Research Program
The goal of the fellowship program is to provide a training environment that is characterized by broad clinical and research opportunities, collegiality, and flexibility. To accomplish this, we have designed a robust curriculum and mentoring system for transitioning from the clinical to research portion of the fellowship training. An active discussion is initiated during the first year to help identify a suitable research mentor and project that will commence in the second year. To help with this process, trainees are relieved of clinical duty during the midway point of first year, usually in the first week of February so they may participate in our Introduction to Research course. This program is led by the research faculty and is designed to introduce the trainees to the research opportunities available to them. During this course, trainees listen in on research presentations, attend lab meetings as well as informal lunch sessions with faculty, and have protected time to meet with faculty to discuss possible research avenues. At the beginning of the second year, trainees participate in practical research training sessions on scientific writing, research integrity, oral presentations, and grant preparation. During the second and third year, clinical time is limited to allow immersion in the laboratory or clinical research setting, giving trainees ample opportunity to develop scholarly pursuits in the field of choice. Some fellows opt to supplement their research experience by taking graduate level courses in molecular biology, immunology, bioinformatics, public health, statistics, programming, and/or epidemiology. Trainees are expected to present their work at national conferences and to publish their research findings, an important milestone for academic physicians.
The research opportunities are divided into four main sections: 1) Infection and Immunity; 2) Regenerative Medicine and Development; 3) Genomics and Bioinformatics; and 4) Clinical Research Sciences. They span over multiple disease interests including asthma/COPD, COVID-19, critical care medicine, interstitial lung disease, tobacco use/lung cancer, and pulmonary hypertension as well as various topic areas including pneumonia biology, immunology, regenerative medicine, computational biomedicine, health services, and implementation. Learn more about some of the research authored by current, recent, and former fellows including their research grant funding below.
Peer-reviewed Publications by Current, Recent, and Former Fellows 2013-2024
Publications by Topic Area: 2024-2025
Air Pollution/Environmental Research
- Zhang CL, Maccarone JR, Grady ST, Collins CM, Moy ML, Hart JE, Kang CM, Coull BA, Schwartz JD, Koutrakis P, Garshick E. Indoor and ambient black carbon and fine particulate matter associations with blood biomarkers in COPD patients. Sci Total Environ. 2024 Mar 22;927:171897. doi: 10.1016/j.scitotenv.2024.171897. Online ahead of print. PMID: 38522542.
Asthma/COPD Research
- Homer-Bouthiette C, Shen BH, Dobie AC, Shankar DA, Pang B, Law AC, Bosch NA. Practice Patterns for Acute Asthma Exacerbation in Adult Patients Admitted to US Intensive Care Units. Ann Am Thorac Soc. 2024 Jun 27. doi: 10.1513/AnnalsATS.202401-085OC. Online ahead of print. PMID: 38935672.
- Kearney CM, Sangani R, Shankar D, O’Connor GT, Law AC, Walkey AJ, Bosch NA. Comparative Effectiveness of Mepolizumab, Benralizumaband Dupilumab among Patients with Difficult-to-Control Asthma. Ann Am Thorac Soc. 2024 Jan 19. doi: 10.1513/AnnalsATS.202306-566OC. Online ahead of print. PMID: 38241013.
- Shen BH, Law AC, Wilson KC. Evidence Synthesis of Outcomes of Extracorporeal Membrane Oxygenation for Life-Threatening Asthma Exacerbations. CHEST Crit Care. 2024 Mar;2(1):100044. PMID: 38605855. PMCID: PMC11008557.
- Zhang J, Moll M, Hobbs BD, Bakke P, Regan EA, Xu H, Dupuis J, Chiles JW 3rd, McDonald MN, Divo MJ, Silverman EK, Celli BR, O’Connor GT, Cho MH. Genetically Predicted Body Mass Index and Mortality in COPD. Am J Respir Crit Care Med. 2024 Mar 12. doi: 10.1164/rccm.202308-1384OC. Online ahead of print. PMID: 38471013.
COVID-19 Research
- Ko D, Treu TM, Tarko L, Ho YL, Preis SR, Trinquart L, Gagnon DR, Monahan KM, Helm RH, Orkaby AR, Lubitz SA, Bosch NA, Walkey AJ, Cho K, Wilson PWF, Benjamin EJ. Incidence and prognostic significance of newly-diagnosed atrial fibrillation among older U.S. veterans hospitalized with COVID-19. Sci Rep. 2024 Jan 10;14(1):952. PMID: 38200186. PMCID: PMC10781702.
- Rucci JM, Law AC, Bolesta S, Quinn EK, Garcia MA, Gajic O, Boman K, Yus S, Goodspeed VM, Kumar V, Kashyap R, Walkey AJ; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry Investigator Group. Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes. CHEST Crit Care. 2024 Mar;2(1):100047. PMID: 38576856. PMCID: PMC10994221.
- Zheng R, Solomon A, DiLorenzo M, Rajendran I, Park J, Dhongade V, Garcia MA, Eberhardt RT, Sloan JM, Weinberg J, Klings ES. The Association of Anticoagulation Intensity with Outcomes in Hospitalized COVID-19 Patients. Adv Hematol. 2024 Mar 11;2024:8838308. PMID: 38500844. PMCID: PMC10948223.
Critical Care Medicine Research
- Bosch NA, Law AC, Shi Z, Jafarzadeh SR, Walkey AJ. A novel measure to summarize blood transfusion practice during critical illness. Transfusion. 2024 Mar 22. doi: 10.1111/trf.17814. Online ahead of print. PMID: 38515390.
- Bosch NA, Myers LC, Jafarzadeh SR, Wunsch H, Stevens JP, Liu VX, Walkey AJ. Temporal Trends in Use of Opioids for Patients with Acute Respiratory Failure following “Analgesia-First” Sedation Guidelines. Ann Am Thorac Soc. 2024 Jan;21(1):179-183. PMID: 37847821.
- Bosch NA, Pereira TV, Teja B. Should Fludrocortisone be Added to Hydrocortisone in Septic Shock? Probably Yes, Based on Available Evidence. Crit Care Med. 2024 Apr 1;52(4):678-682. PMID: 38483227.
- Bosch NA, Vail EA, Law AC, Homer-Bouthiette C, Walkey AJ, Moitra VK. Practice Patterns and Outcomes of Potassium Repletion Thresholds during Critical Illness. Ann Am Thorac Soc. 2024 Mar;21(3):456-463. PMID: 38134433. PMCID: PMC10913769.
- Feeney ME, Law AC, Walkey AJ, Bosch NA. Variation in Use of Medications for Opioid Use Disorder in Critically Ill Patients Across the United States. Crit Care Med. 2024 Mar 19. doi: 10.1097/CCM.0000000000006257. Online ahead of print. PMID: 38501933.
- Law AC, Bosch NA, Song Y, Tale A, Lasser KE, Walkey AJ. In-Hospital vs 30-Day Sepsis Mortality at US Safety-Net and Non-Safety-Net Hospitals. JAMA Netw Open. 2024 May 1;7(5):e2412873. PMID: 38819826. PMCID: PMC11143462.
