Children’s Interstitial Lung Disease (chILD) Induced Pluripotent Stem Cell (iPSC) Biorepository

No chILD left behind

See our catalogue to request an iPSC line

Welcome to the Children’s Interstitial Lung Disease (chILD) iPSC Biorepository.

Childhood/Children’s interstitial lung disease — also known as Children’s interstitial and diffuse lung disease — is a group of rare pediatric lung disorders, including more than 30 subtypes under this umbrella. For more information about the disease, clinical care for those affected and their families, or for more information on the latest research related to these disorders, please refer to the chILD Foundation website.

Through our catalogue you can access induced pluripotent stem cell (iPSC) lines generated by reprogramming somatic cells (blood or fibroblasts) procured with informed consent from patients with children’s interstitial lung disease (chILD). The resulting stem cell lines are archived as frozen, shareable vials housed in our Center for Regenerative Medicine at Boston University and Boston Medical Center. Please access the searchable catalogue of these lines at this link, where information on how to request the lines from our iPSC Core facility is also detailed.

When you click on the above link, you will be taken to a searchable catalogue; try clicking on the “interstitial lung disease” drop down tab, or try typing in the search window the phrase “interstitial lung disease”, or simply type in a gene name relevant to chILD risk (e.g ABCA3, SFTPC, SFTPB, NKX2-1, FOXF1, TBX4, HPS etc).


Lung tissue section

The chILD iPSC Biorepository was launched thanks to an ignition grant from the chILD Foundation (read about this grant award from the Foundation here). We thank the chILD Foundation and the HPS Network, Inc for their generous grant support and the NIH/NHLBI for a U01 consortium grant and R24/N01 resource sharing grants that made the launch of this bank possible. We are particularly grateful to the volunteers, patients, and their family members who donated samples to the repository. We also thank our many physician-scientist collaborators and research leaders from across the country who contributed to and supported this bank, especially Drs. Deterding (U. Colorado), Wambach, Cole and Hamvas (Washington U. St. Louis), Casey, Fishman, and Holtz (Boston Children’s Hospital), Nogee (Johns Hopkins), Austin (Vanderbilt), and Whitsett (Cincinnati Children’s Hospital) .