Mutant CTRC gene has a new way to trigger pancreatitis
GSI faculty member Miklos Sahin-Toth and colleague (Department of Molecular & Cell Biology, GSDM) have demonstrated that misfolding of mutant digestive enzymes also kills acinar cells —those that make and give out digestive enzymes. Click here for details. Szmola R, Sahin-Toth M. Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells. Gut. 2009 Nov 30. [Epub ahead of print] PubMed PMID: 19951900