Researchers Shed Light on Signaling Pathway Responsible for Head and Neck Cancers

A new study from researchers at Boston University Chobanian & Avedisian School of Medicine shows how computational approaches can drive important biomedical discoveries. The study aimed to better characterize oral tumor heterogeneity, including aggressive cell subpopulations, and identify candidate vulnerabilities that could be targeted therapeutically. The findings are of timely significance, providing new information about […]

Identifying New Biomarkers to Detect Lung Cancer Earlier

Source: NIH National Cancer Institute, Division of Cancer Prevention  Lung cancer, the leading cause of cancer deaths worldwide killing 1.8 million people each year, is often diagnosed at an advanced stage when the chances for a cure are limited. In the United States, almost 60% of people diagnosed with localized lung and bronchus cancer are […]

Thesis Defenses – Zhe Wang and Ke Xu

Congratulations to CBM PhD candidates Zhe Wang and Ke Xu, who both passed their thesis defenses on Thursday, April 8. Zhe Wang, of the Campbell lab, defended his thesis entitled“Enhancing Preprocessing and Clustering of Single-Cell RNA Sequencing Data” and Ke Xu, of the Spira/Lenburg lab, defended his thesis entitled “Airway Gene Expression Alterations in Association […]

New Publication – Contextualized Protein-Protein Interactions

Source: Patterns Highlights We present PPI Context: contextualization of existing literature-curated PPIs A resource for filtering PPIs by cell-line information mined from reporting studies A fast and flexible pipeline implementing the presented data mining method The Bigger Picture Existing literature-curated protein-protein interaction (PPI) databases usually aggregate cell-type-agnostic interactions, yet PPIs are dependent on environmental conditions. […]