- Teja B, Bosch NA, Diep C, Pereira TV, Mauricio P, Sklar MC, Sankar A, Wijeysundera HC, Saskin R, Walkey A, Wijeysundera DN, Wunsch H. Complication Rates of Central Venous Catheters: A Systematic Review and Meta-Analysis. JAMA Intern Med. 2024 Mar 4. doi: 10.1001/jamainternmed.2023.8232. Online ahead of print. PMID: 38436976.
- Teja B, Berube M, Pereira TV, Law AC, Schanock C, Pang B, Wunsch H, Walkey AJ, Bosch NA.Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Am J Respir Crit Care Med. 2024 Jan 25. doi: 10.1164/rccm.202310-1785OC. Online ahead of print. PMID: 38271488.
- Myers LC, Bosch NA, Soltesz L, Daly KA, Campbell CI, Schwager E, Salvati E, Stevens JP, Wunsch H, Rucci JM, Jafarzadeh SR, Liu VX, Walkey AJ. Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation. Crit Care Explor. 2024 Jul 17;6(7):e1123. PMID: 39018285. PMCID: PMC11257673.
- Myers LC, Soltesz L, Bosch N, Daly KA, Devis Y, Rucci J, Stevens J, Wunsch H, Jafarzadeh SR, Campbell CI, Liu VX, Walkey AJ. Intravenous Opioid Administration During Mechanical Ventilation and Use After Hospital Discharge. JAMA Netw Open. 2024 Jun 3;7(6):e2417292. PMID: 38874921. PMCID: PMC11179130.
- Wunsch H, Bosch NA, Law AC, Vail EA, Hua M, Shen BH, Lindenauer PK, Juurlink DN, Walkey AJ, Gershengorn HB. Evaluation of Etomidate Use and Association with Mortality Compared with Ketamine Among Critically Ill Patients. Am J Respir Crit Care Med. 2024 Aug 22. Online ahead of print. PMID: 39173173.
Health Services Research
- Ball SL, Rucci JM, Molloy-Paolillo BK, Cutrona SL, Brunner J, Mohr DC, Kim B, Moldestad M, Zepeda ED, Orlander JD, Anderson E, Cohen-Bearak A, Helfrich CD, Sayre G, Rinne ST. “For the first time…I am seriously fighting burnout”: clinician experiences with a challenging electronic health record transition. JAMIA Open. 2024 Jul 15;7(3):ooae067. PMID: 39011033. PMCID: PMC11249389.
Interstitial Lung Disease Research
- Hurley K, Ozaki M, Philippot Q, Galvin L, Crosby D, Kirwan M, Gill DR, Alysandratos KD, Jenkins G, Griese M, Nathan N, Borie R; COST Open-ILD Group Management Committee. A roadmap to precision treatments for familial pulmonary fibrosis. EBioMedicine. 2024 Jun;104:105135. PMID: 38718684. PMCID: PMC11096859.
- Shankar DA, Hawkins F, Alysandratos KD, Wilson KC, Walkey AJ, Bosch NA, Law AC. Uptake of Antifibrotics for Patients with Idiopathic Pulmonary Fibrosis: 2016-2022. Ann Am Thorac Soc. 2024 Jan;21(1):170-173. PMID: 37879035.
Medical Education Research
- Lui JK, Duke JD, Russo JV, Kelm DJ, Hinkle LJ. Leveraging multisource feedback to address diversity, equity, and inclusivity. Postgrad Med J. 2024 Jan 19:qgae002. doi: 10.1093/postmj/qgae002. Online ahead of print. PMID: 38243830.
Pneumonia Research
- Lee MM, Zuo Y, Steiling K, Mizgerd JP, Kalesan B, Walkey AJ. Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk. PLoS One. 2024 Jul 5;19(7):e0296139. PMID: 38968193. PMCID: PMC11226120.
Pulmonary Hypertension Research
- Johnson SW, Wang RS, Winter MR, Gillmeyer KR, Zeder K, Klings ES, Goldstein RH, Wiener RS, Maron BA. Cluster analysis identifies novel real-world lung disease-pulmonary hypertension subphenotypes: implications for treatment response. ERJ Open Res. 2024 May 20;10(3):00959-2023. PMID: 38770008. PMCID: PMC11103711.
Regenerative Medicine Research
- Basil MC, Alysandratos KD, Kotton DN, Morrisey EE. Lung repair and regeneration: Advanced models and insights into human disease. Cell Stem Cell. 2024 Mar 11:S1934-5909(24)00052-3. doi: 10.1016/j.stem.2024.02.009. Online ahead of print. PMID: 38492572.
- Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN. Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell. 2024 May 2;31(5):657-675.e8. PMID: 38642558. PMCID: PMC11147407.
- Koenitzer JR, Gupta DK, Twan WK, Xu H, Hadas N, Hawkins FJ, Beermann ML, Penny GM, Wamsley NT, Berical A, Major MB, Dutcher SK, Brody SL, Horani A. Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway. JCI Insight. 2024 Jul 23:e180198. Online ahead of print. PMID: 39042459.
Sickle Cell Disease Research
- Alwang AK, Law AC, Klings ES, Cohen RT, Bosch NA. Lactated Ringer vs Normal Saline Solution During Sickle Cell Vaso-Occlusive Episodes. JAMA Intern Med. 2024 Sep 9:e244428. PMID: 39250114.
Tobacco Use/Lung Cancer Research
- Flores A, Wiener RS, Hon S, Wakeman C, Howard J, Virani N, Mattus B, Foreman AG, Singh J, Rosen L, Bulekova K, Kathuria H. Sustainability of an Opt-Out Electronic-Health Record-based Tobacco Treatment Consult Service at a large safety-net hospital: A 6-year Analysis. Nicotine Tob Res. 2024 Feb 6:ntae023. PMID: 38320328.
- Kearney LE, Belancourt P, Katki HA, Tanner NT, Wiener RS, Robbins HA, Landy R, Caverly TJ. The Development and Performance of Alternative Criteria for Lung Cancer Screening. Ann Intern Med. 2024 Aug 20. Online ahead of print. PMID: 39159457.
- Kearney L, Bolton RE, Núñez ER, Boudreau JH, Sliwinski S, Herbst AN, Caverly TJ, Wiener RS. Tackling Guideline Non-concordance: Primary Care Barriers to Incorporating Life Expectancy into Lung Cancer Screening Decision-Making-A Qualitative Study. J Gen Intern Med. 2024 Mar 8. doi: 10.1007/s11606-024-08705-x. Online ahead of print. PMID: 38459413.
- Kearney LE, Jansen E, Kathuria H, Steiling K, Jones KC, Walkey A, Cordella N. Efficacy of Digital Outreach Strategies for Collecting Smoking Data: Pragmatic Randomized Trial. JMIR Form Res. 2024 Feb 9;8:e50465. doi: 10.2196/50465. PMID: 38335012. PMCID: PMC10891497.
- Kearney L, Nguyen T, Steiling K. Disparities across the continuum of lung cancer care: a review of recent literature. Curr Opin Pulm Med. 2024 Feb 26. doi: 10.1097/MCP.0000000000001064. Online ahead of print. PMID: 38411202.
