Pathology & Laboratory Medicine News Items – February 2018
Dr. John Kim had a volunteer opportunity serving as a judge for the Science Fair at Excel High School (http://www.excelhigh.org/index.jsp) which is located at the summit of Telegraph Hill in South Boston. Approximately 70 projects were presented by students, and he felt honored and privileged when talking to enthusiastic students about their projects and future in STEM. Dr. Kim would like to encourage all member of pathology community to get involved in another session in next January
Dr. Daniel Remick, M.D., gave the Gustave Dammin Lecture at Brigham and Women’s Hospital on February 12, Sepsis: Progress and Challenges
Daniel Remick, M.D. also presented Grand Rounds at the University of Pittsburgh Department of Pathology on January 24th, Sepsis Heterogeneity
Sandra Cerda MD, was invited as a speaker to discuss “Cytotechnologist Education and Training in the US” at the 41st European Congress of Cytology, to be held from 10 to 13 June, 2018 in Madrid, Spain
Abstract accepted for Oral presentation at the Tenth International Symposium VTEC (Verocytotoxin) 2018, Florence, Italy: Shinichiro Kurosawa, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, D.J. Stearns-Kurosawa. Urtoxazumab (Humanized Monoclonal Anti- Shiga Toxin 2) in the baboon model of Hemolytic Uremic Syndrome and Comparison to in vitro Cytotoxicity. May 6-9, 2018
Dr. Carmen D. Sarita-Reyes organized a cardiology gross demonstration session on 02/14/18 for the BU School of Medicine’s Cardiology Interest Group (comprised of 15 first year medical students). Our residents: Israa Laklouk, Mahmoud Soliman, Weiwei Shi and Ilyas Yambayev, each presented to the students a gross specimen illustrating a specific type of cardiovascular pathology (valve disease, myocardial infarction, atherosclerotic coronary artery disease, etc). The students greatly enjoyed this learning experience and gave rave reviews of our residents’ presentations. We would like to acknowledge our residents for their excellent teaching, enthusiasm, and dedication. BRAVO!!
A pathology heart just because it was on Valentine’s Day
Cardio Demonstration Student Group
Cardio Demonstration Group with Resident Dr. Mahmoud Soliman
Cardio Demonstration Group with Resident Dr. Israa Lakloud
Resident Dr. Ilyas Yambayev with the Cardio Demonstration Group
Nancy S. Miller, M.D. is the ASM Distinguished Lecturer at the Northern California Branch-American Society for Microbiology, March 2-3, in Pleasanton, CA.
Dr. Miller will present The Dr. Gerri Hall Memorial Lecture at the South Central Association for Clinical Microbiology, March 9-10, in French Lick, IN.
- Publications PUBLISHED:
Vural Kara, Chuanhua Duan, Kalpana Gupta, Shinichiro Kurosawa, Deborah J Stearns-Kurosawa, Kamil L Ekinci. Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing. Lab on a Chip 2018, DOI: 10.1039/c7lc01019b. Impact Factor 6.04
Hsieh T, Vaickus MH, Remick DG. Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm. Am J Pathol. 2018;188(1):6-10. PubMed PMID: 28958817; PMCID: PMC5745519
Kasotakis G, Galvan MD, Osathanugrah P, Dharia N, Bufe L, Breed Z, Mizgerd JP, Remick DG. Timing of valproic acid in acute lung injury: prevention is the best therapy? J Surg Res. 2017;220:206-12. PubMed PMID: 29180183; PMCID: PMC5726455
Warner TD, Weil CJ, Andry C, Degenholtz HB, Parker L, Carithers LJ, Feige M, Wendler D, Pentz RD; Broad Consent for Research on Biospecimens: The Views of Actual Donors at Four U.S. Medical Centers.. J Empir Res Hum Res Ethics. 2018 Jan 1:1556264617751204. doi: 10.1177/1556264617751204. [Epub ahead of print]
Pathology & Laboratory Medicine News Items – Winter 2017/2018
- Nancy S. Miller, M.D. presented “A point of view about point of care testing for diagnostic microbiology in the U.S.” at the Global Applied Microbiology Conference, October 18-19, Toronto, Ontario, Canada, and
- Dr. Miller presented also as ASM Distinguished Lecturer at the Southern California Branch-American Society for Microbiology, October 27-28, La Jolla, CA.
- Also at La Jolla, Dr. Miller was invited to a breakout Educators’ Session and presented, “Clinical Microbiology at the Crossroads: A Potpourri of Challenges and Lessons Learned in this Era of Evolving Technology”
- Residents Mahmoud Soliman, MD (presenter) and Israa Laklouk, MD (author) got an Honorable Mention for abstract titled “Predictive Accuracy of Thyroseq V2 for Malignant Thyroid Nodules among Bethesda-III Cytology Subcategories: Atypia of Undetermined Significance (AUS) And Follicular Lesion of Undetermined Significance (FLUS)” in Twelfth Annual MMS Research Poster Symposium for Residents, Fellows and Medical Students (Clinical Research category)
- Dr. Mostafa Belghasem’s work was featured on the front cover of “Science Translational Medicine” Vol 9 Issue 417 (Nov. 22. 2017) titled: Cover story: Anticoagulation strikes a balance Sample cover image attached if you would like to check it out: http://stm.sciencemag.org/content/9/417
- Dr. Susan Winandy has received new grant funding: “Defining programs of gene expression regulated by Ikaros in T cells” NIH/NIAID, R03
- Dr. David Kindelberger reports “we had our first meeting of the new Medical Student Pathology Interest Group right before the holidays. This officially sanctioned student group has as its mission to provide medical students with increased exposure to all areas of pathology through a variety of activities. We had 17 medical students participate in our initial meeting and tour. Dr. Carmen Sarita-Reyes has been instrumental in bringing this together, as have students Natalie Rizzo, Gabriel Lerner, and Brad Zehr. Stay tuned for more news!
- Dr. Artem Shvetsov will be joining our residency program at the end of January. Artem received his MD and PhD (in Pathology and Cell Biology) in Russia and has extensive research experience in molecular virology. He is well-known to the department, having done an observership here. Artem lives in Arlington with his family. Please join us in welcoming Artem to the department!
- Dr. David Sherr gave a talk at Memphis University in November titled “An Environmental Chemical Receptor that Controls Multiple Contributors to Cancer Aggression”.
- Dr. Sherr also gave a talk at the National Academy of Sciences the first week of January 2018 entitled “tracking an AHR regulatory circuit in cancer with AHR inhibitors, CRISPR/Cas9 knockdown, and other tricks”
- Dr. Shinichiro Kurosawa has been re-appointed as a voting member to the Boston University Laboratory Safety Committee Space / Infrastructure Subcommittee through December 2019
- Two Mallory Fund Projects have been awarded:
- Summer Pathology Fellowship – Carmen Sarita-Reyes, M.D.
- Using comparative pathology to develop “one medicine-one pathology” competencies for pathology residents – Nicholas Crossland, D.V.M., Nancy Miller, M.D., and David Kindelberger, M.D.
