for more sensitive diagnostic tests and disease-specific treatments for this disease.  For more information, see Circulation, 133:282-290, 2016.
        • Ozturk S, Papageorgis P, Lambert AW, Wong CK, Thiagalingam A, Abdolmaleky HM, Cohen HT, and Thiagalingam S, 2016. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis. Proc. Natl. Acad. Sci. USA. 113(3): 638-643. http://www.pnas.org/content/113/3/638.full.pdf?with-ds=yes

      Departmental Seminar – January 29, 2016

      January 25th, 2016 in Uncategorized

       

      Seminar Series: Spring 2016 ~~ Friday, January 29, 2016

      2:00-3:00 PM

                    

      “The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention”

       

       

      Nisma Mujahid

      PhD Candidate, David Fisher Lab (MGH);

      Department of Pathology, Boston University School of Medicine

       

      Location & Time:
      670 Albany Street
      Lobby Level #107/108
      2:00-3:00 PM
      Friday, January 29, 2016
      Target Audience: Faculty, Students, Residents, Greater Boston Scientific Community (advertised in MIT’s Bulletin).

      At the conclusion of this activity participants will be able to: 1) recall that ultraviolet-light (UV)-induced tanning is defective in numerous ‘fair-skinned’ individuals, many of whom contain functional disruption of the melanocortin 1 receptor (MC1R); 2) recognize that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blondehaired Mc1re/e mice; and 3) report that ultraviolet (UV) radiation is highly toxic to organisms because it damages cellular constituents such as DNA.

                     

      Course Director: Barbara Slack, PhD

      Boston University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Boston University School of Medicine designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)™.  Physicians should only claim credit commensurate with the extent of their participation in the activity.