- Maccarone JR, Sterns OR, Timmons A, Korpak AM, Smith NL, Nakayama KS, Baird CP, Ciminera P, Kheradmand F, Fan VS, Hart JE, Koutrakis P, Jerrett M, Kuschner WG, Ioachimescu OC, Montgrain PR, Proctor SP, Redlich CA, Wendt CH, Blanc PD, Garshick E, Wan ES. Deployment-related Cigarette Smoking Behaviors and Pulmonary Function Among U.S. Veterans. Mil Med. 2024 Mar 25:usae049. doi: 10.1093/milmed/usae049. Online ahead of print. PMID: 38536226.
- Núñez ER, Bolton RE, Boudreau JH, Sliwinski SK, Herbst AN, Kearney LE, Caverly TJ, Wiener RS. “It Can’t Hurt!”: Why Many Patients With Limited Life Expectancy Decide to Accept Lung Cancer Screening. Ann Fam Med. 2024 Mar-Apr;22(2):95-102. PMID: 38527813.
- Xiao D, Kammer MN, Chen H, Woodhouse P, Sandler KL, Baron AE, Wilson DO, Billatos E, Pu J, Maldonado F, Deppen SA, Grogan EL. Assessing the transportability of radiomic models for lung cancer diagnosis: commercial vs. open-source feature extractors. Transl Lung Cancer Res. 2024 Aug 31;13(8):1907-1917. PMID: 39263016. PMCID: PMC11384473.
Publications by Topic Area: 2023-2024
Air Pollution/Environmental Research
- Maccarone J, Grady ST, Moy ML, Hart JE, Kang CM, Coull BA, Schwartz JD, Koutrakis P, Zhang J, Garshick E. Indoor (residential) and ambient particulate matter associations with urinary oxidative stress biomarkers in a COPD cohort. Sci Total Environ. 2023 Nov 1;897:165352. PMID: 37419349.
Asthma/COPD Research
- Mettler SK, Nath HP, Grumley S, Orejas JL, Dolliver WR, Nardelli P, Yen AA, Kligerman SJ, Jacobs K, Manapragada PP, Abozeed M, Aziz MU, Zahid M, Ahmed AN, Terry NL, Elalami R, Estépar RSJ, Sonavane S, Billatos E, Wang W, Estépar RSJ, Richards JB, Cho MH, Diaz AA. Silent Airway Mucus Plugs in COPD and Clinical Implications. Chest. 2023 Nov 25:S0012-3692(23)05825-7. doi: 10.1016/j.chest.2023.11.033. Online ahead of print. PMID: 38013161.
Computational Biomedicine Research
- Bruhm DC, Mathios D, Foda ZH, Annapragada AV, Medina JE, Adleff V, Chiao EJ, Ferreira L, Cristiano S, White JR, Mazzilli SA, Billatos E, Spira A, Zaidi AH, Mueller J, Kim AK, Anagnostou V, Phallen J, Scharpf RB, Velculescu VE. Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer. Nat Genet. 2023 Aug;55(8):1301-1310. PMID: 37500728. PMCID: PMC10412448.
- Marmor HN, Deppen SA, Welty V, Kammer MN, Godfrey CM, Patel K, Maldonado F, Chen H, Starnes SL, Wilson DO, Billatos E, Grogan EL. Improving Lung Cancer Diagnosis with CT Radiomics and Serum Histoplasmosis Testing. Cancer Epidemiol Biomarkers Prev. 2023 Mar 6;32(3):329-336. PMID: 36535650. PMCID: PMC10128087.
- Marmor HN, Kammer MN, Deppen SA, Shipe M, Welty VF, Patel K, Godfrey C, Billatos E, Herman JG, Wilson DO, Kussrow AK, Bornhop DJ, Maldonado F, Chen H, Grogan EL. Improving lung cancer diagnosis with cancer, fungal, and imaging biomarkers. J Thorac Cardiovasc Surg. 2023 Sep;166(3):669-678.e4. PMID: 36792410. PMCID: PMC10287834.
- Menon AA, Lee M, Ke X, Putman RK, Hino T, Rose JA, Duan F, Ash SY, Cho MH, O’Connor GT, Dupuis J, Hatabu H, Lenburg ME, Billatos ES, Hunninghake GM; DECAMP Investigators. Bronchial epithelial gene expression and interstitial lung abnormalities. Respir Res. 2023 Oct 10;24(1):245. PMID: 37817229. PMCID: PMC10566143.
- Xu K, Diaz AA, Duan F, Lee M, Xiao X, Liu H, Liu G, Cho MH, Gower AC, Alekseyev YO, Spira A, Aberle DR, Washko GR, Billatos E, Lenburg ME; DECAMP investigators. Bronchial gene expression alterations associated with radiological bronchiectasis. Eur Respir J. 2023 Jan 27;61(1):2200120. PMID: 36229050. PMCID: PMC9881226.
COVID-19 Research
- Audhya X, Bosch NA, Stevens JP, Walkey AJ, Law AC. Changes to Hospital Availability of Prone Positioning after the COVID-19 Pandemic. Ann Am Thorac Soc. 2022 Sep;19(9):1610-1613. PMID: 35580345. PMCID: PMC9447395.
- Bosch NA, Law AC, Peterson D, Walkey AJ. Validation of the International Classification of Diseases Code for COVID-19 among Critically Ill Patients. Ann Am Thorac Soc. 2022 May;19(5):861-863. PMID: 34851812. PMCID: PMC9116339.
- Herrera VLM, Bosch NA, Lok JJ, Nguyen MQ, Lenae KA, deKay JT, Ryzhov SV, Seder DB, Ruiz-Opazo N, Walkey AJ. Circulating neutrophil extracellular trap (NET)-forming ‘rogue’ neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19- an observational study. Transl Med Commun. 2023;8(1):12. PMID: 37096233. PMCID: PMC10111078.
- Kearney C, Lesieur M, Bosch NA, Walkey AJ. Corticosteroid Uptake For COVID-19 after Publication of RECOVERY: A Difference in Difference Model. Ann Am Thorac Soc. 2023 Mar;20(3):473-476. PMID: 36525470. PMCID: PMC9993153.
- Shankar DA, Bosch NA, Walkey AJ, Law AC. Practice Changes Among Patients Without COVID-19 Receiving Mechanical Ventilation During the Early COVID-19 Pandemic. Crit Care Explor. 2023 Apr 3;5(4):e0889. PMID: 37025306. PMCID: PMC10072312.
Critical Care Medicine Research
- Bosch NA, Law AC, Vail EA, Gillmeyer KR, Gershengorn HB, Wunsch H, Walkey AJ. Inhaled Nitric Oxide vs Epoprostenol During Acute Respiratory Failure: An Observational Target Trial Emulation. Chest. 2022 Dec;162(6):1287-1296. PMID: 35952768. PMCID: PMC9899639.
- Bosch NA, Law AC, Walkey AJ. Phenobarbital for Severe Alcohol Withdrawal Syndrome: A Multicenter Retrospective Cohort Study. Am J Respir Crit Care Med. 2022 Nov 1;206(9):1171-1174. PMID: 35833888.
- Bosch NA, Lee MM, LeSieur MN, Law AC, Walkey AJ. Death due to irreversible hypoxemic respiratory failure in ARDSnet clinical trials. J Crit Care. 2022 Feb;67:85-87. PMID: 34735903. PMCID: PMC8671319.
- Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med. 2023 May 1;183(5):451-459. PMID: 36972033.