- Bravo to Morgan Thompson, recent MS Graduate, her abstract has been accepted for presentation in a Poster Session at the American Association for Cancer Research (AACR) Annual Meeting, April 14-168, 2018 in Chicago, Illinois, and the piece will be published in the 2018 Proceedings of the AACR; “Effect of preanalytic variables on established and emerging thrombosis-related biomarkers in an ethnically and racially diverse population of cancer patients and healthy subjects at a safety net hospital” Morgan P. Thompson1, Elizabeth R Duffy1,2, DJ Stearns-Kurosawa2, Jasmin Bavarva3, Shinichiro Kurosawa2, Jiyoun Kim2, Cheryl Spencer1, Daniel Remick1,2, Mark Sloan1,2, Joel Henderson1,2, Kerrie P Nelson2, Joseph Y Tashjain2, Yibing Wei2, Rachana Agarwal3, Michelle A. Berny-Lang4, Chris Andry1,2
- Publications PUBLISHED:
- Martin Peter Steinbuck, Ksenia Arakcheeva and Susan Winandy; “Novel TCR-mediated mechanisms of Notch activation and signaling” The Journal of Immunology. 2017. Dec 29. pii: ji1700070. doi: 10.4049/jimmunol.1700070. [Epub ahead of print]
- N. Rahimi. Defenders and Challengers of Endothelial Barrier Function. Front Immunol. 2017 Dec 18;8:1847. doi: 10.3389/fimmu.2017.01847. eCollection 2017. https://www.frontiersin.org/articles/10.3389/fimmu.2017.01847/full
- Ho RX, Meyer RD, Chandler KB, Ersoy E, Park M1, Bondzie PA, Rahimi N, Xu H, Costello CE, Rahimi N. MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth. J Mol Cell Biol. 2018 Jan 10. doi: 10.1093/jmcb/mjy002. [Epub ahead of print https://academic.oup.com/jmcb/advance-article/doi/10.1093/jmcb/mjy002/4796960
- Rosana D Meyer,, Xueqing Zou, Marwa Ali, Esma Ersoy, Philip Apraku Bondzie, Mehrdad Lavaei, Ilya Alexandrov, Joel Henderson and Nader Rahimi. TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer. Oncotarget Dec. 2017 http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path=23822&path=74949
- Moshe Shashar, Mostafa Belghasem*, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi1, Keshab Rijal, Vijaya B. Kolachalama, Mercedes Balcells, Kazuo Nagasawa, Joel M. Henderson, Amitabh Gautam, Jean Francis, Kumaran Kolandaivelu, David H. Sherr, Katya Ravid, Vipul C. Chitalia. “Targeting uremic thrombosis axis normalizes hyperthrombotic phenotype without increasing the bleeding risk.” Science Translational Medicine, Sci Transl Med. 2017 Nov 22;9(417). pii: eaam8475. doi: 10.1126/scitranslmed.aam8475 *= First co-author
- Vijaya B. Kolachalama, Priyamvada Singh, Christopher Q. Lin, Dan Mun, Mostafa Belghasem, Joel M. Henderson, Jean M. Francis, David J. Salant, Vipul C. Chitalia “Association of pathological fibrosis with renal survival using deep neural networks.” Kidney International Reports, Nature. Kidney Int Rep (Jan. 11. 2018); https://doi.org/10.1016/j.ekir.2017.11.002
- Vijaya Kolachalama, Moshe Shashar, Faisal Alousi, Sowmya Shivanna, Keshab Riajl, Mostafa Belghasem, Joshua Walker, Shinobu Matsuura, Gary Chang, C Michael Gibson, Laura Dember, Jean Francis, Katya Ravid, Vipul C. Chitalia. “Uremic solute-Aryl Hydrocarbon Receptor -Tissue Factor Axis Associates with Post-Vascular Injury Thrombosis in Humans.” Journal of the American Society of Nephrology; J AmSoc Nephrol 29: ccc–ccc, Jan. 17. 2018. doi: https://doi.org/10.1681/ASN.2017080929
- Ritter, JL & Genco, GA. Neisseria gonorrhoeae–Induced Inflammatory Pyroptosis in Human Macrophages is Dependent on Intracellular Gonococci and Lipooligosaccharide. Journal of Cell Death http://journals.sagepub.com/doi/abs/10.1177/1179066017750902
Pathology & Laboratory Medicine News Items – Fall 2017
On August 20, 2017, Dr. Huihong Xu gave a presentation of “Molecular Diagnostics in Lung Cancer” at the Hot and Practical Topics in Diagnostic Pathology-2017 Chicago, the 3rd CAPA Diagnostic Pathology Meeting
Pathology Resident, Weiwei Shi, MD was awarded a Resident Travel Scholarship for the ASCP Annual Meeting in Chicago for September to present his abstract poster, “Intravascular leiomyomatosis: an unusual case of inferior vena caval (IVC) filter involvement”
Dr. Barbara Nikolajczyk will join the University of Kentucky on Oct 1 2017 as Associate Director of Translational Science in the Barnstable Brown Diabetes and Obesity Research Center, and Associate Professor of Pharmacology and Nutritional Sciences
Dr. Barbara Slack has been reappointed as a member of the Boston University Institutional Biosafety Committee (IBC) through June 30, 2020
Dr. Barbara Slack has been reappointed as a member of the Boston University Institutional Biosafety Committee through June 30, 2020
Dr. Israa Laklouk presented an oral platform presentation abstract at the 29th European Congress of Pathology in Amsterdam on September 6th, “Predictive Accuracy of Thyroseq v2 for Malignant Thyroid Nodules Among Bethesda-III Cytology Subcategories: Atypia of Undetermined Significance (AUS) And Follicular Lesion of Undetermined Significance (FLUS)” Israa Lakloud, Mahmoud Soliman, Dhay Kamel, Huihong Xu, Sandra Cerda
Sandra Cerda, MD is the new Secretary for the NEW ENGLAND SOCIETY OF PATHOLOGISTS, INC.
