Dr. Joshua Campbell Receives Shipley Prostate Cancer Pilot Grant Award

Source: BU School of Medicine

Dr. Joshua Campbell, Assistant Professor Medicine/Computational Biomedicine, received a Shipley Prostate Cancer Pilot Grant Award. Please see below for more information on Dr. Campbell’s joint project with Drs. Gerald Denis and Andrew Emili:

Protein-protein interactions (PPIs), which constitute an essential step in cell biology that, when disrupted, can cause profound functional abnormalities, are important to understand. Drs. Campbell and Denis will work with Pathology & Laboratory Medicine to grow organoid cultures from prostatectomy derived from patients with low- and high-grade disease. Specific subpopulations of epithelial cells will be sorted using flow cytometry and then profiled with mass spectrometry using Dr. Emili’s precision facilities of the BU Center for Network Systems Biology to identify differences in protein abundance or connectivity in protein interaction networks between grades in each cell type. Overall these data will identify key cofactors for aggressive disease.