- Bosch NA, Teja B, Law AC, Wunsch H, Walkey AJ. Arterial Pressure Response to an Increase in Norepinephrine Varies Depending on the Baseline Norepinephrine Dose in Patients With Septic Shock. Chest. 2023 Nov;164(5):1228-1231. PMID: 37169282.
- Dinh J, Hinkle CF, Law AC, Walkey AJ, Bosch NA. Effect of Respiratory Viral Panel Adoption on Antibiotic Use in Ventilated Patients. Ann Am Thorac Soc. 2023 Dec;20(12):1777-1783. PMID: 37748086.
- Gandotra S, Wunsch H, Bosch NA, Walkey AJ, Teja B. Reducing Central Venous Catheter Use through Adoption of Guidelines for Peripheral Catheter-based Vasopressor Delivery. Ann Am Thorac Soc. 2023 Aug;20(8):1219-1223. PMID: 37220220.
- Garcia MA, Bosch NA, Peltan ID, Walkey AJ. Variation in Troponin I Measurement and the Cardiovascular Management Approach Following Elevated Troponin I Among Critically Ill Patients With Sepsis. Crit Care Explor. 2023 Jan 10;5(1):e0842. PMID: 36699250. PMCID: PMC9833455.
- Jarzebowski ML, Hill AD, Burry L, Bosch NA, Viglianti EM, Teja B, Wunsch H. Patterns of opioid prescribing in mechanically ventilated patients with septic shock. Br J Anaesth. 2023 Dec;131(6):e197-e199. PMID: 37863771.
- Law AC, Bosch NA, Peterson D, Walkey AJ. Comparison of Heart Rate After Phenylephrine vs Norepinephrine Initiation in Patients With Septic Shock and Atrial Fibrillation. Chest. 2022 Oct;162(4):796-803. PMID: 35526604. PMCID: PMC9808602.
- Law AC, Bosch NA, Song Y, Tale A, Yeh RW, Kahn JM, Stevens JP, Walkey AJ. Patient Outcomes After Long-Term Acute Care Hospital Closures. JAMA Netw Open. 2023 Nov 1;6(11):e2344377. PMID: 37988077. PMCID: PMC10663966.
- Lee SY, Modzelewski KL, Law AC, Walkey AJ, Pearce EN, Bosch NA. Comparison of Propylthiouracil vs Methimazole for Thyroid Storm in Critically Ill Patients. JAMA Netw Open. 2023 Apr 3;6(4):e238655. PMID: 37067797. PMCID: PMC10111182.
- LeSieur MN, Bosch NA, Walkey AJ. Hospital Variation in Mortality and Ventilator Management among Mechanically Ventilated Patients with ARDS. J Intensive Care Med. 2023 Feb;38(2):179-187. PMID: 35786134.
- Li J, Luo J, Pavlov I, Perez Y, Tan W, Roca O, Tavernier E, Kharat A, McNicholas B, Ibarra-Estrada M, Vines DL, Bosch NA, Rampon G, Simpson SQ, Walkey AJ, Fralick M, Verma A, Razak F, Harris T, Laffey JG, Guerin C, Ehrmann S; Awake Prone Positioning Meta-Analysis Group.
- Pang B, Kearney L, Maccarone J, Zhang J, Kearney C, Sangani R, Shankar DA, Gillmeyer KR, Law AC, Bosch NA. Association between Early Venous Thromboembolism Prophylaxis, Bleeding Risk, and Venous Thromboembolism among Critically Ill Patients with Thrombocytopenia. Ann Am Thorac Soc. 2023 Jun;20(6):917-920. PMID: 36867519.
- Teja B, Bosch NA, Walkey AJ. How We Escalate Vasopressor and Corticosteroid Therapy in Patients With Septic Shock. Chest. 2023 Mar;163(3):567-574. PMID: 36162481.
- Vail EA, Bosch NA, Law AC, Gershengorn HB, Wunsch H, Walkey AJ. Adoption of a Novel Vasopressor Agent in Critically Ill Adults. Ann Am Thorac Soc. 2023 Nov;20(11):1662-1667. PMID: 37590119.
Health Services Research
- Ahlness EA, Orlander J, Brunner J, Cutrona SL, Kim B, Molloy-Paolillo BK, Rinne ST, Rucci J, Sayre G, Anderson E. “Everything’s so Role-Specific”: VA Employee Perspectives’ on Electronic Health Record (EHR) Transition Implications for Roles and Responsibilities. J Gen Intern Med. 2023 Oct;38(Suppl 4):991-998. PMID: 37798577. PMCID: PMC10593626.
- Anderson E, Krones A, Vimalananda VG, Cutrona SL, Orlander JD, Strymish JL, Rinne ST. Understanding suboptimal e-consult requests: lessons from the VA. Am J Manag Care. 2023 Dec 1;29(12):e378-e385. PMID: 38170529.
- Miake-Lye IM, Cogan AM, Mak S, Brunner J, Rinne S, Brayton CE, Krones A, Ross TE, Burton JT, Weiner M. Transitioning from One Electronic Health Record to Another: A Systematic Review. J Gen Intern Med. 2023 Oct;38(Suppl 4):956-964. PMID: 37798580. PMCID: PMC10593710.
- Molloy-Paolillo B, Mohr D, Levy DR, Cutrona SL, Anderson E, Rucci J, Helfrich C, Sayre G, Rinne ST. Assessing Electronic Health Record (EHR) Use during a Major EHR Transition: An Innovative Mixed Methods Approach. J Gen Intern Med. 2023 Oct;38(Suppl 4):999-1006. PMID: 37798584. PMCID: PMC10593729.
- Rucci JM, Ball S, Brunner J, Moldestad M, Cutrona SL, Sayre G, Rinne S. “Like One Long Battle:” Employee Perspectives of the Simultaneous Impact of COVID-19 and an Electronic Health Record Transition. J Gen Intern Med. 2023 Oct;38(Suppl 4):1040-1048. PMID: 37798583. PMCID: PMC10593661.
Interstitial Lung Disease Research
- Mesfin N, Sangani R, Shankar DA, Reardon C. New Frontiers in Therapeutics for Interstitial Lung Diseases. Am J Respir Crit Care Med. 2023 Apr 15;207(8):1089-1091. PMID: 36735934.
- Shankar DA, Walkey AJ, Hawkins FJ, Bosch NA, Peterson D, Law AC. Hospital-level variation in practices and outcomes for patients with severe acute exacerbations of idiopathic pulmonary fibrosis: a retrospective multicentre cohort study. BMJ Open Respir Res. 2023 Apr;10(1):e001593. PMID: 37076251. PMCID: PMC10124258.
Medical Education Research
- Wong DH, Lui JK. Telehealth and virtual learning. Clin Teach. 2023 Aug;20(4):e13581. PMID: 37157137.
- Lui JK, Duke JD, Russo JV, Kelm DJ, Hinkle LJ. Multisource feedback in health professions education. Clin Teach. 2023 Feb;20(1):e13555. PMID: 36446412.