Alpha Omega Alpha (AOA) is the only national honor medical society, and it is organized exclusively for educational purposes. Its aims are the promotion of scholarship and research in medical schools, the encouragement of high standards of character and conduct among medical students and graduates, and the recognition of high attainment in medical sciences, practice, and related fields. Its motto is: “Be worthy to serve the suffering.” We look forward to the students participating in an energetic Chapter that is a vital part of our campus. A formal induction ceremony will be held in the spring; meanwhile, please join us in congratulating the inductees. Our own MD/PhD Terry Hsieh, who did his PhD research in the Remick Lab is a newly installed member
Max Vaickus, graduated Masters Student – May 2017, receiving his Travel Award for his Young Investigator’s Presentation at the 40th Annual Conference on Shock this past June down in Ft. Lauderdale, Florida. Max’s talk was titled: “Augmented Pseudomonas aeruginosa clearance occurs through mild traumatic brain injury induced gene expression changes”
Max, SHOCK President, Dr. Ping Wang and Dr. Daniel Remick at the 2017 Shock Awards dinner
Resident, Roghayeh Fazeli, MD presented a poster at the 65th Annual Scientific Meeting of the American Society of Cytopathology in Phoenix AZ November 10-13, 2017: “Impact of ThyroSeq v2 Testing on The Clinical Management of Patients with Indeterminate Thyroid Nodules by Fine Needle Aspiration.” Roghayeh Fazeli, MD, Huihong Xu, MD, David Kindelberger, MD, Sandra Cerda, MD
Dr. Karen Quillen was the Honored Robbins Lecture Guest Speaker at this year’s New England Society of Pathologists Annual Event on Tuesday, November 14, 2017
Residents Dr. Andrey Prilutskiy and Dr. Reyhan Gedik
Ding Y, Francis JM, Gautam A, Pelletier L, Sanchorawala V, Quillen K. Durable renal response after combination bortezomib, corticosteroids, and plasmapheresis for chronic antibody-mediated renal transplant rejection. Clinical Nephrology
Gregory Hall, Shinichiro Kurosawa, Deborah J. Stearns-Kurosawa. Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel) Toxins 2017, 9(9), 291; doi:10.3390/toxins9090291. In pres
Israa Laklouk, MD, Mahmoud L. Soliman, MD, PhD, Robert W. Pistey, MD, Sandra R. Cerda, MD; Primary unresectable locally invasive biatrial paraganglioma presenting with chest pain. Human Pathology March 2018
Lei Li, MD PhD; Sandra Cerda, MD; David Kindelberger, MD; Jing Yang, MD PhD; Carmen Sarita-Reyes, MD “Isolated Acrania in the Presence of Amniotic Band Syndrome;” North American Journal of Medicine and Science; Jul 2017 Vol 10 No.3; pages 100-102
Seble Aregawi – (Microbiology Medical Technologist II) – along with Dr. Lei Li and Dr. Caterina Miraglia had a recently published paper “Malaria rapid diagnostic test and Giemsa” in Clinical Laboratory Science, Spring, 2017
Olivia Chavez, a PiBS who rotated in Dr. Ivana Delalle’s Lab this spring, was productive enough to obtain authorship on our recent publication in Journal of Alzheimer’s Disease: https://preview.ncbi.nlm.nih.gov/pubmed/28777754
Leibler JH, León C, Cardoso LJP, Morris JC, Miller NS, Nguyen DD, Gaeta JM. Prevalence and risk factors for MRSA nasal colonization among persons experiencing homelessness in Boston, MA. J Med Microbiol. 2017 Aug 04. PMID: 28771129
N Woolf, B E Pearson, P A Bondzie, R D Meyer, M Lavaei, A C Belkina, V Chitalia and N Rahimi. Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy. Oncogenesis (2017) 6, e378; doi:10.1038/oncsis.2017.77 http://www.nature.com/oncsis/journal/v6/n9/full/oncsis201777a.html?foxtrotcallback=true
Pathology & Laboratory Medicine News Items – June/July 2017
- One of our recently Defended MD/PhDs, Nisma Mujahid, PhD, first authored paper came out in Cell Reports on Tuesday (6/13/2017) (please find details below), and it’s gotten a press. Nisma’s paper’s been featured in BBC (front page Health News), Time, Science, ScienceMag, Smithsonian…among others. http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30684-8 http://www.bbc.com/news/health-40260029
- Sandra Cerda MD, was invited as a guest speaker and scientific session Chair and moderator at the “3rd International Conference on Cytopathology & Histopathology” that took place in Philadelphia on June 22-23. Theme “Transforming the Future of Cytopathology & Histopathology”
- Reyhan Gedik, MD presented a poster at ACLPS 2017 Annual Meeting, June 15-17, 2017 in New Haven, CT. Her poster title was “Computerized Approach to Antibody Identification in Pre-transfusion Testing”
- Dr. Ivana Delalle has accepted an invitation to become an Associate Editor in Journal of Alzheimer’s Disease
- Dr. Delalle has also been invited to give a talk on her research at Molecular Pathology seminar series at Johns Hopkins Medical School
- Dr. Daniel Remick was invited to speak at the Association of Pathology Chairs annual meeting at the new chairs bootcamp. The title of his talk was “The Unique Leadership Challenges in the Pathology Research Mission”
- Dr. Daniel Remick became the President of the American Society of Investigative Pathology on July 1, 2017. He will serve for a one year term
- Dr. David Sherr and his team resubmitted their competitive renewal for the BU Superfund Research Center and were awarded a $3,500,000 grant over 2.5 years; http://www.bu.edu/sph/research/research-landing-page/superfund-research-program-at-boston-university/
- Resident Israa Laklouk, MD submitted abstract entitled “Predictive accuracy of thyroseq v2 for malignant thyroid nodules among Bethesda-III cytology subcategories: Atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS)” has been accepted as an Oral Presentation and will be part of the Scientific Programme during the 29th European Congress of Pathology to be held in Amsterdam, The Netherlands. The authors list: Israa Laklouk, MD; Mahmoud Soliman MD, PhD; Dhay Kamel ,MD; Huihong Xu, MD; Sandra Cerda, MD
- Please Welcome our New Residency Coordinator Daphney Noel! Daphney comes to us via Brigham and Women’s Hospital. In her recent position as a program coordinator at BWH’s Center for Faculty Development and Diversity Daphney was responsible for planning and arranging programs in support of the faculty and research community. Daphney graduated from Colby-Sawyer College with a BA in History and hopes to get her MS of education in counseling
- 2017 Graduation Celebration was held this year at Cinquecento Restaurant; Congratulations to All!!
|n BU-CTSI Spring 2017 Pilot Awardees|
|Boston University Clinical and Translational Science Institute (BU-CTSI) is pleased to announce the recipients of the Spring 2017 Integrated Pilot Grant Program. This cycle we received 47 applications, 22 applicants were awarded, including 12 deferred from fall 2016. Each awardee received $20,000 in funding . The CTSI would like to recognize the faculty who reviewed the applicants and offer our sincere thanks for their time and efforts.
The purpose of the Integrated Pilot Grant Award mechanism is to stimulate scientific discovery in all areas of basic or translational research related to the prevention, diagnosis, and management of human disease.
The Department of Pathology and Laboratory Medicine launched a series of initiatives to increase scholarly activity and increase grant funding. These initiatives arose from the strategic planning process. The Department was recently asked to provide information about specific faculty development programs, and we provided the information below.
- Writing workshops. A 9 part series of workshops were presented on how to prepare a manuscript. Topics included using bibliography and graphing software, writing an abstract and selecting the most appropriate journal for the manuscript etc. Faculty involved included Daniel Remick, M.D., and Shinichiro Kurosawa, M.D., Ph.D.
- Manuscript accelerator sessions. These sessions are held each week with the intent of accelerating the completion of manuscripts. Participants (grad students, fellows, junior faculty etc.) participate in a 4 part series by bringing different portions of the manuscript to the session. The senior faculty member at the session serves more as an editor than actual reviewer of the manuscript. A 2017 survey of the faculty showed that 82% of the respondents felt these accelerator sessions should be continued. The faculty involved included Drs. Sharon, O’Brien, Kurosawa, Stearns-Kurosawa, Remick, Panchenko and others.
- Internal grant reviews. During each grant review cycle the Department offers internal review of grant submissions. Faculty send in their abstract and specific aims page, and another faculty member is assigned as the reviewer. This initiative has just been started, so it is too early to track success in a systematic manner. However, at least 2 CTSI grants, a Dahoud biobank and Shipley Prostate biobank study have been funded after internal review.
