Subchondral bone length in knee osteoarthritis: A deep learning derived imaging measure and its association with radiographic and clinical outcomes
(Source: Wiley Online Library)
New Publication from Dr. Vijaya Kochalama, Assistant Professor of Medicine in the Section of Computational Biomedicine. Please see below for a brief summary and click the link to read the full article.
Objective
Develop a bone shape measure that reflects the extent of cartilage loss and bone flattening in knee osteoarthritis (OA) and test it against estimates of disease severity.
Methods
A fast region‐based convolutional neural network was trained to crop the knee joints in sagittal dual‐echo steady state MRI sequences obtained from the Osteoarthritis Initiative (OAI). Publicly available annotations of the cartilage and menisci were used as references to annotate the tibia and the femur in 61 knees. Another deep neural network (U‐Net) was developed to learn these annotations. Model predictions were compared with radiologist‐driven annotations on an independent test set (27 knees). The U‐Net was applied to automatically extract the knee joint structures on the larger OAI dataset (9,434 knees). We defined subchondral bone length (SBL), a novel shape measure characterizing the extent of overlying cartilage and bone flattening, and examined its relationship with radiographic joint space narrowing (JSN), concurrent WOMAC pain and disability as well as subsequent partial or total knee replacement (KR). Odds ratios for each outcome were estimated using relative changes in SBL on the OAI dataset into quartiles.