Obstructive Sleep Apnea Research
- Donovan LM, Hoyos CM, Kimoff RJ, Morrell MJ, Bosch NA, Chooljian DM, McEvoy RD, Sawyer AM, Wagner TH, Al-Lamee RR, Bishop D, Carno MA, Epstein M, Hanson M, Ip MSM, Létourneau M, Pamidi S, Patel SR, Pépin JL, Punjabi NM, Redline S, Thornton JD, Patil SP. Strategies to Assess the Effect of Continuous Positive Airway Pressure on Long-Term Clinically Important Outcomes among Patients with Symptomatic Obstructive Sleep Apnea: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 Jul;20(7):931-943. PMID: 37387624.
Pulmonary Hypertension Research
- El-Adili F, Lui JK, Najem M, Farina G, Trojanowska M, Sam F, Bujor AM. Periostin overexpression in scleroderma cardiac tissue and its utility as a marker for disease complications. Arthritis Res Ther. 2022 Nov 11;24(1):251. PMID: 36369212. PMCID: PMC9650849.
- Gillespie ML, Spring MR, Cohen RT, Klings ES. The interplay of sleep disordered breathing, nocturnal hypoxemia, and endothelial dysfunction in sickle cell disease. Prog Pediatr Cardiol. 2023 Mar;68:101602. doi: 10.1016/j.ppedcard.2022.101602.
- Gillmeyer KR, Johnson SW, Bolton RE, McCullough MB, Wiener RS. Organization of pulmonary hypertension care in non-expert care settings: Lessons learned from a multi-site study. Health Serv Res. 2023 Jun;58(3):663-673. PMID: 36518045.
- Lui JK, Cozzolino M, Winburn M, Trojanowski MA, Wiener RS, LaValley MP, Bujor AM, Gopal DM, Klings ES. Chest. 2023 Dec 19:S0012-3692(23)05932-9. doi: 10.1016/j.chest.2023.12.018. Online ahead of print. PMID: 38128607.
- Lui JK, Gillmeyer KR, Sangani RA, Smyth RJ, Gopal DM, Trojanowski MA, Bujor AM, Soylemez Wiener R, LaValley MP, Klings ES. A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension. Lung. 2023 Dec;201(6):565-569. PMID: 37957388. Role of Left Ventricular Dysfunction in Systemic Sclerosis-Related Pulmonary Hypertension.
- Lui JK, Sangani RA, Gillmeyer KR, Vakhshoorzadeh J, Trojanowski MA, Bujor AM, Gopal DM, Wiener RS, LaValley MP, Klings ES. Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension. Cardiovasc Drugs Ther. 2023 Jan 6:10.1007/s10557-022-07420-1. doi: 10.1007/s10557-022-07420-1. Online ahead of print. PMID: 36607535.
- Morland K, Gerges C, Elwing J, Visovatti SH, Weatherald J, Gillmeyer KR, Sahay S, Mathai SC, Boucly A, Williams PG, Harikrishnan S, Minty EP, Hobohm L, Jose A, Badagliacca R, Lau EMT, Jing ZC, Vanderpool RR, Fauvel C, Leonidas Alves J Jr, Strange G, Pulido T, Qian J, Li M, Mercurio V, Zelt JGE, Moles VM, Cirulis MM, Nikkho SM, Benza RL, Elliott CG. Real-world evidence to advance knowledge in pulmonary hypertension: Status, challenges, and opportunities. A consensus statement from the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative’s Real-world Evidence Working Group. Pulm Circ. 2023 Dec 21;13(4):e12317. PMID: 38144948. PMCID: PMC10739115.
- Vakhshoorzadeh J, Lui JK, Sangani RA, Trojanowski MA, Bujor AM, LaValley MP, Klings ES. Emphysema and interstitial lung disease in systemic sclerosis-related pulmonary hypertension. Respir Med. 2023 Sep;216:107333. PMID: 37336329.
Regenerative Medicine Research
- Ma L, Thapa BR, Le Suer JA, Tilston-Lünel A, Herriges MJ, Berical A, Beermann ML, Wang F, Bawa PS, Kohn A, Ysasi AB, Kiyokawa H, Matte TM, Randell SH, Varelas X, Hawkins FJ, Kotton DN. Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell. 2023 Sep 7;30(9):1199-1216.e7. PMID: 37625411.
Tobacco Use/Lung Cancer Research
- Booras A, Wiener RS, Maccarone J, Stokes AC, Fetterman JL, Hamburg NM, Singh J, Bulekova K, Kathuria H. A Longitudinal Study of Perceptions of the Massachusetts Menthol Ban and Its Impact on Smoking Behaviors among Marginalized Individuals. Int J Environ Res Public Health. 2023 May 11;20(10):5790. PMID: 37239518. PMCID: PMC10218059.
- Kearney LE, Butler C, Nunez ER, Qian S, Slatore CG, Spalluto L, Wiener RS. Highly variable reporting of incidental findings in a national cohort of US veterans screened for lung cancer. Clin Imaging. 2023 Aug;100:21-23. doi: 10.1016/j.clinimag.2023.04.017. Epub 2023 May 2. PMID: 37146522.
- Núñez ER, Gould MK, Wiener RS. Time to Update Lung-RADS v1.1? Incorporating evidence from recent observational studies. J Am Coll Radiol. 2023 Sep;20(9):915-918. PMID: 35970258. PMCID: PMC10612120.
- Núñez ER, Slatore CG, Tanner NT, Melzer AC, Crothers KA, Lewis JA, Fabbrini AE, Brown JK, Wiener RS. National Survey of Lung Cancer Screening Practices in Veterans Health Administration Facilities. Am J Prev Med. 2023 Nov;65(5):901-905. PMID: 37169315.
- Shusterman S, Villarreal-Calderon R, Gunawan A, Gallardo Foreman A, O’Donnell C, Wakeman C, Javeed H, Keteyian J, Howard J, Bulekova K, de Silva S, Campbell T, Lasser K, Kathuria H. A Financial Incentives Program to Promote Smoking Cessation Among Recently Hospitalized Individuals: Feasibility and Acceptability Study. JMIR Form Res. 2023 May 29;7:e44979. PMID: 37247216. PMCID: PMC10262029.
- Van Lewen D, Janke T, Austin R, Lee H, Billatos E, Russo S. A Millimeter-Scale Soft Robot for Tissue Biopsy Procedures. Adv Intell Syst. 2023 May;5(5):2200326. PMID: 37637939.
- Vazirani A, Rodriguez A, Pavesi F, McDermott S, Cabral H, Billatos E, Suzuki K. Black race and lower age at surgery are associated with smoking relapse in a safety-net setting after surgery for stage I non-small cell lung cancer. J Thorac Dis. 2023 Sep 28;15(9):4757-4764. PMID: 37868906. PMCID: PMC10586932.
Publications by Topic Area: 2022-2023
Asthma/COPD Research
- Zhang J, Xu H, Qiao D, DeMeo DL, Silverman EK, O’Connor GT, Hobbs BD, Dupuis J, Cho MH, Moll M. A polygenic risk score and age of diagnosis of COPD. Eur Respir J. 2022 Sep 15;60(3):2101954. PMID: 35115341. PMCID: PMC9969342.
COVID-19 Research
- Garcia MA, Johnson SW, Sisson EK, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Bogojevic M, Domecq JP, Lal A, Heavner S, Cheruku SR, Lee D, Anderson HL, Denson JL, Gajic O, Kashyap R, Walkey AJ; from the Society of Critical Care Medicine’s Discovery Viral Infection and Respiratory Illness Universal Study Investigators. Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19. Respir Care. 2022 Aug;67(8):929-938. PMID: 35672139. PMCID: PMC9451494.