- Publications ACCEPTED:
- Parul Agnihotri, Nicholas M. Robertson, Sarah E. Umetsu, Ksenia Arakcheeva and Susan Winandy; Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells. Accepted for publication in Immunology
- Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, and Delalle I: Methionine sulfoxide reductase-B3 (MsrB3) protein associates with synaptic vesicles and its expression changes in the hippocampi of Alzheimer’s disease patients. Accepted for publication in the Journal of Alzheimer’s Disease
- Agis-Balboa RC, da Silva Pinheiro PC, Rebola N, Kerimoglu C, Benito E, Gertig M, Bahari-Javan S, Jain G, Burkhardt S, Delalle I, Jatzko A, Dettenhofer M, Zunszain P, Schmitt A, Falkai P, Pape J, Binder E, Mulle C, and Sananbenesi F: Formin 2 links neuropsychiatric phenotypes at young age to an increased risk of dementia. Accepted for publication in EMBO Journal, June 27, 2017
- Publications PUBLISHED:
- Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher; A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Reports, Volume 19, Issue 11, p2177–2184, 13 June 2017
- Yang JH, Siroky MB, Yall SV and Azadzoi KM: Mitochondrial Stress and Activation of Phosphoinositol 3 Kinase (PI3K) and Protein Kinase B (Akt) Survival Pathway in Bladder Ischemia. Res Rep Urol 2017, June 10, 9:93-100
- Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging. Comprehensive Physiology (In Press).
- Agrawal, M, Kern, PA, Nikolajczyk BS. The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths. Current Diabetes Reports (In Press
Pathology & Laboratory Medicine News Items – April/May 2017
A Mallory grant “The Utility of Ki-67 and Phosphohistone H3 in the Differentiation Between Classic Papillary Thyroid Carcinoma, Follicular Variant of Papillary Thyroid Carcinoma and Non-invasive Follicular Neoplasm with Papillary-like Nuclear Features” was funded. This will support the work of Drs. Jing Yang, Cerda and Tan.
The T32 training grant, T32GM086308 “Immunobiology of Trauma” was funded for an additional 5 years with a budget of $1,401,170. This grant provides salary support for BMC residents to engage in basic science research full time for two years. Daniel Remick, M.D. is the principal investigator.
Max Vaickus, graduating Masters student had his abstract accepted for the 40th Annual Conference on SHOCK in June in Fort Lauderdale, Florida. His abstract title is: “Mild traumatic brain injury induces genetic changes in mouse lung to augment Pseudomonas aeruginosa clearance”
Max also received a Travel Award of $1000 to attend the SHOCK Conference
On Behalf of Dr. Barbara Slack, Pathology Department Russek Awards Committee
- I am pleased to announce that this year’s H.I. Russek Student Achievement Award recipients in the Department of Pathology and Laboratory Medicine are:
- First Prize -Stephanie Adams (Delalle lab)
- Second Prize – Elizabeth Moses (Spira-Lenburg lab)
- Third Prize – Nisma Mujahid (Fisher lab, MGH)
- Congratulations to the award winners, and thank you to everyone who submitted abstracts for the poster session. Russek Day was held on Friday, April 21st in the Hiebert, The keynote speaker this year was Dr. Carla Shatz, Professor of Biology and Neurobiology at the Stanford Neurosciences Institute https://www.bumc.bu.edu/gms/students/phd/23rd-annual-henry-i-russek-student-achievement-day-april-21/
- I would also like to thank Dr. Rahimi, Dr. Andry, and Dr. Stearns-Kurosawa, for serving on the departmental Russek committee this year.
Richard Kozak retired April 30th after 38+ years in the Clinical Microbiology Laboratory; thank you!
For Nancy S. Miller, MD:
- Was an invited speaker at a full-day Medical Mycology Workshop presented at the 2nd joint meeting of the Northeast Association for Clinical Microbiology and Infectious Disease (NACMID) and Northeast Branch-American Society for Microbiology (NEBASM), April 3, 2017, Wakefield, MA
- An invited guest also for, “Micro meets multiplex: A case-based view of syndromic panel testing”, presented at the Syndromic Testing Symposium, April 6 in Burlington, MA
- Dr. Miller will present a Meet-the-Experts session at ASM Microbe 2017 on June 5th, at the international conference of the American Society for Microbiology June 1-5 in New Orleans. Session Title: “Who knew? And what to do? Tales from the benches and trenches.”
It was Medical Laboratory Professionals Week April 23 -28!! Activities included:
- Some of the Lab Areas had breakfast and lunches for staff throughout the week
- There were two Luncheon Seminar Talks with Pizza
- Cake and Ice Cream on Friday Dessert Day, April 28th for everyone
- Staff were allowed to wear jeans if they donated $2 to a BMC Fund we raised $150 going to pieces of home back pack project at BMC which serves children who are in foster care
- Thank you one & all!!!!
Nisma Mujahid, MD/PhD (Off-Site at MGH, David Fisher Lab) successfully defended her Thesis, “The LKB1-SIK Pathway: Dysregulation in Melanomagenesis and Regulated Use in Skin Cancer Prevention” on May 1st, 2017. HOORAY!!
Stephanie Adams, OD/PhD (Blusztajn/Delalle Lab) successfully defended her Thesis, NEURONAL PHENOTYPES IN HUMAN HIPPOCAMPUS AND NEOCORTEX IN LATE-ONSET ALZHEIMER’S DISEASE: PROTEIN EXPRESSION OF NOVEL GENES IMPLICATED IN PATHOGENESIS” on May 1st, 2017. HOORAY!!
Caitlin Miller, PhD (Gummuluru Lab) successfully defended her Thesis, “Role of viral protein R in infection of human dendritic cells by primate lentiviruses” on May 9th 2017. HOORAY!!
Dr. Daniel Remick was invited to the 9th Wiggers-Bernard Conference at the Ludwig Bolzmann Institute in Vienna, Austria the first week of May. He chaired the working group on defining organ injury in pre-clinical models of sepsis
Dr. Remick also presented a proposal to Wacker Biosolutions in Munich Germany for Boston University. The proposal would potentially fund a student at either the undergraduate or medical campus
Barb Nikolajczyk, PhD participated in the IMMUNOLOGY 2017TM Capitol Hill Day held on May 16 in conjunction with the Annual Meeting of the American Association of Immunologists. She was one of a contingent from MA who met with staff of Representatives from MA Districts 2 and 7 and both Senators to promote a consistent and robust increase in NIH and other science funding “over the long haul”. Check out #AAIHillDay on Twitter to see more.
Daniel Remick was invited to speak at the American Thoracic Society’s annual meeting in Washington DC. His presentation was titled “Heterogeneity in the Septic Inflammatory Response”
Dr. Ivana Delalle is pleased to report that she will give a platform presentation entitled “Expression of MSRB3, Implicated in Decreased Hippocampal Volume, Changes in Alzheimer’s Disease and Associates With Synaptic Vesicles” on June 9 at the Annual Meeting of American Association of Neuropathologists in Orange County, CA.
Dr. Nikolajczyk was invited to give a seminar at East Carolina University, EDCOI Center, Greenville, NC, Mechanisms Driving Inflammation in Human Obesity and Type 2 Diabetes, 2017.
- Masters Degrees:
- Keith Keller, MS
- Denis Kyabaggu, MS
- Carolina Lyon de ana, MS
- Morgan Thompson, MS
- Max Vaickus, MS
- Stephanie Adams, PhD/OD
- Liz Moses, PhD – Liz by the way was the PhD Commencement Speakers, BRAVO LIZ!!!!
