Paul Maglione, MD, PhD
Assistant Professor of Medicine
MD/PhD, Albert Einstein College of Medicine
Dr. Maglione studies human B cell biology through the lens of primary immunodeficiency. Dr. Maglione’s clinical focus on antibody deficiency syndromes dovetails with his research focus on mechanisms of B cell dysfunction in humans. For numerous years, he has been investigating mechanisms underlying non-infectious complications of the most prevalent form of symptomatic primary antibody deficiency, common variable immunodeficiency (CVID). Recent work has focused upon the pathogenesis of interstitial lung disease affecting CVID patients, particularly upon the biology of B cell dysfunction in this disease. Dr. Maglione has helped devise therapeutic strategies to treat gastrointestinal and pulmonary complications of common variable immunodeficiency. His research utilizes high throughput strategies that include seromics, antibody arrays, genomics, and RNA sequencing coupled with cell culture, biopsies, and information from the medical record to define how B cell defects shape human disease.
In addition to running a research laboratory, Dr. Maglione provides clinical care for patients with immunodeficiency disorders and has particular interest and expertise in common variable immunodeficiency (CVID) and its related complications, including chronic lung disease. His publications include identification of novel biomarkers and treatment of CVID interstitial lung disease.