- Kee J, Thudium S, Renner DM, Glastad K, Palozola K, Zhang Z, Li Y, Lan Y, Cesare J, Poleshko A, Kiseleva AA, Truitt R, Cardenas-Diaz FL, Zhang X, Xie X, Kotton DN, Alysandratos KD, Epstein JA, Shi PY, Yang W, Morrisey E, Garcia BA, Berger SL, Weiss SR, Korb E. SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry. Nature. 2022 Oct;610(7931):381-388. PMID: 36198800. PMCID: PMC9533993.
- Johnson SW, Garcia MA, Sisson EKQ, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Lal A, Domecq JP, Melamed RR, Christie AB, Husain A, Yus S, Gajic O, Kashyap R, Walkey AJ. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19. Crit Care Explor. 2022 Feb 18;10(2):e0638. PMID: 35211681. PMCID: PMC8860338.
- Law AC, Peterson D, Walkey AJ, Bosch NA. Lottery-Based Incentives and COVID-19 Vaccination Rates in the US. JAMA Intern Med. 2022 Feb 1;182(2):235-237. PMID: 34982111. PMCID: PMC8728655.
- Li J, Luo J, Pavlov I, Perez Y, Tan W, Roca O, Tavernier E, Kharat A, McNicholas B, Ibarra-Estrada M, Vines DL, Bosch NA, Rampon G, Simpson SQ, Walkey AJ, Fralick M, Verma A, Razak F, Harris T, Laffey JG, Guerin C, Ehrmann S; Awake Prone Positioning Meta-Analysis Group. Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis. Lancet Respir Med. 2022 Jun;10(6):573-583. PMID: 35305308. PMCID: PMC8926412.
- Mesfin N, Wormwood J, Wiener RS, Still M, Xu CS, Palmer J, Linsky AM. Impact of the COVID-19 Pandemic on Providing Recommendations During Goals-of-Care Conversations: A Multisite Survey. J Palliat Med. 2023 Jul;26(7):951-959. PMID: 36944150.
- Palmer JA, Mccullough M, Wormwood J, Soylemez Wiener R, Mesfin N, Still M, Xu CS, Linsky AM. Addressing clinician moral distress: Implications from a mixed methods evaluation during Covid-19. PLoS One. 2023 Sep 15;18(9):e0291542. PMID: 37713379. PMCID: PMC10503769.
- Pare JR, Gjesteby LA, Telfer BA, Tonelli MM, Leo MM, Billatos E, Scalera J, Brattain LJ. Transfer Learning for Automated COVID-19 B-Line Classification in Lung Ultrasound. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:1675-1681. PMID: 36086232.
- Rampon G, Jia S, Agrawal R, Arnold N, Martín-Quirόs A, Fischer EA, Malatack J, Jagan N, Sergew A, Case AH, Miller K, Tanios M, Doros G, Ross CS, Garcia MA, Gillmeyer KR, Griffiths NG, Jandali B, Modzelewski KL, Rucci JM, Simpson SQ, Walkey AJ, Bosch NA. Smartphone-Guided Self-prone Positioning vs Usual Care in Nonintubated Hospital Ward Patients With COVID-19: A Pragmatic Randomized Clinical Trial. Chest. 2022 Oct;162(4):782-791. PMID: 35597286. PMCID: PMC9116967.
- Rucci JM, Bosch NA, Peterson D, Walkey AJ. Estimating the Impact of COVID-19 on Invasive Mechanical Ventilation Trends in the United States. Ann Am Thorac Soc. 2022 Dec;19(12):2105-2108. PMID: 35857409. PMCID: PMC9743481.
- Xu K, Shi X, Husted C, Hong R, Wang Y, Ning B, Sullivan TB, Rieger-Christ KM, Duan F, Marques H, Gower AC, Xiao X, Liu H, Liu G, Duclos G, Platt M, Spira AE, Mazzilli SA, Billatos E, Lenburg ME, Campbell JD, Beane JE. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Sci Rep. 2022 Oct 28;12(1):18168. PMID: 36307504. PMCID: PMC9615627.
Critical Care Research
- Bosch NA, Law AC, Bor J, Myers LC, Roubinian NH, Liu VX, Walkey AJ. Red Blood Cell Transfusion at a Hemoglobin Threshold of 7 g/dl in Critically Ill Patients: A Regression Discontinuity Study. Ann Am Thorac Soc. 2022 Jul;19(7):1177-1184. PMID: 35119978. PMCID: PMC9278636.
- Bosch NA, Law AC, Rucci JM, Peterson D, Walkey AJ. Predictive Validity of the Sequential Organ Failure Assessment Score versus Claims-based Scores among Critically Ill Patients. Ann Am Thorac Soc. 2022 Jun;19(6):1072-1076. PMID: 35266866. PMCID: PMC9797032.
- Law AC, Bosch NA, Walkey AJ. Procedure Codes for Intubated Prone Positioning: A Turn for the Better. Ann Am Thorac Soc. 2022 Oct;19(10):1634-1635. PMID: 35608404. PMCID: PMC9528737.
- Rucci JM, Bosch NA, Quinn EK, Chon KH, McManus DD, Walkey AJ. External Validation of a Risk Score for Daily Prediction of Atrial Fibrillation among Critically Ill Patients with Sepsis. Ann Am Thorac Soc. 2022 Apr;19(4):697-701. PMID: 34914569. PMCID: PMC8996280.
- Teja B, Bosch NA, Wijeysundera DN, Wijeysundera HC, Saskin R, Hill AD, Stelfox HT, Walkey AJ, Wunsch H. First-Line Vasopressor Use in Septic Shock and Route of Administration: An Epidemiologic Study. Ann Am Thorac Soc. 2022 Oct;19(10):1713-1721. PMID: 35709214.
Pulmonary Hypertension Research
- Gillmeyer KR, Rinne ST, Qian SX, Maron BA, Johnson SW, Klings ES, Wiener RS. Socioeconomically disadvantaged veterans experience treatment delays for pulmonary arterial hypertension. Pulm Circ. 2022 Oct 1;12(4):e12171. PMID: 36568691. PMCID: PMC9768567.
- Johnson SW, Finlay L, Mathai SC, Goldstein RH, Maron BA. Real-world use of inhaled treprostinil for lung disease-pulmonary hypertension: A protocol for patient evaluation and prescribing. Pulm Circ. 2022 Jul 1;12(3):e12126. PMID: 36092795. PMCID: PMC9450844.
- Johnson SW, Gillmeyer KR, Bolton RE, McCullough MB, Qian SX, Maron BA, Klings ES, Wiener RS. Variable Monitoring of Veterans with Group 3 Pulmonary Hypertension Treated with Off-Label Pulmonary Vasodilator Therapy. Ann Am Thorac Soc. 2022 Jul;19(7):1236-1239. PMID: 35312466. PMCID: PMC9278628.
- Johnson SW, Maron BA. COUNTERPOINT: Did the World Symposium on Pulmonary Hypertension Get It Right in Redefining Abnormal Pulmonary Arterial Pressure? No. Chest. 2022 Feb;161(2):313-315. PMID: 35131055.