- Jessica Ritter, PhD
Pathology Residency Completed: (Photos to come next issue)
- Cecilia Ponchiardi, MD
- Dhay Kamel, MD – from the Cytopathology Program
Nancy L.R> Bucher, MD; Celebration of Life & Legacy
- On Thursday, May 4th the department, friends and family gathered to celebrate and honor the remarkable life and legacy of Professor Nancy L.R. Bucher of Harvard Medical School and Boston University School of Medicine. Dr. Bucher was a pioneer in liver regeneration studies and hepatocyte cultures. Dr. Bucher was a Fellow of the American Association for the Advancement of Science as well as the American Academy of Arts and Sciences. She also received The Distinguished Scientific Achievement Award from the American Liver Foundation.
- Miller, C.; Akiyama, H.; Agosto, L.; Emery, A.; Ettinger, C.; Swanstrom, R.; Henderson, A.; Gummuluru, S. Virion associated Vpr alleviates a post-integration block to HIV-1 infection of dendritic cells. Journal of Virology. 2017
- Li, L., A. Gautam and N.S. Miller. Actinomyces neuii, An Uncommon Bacterial Isolate from a Neck Abscess. Accepted for publication April 10, 2017, Internal Medicine Review
- Bi B, Li F, Guo J, Li C, Jing R, Lv X, Chen X, Wang F, Azadzoi KM, Wang L, Liu Y, Yang JH. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. Neuroscience. 2017 Mar 21;351:84-95. doi: 10.1016/j.neuroscience.2017.03.023. [Epub ahead of print] PMID: 28341197
- Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH. Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle. 2017 Apr 3;16(7):649-659. doi: 10.1080/15384101.2017.1281481. Epub 2017 Jan 19. PMID: 28103160
- Bharath, LP, Ip, B, Nikolajczyk BS. 2017. Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging (In Press, Comprehensive Physiology)
- Sanaz Bahari-Javan, Hristo Varbanov, Rashi Halder, Eva Benito, Lalit Kaurani, Susanne Burkhardt, Heike Anderson-Schmidt, Ion Anghelescu, Monika Budde, Roman M. Stilling, Joan Costa, Juan Medina, Detlef E. Dietrich, Christian Figge, Here Folkerts, Katrin Gade, Urs Heilbronner, Manfred Koller, Carsten Konrad, Sara Y. Nussbeck, Harald Scherk, Carsten Spitzer, Sebastian Stierl, Judith Stöckel, Andreas Thiel, Martin von Hagen, Jörg Zimmermann, Antje Zitzelsberger, Sybille Schulz, Andrea Schmitt, Ivana Delalle, Peter Falkai, Thomas G. Schulze, Alexander Dityatev, Farahnaz Sananbenesi, and André Fischer; “HDAC1 LINKS EARLY LIFE STRESS TO SCHIZOPHRENIA-LIKE PHENOTYPES” PNAS 2017 ; published ahead of print May 22, 2017, doi:10.1073/pnas.1613842114
Pathology & Laboratory Medicine News Items – February/March 2017
- Our Resident, Israa Laklouk, MD had the following abstract ” Diagnostic Implication of ThyroSeq Sequencing Assay on Thyroid Nodules with FNA Cytology Diagnosis of Bethesda III: Atypia of Undetermined Significance versus Follicular Lesion of Undetermined Significance ” authors: Israa Laklouk, Mahmoud L Soliman, Dhay Kamel, Huihong Xu, Sandra Cerda; selected for a Poster Presentation at the United States & Canadian Academy of Pathology’s (USCAP) 106th Annual Meeting, March 4 – 10, 2017 in San Antonio, Texas http://viewer.zmags.com/publication/84c2f7ae#/84c2f7ae/10
- Lawreen H. Connors, PhD and Frederick L. Ruberg, MD presented “Transthyretin-associated (ATTR) cardiomyopathy: A not uncommon, rare disease” at BUSM Department of Medicine Medical Grand Rounds on Feb. 17, 2017 https://echo360.bu.edu:8443/ess/echo/presentation/66b063a7-a6f2-4ef9-8957-81e40ec68bb3
- Carolina Lyon de Ana, a current Masters student in Dr. Susan Winandy’s Lab and Bo Shao, a technician with Dr. Maria Panchenko’s Lab were both accepted into BU’s PhD PIBS Program! Congratulations!!
- Dr. Ivana Delalle News:
- On March 24 Dr. Delalle gave an invited lecture at the Croatian Institute for Brain Research (CIBR) on “The brain expression of novel genes implicated in AD and low hippocampal volume”
- She also presented her group’s latest work at AD/PD International Meeting in Vienna, March 29 – April 2: “Protein expression of low hippocampal volume- associated risk allele candidate MSRB3 in AD” by Stephanie L Adams1, Laurent Benayoun1, Jayandra J. Himali2,3, Kathy Tilton1, Sudha Seshadri2,3, and Ivana Delalle1,3. 1Pathology, Boston University School of Medicine; 2Framingham Heart Study, Boston University School of Public Health; 3Neurology, Boston University School of Medicine
- Dr. Delalle has also been invited to give a talk at the 3rd Annual Next Generation Sequencing & Single Cell Analysis Congress, scheduled for 23 – 24 October 2017 in Boston. The title of her talk will be: “Extracellular vesicles microRNA (EV miRNA) as Bipolar Disorder (BD) Biomarkers”, based on her senior author paper published ahead of print on February
- Jessica (Allen) Ritter, PhD (Caroline Genco Lab) successfully defended her Thesis, “Induction of Human Macrophage Cell Death by Neisseria gonorrhoeae” on March 10th, 2017. BRAVO!!
- Elizabeth Moses, PhD (Spira/Lenburg Lab) successfully defended her Thesis, “Characterizing the Airway Epithelium following Chemical Exposure: Molecular Alterations and their Potential Utility in the Treatment of Lung Disease” on March 21st, 2017. HOORAY!!
- News for Dr. Barbara Nikolajczyk:
- Dr. Nikolajczyk gave a talk at the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
- She also presented for The Hormel Institute, University of Minnesota, Austin, MN, Defining Inflammation in Human Obesity and Type 2 Diabetes, 2017
- Dr. Nikolajczyk also received a Grant Title; “Does salt drive a human immune profile in a mouse model of obesity?” from the Boston University Nutrition and Obesity Research Consortium
- Dr. David Sherr along with Dr. Stefano Monti and presenting work of Amy Li, gave an invited talk at the Clinical and Translational and Sciences Institute Symposium about development of a high throughput genomic platform to identifying which of the 84,000 chemicals in our environment are carcinogens.
- Nancy S. Miller, M.D. – was invited to teach a webinar for Rutgers, The State University of New Jersey, School of Health Professions , Department of Clinical Laboratory Sciences, on March 27 “Improved technology for microbial identification: challenges and lessons learned”
- Welcome New Residents!:
- Marianinha Joanes
- International American University
- Iiyas Yambayev
- Kazakh National Medical University
- FASEB Capitol Hill Day 2017
- On March 9, 2017 scientists from across the country gathered in Washington D.C. to participate in the Federation of American Societies for Experimental Biology (FASEB) Capitol Hill day. The purpose of the day was to advocate for federal funding for research, which includes the National Institutes of Health, National Science Foundation, Centers for Disease Control and other agencies.
