Darrell N. Kotton, MD


Professor of Medicine and Pathology & Laboratory Medicine

Training:

Medical School: Washington University School of Medicine
Internship:
University of Pennsylvania
Residency:
University of Pennsylvania
Fellowship:
Boston University
Post-Doctoral Research Fellowship:
Harvard Medical School
Board Certifications: Internal Medicine, Pulmonary Medicine, Critical Care Medicine

Special Interests:

RESEARCH:

CLINICAL:

Dr. Kotton is Assistant Professor in the Department of Pathology and Laboratory Medicine as well as in the Department of Medicine. He attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.

Dr. Kotton’s research focuses on stem cell biology and gene therapy related to lung injury and repair. He is an NIH-funded Principal Investigator and a member of several research groups, including the Stem Cell Biology and Gene Therapy Group, and the Pulmonary Developmental Biology Group. Dr. Kotton’s laboratory currently utilizes several stem cell populations, including bone marrow-derived stem cells and embryonic stem cells in order to develop novel stem cell-based therapies for lung disease. In addition, Dr. Kotton specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors. Projects in his lab are currently focused on utilizing these novel vectors for the study of alpha-1 anti-trypsin deficiency, COPD, and lung inflammatory pathways.

For more detailed information on Dr. Kotton’s research, see the Kotton Lab website (www.kottonlab.com).

Selected Publications:

  1. Murphy GJ, Mostoslavsky G, Kotton DN, and Mulligan RC. “Exogenous Control of Mammalian Gene Expression via Modification of Translational Termination.” Nature Medicine 12(9):1093-9. Sept 2006.
  2. Kotton DN, Fabian AJ, Mulligan RC. “Failure of Bone Marrow to Reconstitute Lung Epithelium.” Am J Respir Cell Mol Biol. 33:328-334. Oct 2005.
  3. Kotton DN, Fabian AJ, Mulligan RC. “A novel stem cell population in adult liver with potent hematopoietic reconstitution activity.” Blood. 106:1574-1580. Sept 2005.
  4. Mostoslavsky G, Kotton DN, Fabian AJ, Grey JT, Mulligan RC. “Efficiency of transduction of highly purified hematopoietic stem cells by lentiviral and retroviral vectors under conditions of minimal in vitro manipulation.” Molecular Therapy 11(6):932-40. June 2005.
  5. Summer R, Kotton DN, Liang S, Fitzsimmons K, Sun X, Fine A. “Embryonic lung side population cells are hematopoietic and vascular precursors”. Am J Respir Cell Mol Biol. 33:32-40. July 2005.
  6. Kotton DN, Summer R, and Fine A. “Lung stem cells: New paradigms.” Exp Hematol. 32(4): 340. Apr 2004.
  7. Summer R, Kotton DN, Sun X, Fitzsimmons K, and Fine A. “The Origin and Phenotype of Lung Side Population Cells.” Am J Physiol Lung Cell Mol Physiol. Mar 2004.
  8. Summer R, Kotton DN, Sun X, Ma B, Fitzsimmons K, Fine A. “Side population cells and Bcrp1 expression in lung.” Am J Physiol Lung Cell Mol Physiol. 285(1):L97-104. July 2003.
  9. Kotton DN, Summer RS, Sun X, Ma BY, Fine A. “Stem cell antigen-1 expression in the pulmonary vascular endothelium.” Am J Physiol Lung Cell Mol Physiol. 284(6):L990-6. June 2003.
  10. Kotton D and Fine A. “Derivation of lung epithelium from bone marrow cells.” Cytotherapy. 5(2):169-73.. May 2003.
  11. Kotton DN, Ma BY, Cardoso, WV, Sanderson EA, Summer, RS, Williams MC, and Fine A. “Bone Marrow-Derived Cells as Progenitors of Lung Alveolar Epithelium.” Development 128: 5181-5188. December 2001.