- Johnson SW, Maron BA. Rebuttal From Drs Johnson and Maron. Chest. 2022 Feb;161(2):316-317. PMID: 35131057.
- Lui JK, Gillmeyer KR, Sangani RA, Smyth RJ, Gopal DM, Trojanowski MA, Bujor AM, Soylemez Wiener R, LaValley MP, Klings ES. A Multimodal Prediction Model for Diagnosing Pulmonary Hypertension in Systemic Sclerosis. Arthritis Care Res (Hoboken). 2023 Jul;75(7):1462-1468. PMID: 35678779.
- Lui JK, Sangani RA, Chen CA, Bujor AM, Trojanowski MA, Gopal DM, LaValley MP, Soylemez Wiener R, Klings ES. Prognostic Value of Cardiac Axis Deviation in Systemic Sclerosis-Related Pulmonary Hypertension. Arthritis Care Res (Hoboken). 2022 Jul;74(7):1219-1226. PMID: 34085410. PMCID: PMC8639831.
- Sangani RA, Lui JK, Gillmeyer KR, Trojanowski MA, Bujor AM, LaValley MP, Klings ES. Clinical characteristics and outcomes in pulmonary manifestations of systemic sclerosis: Contribution from pulmonary hypertension and interstitial lung disease severity. Pulm Circ. 2022 Oct 1;12(4):e12117. PMID: 36238967. PMCID: PMC9535436.
- Walsh KF, Lui JK. Post-tuberculosis pulmonary hypertension: a case of global disparity in health care. Lancet Glob Health. 2022 Apr;10(4):e476. PMID: 35303453.
Regenerative Medicine Research
- Abo KM, Sainz de Aja J, Lindstrom-Vautrin J, Alysandratos KD, Richards A, Garcia-de-Alba C, Huang J, Hix OT, Werder RB, Bullitt E, Hinds A, Falconer I, Villacorta-Martin C, Jaenisch R, Kim CF, Kotton DN, Wilson AA. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI Insight. 2022 Mar 22;7(6):e155589. PMID: 35315362. PMCID: PMC8986076.
- Berical A, Beermann ML, Suzuki S, LeSuer J, Matte T, Davis B, Kotton D, Hawkins F. Generation of Airway Epithelial Cell Air-Liquid Interface Cultures from Human Pluripotent Stem Cells. J Vis Exp. 2022 Jun 14;(184). PMID: 35781291.
- Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ. A multimodal iPSC platform for cystic fibrosis drug testing. Nat Commun. 2022 Jul 29;13(1):4270. PMID: 35906215. PMCID: PMC9338271.
- Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, Bullitt E, Ericsson M, White MR, Turcinovic J, Thao TTN, Hekman RM, Kaserman JE, Huang J, Alysandratos KD, Toth GE, Jakab F, Kotton DN, Wilson AA, Emili A, Thiel V, Connor JH, Kemenesi G, Cifuentes D, Mühlberger E. Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog. 2022 Feb 4;18(2):e1010268. PMID: 35120176. PMCID: PMC8849519.
- Kaserman JE, Werder RB, Wang F, Matte T, Higgins MI, Dodge M, Lindstrom-Vautrin J, Bawa P, Hinds A, Bullitt E, Caballero IS, Shi X, Gerszten RE, Brunetti-Pierri N, Liesa M, Villacorta-Martin C, Hollenberg AN, Kotton DN, Wilson AA. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Rep. 2022 Dec 6;41(10):111775. PMID: 36476855. PMCID: PMC9780780.
- Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 2022 Jan;24(1):10-23. PMID: 34969962. PMCID: PMC8761168.
- Scoon WA, Mancio-Silva L, Suder EL, Villacorta-Martin C, Lindstrom-Vautrin J, Bernbaum JG, Mazur S, Johnson RF, Olejnik J, Flores EY, Mithal A, Wang F, Hume AJ, Kaserman JE, March-Riera S, Wilson AA, Bhatia SN, Mühlberger E, Mostoslavsky G. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes. Stem Cell Reports. 2022 Oct 11;17(10):2286-2302. PMID: 36084636. PMCID: PMC9561183.
- Sitaraman S, Alysandratos KD, Wambach JA, Limberis MP. Gene Therapeutics for Surfactant Dysfunction Disorders: Targeting the Alveolar Type 2 Epithelial Cell. Hum Gene Ther. 2022 Oct;33(19-20):1011-1022. PMID: 36166236. PMCID: PMC9595619.
- Werder RB, Huang J, Abo KM, Hix OT, Minakin K, Alysandratos KD, Merritt C, Berthiaume K, Alber AB, Burgess CL, Kotton DN, Wilson AA. Generating 3D Spheres and 2D Air-Liquid Interface Cultures of Human Induced Pluripotent Stem Cell-Derived Type 2 Alveolar Epithelial Cells. J Vis Exp. 2022 Apr 15;(182). PMID: 35499347.
Tobacco Use/Lung Cancer Research
- Kathuria H, Shankar D, Cobb V, Newman J, Bulekova K, Werntz S, Borrelli B. Integrating Social Determinants of Health With Tobacco Treatment for Individuals With Opioid Use Disorder: Feasibility and Acceptability Study of Delivery Through Text Messaging. JMIR Form Res. 2022 Sep 1;6(9):e36919. PMID: 36048509. PMCID: PMC9478816.
- Kearney L, Wiener RS, Dahodwala M, Fix GM, Hicks J, Little F, Howard J, Foreman AG, Wakeman C, O’Donnell C, Bulekova K, Drainoni ML, Kathuria H. A mixed methods study to inform and evaluate a longitudinal nurse practitioner/community health worker intervention to address social determinants of health and chronic obstructive pulmonary disease self-management. BMC Pulm Med. 2022 Mar 1;22(1):74. PMID: 35232414.
- Núñez ER, Caverly TJ, Zhang S, Glickman ME, Qian SX, Boudreau JH, Miller DR, Wiener RS. Invasive Procedures and Associated Complications After Initial Lung Cancer Screening in a National Cohort of Veterans. Chest. 2022 Aug;162(2):475-484. PMID: 35231480. PMCID: PMC9424329.
- Núñez ER, Caverly TJ, Zhang S, Glickman ME, Qian SX, Boudreau JH, Miller DR, Slatore CG, Wiener RS. Factors Associated With Declining Lung Cancer Screening After Discussion With a Physician in a Cohort of US Veterans. JAMA Netw Open. 2022 Aug 1;5(8):e2227126. PMID: 35972738. PMCID: PMC9382440.
- Shankar D, Borrelli B, Cobb V, Quintiliani LM, Palfai T, Weinstein Z, Bulekova K, Kathuria H. Text-messaging to promote smoking cessation among individuals with opioid use disorder: quantitative and qualitative evaluation. BMC Public Health. 2022 Apr 6;22(1):668. PMID: 35387648.