- The group met with congressional staff from the offices of our Representatives and Senators. During these meetings we emphasized the importance of research funding that drives scientific discoveries by sharing individual stories. We also emphasized how these scientific advances improve the care of patients and health of the nation. Information was provided about the positive economic impact of NIH and NSF funding for each state and congressional district.
- Our specific request was to have research funded to the full amount in the 2017 budget. Since the federal government currently operates under a continuing resolution, NIH has been withholding 10% from grants until the budget has been finalized.
- The Massachusetts representatives all strongly supported research funding. However, they were also pessimistic given the current political climate in Washington DC, even though there is strong bipartisan support for research.
- This pessimism was justified when the White House released the first version of their budget, which calls for cutting the NIH budget by $5.8 billion, or 18%.
- The Massachusetts delegation included Laura Coleman representing the American Society for Nutrition, Shoumita Dasgupta and Daniel Remick from Boston University School of Medicine and Boston Medical Center, Ming Ming Ning from Massachusetts General Hospital and Hanno Steen from Boston Children’s Hospital and Harvard Medical School. Derek Scholes the Director of Scientific Policy for the American Society of Human Genetics escorted us throughout the day.
- Publications ACCEPTED:
- Leena P. Bharath, Blanche C. Ip, Barbara S. Nikolajczyk Manuscript accepted into: “Adaptive immunity and metabolic health: harmony becomes dissonant in obesity and aging” Comprehensive Physiology
- Woodworth, M., E.M. Neish, N. S. Miller, Tanvi Dhere, E.M. Burd, Cynthia Carpentieri, K. L. Sitchenko, and C.S. Kraft. Laboratory Testing of Donors and Stool for Fecal Microbiota Transplantation for Recurrent C. difficile Infection. Journal of Clinical Microbiology. Epub ahead of print 2017 Jan 11. doi:10.1128/JCM.02327-16. PMID: 28077694.
- Publications PUBLISHED:
- Chan GG, Koch CM, and Connors LH: Blood proteomic profiling in inherited (ATTRm) and acquired (ATTRwt) forms of transthyretin-associated cardiac amyloidosis. J Proteome Res. 2017 Feb 14. doi: 10.1021/acs.jproteome.6b00998. [Epub ahead of print] PMID: 28196416
- Arvanitis M, Koch CM, Chan GG, Torres-Arancivia C, LaValley MP, Jacobson DR, Berk JL, Connors LH, Ruberg FL: Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model. JAMA Cardiol. 2017 Feb 8. doi: 10.1001/jamacardio.2016.5864. [Epub ahead of print] PMID: 28196196
- Wang Z, Monti S, DH S. The diverse and important contributions of the AHR to cancer and cancer immunity. Curr Opinion Toxicol. 2017 ;http://www.sciencedirect.com/science/article/pii/S2468202016300365
- Blandine Bustamante Helfrich, MD, MPH, Nymisha Chilukuri, BSc, Huan He, PhD, MHS, MMgt, Sandra R. Cerda, MD, Xiumei Hong, MD, PhD, Guoying Wang, MD, PhD, Colleen Pearson, BA, Irina Burd, MD, Xiaobin Wang, MD, MPH, ScD. “DOI:Maternal vascular malperfusion of the placental bed associated with hypertensive disorders in the Boston Birth Cohort” http://dx.doi.org/10.1016/j.placenta.2017.02.016
Pathology & Laboratory Medicine News Items – December 2016/January 2017
- The Pathology Residency and Cytopathology Fellowship Programs, are proud to announce the ACGME’s decision for the Continued Accreditation for both programs. Congratulations and thanks to everyone for a job well done!
- A recently published paper from the Rahimi Lab in the Journal of Molecular Biology was featured on the cover of the journal (http://www.journals.elsevier.com/journal-of-molecular-biology/cover-gallery/cover-of-volume-428-issue-24b). Walter Wang (MAMS Student) and Philip Bondzie (former PhD student & postdoc) were the co-first authors of the paper. The paper was also featured in the F1000prime (http://f1000.com/prime/ext/726966815?referrer=GOOGLE). The papers recommended by the F1000 faculty for biology and medicine are considered the most important papers in the field.
- Dr. Grace Zhao reported; “Congratulations, your Mallory Project is approved with a total budget of $6925. The approved budget is over the budget cap of $5000 because of the potential to expand the IHC list of stains within the Department”
- Dr. Deborah Stearns-Kurosawa was invited to be a member of the scientific steering committee for the 10th International Symposium on Shiga Toxin (Verocytotoxin) Producing E.coli Infections (VTEC 2018) to be held in Florence, Italy in May 2018
- Dr. Carmen Sarita-Reyes’s Mallory Proposal has been approved. The Department has provided funds for two medical students to participate in the 8 summer fellowship through the Mallory funds
- Dr. Barbara Nikolajczyk presented at the following:
- Endocrinology Grand Rounds, Boston University School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, November 14 2016
- Endocrinology Grand Rounds, University of Massachusetts School of Medicine, Defining Inflammation in Human Obesity and Type 2 Diabetes, December 13, 2016
- Dr. Daniel Remick presented in December:
- Grand Rounds Speaker, Yale School of Medicine, Department of Pathology, “Traumatic Brain Injury Augments Host Defenses”
- Grand Rounds Speaker, Boston Medical Center, Department of Internal Medicine, “Sepsis: A Moving Target”
- Dr. Daniel Remick in January:
- The Houston Methodist Hospital held their first Annual Pathology Research Day on Saturday, January 14th. First year pathology residents presented posters and the upper year residents and fellows each gave 5-7 minute presentation on their projects. Dr. Remick was the Keynote Speaker and gave the talk “Mild Traumatic Brain Injury Augments Innate Immunity”
- Jason Sutin, PhD (Off-Site at MGH Franceschini Lab) successfully defended his Thesis, “Development of a Novel Diffuse Correlation Spectroscopy Platform for Neuromonitoring Cerebal Blood Flow and Oxygen Metabolism: From Novel Concepts and Devices to Preclinical Live Animal Studies” Fall 2016, BRAVO!!
- Barbara Nikolajczyk, PhD received a $20,000.00 grant titled “Inflammation in type 1 diabetes” from Boston University CTSI
- Dr. Nikolajczyk will also be a reviewer on two NIH panels in Feb:
- Cellular Aspects of Diabetes and Obesity Study Section, Ad-hoc (2017)
- NIDDK Fellowship and Conflict Study Section, Ad-hoc (2017)
- New People:
- The Nikolajczyk Lab has added Joseph Lee, Masters in Nutrition student
- Publications ACCEPTED:
- Mahmoud L Soliman, MD PhD, Ashish Tiwari, MD, Grace Zhao MD, PhD “Coexisting tubular adenoma with a high-grade neuroendocrine carcinoma of colon allowing early surgical intervention and implicating a shared stem cell origin.” The World Journal of Gastroenterology
- Li C, Wang D, Lv X, Jing R, Bi B, Chen X, Guo J, Wang F, Sun S, Azadzoi KM, Yang JH: Yersinia pestis acetyltransferase-mediated dual acetylation at the serine and lysine residues enhances the auto-ubiquitination of ubiquitin ligase MARCH8 in human cells. Cell Cycle (accepted for publication)
- Nicholas DA, Proctor EA, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA and Nikolajczyk BS. 2017. Advances in the Quantification of Mitochondrial Function in Primary Human Immune Cells through Extracellular Flux Analysis (Accepted, PLOS ONE)
- Publications PUBLISHED:
- Mahmoud L. Soliman, Sandra R. Cerda and Huihong Xu; “Invasive Moderately-Differentiated Mucinous Adenocarcinoma Incidentally Identified in Perforated Acute Diverticulitis With Abscess Formation.” In press in the Pathology and Laboratory Medicine Open Journal
- Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD and Perissi V. 2017. Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell developments (In Press J Biol. Chem).
- The Department’s strategic plan included increasing our academic stature. To achieve this the guidelines for Mallory Research Projects were sent to the faculty. There was an excellent response and the following Mallory proposals were funded in the Fall of 2016.
- Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
- Drs. Panchenko, O’Brien and Tan
- Defining gene programs regulated by Ikaros in T cells
- Drs. Winandy and Lee
- Validation of Maspin/VHL immunostain for distinguishing carcinoma from reactive atypia in pancreas
- Drs. Tan, Yang, and Zha
- Local Release of Substance P after mild traumatic brain injury primes the host to survive a subsequent pathogen challenge
- Drs. Remick and Kim
- Cell cycle regulator JADE1 protein: a novel marker of colon cancer in humans
Pathology & Laboratory Medicine News Items – November 2016
- Dr. Shinichiro Kurosawa has been reappointed to the Boston University Laboratory Safety Committee. The term of his appointment is through December 31, 2018
- Dr. Chris Andry has had his appointment extend as Chair of the Boston University Laboratory Safety Committee. The term of his extension is through December 31, 2018
- Jacquelyn Sikora Hanson, PhD (Lawreen Connors Lab) successfully defended her Thesis, “Transthyretin gene regulation in wild-type transthyretin amyloidosis” on November 21st, 2016, BRAVO!!
- Dr. Sikora Hanson’s Defense Dissertation
- Jacquelyn’s Thesis Committee: Dr. Vickery Trinkaus-Randall,
- Dr. Lawreen Connors (PI), new Dr. Sikora Hanson and Dr. David Sherr
- Dr. Jacquelyn Sikora Hanson and her proud family
- Shark Tank Winners. The Cancer Center held a retreat on November 29th that featured a “Shark Tank” styled competition for research funds. Prior to the retreat faculty were asked to submit brief proposals and the top 4 proposals were selected for presentation. During lunch each group had 5 minutes to make their pitch to the Sharks on the expert panel. David Sherr and Dan Remick submitted a proposal AHR Inhibitors as Novel Immune Checkpoint Inhibitors. Their idea was selected as the winner. Portions of the funds will be used for processing specimens in the Ex+.
- Hot Off the Presses: The manuscript below has been accepted for publication in Neuropsychiatric Genetics. While the first four authors worked in Dr. Ivana Delalle’s laboratory, it is really a multi-institutional effort that Dr. Delalle was fortunate to lead. “Exosomal miR-149 and miR-29c as Candidates for Bipolar Disorder Biomarkers” by Jason L. Choi1, Patricia F. Kao1, Elena Itriago1, Yougen Zhan1, James A. Kozubek2, Andrew G. Hoss3, Meredith G. Banigan4, Charles R. Vanderburg4, Amir H. Rezvani5, Jeanne C. Latourelle3, Howard Cabral6, and Ivana Delalle1#; 1Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118; 2Broad Institute, Cambridge, MA 02142; Brigham and Women’s Hospital, Boston, MA 02112; 3Department of Neurology, Boston University School of Medicine, Boston, MA 02118; 4Advanced Tissue Resource Center, Harvard NeuroDiscovery Center, Charlestown, MA 02129; 5Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710; 6Department of Biostatistics, Boston University School of Public Health and Boston University Clinical and Translational Science Institute, Boston, MA, 02118
- Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM, Costello CE, Rahimi N. IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol. 2016 Nov 9. pii: S0022-2836(16)30472-7. doi: 10.1016/j.jmb.2016.11.003. [Epub ahead of print]
The Department has been actively engaged in biobanking initiatives for several years. These important biobanking projects provide specimens to several investigators to help understand the basic mechanisms of disease. Banking these specimens also honors the patients’ wishes to provide tissue for research.On behalf of the patients who donated biospecimens, and investigators who use the biospecimens, thank you. Your efforts ensure that pathology provides high quality biospecimens.Here is the impressive list of current and recent projects, including the pathology personnel that are participating in each project.
Biobanking grants in Pathology and Laboratory Medicine
- 2016-2018: Thrombosis in Cancer Patients (TCP). Pre-analytic Variables that May Impact Standardization,
- NCI. Contract award HHSN261200800001E – $1.4M total cost
- PI: Dr. Andry.
- Co-I: Drs. Stearns-Kurosawa, Kurosawa, Henderson, Sloane, & Ms. Duffy, Sun
- Other personnel: Cheryl Spencer, Morgan Thompson
- 2016-2017: Boston Medical Center Biospecimen Source Site for the Clinical Proteomic Tumor Analysis Consortium (CPTAC)
- NCI contract HHSN261201600011I – $89,229.07.
- PI: Dr. Andry
- Co-I: Henderson
- Other personnel: Spencer, Kim, Chen
- 2011-2017: Detection of Early Lung Cancer Among Military Personnel (DE-CAMP), pulmonary
- Department of Defense W81XWH-11-2-0161 – $2,378,826
- PI: Avrum Spira, M.D.
- Co-I: Remick, Pistey
- Other personnel: Spencer
- 2016-present: Framingham Heart Study Biospecimen Core
- Lab Director – Dr. Henderson
- 2014-2016: Biospecimen Source Site for Cancer Human Biospecimens (caHUB).
- NCI. Biospecimen Preanalytical Variables Program 11XS1007T1 – $332,508
- Co-I: Drs. Pistey, Henderson
- Other personnel: Spencer, Duffy
- 2014-2015: Biospecimen Source Site for the National Disease Research Interchange (NDRI)
- Biospecimen procurement contract – $14,600
- PI: Dr. Andry
- Other personnel: Bondzie, Spencer
- 2013-2015: Tissue Source Site for The Cancer Genome Atlas Project (TCGA)
- NCI. Initial Task Order 13XS114 – $15,350
- PI: Dr. Andry
- Co-I: Henderson
- Other personnel: Spencer, Mei Cao
Pathology & Laboratory Medicine News Items – October 2016
- Nancy S. Miller, MD led a discussion and tour of the BMC Clinical Microbiology Laboratory for participants of the International Infectious Disease Symposium, October 13, The tour was part of a 3-day BUSM CME conference on Emerging Infectious Diseases that hosted pulmonologists and infectious diseases physicians visiting from the Middle East.
- Miller, MD was the ASM Distinguished Lecturer at the Fall Meeting of the Western New York branch of the American Society for Microbiology, Buffalo, NY, October 25, 2016. Her topic was diagnostic clinical mycology: “Fungal Fest: Challenges, conundrums, and lessons learned.”