Current/Recent Fellows (bolded & underlined); Former Fellows 2013-2019 (bolded)
Research Funding Awards by Current, Recent, and Former Fellows 2013-2024
NIH/VA Research Funding Awards
Fellowship Year | Name | Grant Number | Title |
2020 | Divya Shankar | 1F32HL168959 | Corticosteroids for Acute Exacerbations of Idiopathic Pulmonary Fibrosis: Patterns and Outcomes |
2020 | Daniel “DJ” Wallman | 1F32HL170761 | Map the human airway basal cell niche and the role that FGFR2 plays within it |
2019 | Shelsey Johnson | 1F32HL164090 | Novel methods to sub-phenotype patients with pulmonary hypertension due to chronic lung disease with implications for treatment |
2018 | Michael “Mike” Garcia | 1F32HL160062 | Characterizing contemporary practices in the approach to elevated troponin I levels during sepsis |
2018 | Jin Yuan | 1F32HL160094 | The Role of Lung Multiciliated Cell MIWI2 in Influenza Pathogenesis |
2018 | Eduardo “Eddie” Nunez | 1F32CA265053 | Determining organizational structures and processes that improve lung cancer screening adherence among underserved populations |
2017 | Justin Lui | 1F32HL156614 | Left Ventricular Strain in Systemic Sclerosis-related Pulmonary Hypertension |
2016 | Kari Gillmeyer | 1F32HL149236 | Determining disparities in treatment of pulmonary arterial hypertension nationally |
CDA 22-140 |
Veteran-Centered Transformation of Pulmonary Hypertension Organization into a Regional Model of Care in VA (TRANSPHORM-VA)
|
||
2016 | Nicholas “Nick” Bosch | 1F32GM133061 | Normalizing vasopressor dose to standardize vasopressors practice in septic shock |
1K23HL173709 | A Learning Health System Approach to Improve the Effectiveness of Blood Transfusions during Septic Shock | ||
2015 | Konstantinos “Kostas” Alysandratos | 1K08HL163494 | Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis |
Foundation/Industry Research Funding Awards
Fellowship Year | Name | Foundation/Industry | Title |
2020 | Daniel “DJ” Wallman | American Lung Association Catalyst Award | Genotype to Phenotype Assessment of Primary Ciliary Dyskinesia Variants in Under Studied Populations |
2020 | Divya Shankar | American Lung Association Catalyst Award | Addressing racial and ethnic disparities in pulmonary fibrosis diagnostic-treatment pathways: A pre-intervention study |
2020 | Anat Kohn | Cystic Fibrosis Foundation | Preclinical murine model for targeted airway cell transplantation |
2019 | Erin Crossey | American Heart Association | Origin and function of lung lymphatic endothelial cell subsets during Influenza-induced lymphangiogenesis |
2018 | Robert “Rob” Smyth | International Association for Study of Lung Cancer | Development of a lung cancer nasal gene expression classified in patients with indeterminate pulmonary nodules |
2018 | Eduardo “Eddie” Nunez | LUNGevity Foundation | Improving lung cancer screening adherence among underserved populations |
2017 | Justin Lui | American Heart Association | Role of regional left ventricular strain patterns in systemic sclerosis-related pulmonary hypertension |
National Scleroderma Foundation | Cardiac strain phenotyping of systemic sclerosis-related pulmonary hypertension | ||
United Therapeutics Corporation | Biomarkers of Left Ventricular Strain in Systemic Sclerosis-related Pulmonary Hypertension | ||
2016 | Kari Gillmeyer | Parker B. Francis Fellowship Program | Characterizing Care Coordination in Pulmonary Hypertension: A Mixed Methods Study |
Doris Duke Foundation – Doris Duke Fund to Retain Clinical Scientists | Characterizing Care Coordination in Pulmonary Hypertension: A Mixed Methods Study | ||
2016 | Eric Abston | CHEST Foundation | Noninvasive Quantification of Pulmonary Fibrosis Due to Radiation Induced Lung Injury Using [68Ga]CBP8 Type 1 Collagen Probe |
2016 | Nicholas “Nick” Bosch | American Heart Association | Improving the Effective Use of Blood Transfusions During Critical Illness for Patients with Heart Failure |
2016 | Andrew Berical | Emily’s Entourage | In-vivo human airway epithelial cells for CFTR gene therapy |
Cystic Fibrosis Foundation | iPSC-Derived Small Airway Epithelial Cells as a Novel Model for Cystic Fibrosis | ||
Cystic Fibrosis Foundation | A multi-omic and genetically-controlled assessment of iPSC-derived airway cells to advance therapies for CF | ||
2015 | Konstantinos “Kostas” Alysandratos | Pulmonary Fibrosis Foundation | Utilizing a pluripotent stem cell model system to unravel the pathogenesis of pulmonary fibrosis |
2014 | Killian Hurley | Alpha-1 Foundation | Modelling AATD Lung Disease Using Alveolar Epithelial Cells Derived from Gene-Edited iPSC |
2013 | Ehab Billatos | Aquyre Biosciences, Inc. | Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens |
Veracyte Inc. | NIGHTNGALE: Clinical Utility of Management of Patients with CT and LDCT Identified Pulmonary Nodules Using the Percepta Nasal Swab Classifier | ||
Johnson & Johnson | DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers | ||
Novartis Institutes for BioMedical Research | DECAMP Novartis: Infrastructure and Science | ||
Janssen Research & Development, LLC | DECAMP | ||
2013 | Jonathan “Jon” Iaccarino | Charles A. Kings Trust | Comorbidities in Lung Cancer Screening: Improving Decision-Making and Patient Selection |
Conquer Cancer Foundation of ASCO | Effect of serious comorbidities on lung cancer screening decision-making and outcomes | ||
2013 | Joseph “Joe” Kaserman | Alpha-1 Foundation | CRISPR-DIRECTED Editing Of Patient-iPSCs To Determine Genetic Contributors |
Alpha-1 Foundation | Defining PiMZ AATD Liver Disease Susceptibility with CRISPR Targeted Syngeneic iPSCs | ||
Alpha-1 Foundation | Mechanisms of Hepatic Heterogeneity and ATF6 Mediated Metabolic Dysfunction in AATD |
BU/BMC Research Funding Awards
Fellowship Year | Name | BU/BMC | Award | Title |
2021 | Lauren Kearney | BMC | Health Equity Accelerator Seed Grant | Advancing Health Equity in Lung Cancer Screening – Understanding the Perspective of Black Patients at a Large Safety Net Hospital |
2020 | Daniel “DJ” Wallman | BU | BU Ignition Award | CilioMAP: Ciliopathy Genotype to Phenotype Mapping |
2017 | Justin Lui | BU | CTSI Integrated Pilot Grant | Cardiopulmonary Biomarkers of Systemic Sclerosis |
2016 | Kari Gillmeyer | BU | CTSI Integrated Pilot Grant | Characterizing Care Coordination in Pulmonary Hypertension: A Qualitative Study |
2016 | Nicholas “Nick” Bosch | BU | CTSI KL2 Career Development Award | A Learning Health System Approach to Identify the Optimal Initiation of Secondary Vasopressors in Septic Shock |
2015 | Konstantinos “Kostas” Alysandratos | BU | CTSI Integrated Pilot Grant | A Patient-Specific Induced Pluripotent Stem Cell (iPSC)-based Organoid Model of Pulmonary Fibrosis |
2013 | Joseph “Joe” Kaserman | BU | CTSI Integrated Pilot Grant | Determining Contributions of Hepatocyte Heterogeneity to ZZ AATD-Associated Liver Disease |