- Barb Nikolajczyk, PhD presented her team’s work entitled “Identity and Mechanisms of Inflammation in Human Obesity and Type 2 Diabetes” at Memorial Sloan Kettering Cancer Center, NYC, on October 24, 2016
- Daniel Remick, MD, organized a workshop for the 8th International Congress of the International Federation of Shock Societies held October 3 – 5 in Tokyo, Japan. The workshop was titled: Immunopathology of Traumatic Brain Injury.
- Remick also gave a presentation: “Mild Traumatic Brain Injury but not Tail Trauma Augments Pulmonary Clearance of Substance P”
- Daniel Remick, MD, was also invited to give a presentation at the 8th International Congress of the International Federation of Shock Societies in Tokyo, Japan titled: “Understanding the Heterogeneity of the Host Response to Infection May Direct Therapy”
- Mostafa Belghasem, PhD presented two posters at BU’s Annual Evans Days 2016 Meeting, October 13 & 14, 2016:
- “Aryl Hydrocarbon Receptor signaling is an in vivo targetable antithrombotic pathway and it correlates with thrombosis in humans” Mostafa Belghasem, Moshe Shashar, Jamaica Siwak, Faisal Alousi, Joel Henderson, Anqi Zhang, Jean Francis, Vijaya B. Kolachalama, Vipul Chitalia.
- “CHIP: A Novel Target For Thrombosis” Moshe Shashar, Mostafa Belghasem, Shinobu Matsuura, Faisal Alousi, Keshab Raji, Jean Francis, Vijaya Kolachalama, Joel Henderson, Mercedes Balcells, Kumaran Kolandaivelu, Katya Ravid, Vipul Chitalia
- Keith Keller, Masters Student in the Henderson Lab has been selected to participate in Kidney STARS 2016 program organized by the American Society of Nephrology (ASN). Keith also received a travel grant from ASN to attend Kidney Week 2016
- The Kurosawa Lab welcomes Daniel Buhl a master’s student coming to their lab from the University of Heidelberg in Germany from November – February
- Daniel Remick, MD, just completed a four term of service as a Section Editor for the Journal of Immunology
- Publications: ACCEPTED:
- Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony Coyle, David J. Salant, Stephen Berasi, Weining Lu. “SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion.” Journal of Clinical Investigation Insight; Accepted Oct 2016
Pathology & Laboratory Medicine News Items – September 2016
- Ahmad Al-Moujahed, Pathology PhD Candidate in Dr. Demetrious Vavvas’s Lab (off-site at Massachusetts Eye and Ear Infirmary) has been selected to be a Fall 2016 fellow of the MIT IMPACT program. It is a career development program for post-doctoral and advanced pre-doctoral trainees (here is a good website for the details; http://impactprogram.mit.edu). Ahmad applied last June; he interviewed and was accepted over the Summer. Ahmad started his first session Tuesday, September 13th
- From Sandra Cerda, Cytology Fellowship Director, as of July 2016… “Accordingly, the Residency Review Committee for Pathology, functioning in accordance with the policies and procedures of the Accreditation Council for Graduate Medical Education (ACGME), has removed previous citations for the following program: Cytopathology Boston University Medical Center Program/Boston University Medical Center” Bravo!!!
- Barb Nikolajczyk, PhD was an invited speaker at the University of Kentucky, Lexington, KY, Department of Pharmacology, “Defining Inflammation in Human Obesity and Type 2 Diabetes,” September 14, 2016
- Dr Sandra Cerda collaborated with the Endocrine Department in an abstract selected for poster presentationat the 86th Annual Meeting of the AMerican Thyroid Association in Denver, Colorado from September 21 – 25, 2016: “Large Independent Prospective Study to Evaluate the Performances of ThyroSeq2 ® Multigene Next Generation Sequencing Panel Analysis on Cancer Diagnosis in Thyroid Nodules with Indeterminate Cytopathology.” Toraldo Gianluca MD, Godley Frederick A MD, Cerda Sandra R MD, Doherty Gerard MD, Braverman Lewis MD, Lee Stephanie MD
- Nader Rahimi, PhD was invited to give a lecture at the Department Pathology, Boston Children Hospital, Harvard Medical School on September 22, 2016. The title of his lecture was “Adhesion signaling in tumor growth and angiogenesis”
- Nancy S. Miller, MD was the invited speaker at the Boston area Microbiology Supervisors Meeting at Faulkner Hospital, Jamaica Plain on September 28th Dr. Miller presented “GPC Potpourri – a collection of pesky staph and streps”
- Dr. Miller will also be the ASM Distinguished Lecturer at the Fall Meeting of the New York City branch of the American Society for Microbiology, NYC, October 7, 2016. Dr. Miller will present “From the bench: Challenges, conundrums, and lessons learned in this era of improved microbial identification”
- CAP 2016:
- Lei Li, Dr. Sandra Cerda, Dr. Reine Gedeon and Dr. Carmen Sarita-Reyes had an abstract accepted for the College of American Pathologists (CAP) in Las Vegas, Nevada from September 25th-28th 2016 titled; “Acrania Without Anencephaly In The Presence Of Amniotic Band Syndrome;” Lei Li, MD, PhD., Sandra Cerda, M.D., Reine Gedeon, M.D., and Carmen Sarita-Reyes, MD
- Dr. Lei Li presenting at CAP 2016
- Also presented at CAP: Israa Laklouk, MD, Mahmoud Soliman, MD, Robert Pistey, MD, and Sandra Cerda, MD; “Primary Unresectable Locally Invasive Right Atrial Paraganglioma Presenting with Chest Pain” Presented in CAP 2106 http://www.archivesofpathology.org/
- Mahmoud Soliman presenting at CAP 2016
- Soliman was quite busy at CAP, he also presented; Mahmoud L Soliman, MD, PhD, Sandra Cerda MD, Huihong Xu MD, “An Invasive Moderately Differentiated Adenocarcinoma incidentally identified in Perforated Diverticulitis with Abscess Formation” Presented in CAP 2106 http://www.archivesofpathology.org/
- Mahmoud Soliman presenting a second poster at CAP 2016
- Welcome to our two new Masters Students:
- Subha Singh joins us directly as a McNair Scholars Fellow from the University of New Hampshire:
- Rawan Tahboub is already an accomplished physician finishing in the top of her class at Jordan University of Science and Technology:
- Publications: ACCEPTED:
- Elizabeth Moses, Teresa Wang, Sean Corbett, George R Jackson, Eduard Drizik, Catalina Perdomo, Claudia Perdomo, Eric Kleerup, Daniel Brooks, George O’Connor, Steven Dubinett, Patrick Hayden, Marc E. Lenburg, and Avrum Spira. “Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium.” Accepted to Toxicological Sciences.
- Publications: PUBLISHED:
- Hafida, S, Mirshahi, T, Nikolajczyk BS. 2016. The impact of bariatric surgery on inflammation: quenching the fire of obesity? Current Opin Endocrinol, Diab and Obesity. 23:373-8. PMID: 27455515
- Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV. 2016. BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer. Cell Mol Life Sci. (In Press). PMID: 27491296
- Moshe S, Siwak J, Tapan U, Lee SY, Meyer RD, Parrack P, Tan J, Khatami F, Francis J, Zhao Q, Hartshorn K, Kolachalama VB, Rahimi N, Chitalia V. c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors. Oncotarget. 2016 Sep 20. doi: 10.18632/oncotarget.12107